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| 1 | 1770年以来青藏高原错鄂地区古气候定量恢复显示文摘通过对1999年所采错鄂CE 1孔自生碳酸盐碳、氧同位素与1955—1999年器测温度降水资料的统计分析,获取了自生碳酸盐碳、氧同位素与气候要素的定量关系,并据此恢复了1770年以来该地区的古气候。结果表明,错鄂沉积物中自生方解石氧同位素与气温显示出较好的正相关性,而与降水相关性不明显;碳同位素刚好相反,它与降水负相关,而与气温相关性不显著。1770年以来,错鄂地区在20世纪初气候环境发生了根本的改变,1900年以前降水偏少,为沼泽环境,1900年后降水增加,湖泊发育;1900年前后气温开始上升,30年代后期气温达到峰值,50年代初气温稍有下降。1935—1999年平均气温较前一百多年升高了近1℃。所获结果有较好的区域对比性。 | 吴艳宏 王苏民 夏威岚 李世杰 Gerhard H Schleser Andreas Luecke | 2003 | 海洋地质与第四纪地质2003，23，4： | 12 |
| 2 | 仿真外科训练系统在微创外科的应用显示文摘目的 通过比较计算机模拟仿真训练和传统训练模型的训练效果,对模拟仿真训练的有效性和可行性进行评价。方法 17名低年外科医生和24名医学生被随机分成4组,分别受到计算机模拟仿真训练或传统训练模型的训练1 h。在接受训练后,他们将在传统训练模型中接受连续缝合测试30 min,根据完成缝合的数量和准确性来评价被测试者的能力。结果 无论接受何种训练,低年外科医生的测试结果都优于医学生,尤其在缝合速度方面。无论低年外科医生还是医学生,接受计算机模拟仿真训练的测试结果优于传统训练。结论 计算机模拟仿真训练将可能在腹腔镜外科训练中发挥重要作用。 | 夏强 Gerhard Hbarth Mustafa Yanik Selman Uranüs Gerhard Bretthauer | 2002 | 中华消化内镜杂志2002，19，6： | 5 |
| 3 | Comprehensive evaluation of the metabolic effects of insect meal from Tenebrio molitor L.in growing pigs by transcriptomics, metabolomics and lipidomics显示文摘Background:The hypothesis was tested that insect meal(IM)as protein source influences intermediary metabolism of growing pigs.To test this,30 male,5-week-old crossbred pigs were randomly assigned to 3 groups of 10 pigs each with similar body weights(BW)and fed isonitrogenous diets either without(CON)or with 5%IM(IM5)or 10%IM(IM10)from Tenebrio molitor L.for 4 weeks and key metabolic tissues(liver,muscle,plasma)were analyzed using omics-techniques.Results:Most performance parameters did not differ across the groups,whereas ileal digestibilities of most amino acids were 6.7 to 15.6%-units lower in IM10 than in CON(P<0.05).Transcriptomics of liver and skeletal muscle revealed a total of 166 and 198,respectively,transcripts differentially expressed between IM10 and CON(P<0.05).Plasma metabolomics revealed higher concentrations of alanine,citrulline,glutamate,proline,serine,tyrosine and valine and a lower concentration of asparagine in IM10 than in CON(P<0.05).Only one out of fourteen quantifiable amino acid metabolites,namely methionine sulfoxide(MetS),in plasma was elevated by 45%and 71%in IM5 and IM10,respectively,compared to CON(P<0.05).Plasma concentrations of both,major carnitine/acylcarnitine species and bile acids were not different across groups.Lipidomics of liver and plasma demonstrated no differences in the concentrations of triacylglycerols,cholesterol and the main phospholipids,lysophospholipids and sphingolipids between groups.The percentages of all individual phosphatidylcholine(PC)and phosphatidylethanolamine(PE)species in the liver showed no differences between groups,except those with 6 double bonds(PC 38:6,PC 40:6,PE 38:6,PE 40:6),which were markedly lower in IM10 than in CON(P<0.05).In line with this,the percentage of C22:6n-3 in hepatic total lipids was lower in IM10 than in the other groups(P<0.05).Conclusions:Comprehensive analyzes of the transcriptome,lipidome and metabolome of key metabolic tissues indicate that partial or complete replacement of a conventional protein source by IM in the diet has only a weak impact on the intermediary metabolism of growing pigs.Thus,it is concluded that IM from Tenebrio molitor L.can be used as a dietary source of protein in pigs without causing adverse effects on metabolism. | Sandra Meyer Denise K.Gessner Maria S.Braune Theresa Friedhoff Erika Most Marcus Höring Gerhard Liebisch Holger Zorn Klaus Eder Robert Ringseis | 2020 | Journal of Animal Science and Biotechnology2020，11，2： | 4 |
| 4 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis: Special situations显示文摘 | Gert Van Assche Axel Dignass Bernd Bokemeyer Silvio Danese Paolo Gionchetti Gabriele Moser Laurent Beaugerie Fernando Gomollón Winfried H?user Klaus Herrlinger Bas Oldenburg Julian Panes Francisco Portela Gerhard Rogler Jürgen Stein Herbert Tilg Simon Tra | 2012 | Journal of Crohn’s and Colitis2012，，： | 4 |
| 5 | 海洋真菌Aspergillus sp.中的抗肿瘤成分显示文摘目的:研究一株分离自条斑紫菜丝状体上的真菌代谢产物的活性成分。方法:利用电镜观察真菌形态特征,利用MEA培养基进行大规模发酵,经硅胶层析、葡聚糖凝胶层析等各种层析手段分离化合物,通过波谱技术鉴定化合物结构,并利用MTT法测定化合物抗肿瘤活性。结果:该菌属于曲霉属,分离得到了两个化合物1和2,分别为cyclo(L-Trp-L-Phe)(1)和WIN64821(2)。MTT法测试结果表明,cyclo(L-Trp-L-Phe)和WIN64821对37株人体肿瘤细胞株具有中等细胞毒活性,其平均IC50分别为3.3和5.8μg·mL-1。结论:第一次报道这两种化合物的抗肿瘤活性。 | 丁玲 李富超 秦梅 秦松 KELTER Gerhard FIEBIG Heinz H LAATSCH Hartmut | 2008 | 中国天然药物2008，6，6： | 3 |
| 6 | Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication显示文摘 | Hilde M van der Schaar Lonneke van der Linden Kjerstin H W Lanke Jeroen R P M Strating Gerhard Purstinger Erik de Vries Cornelis A M de Haan Johan Neyts Frank J M van Kuppeveld | 2012 | Cell Research2012，22，11： | 3 |
| 7 | Ion beam synthesis of diamond-like carbon thin films containing copper nanocrystals 显示文摘 | Gerhards I Ronning C Hofsass H | 2003 | Journal of Applied Physics2003，93，2： | 1 |
| 8 | The digital front-end of software radio terminals 显示文摘 | Tim H Matthias H Gerhard F | 1999 | IEEE Personal Communications1999，6，8： | 1 |
| 9 | Specific detection of carci-noembryonic antigen2 expressing tumor cells in bone marrow aspirates by polymerase chain reaction显示文摘 | Gerhard M Juhl H Kalthoff H | 1994 | J Clin Onco11994，12，4： | 1 |
| 10 | Value of the prednisolone test in my opathydiagnosis显示文摘 | Jorg J Gerhard H | 1984 | Fortschr NeurolPsychiatar1984，52，： | 1 |
| 11 | Racl in human breast cancer: Ovcrexpression, mutation analysis, and characterization of a new isoform, Racl b 显示文摘 | Sehnelzer A Prechtel D Knaus U Dehne K Gerhard M Graeff H | 2000 | Oncogene2000，19，26： | 1 |
| 12 | Specific detection of carcinoembryonic antigenexpressing tumor cells in bone marrow aspirates by polymerase chain reaction 显示文摘 | Gerhard M Juhl H Kalthoff H | 1994 | J Clin Oncol1994，12，4： | 1 |
| 13 | Value of the prednisolonetestin myopathy diagnosis显示文摘 | Jorg J Gerhard H | 1984 | Forrschr Neurol Psychiatar1984，52，1： | 1 |
| 14 | Pressure calculation in polar and charged systems using Ewald summation: results for the extended simple point charge model water显示文摘 | GERHARD H NIELS G J | 1998 | Journal of Chemical Physics1998，109，7： | 1 |
| 15 | Air-water gas transfer in uniform channel flow显示文摘 | Douglas B M Gerhard H J | 1999 | Journal of hydraulic engineering1999，125，1： | 1 |
| 16 | Detection of Herpes Simplex Vi- rus DNA by Real - Time PCR显示文摘 | Harald H Gerhard M Beate R | 2000 | J Clin Microbiol2000，38，7： | 1 |
| 17 | Cyclodextrin rotaxanes and polyrotaxanes显示文摘 | Gerhard W Han B H Axel M | 2006 | Chemical Reviews2006，106，： | 1 |
| 18 | Immunological biomark- ers of tuberculosis显示文摘 | Gerhard W Katharina R Willem H | 2011 | Nat Rev Immunol2011，5，11： | 1 |
| 19 | Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reaction显示文摘 | Juhi H Kalthoff H | 1994 | J Clin Oncol1994，12，4： | 1 |
| 20 | Specific detection of carcinoembryonic antigen- expressing tumor cells in bone marrow aspirates by polymerase chain reaction显示文摘 | Juhl H Kalthoff H | 1994 | J Clin Oncol1994，12，4： | 1 |
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