Acupuncture effects on the hippocampal cholinergic system in a rat model of neuropathic pain

查看全文 作　　者：Junying Wang Junling Liu Shuping Chen Yonghui Gao Fanying Meng Lina [1]Qiao

机构地区：[1]Institute of Acu-moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China

出　　处：《Neural Regeneration Research》索引2012年第7卷第3期,共7页

基　　金：supported by the National Natural Science Foundation of China, No. 30472241, key project: 90709031;the Ministry of Science and Technology of China ('973' Project), No. 2007CB512505 摘　　要：The present study observed the effects of repeated electroacupuncture of Zusanli (ST36) and Yanglingquan (GB34) on expression of hippocampal acetylcholinesterase, vesicular acetylcholine transporter, and muscarinic M1 receptor mRNA in chronic constrictive injury (neuropathic pain) and/or ovariotomy rats. Results demonstrated increased expression of hippocampal acetylcholinesterase, vesicular acetylcholine transporter, and muscarinic M1 receptor mRNA, as well as decreased pain threshold, in a rat model of chronic neuropathic pain after electroacupuncture. The effects of electroacupuncture increased with prolonged time, but the above-mentioned effects decreased in memory-deficient animals. Results indicated that repeated electroacupuncture has a cumulative analgesic effect, which is closely associated with upregulation of acetylcholinesterase and vesicular acetylcholine transporter activity, as well as M1 receptor mRNA expression and memory. 关键词：大鼠模型神经痛胆碱能系统海马乙酰胆碱酯酶 mRNA表达疼痛针灸

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Acupuncture effects on the hippocampal cholinergic system in a rat model of neuropathic pain

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