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| 1 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 2 | Complex behaviour of trivalent rare earth elements by humic acids显示文摘ComplexbehaviouroftrivalentrareearthelementsbyhumicacidsGengAnchaoResearchInstituteofEnvironmentalEngineering,FushunPetrole... | Geng An chaoResearch Institute of Environmental Engineering,Fushun Petroleum Institute,Liaoning 113001,ChinaZhang Shen Institute of Geography,Chinese Academy of Sciences,Beijing 100101,ChinaHarald Hфiland Department of Chemistry,Univers | 1998 | Journal of Environmental Sciences1998，10，3： | 4 |
| 3 | Photochemical internalization (PCI) of immunotoxins targeting CD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties显示文摘 | Monica Bostad Kristian Berg Anders H?gset Ellen Skarpen Harald Stenmark P?l K. Selbo | 2013 | Journal of Controlled Release2013，，3： | 4 |
| 4 | Binding pathway determines norepinephrine selectivity for the human β_(1)AR over β_(2)AR显示文摘Beta adrenergic receptors(βARs)mediate physiologic responses to the catecholamines epinephrine and norepinephrine released by the sympathetic nervous system.While the hormone epinephrine binds β_(1)AR and β_(2)AR with similar affinity,the smaller neurotransmitter norepinephrine is approximately tenfold selective for the β_(1)AR.To understand the structural basis for this physiologically important selectivity,we solved the crystal structures of the human β_(1)AR bound to an antagonist carazolol and different agonists including norepinephrine,epinephrine and BI-167107.Structural comparison revealed that the catecholamine-binding pockets are identical between β_(1)AR and β_(2)AR,but the extracellular vestibules have different shapes and electrostatic properties.Metadynamics simulations and mutagenesis studies revealed that these differences influence the path norepinephrine takes to the orthosteric pocket and contribute to the different association rates and thus different affinities. | Xinyu Xu Jonas Kaindl Mary J.Clark Harald Hübner Kunio Hirata Roger K.Sunahara Peter Gmeiner Brian K.Kobilka Xiangyu Liu | 2021 | Cell Research2021，31，5： | 2 |
| 5 | Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial显示文摘 | Caroline AH Klazen Paul NM Lohle Jolanda de Vries Frits H Jansen Alexander V Tielbeek Marion C Blonk Alexander Venmans Willem Jan J van Rooij Marinus C Schoemaker Job R Juttmann Tjoen H Lo Harald JJ Verhaar Yolanda van der Graaf Kaspar J van Everdingen Al | 2010 | 2010 (9746)2010，，9746： | 2 |
| 6 | Polymer mierocapsules by interfacial polyaddition between styrene-maleic anhydride copolymers and amines显示文摘 | Harald D H Stover | 2002 | Journal of Membrane Science2002，209，2： | 1 |
| 7 | ClC-3 is a critical regulator of thecell cycle in normal and malignant glial cells显示文摘 | Christa H Michelle O Harald S | 2008 | J Neurosci2008，9，： | 1 |
| 8 | The Swiss lithoclast:a new device for endoscopic stone disintegration显示文摘 | Harald S Gerald H Marco P | 1993 | J urol1993，149，3： | 1 |
| 9 | Gender Differences in the Outcome of Cardiac Interventions显示文摘 | Prof. Dr. Harald Tillmanns Wolfgang Waas Reinhard Voss Erika Grempels Hans H?lschermann Werner Haberbosch Bernd Waldecker | 2005 | Herz Kardiovaskul?re Erkrankungen2005，，5： | 1 |
| 10 | 肿瘤18F-FDG PET/MRI全身显像专家共识(德国)显示文摘PET/MRI一体机在2006年被首次提出可应用于临床;2010年,首台临床型PET/MRI一体机诞生。在20世纪早期,PET/CT和SPECT/CT一体机的广泛应用体现了融合显像的优势,为PET/MRI一体机的产生奠定了基础。目前,全球大约有150台全身PET/MRI一体机投入了临床应用,其中肿瘤显像是PET/MRI的主要应用领域之一。迄今为止,尽管PET/MRI临床应用在增加,但标准化的PET/MRI扫描方案还很少。因此,有必要制定患者检查和多中心研究都可遵循的标准化且一致性好的显像方案。该文总结了18F-脱氧葡萄糖(FDG)PET/MRI全身显像的患者就诊、检查准备、工作流程、显像方案以及报告书写等主要方面的专家共识,由长期使用PET、MRI和较早使用PET/MRI的相关资深专家制定。 | 王洋洋 杨光杰(译) 王振光(审校) Lale Umutlu Thomas Beyer Johannes Stefan Grueneisen Christoph Rischpler Harald H Quick Veit-Haibach Patrick Matthias Eiber Sandra Purz Gerald Antoch Sergios Gatidis Konstantin Nikolaou Jürgen FSchaefer IvoRausch Herrmann Ken K.Herrmann B.J.Krause S.O.Schoenberg L.Umutlu F.Anton G.Antoch M.Hacker M.Luster S.Neumann D.Vorwerk | 2020 | 中华核医学与分子影像杂志2020，40，9： | 1 |
| 11 | Conservative management of thoracolumbar and lumbar spine eompression and burst fractures:functional and radiographic outcomes in 136 cases treated by closed reduction and casting显示文摘 | Patrick W Arthur S Harald H | 2009 | Arch Orthop Trauma surg2009，129，： | 1 |
| 12 | Synthesis and Biological Investigations of Dopaminergic Partial Agonists Preferentially Recognizing the D4 Receptor Subtype 显示文摘 | Stefan L Harald H Peter G | 2006 | Bioorg Med Chem Lett2006，16，11： | 1 |
| 13 | Detection of Herpes Simplex Vi- rus DNA by Real - Time PCR显示文摘 | Harald H Gerhard M Beate R | 2000 | J Clin Microbiol2000，38，7： | 1 |
| 14 | Free radical and thermal curing of terpyridine modified terpolymers 显示文摘 | Harald H Abdelkrim E Ulrich S S | 2004 | Journal of Polymer Science Part A:Polymer Chemistry2004，42，40： | 1 |
| 15 | Growth mechanism of poly(divinylbenzene) microspheres in precipitation polymerization显示文摘 | Jeffrey S D Li W H Harald D H | 1999 | Macromolecules1999，32，： | 1 |
| 16 | Perspective on future role of biological markers in clinical therapy trials of Alzheimer's dis- ease : A long-range point of view beyond 2020 显示文摘 | Harald H Simone L Stefan JT | 2014 | Biochem Pharmacol2014，88，4： | 1 |
| 17 | Cross-approximate entropy of cortical local field potentials quantifies effects of anesthesia-a pilot study in rats显示文摘 | Kreuzer M Harald H Autkowiak B | 2010 | BMC Neuroscience2010，11，： | 1 |
| 18 | Stimulation of TNF receptor type 2 expands regulatory T cells and ameliorates established collagen-induced arthritis in mice显示文摘Tumor necrosis factor(TNF)and its receptors TNF receptor type 1(TNFR1)and type 2(TNFR2)have a central role in chronic inflammatory diseases.While TNFR1 mainly confers inflammation,activation of TNFR2 elicits not only pro-inflammatory but also anti-inflammatory effects.In this study,we wanted to investigate the anti-inflammatory therapeutic potential of selective activation of TNFR2 in mice with established collageninduced arthritis.Mice with established arthritis induced by immunization with bovine collagen type II were treated with six injections of the TNFR2-specific agonist TNCscTNF80,given every second day.Two days after treatment cessation,the cell compositions of bone marrow,spleen and lymph nodes were analyzed.Mice were visually scored until day 30 after the start of therapy and the degree of joint inflammation was determined by histology.Treatment with TNCscTNF80 increased arthritis-induced myelopoiesis.Little effect was seen on the infiltration rate of inflammatory immature myeloid cells and on the reduction of lymphoid cells in secondary lymphoid organs.Upon treatment,frequency of regulatory T(Treg)cells in the CD4+T-cell population was increased in both spleen and inguinal lymph nodes.In addition,the expression of TNFR2 on Treg cells was enhanced.The clinical score started to improve 1 week after cessation treatment and remained lower 30 days after initiation of therapy.The histological score also revealed amelioration of joint inflammation in TNCscTNF80-treated versus control mice.Activation of TNFR2 might provide a suitable therapeutic strategy in autoimmune arthritis by increasing the numbers of regulatory cell types,in particular Treg cells,and by attenuation of arthritis. | Vanessa Lamontain Tobias Schmid Dorothea Weber-Steffens David Zeller Zsuzsa Jenei-Lanzl Harald Wajant Rainer H Straub Daniela N Männel | 2019 | Cellular & Molecular Immunology2019，16，1： | 1 |
| 19 | Interventional MRA and intravascular imaging显示文摘 | Mare E L Harald H Q Jorg F D | 2000 | JMRI2000，12，： | 1 |
| 20 | The swiss lithoclast:a new device for endoscopic stone disintegration显示文摘 | Harald S Garald H Marco P | 1993 | J Urol1993，149，1： | 1 |
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