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| 1 | PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies显示文摘 | Yonghui Sun Xingwang Zhao Ning Ding Hongying Gao Yue Wu Yiqing Yang Meng Zhao Jinseok Hwang Yuqin Song Wanli Liu Yu Rao | 2018 | Cell Research2018，28，7： | 29 |
| 2 | Correlation between the cumulative analgesic effect of electroacupuncture intervention and synaptic plasticity of hypothalamic paraventricular nucleus neurons in rats with sciatica显示文摘In the present study, a rat model of chronic neuropathic pain was established by ligation of the sciatic nerve and a model of learning and memory impairment was established by ovariectomy to investigate the analgesic effect of repeated electroacupuncture stimulation at bilateral Zusanli (ST36) and Yanglingquan (GB34). In addition, associated synaptic changes in neurons in the paraventricular nucleus of the hypothalamus were examined. Results indicate that the thermal pain threshold (paw withdrawal latency) was significantly increased in rats subjected to 2-week electroacupuncture intervention compared with 2-day electroacupuncture, but the analgesic effect was weakened remarkably in ovariectomized rats with chronic constrictive injury. 2-week electroacupuncture intervention substantially reversed the chronic constrictive injury-induced increase in the synaptic cleft width and thinning of the postsynaptic density. These findings indicate that repeated electroacupuncture at bilateral Zusanli and Yanglingquan has a cumulative analgesic effect and can effectively relieve chronic neuropathic pain by remodeling the synaptic structure of the hypothalamic paraventricular nucleus. | Qiuling Xu Tao Liu Shuping Chen Yonghui Gao Junying Wang Lina Qiao Junling Liu | 2013 | Neural Regeneration Research2013，8，3： | 6 |
| 3 | A Scheme for a Sustainable Urban Water Environmental System During the Urbanization Process in China显示文摘 | Huibin Yu Yonghui Song Xin Chang Hongjie Gao Jianfeng Peng | 2018 | Engineering2018，4，2： | 6 |
| 4 | FAK-targeting PROTAC as a chemical tool for the investigation of non-enzymatic FAK function in mice显示文摘Dear Editor,Animal models,most commonly mice,that lack a protein of interest play an important role in phenotypic and functional studies of a target gene,allowing researchers to answer various biological questions(Chaible et al,2010).At pre-sent,a variety of tools act at the DNA or RNA level to enable researchers to model gene function(and thus protein)deficiency,including nucleic acid based RNA interference(EI-bashir et al.,2001),antisense oligonucleotides(Schoch and Miller,2017),and genome editing-based CRISPR-Cas9(Doudna and Charpentier,2014)strategies.However,challenges remain. | Hongying Gao Chunwei Zheng Jian Du Yue Wu Yonghui Sun Chunsheng Han Kehkooi Kee Yu Rao | 2020 | Protein & Cell2020，11，7： | 5 |
| 5 | Acupuncture effects on the hippocampal cholinergic system in a rat model of neuropathic pain显示文摘The present study observed the effects of repeated electroacupuncture of Zusanli (ST36) and Yanglingquan (GB34) on expression of hippocampal acetylcholinesterase, vesicular acetylcholine transporter, and muscarinic M1 receptor mRNA in chronic constrictive injury (neuropathic pain) and/or ovariotomy rats. Results demonstrated increased expression of hippocampal acetylcholinesterase, vesicular acetylcholine transporter, and muscarinic M1 receptor mRNA, as well as decreased pain threshold, in a rat model of chronic neuropathic pain after electroacupuncture. The effects of electroacupuncture increased with prolonged time, but the above-mentioned effects decreased in memory-deficient animals. Results indicated that repeated electroacupuncture has a cumulative analgesic effect, which is closely associated with upregulation of acetylcholinesterase and vesicular acetylcholine transporter activity, as well as M1 receptor mRNA expression and memory. | Junying Wang Junling Liu Shuping Chen Yonghui Gao Fanying Meng Lina Qiao | 2012 | Neural Regeneration Research2012，7，3： | 4 |
| 6 | Differential protein expression in spinal cord tissue of a rabbit model of spinal cordischemia/reperfusion injury显示文摘New Zealand rabbits were randomly divided into an ischemia group(occlusion of the abdominal aorta for 60 minutes),an ischemia-reperfusion group(occlusion of the abdominal aorta for 60 minutes followed by 48 hours of reperfusion) and a sham-surgery group.Two-dimensional gel electrophoresis detected 49 differentially expressed proteins in spinal cord tissue from the ischemia and ischemia/reperfusion groups and 23 of them were identified by mass spectrometry.In the ischemia group,the expression of eight proteins was up regulated,and that of the remaining four proteins was down regulated.In the ischemia/reperfusion group,the expression of four proteins was up regulated,and that of two proteins was down regulated.In the sham-surgery group,only one protein was detected.In the ischemia and ischemia/reperfusion groups,four proteins overlapped between groups with the same differential expression,including three that were up regulated and one down regulated.These proteins were related to energy metabolism,cell defense,inflammatory mechanism and cell signaling. | Qi Gao Yonghui Liang Xiaoyu Yang Guifeng Liu Xiaoxue Li Benqing Zhu Jian Liu Maoguang Yang Weiwei Xia Jian Dong Jianhang Jiao | 2012 | Neural Regeneration Research2012，7，20： | 4 |
| 7 | Acute carbon monoxide poisoning in Shandong, China: an observational study显示文摘Background: Carbon monoxide (CO) poisoning remains a major cause of accidental injuries and multiple studies have indicated that CO is also associated with significantly severe or long-term toxicity to the central nervous system. Given that CO poisoning causes serious morbidity and mortality, a better understanding of epidemiological features and clinical characteristics of acute CO poisoning in China is crucial.Methods: We collected the clinical data of acute CO poisoning in patients between November 2019 and April 2020 across Shandong province, China and analyzed its characteristics focusing on the weekly amount and the severity of the confirmed cases.Results: A total number of 21,088 acute CO poisoning cases were diagnosed. The overall incidence of acute CO poisoning was approximately 0.021%. On severity rankings, 63% of confirmed cases (n=13,378) were mild, 27%(n=5635) were moderate, and 10% (n=2075) were severe. Interestingly, the coastal cities had more confirmed cases than the inland/suburban areas in Shandong. Meanwhile, the number of confirmed cases was negatively correlated with the local mean daily temperature (P=0.0167).Conclusions: Mild acute CO poisoning cases accounted for the majority of all confirmed cases during the winter of 2019. In Shandong province, which is located in east China, residents of the coastal cities are more susceptible to CO poisoning than residents of inland cities. | Lina Zhang Di Wu Mingyue Xu Yonghui Bian Youcun Wang Guangkai Gao Qing Sun | 2022 | Chinese Medical Journal2022，，13： | 4 |
| 8 | The cumulative analgesic effect of repeated electroacupuncture involves synaptic remodeling in the hippocampal CA3 region显示文摘In the present study, we examined the analgesic effect of repeated electroacupuncture at bilateral Zusanli (ST36) and Yanglingquan (GB34) once a day for 14 consecutive days in a rat model of chronic sciatic nerve constriction injury-induced neuropathic pain. In addition, concomitant changes in calcium/calmodulin-dependent protein kinase II expression and synaptic ultrastructure of neurons in the hippocampal CA3 region were examined. The thermal pain threshold (paw withdrawal latency) was increased significantly in both groups at 2 weeks after electroacupuncture intervention compared with 2 days of electroacupuncture. In ovariectomized rats with chronic constriction injury, the analgesic effect was significantly reduced. Electroacupuncture for 2 weeks significantly diminished the injury-induced increase in synaptic cleft width and thinning of the postsynaptic density, and it significantly suppressed the down-regulation of intracellular calcium/ calmodulin-dependent protein kinase II expression in the hippocampal CA3 region. Repeated electroacupuncture intervention had a cumulative analgesic effect on injury-induced neuropathic pain reactions, and it led to synaptic remodeling of hippocampal neurons and upregulated calcium/calmodulin-dependent protein kinase II expression in the hippocampal CA3 region. | Qiulinq Xu Tao Liu Shuping Chen Yonghui Gao Junying Wang Lina Qiao Junling Liu | 2012 | Neural Regeneration Research2012，7，18： | 3 |
| 9 | Profiling human protein degradome delineates cellular responses to proteasomal inhibition and reveals a feedback mechanism in regulating proteasome homeostasis显示文摘在蛋白质周转(蛋白质 degradome ) 的全球变化组成对内在或外来的刺激的细胞的回答的中央部分。然而,介绍蛋白质 degradome 仍然保持技术上挑战性。最近, proteasome 的抑制,例如由使用 bortezomib (BTZ ) ,为对待多重骨髓瘤和其它人恶意,但是药行动和肿瘤药抵抗还有待于被完成的为 BTZ 的机制的系统的理解作为主要化学疗法的策略出现了。这里,我们开发了并且适用 dual-fluorescence-based 蛋白质周转试金(ProTA ) 到份量上在导致 BTZ 的 proteasomal 抑制之上在人的蛋白质 degradome 介绍全球变化。ProTA 和随后的网络分析描出在 BTZ 化疗的 BTZ 行动和肿瘤药抵抗的潜在的分子的基础。最后,把 BTZ 的使用与指向识别 ProTA 的关键基因的药相结合或在 BTZ 行动的小径在多重骨髓瘤房间减少了 BTZ 抵抗。显著地, BTZ 稳定 proteasome 子单元 PSMC1 和 proteasome 集会因素 PSMD10,建议为调整 proteasome 动态平衡的以前下面欣赏的机制。因此, ProTA 是为介绍人的蛋白质 degradome 阐明的一个新奇工具药行动和抵抗的潜在的机制,它可能便于指向 proteostasis 对待人的混乱的治疗学的开发。 | Tao Yu Yonghui Tao Meiqiang Yang Peng Chen Xiaobo Gao Yanbo Zhang Tao Zhang Zi Chen Jian Hou Yan Zhang Kangcheng Ruan Hongyan Wang Ronggui Hu | 2014 | Cell Research2014，24，10： | 2 |
| 10 | Degradation of dissolved organic matter in effluent of municipal wastewater plant by a combined tidal and subsurface flow constructed wetland显示文摘Dissolved organic matter(DOM)is an important constituent of wastewater treatment plant(WWTP)effluent.A novel combined tidal and subsurface flow constructed wetland(TF-SSFCW)of 90 L was constructed for a ten-month trial of advanced treatment of the WWTP effluent.Excitation emission matrix(EEM)fluorescence spectroscopy,parallel factor(PARAFAC)analysis and a two end-member mixing model were employed to characterize the composition and removal process of the effluent DOM(EfOM)from the WWTP.The results showed that the TF-SSF-CW performed an efficient EfOM removal with dissolved organic carbon(DOC)removal rate of 88%and dissolved organic nitrogen(DON)removal rate of 91%.Further analysis demonstrated that the EfOM consisted mainly of two protein moieties and two humic-like groups;protein moieties(76%)constituted the main content of EfOM in raw water and humic-like groups(57%)became the dominating contributor after treatment.The EfOM from the WWTP was mainly of aquatic bacterial origin and evolved to a higher proportion of terrigenous origin with higher humification in the TF-SSF-CW effluent.A common controlling treatment-related factor for determining the concentrations of the same kind of substances(protein groups or humic-like groups)was revealed to exist,and the ratio of removal rates between the same substances in treatment was calculated.Our study demonstrates that the TF-SSF-CW can be a novel and effective treatment method for the EfOM from WWTPs,and is helpful for understanding of the character of EfOM in wetland treatment. | Chunjian Lyu Ruixia Liu Xiaojie Li Yonghui Song Hongjie Gao | 2021 | Journal of Environmental Sciences2021，33，8： | 2 |
| 11 | Genetic architecture of maize yield traits dissected by QTL mapping and GWAS in maize显示文摘The study of yield traits can reveal the genetic architecture of grain yield for improving maize production.In this study, an association panel comprising 362 inbred lines and a recombinant inbred line population derived from X178 × 9782 were used to identify candidate genes for nine yield traits. High-priority overlap(HPO) genes, which are genes prioritized in a genome-wide association study(GWAS), were investigated using coexpression networks. The GWAS identified 51 environmentally stable SNPs in two environments and 36 pleiotropic SNPs, including three SNPs with both attributes. Seven hotspots containing 41 trait-associated SNPs were identified on six chromosomes by permutation. Pyramiding of superior alleles showed a highly positive effect on all traits, and the phenotypic values of ear diameter and ear weight consistently corresponded with the number of superior alleles in tropical and temperate germplasm. A total of 61 HPO genes were detected after trait-associated SNPs were combined with the coexpression networks. Linkage mapping identified 16 environmentally stable and 16 pleiotropic QTL.Seven SNPs that were located in QTL intervals were assigned as consensus SNPs for the yield traits.Among the candidate genes predicted by our study, some genes were confirmed to function in seed development. The gene Zm00001 d016656 encoding a serine/threonine protein kinase was associated with five different traits across multiple environments. Some genes were uniquely expressed in specific tissues and at certain stages of seed development. These findings will provide genetic information and resources for molecular breeding of maize grain yield. | Xiao Zhang Zhiyong Ren Bowen Luo Haixu Zhong Peng Ma Hongkai Zhang Hongmei Hu Yikai Wang Haiying Zhang Dan Liu Ling Wu Zhi Nie Yonghui Zhu Wenzhu He Suzhi Zhang Shunzong Su Yaou Shen Shibin Gao | 2022 | The Crop Journal2022，10，2： | 2 |
| 12 | Triflic Acid-Functionalized Silica-Coated Magnetic Nanoparticles as a Magnetically Separable Catalyst for Synthesis of gem-Dihydroperoxides显示文摘 | Liu Yonghui Deng Jia Gao Jianwu | | 0，，3： | 1 |
| 13 | Rational construction of self-assembly azobenzene derivative monolayers with photoswitchable surface properties显示文摘Photo-responsive azobenzene(ABZ) derivatives with different end groups(R) as photoswitchable molecules were employed to construct self-assembled monolayers(SAMs) on silicon substrate by using3-glycidoxypropyltrimethoxysilane(GPTS) as the bridging molecules. The assembly process was optimized by changing various parameters, including the type and concentration of ABZ derivatives,reaction time, etc. The obtained SAMs were fully characterized and evaluated using UV spectroscopy,atomic force microscope(AFM), elllipsometer, static contact angle and X-ray photoelectron spectroscopy(XPS). It is found that the end group property of azobenzene derivatives is critical to the obtained SAMs' photoresponsive properties. Compared with hydrophobic compounds(4-(4'-aminophenylazo) benzoic acid, ABZ-CF_3),the hydrophilic compounds(4-(4'-aminophenylazo) benzoic acid, ABZ-COOH) show excellent reversible photoswitching performance with a large contact angle change of 35° under optimized process, and the SAMs are removable by thermal treatment at 240℃ in air for only 5 min. | Yu Zhang Peng Gao Qin Yue Peter Trefonas Yonghui Deng | 2018 | Chinese Chemical Letters2018，29，11： | 1 |
| 14 | Boundedness of sublinear operators on the Herz-Morrey spaces of homogeneous type显示文摘 | Cao Yonghui and Gao Wenhua | 2004 | Journal of Xinjiang University:Natural Science Edition2004，21，3： | 1 |
| 15 | Study on degradaton for aqueous methyl orange solution with uhrasonie- Fenton reagent process 显示文摘 | Tang Qian Gao Yonghui | 2008 | Journal of Jilin Normal University: Natural Science Edi- tion2008，29，4： | 1 |
| 16 | New cyclopiane diterpenes with anti-inflammatory activity from the sea sediment-derived fungus Penicillium sp.TJ403-2显示文摘Three new rare cyclopiane diterpenes(1-3),together with thirteen known compounds(4-16),were isolated and identified from a sea sediment-derived fungus Penicillium sp.TJ403-2.The planar and relative structures of compounds 1-3 were elucidated by HRESIMS,one-and two-dimensional NMR analyses,and their absolute configurations were further established by X-ray crystallography experiment.Compounds 1-3 were evaluated for the anti-inflammatory activity against LPS-induced NO production,and compound 1 showed notable inhibitory potency with an IC50 value of2.19±0.25μmol/L,which was three fold lower than the positive control indomethacin(IC50=8.76±0.92μmol/L).Further Western blot and immunofluorescence experiments demonstrated its mechanism of action to be that 1 inhibited the NF-κB-activated pathway,highlighting it as a promising starting point for the development of new anti-inflammatory agents. | Fengli Li Weiguang Sun Sitian Zhang Weixi Gao Shuang Lin Beiye Yang Chenwei Chai Huaqiang Li Jianping Wang Zhengxi Hu Yonghui Zhang | 2020 | Chinese Chemical Letters2020，31，1： | 1 |
| 17 | TNF-α promotes early atherosclerosis by increasing transcytosis of LDL across endothelial cells: Crosstalk between NF-κB and PPAR-γ显示文摘 | Youzhi Zhang Xiaoyan Yang Fang Bian Pinhui Wu Shasha Xing Gao Xu Wenjing Li Jiangyang Chi Changhan Ouyang Tao Zheng Dan Wu Yonghui Zhang Yongsheng Li Si Jin | 2014 | Journal of Molecular and Cellular Cardiology2014，，： | 1 |
| 18 | Seven facts and five initiatives for gut microbiome research显示文摘The gut microbiome has attracted increasing attention over the past 15 years.Along with the fast-growing body of research literature and media reports,the public's opinions on the gut microbiome have begun to appear polarized.Some believe that the gut microbiome is at the core of human health and is related to every single disease.To the opposite,some people question the scientific basis of gut microbiome studies and criticize that many of them are farfetched;there is even a joke spreading in the biomedical research field—'keeping gut microbiome in mind,no mechanism is hard to find'. | Danyi Li Chunhui Gao Faming Zhang Ruifu Yang Canhui Lan Yonghui Ma Jun Wang | 2020 | Protein & Cell2020，11，6： | 1 |
| 19 | n-Channel Organic Transistors Processed from Halogen-Free Solvents: Solvent Effect on Thin-Film Morphology and Charge Transport显示文摘非使氯化的溶剂为由于他们的环境地友好的特征的器官的电子处理高度更好。四不同没有卤素的溶剂, tetrafuran,甲苯,元二甲苯和 1,2,4-trimethylbenzene,被选择制作 n 隧道基于 3-hexylundecyl,代替的萘 diimides 熔化了与的器官的薄电影晶体管(OTFT )(1,3-dithiol-2-ylidene ) malononitrile 组(NDI3HU-DTYM2 ) 。OTFT 在周围的状况下面基于 NDI3HU-DTYM2 显示出多达 1.37 厘米 2·V−1·s−1 的电子活动性。这在为从没有卤素的溶剂处理的 n 隧道 OTFT 的最高的设备表演之中。不同薄电影的形态学,从无特色的低水晶的形态学到排列得好的 nanofibres,在设备表演上有大效果。这些结果可能为器官的电子设备阐明溶剂选择和产生解决方案进程。 | Simin Gao Yonghui Hu Zhiming Duan Xike Gao | 2016 | Chinese Journal of Chemistry2016，34，7： | 1 |
| 20 | Long noncoding RNA(lncRNA)H19:An essential developmental regulator with expanding roles in cancer,stem cell differentiation,and metabolic diseases显示文摘Recent advances in deep sequencing technologies have revealed that,while less than 2%of the human genome is transcribed into mRNA for protein synthesis,over 80%of the genome is transcribed,leading to the production of large amounts of noncoding RNAs(ncRNAs).It has been shown that ncRNAs,especially long non-coding RNAs(lncRNAs),may play crucial regulatory roles in gene expression.As one of the first isolated and reported lncRNAs,H19 has gained much attention due to its essential roles in regulating many physiological and/or pathological processes including embryogenesis,development,tumorigenesis,osteogen-esis,and metabolism.Mechanistically,H19 mediates diverse regulatory functions by serving as competing endogenous RNAs(CeRNAs),Igf2/H19 imprinted tandem gene,modular scaffold,cooperating with H19 antisense,and acting directly with other mRNAs or lncRNAs.Here,we summarized the current understanding of H19 in embryogenesis and development,cancer development and progression,mesenchymal stem cell lineage-specific differentiation,and metabolic diseases.We discussed the potential regulatory mechanisms underlying H19’s func-tions in those processes although more in-depth studies are warranted to delineate the exact molecular,cellular,epigenetic,and genomic regulatory mechanisms underlying the physiolog-ical and pathological roles of H19.Ultimately,these lines of investigation may lead to the development of novel therapeutics for human diseases by exploiting H19 functions. | Junyi Liao Bowen Chen Zhenglin Zhu Chengcheng Du Shengqiang Gao Guozhi Zhao Piao Zhao Yonghui Wang Annie Wang Zander Schwartz Lily Song Jeffrey Hong William Wagstaff Rex CHaydon Hue HLuu Jiaming Fan Russell RReid Tong-Chuan He Lewis Shi Ning Hu Wei Huang | 2023 | Genes & Diseases2023，10，4： | 1 |
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