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| 1 | Natural Variation in the Promoter of GSE5 Contributes to Grain Size Diversity in Rice显示文摘自然基因变化的利用极大地在庄稼贡献重要农学的特点的改进。为谷物尺寸的自然变化理解基因基础能帮助 breeders 开发产量很高的米饭变化。在这研究,我们识别以前未被认出的基因,命名 GSE5,与功能的分析在由联合染色体宽的协会控制米饭谷物尺寸的 qSW5/GW5 地点学习。GSE5 编码血浆有 IQ 领域的联系膜的蛋白质,与米饭 calmodulin 蛋白质交往, OsCaM1-1。我们发现 GSE5 功能的损失引起了宽、重的谷物,当 GSE5 的 overexpression 导致了狭窄的谷物时。我们证明 GSE5 由在小穗状花小穗壳影响房间增长主要调整谷物尺寸。GSE5 的三主要 haplotypes (GSE5, GSE5 DEL1+IN1 , 和 GSE5 在栽培米饭的 DEL2 ) 在它的倡导者区域基于删除 / 插入类型被识别。我们表明了那在带 GSE5 在带 GSE5 haplotype 和 1212-bp 删除(DEL2 )> 与 GSE5 的减少的表示联系的 DEL2 haplotype,导致宽谷物。进一步的分析显示野米饭就职包含 GSE5 的所有三 haplotypes,建议在栽培米饭在场的 GSE5 haplotypes 是可能的从在米饭驯服期间的不同野米饭就职发源。一起拿,我们的结果显示在 qSW5/GW5 地点的以前未被认出的 GSE5 基因,被米饭 breeders 广泛地利用,控制谷物缩放,并且表明在 GSE5 的倡导者区域的那个自然变化在米饭贡献谷物尺寸差异。 | Penggen Duan Jinsong Xu Dali Zeng Baolan Zhang Mufan Geng Guozheng Zhang Ke Huang Luojiang Huang Ran Xu Song Ge Qian Qian Yunhai Li | 2017 | Molecular Plant2017，10，5： | 31 |
| 2 | Preliminary molecular epidemiology of the Staphylococcus aureus in lower respiratory tract infections: a multicenter study in China显示文摘 | LI De-zhi CHEN Yu-sheng YANG Jing-ping ZHANG Wei HU Cheng-ping LI Jia-shu MU Lan HU Ying-hui GENG Rong HU Ke CAI Shao-xi WAN Huan-ying WANG Qiu-yue WEI Li-ping DU Juan YU Qin ZHONG Xiao-ning WANG Rui-qin MA Jian-jun TIAN Gui-zhen WANG Si-qin GAO Zhan-cheng | 2011 | Chinese Medical Journal2011，，5： | 21 |
| 3 | Deep Structural Framework and Genetic Analysis of Gold Concentration Areas in the Northwestern Jiaodong Peninsula, China: A New Understanding based on High-Resolution Reflective Seismic Survey显示文摘The gold concentration areas in the northwestern Jiaodong Peninsula constituted an important gold metallogenetic region in Eastern China during the Mesozoic. The deep geological bodies' texture characteristic is important for exploring the resources thoroughly and understanding the metallogenic process. The detailed textures were revealed using high-resolution seismic profiles through the three major ore-controlling structures-Sanshandao fault zone, Jiaojia fault zone and Zhaoping fault zone. This study aims to establish a deep structural framework of this area. Based on their formation mechanism, the fault structures developed in the area can be divided into regional and local fault structures. The structural styles are characterised by superimposing their compressional, strike-slip and extensional multi-stage activities. The crust is cut by vertical structures corresponding to a left-lateral strike-slip fault system on the surface. Nearby these structures are the arc-shape structures formed by multi-stage magma intrusions into the upper crust. Bounded by the Tancheng–Lujiang and Muping–Jimo fault zones, the current Jiaodong block, developed a series of NE-trending strike-slip fault systems, was probably formed by the assemblage of several obliquely aligned blocks. The intensive magmatism and hydrothermal activity between the blocks induced large-scale mineralisation. It provides a new angle of view for understanding the cratonic destruction and large ore-concentration formed during the Mesozoic. | YU Xuefeng SHAN Wei XIONG Yuxin GENG Ke SUN Yuqin CHI Naijie GUO Baokui LI Dapeng LI Hongkui SONG Yingxin YANG Deping | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 19 |
| 4 | Ginsenoside Rg1 enhances the resistance of hematopoietic stem/progenitor cells to radiation- induced aging in mice显示文摘 | Cui CHEN Xin-yi MU Yue ZHOU Ke SHUN Shan GENG Jun LIU Jian-wei WANG Jie CHEN Tin-yu LI Ya-ping WANG | 2014 | Acta Pharmacologica Sinica2014，35，1： | 15 |
| 5 | Study on β-TCP Coated Porous Mg as a Bone Tissue Engineering Scaffold Material显示文摘Three-dimensional honeycomb-structured magnesium (Mg) scaffolds with interconnected pores of accurately controlled pore size and porosity were fabricated by laser perforation technique. Biodegradable and bioactive β-tricalcium phosphate (β-TCP) coatings were prepared on the porous Mg to further improve its biocompatibility, and the biodegradation mechanism was simply evaluated in vitro. It was found that the mechanical properties of this type of porous Mg significantly depended on its porosity. Elastic modulus and compressive strength similar to human bones could be obtained for the porous Mg with porosity of 42.6%-51%. It was observed that the human osteosarcoma cells (UMR106) were well adhered and proliferated on the surface of the β-TCP coated porous Mg, which indicates that the β-TCP coated porous Mg is promising to be a bone tissue engineering scaffold material. | Fang Geng Lili Tan Bingchun Zhang Chunfu Wu Yonglian He Jingyu Yang Ke Yang | 2009 | Journal of Materials Science & Technology2009，25，1： | 13 |
| 6 | Drug-resistant genes carried by Acinetobacter baumanii isolated from patients with lower respiratory tract infection显示文摘 | DAI Ning LI De-zhi CHEN Ji-chao CHEN Yu-sheng GENG Rong HU Ying-hui YANG Jing-ping DU Juan HU Cheng-ping ZHANG Wei LI Jia-shu YU Qin WAN Huan-ying MU Lan ZHONG Xiao-ning WEI Li-ping MA Jian-jun WANG Qiu-yue HU Ke TIAN Gui-zhen CAI Shao-xi WANG Rui-qin HE Bei WANG Si-qin WANG Zhan-wei ZHAO Su-rui GAO Zhan-cheng | 2010 | Chinese Medical Journal2010，，18： | 13 |
| 7 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping Zhu Zhi-Nan Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 8 | Inhibition effect of magnetic field on nitrous oxide emission from sequencing batch reactor treating domestic wastewater at low temperature显示文摘This study aims to investigate the effect of a magnetic field on nitrous oxide(N2O)emission from a sequencing batch reactor treating low-strength domestic wastewater at low temperature(10℃).After running for 124 days in parallel,results indicated that the conversion rate of N2O for a magnetic field-sequencing batch reactor(MF-SBR)decreased by34.3%compared to that of a conventional SBR(C-SBR).Meanwhile,the removal efficiencies for total nitrogen(TN)and ammonia nitrogen(NH4-N)of the MF-SBR were 22.4%and 39.5%higher than those of the C-SBR.High-throughput sequencing revealed that the abundances of AOB(Nitrosomonas),NOB(Nitrospira)and denitrifiers(Zoogloea),which could reduce N2O to N2,were promoted significantly in the MF-SBR.Enzyme activities(Nir)and gene abundances(nos Z nir S and nir K)for denitrification in the MF-SBR were also notably higher compared to C-SBR.Our study shows that application of a magnetic field is a useful approach for inhibiting the generation of N2O and promoting the nitrogen removal efficiency by affecting the microbial characteristics of sludge in an SBR treating domestic wastewater at low temperature. | Dan Xu Hongmin Ji Hongqiang Ren Jinju Geng Kan Li Ke Xu | 2020 | Journal of Environmental Sciences2020，32，1： | 7 |
| 9 | Chimeric flagellin expressed by Salmonella typhimurium induces an ESAT-6-specific Th1-type immune response and CTL effects following intranasal immunization显示文摘The flagellin component FliC of Salmonella typhimurium is capable of activating the innate immune system via specific interactions with TLR5 and can also act as a carrier of foreign antigen to elicit antigen-specific immune responses.Thus,we constructed an attenuated Salmonella strain SL5928(fliC/esat)expressing chimeric flagellin that contained the ESAT-6 antigen coding sequence of Mycobacterium tuberculosis inserted into the highly variable region of the Salmonella flagellin coding gene fliCi.The chimeric flagellin functioned normally,as demonstrated using a flagella swarming assay and electron microscopy.To analyze the effects of chimeric flagellin,the cell-mediated immune response and cytotoxic T lymphocyte(CTL)effects specific for ESAT-6 antigen were tested after intranasal immunization of mice with flagellated Salmonella SL5928(fliC/esat).The results showed that SL5928(fliC/esat)intranasal immunization can strongly elicit an ESAT-6-specific T helper(Th)1-type immune response in mucosal lymphoid tissues,such as nasopharynx-associated lymph nodes,lung and Peyer’s patches,and a Th1/Th2 response was elicited in spleen and mesenteric lymph nodes.Furthermore,intranasal immunization of SL5928(fliC/esat)produced efficient CTL effects,as demonstrated using a 5-and 6-carboxyfluorescein diacetate succinimidyl ester(CFSE)assay.Thus,our study revealed that Salmonella flagellin acts as a carrier for foreign antigen and triggers strong Th1 and CTL responses during intranasal immunization.Chimeric flagellin is potentially an effective strategy for the development of novel vaccines against tuberculosis in humans and animals. | Hui Zhang Liu Liu Ke Wen Jinlin Huang Shizhong Geng Junsong Shen Zhiming Pan Xinan Jiao | 2011 | Cellular & Molecular Immunology2011，8，6： | 6 |
| 10 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 11 | A new chromatographic method for fast separation of active proteins显示文摘A new method with only a single chromatographic column to accomplish the separation of intact protein molecules by the combination of ion exchange chromatography and hydrophobic interaction chromatography is firstly presented. By selecting twice a suitable stationary phase, mobile phase, buffer exchange condition, and sample injection, some proteins usually required to separate with two-dimensional chromatography can now be accomplished only using the single column in one hour. In addition, the separated proteins can maintain their original three-or four-dimensional molecular structure. It would be expected that this method can also provide a new thought for sample pre-frac-tionation in proteomic investigation, especially, for the limitation of sample source. | KE CongYu GENG XinDu | 2008 | Chinese Science Bulletin2008，53，7： | 4 |
| 12 | Wheat breeding history reveals synergistic selection of pleiotropic genomic sites for plant architecture and grain yield显示文摘Diversity surveys of crop germplasm are important for gaining insights into the genomic basis for plant architecture and grain yield improvement,which is still poorly understood in wheat.In this study,we exome sequenced 287 wheat accessions that were collected in the past 100 years.Population genetics analysis identified that 6.7%of the wheat genome falls within the selective sweeps between landraces and cultivars,which harbors the genes known for yield improvement.These regions were asymmetrically distributed on the A and B subgenomes with regulatory genes being favorably selected.Genome-wide association study(GWAS)identified genomic loci associated with traits for yield potential,and two underlying genes,TaARF12 encoding an auxin response factor and TaDEP1 encoding the G-proteinγ-subunit,were located and characterized to pleiotropically regulate both plant height and grain weight.Elite single-nucleotide haplotypes with increased allele frequency in cultivars relative to the landraces were identified and found to have accumulated over the course of breeding.Interestingly,we found that TaARF12 and TaDEP1 function in epistasis with the classical plant height Rht-1 locus,leading to propose a“Green Revolution”-based working model for historical wheat breeding.Collectively,our study identifies selection signatures that fine-tune the gibberellin pathway during modern wheat breeding and provides a wealth of genomic diversity resources for the wheat research community. | Aili Li Chenyang Hao Zhenyu Wang Shuaifeng Geng Meiling Jia Fang Wang Xiang Han Xingchen Kong Lingjie Yin Shu Tao Zhongyin Deng Ruyi Liao Guoliang Sun Ke Wang Xingguo Ye Chengzhi Jiao Hongfeng Lu Yun Zhou Dengcai Liu Xiangdong Fu Xueyong Zhang Long Mao | 2022 | Molecular Plant2022，15，3： | 4 |
| 13 | Pyridine-induced interfacial structural transformation of tetraphenylethylene derivatives investigated by scanning tunneling microscopy显示文摘The two-dimensional self-assembly behaviors of tetraphenylethylene (TPE)molecules are significant for further applications, but reports are rare. The self-assembled structures of two C2-symmetry TPE derivatives (H4TCPE and H4ETrC)possessing propeller structures and their stimulus responses to the additionof vinylpyridine derivatives were thoroughly studied with the assistance ofscanning tunneling microscopy (STM) technique in combination with densityfunctional theory (DFT) calculations. Although their chemical structures weresimilar, the H4TCPE and H4ETTC molecules self-assembled into closely packedlamellar and quadrilateral structures, respectivel3~ at the 1-heptanoic acid/HOPGinterface. After the addition of pyridine derivatives (DPE, PEBP-C4, andPEBP-C8), H4TCPE and H4ETTC showed different responsiveness resultingin different co-assembly structures. The results indicated that the structuresof pyridine derivatives--including backbones and substituents--affected theintermolecular interactions of both H4TCPE/pyridine and H4ETTC/pyridinesystems. The modification of the self-assembly behaviors of propeller-shapedI-hTCPE and H4ETTC would contribute to the construction of more complexmultilevel nanostructures. | Xuan Peng Linxiu Cheng Xiaoyang Zhu Yanfang Geng Fengying Zhao Kandong Hu Xuan Guo Ke Deng Qingdao Zeng | 2018 | Nano Research2018，11，11： | 4 |
| 14 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 15 | Phylogenetic relationship and morphological evolution in the subfamily Limenitidinae(Lepidoptera:Nymphalidae)显示文摘mitochondrial 细胞色素氧子单元我(COI ) 基因和原子延伸因子 1 α(EF-1 α) 基因从 Nymphalidae 的 29 种类被定序(Nymphalidae,鳞翅目) 。种系发生的树基于从 29 种类决定的序列和在 GenBank 扔用的另外的 36 种类的序列被构造加入邻居(NJ ) ,最大的可能性(ML ) 和有 Libythea celtis (Libytheinae ) 的贝叶斯的方法作为外集团。我们的种系发生的树显示了四主要 clades。Clade A 包括三个亚科:Apaturinae, Nymphalinae,和 Limenitidinae,排除部落 Limenitidini;Clade B 包括亚科 Heliconiinae 和部落 Limenitidini;Clade C 包括 Satyrinae, Calinaginae, Charaxinae 和 Morphinae;并且 Clade D 包括亚科 Danainae。我们的学习建议部落 Pseudergolini, Biblidini, Limenitidini 和 Cyrestidini 应该被看作亚科并且在亚科 Pseudergolinae 以内证实了种间的关系,也就是 Amnosia +(Pseudergolis +(Stibochiona + Dichorragia )) 。我们然后印射三个词法字符(从后部的翅膀的外部边缘的肛门角度,视觉器官,和过程的点) 到 ML 分析用联合顺序数据构造的种系发生的树上。把这些词法人物的进化模式基于这被识别,他们显示三个人物在家庭 Nymphalidae 反复演变。 | Min Zhang Yang Zhong Tianwen Cao Yupeng Geng Yuan Zhang Ke Jin Zhumei Ren Rui Zhang Yaping Guo Enbo Ma | 2008 | Progress in Natural Science:Materials International2008，18，11： | 2 |
| 16 | Deep gold mineralization features of Jiaojia metallogenic belt,Jiaodong gold Province:Based on the breakthrough of 3000 m exploration drilling显示文摘Recently,continuous breakthroughs have been made about deep gold prospecting in the Jiaodong gold province area of China.Approximately 5000 t of cumulative gold resources have been explored in Jiaodong,which has thus become an internationally noteworthy gold ore cluster.The gold exploration depth has been increased to about 2000 m from the previous<1000 m.To further explore the mineralization potential of the Jiaodong area at a depth of about 3000 m,the Shandong Institute of Geological Sciences has drilled an exploratory drillhole named“Deep drillhole ZK01”to a depth of 3266 m.Hence,as reported herein,the mineralization characteristics of the Jiaojia metallogenic belt have been successfully documented.ZK01 is,to date,the deepest borehole with an gold intersect in China,and constitutes a significant advance in deep gold prospecting in China.The findings of this study further indicate that the depth interval of 2000 m to 4000 m below the ground surface in the Wuyi Village area incorporates 912 t of inferred gold resources,while the depth interval of 2000 m to 4000 m below the surface across the Jiaodong area possesses about 4000 t of inferred gold resources.The Jiaojia Fault Belt tends to gently dip downward,having dip angles of about 25°and about 20°at vertical depths of 2000 m and 2850 m,respectively.The deep part of the Jiaojia metallogenic belt differs from the shallow and moderately deep parts about fracturing,alteration,mineralization,and tectonic type.The deep zones can generally be categorized from inside outward as cataclastic granite,granitic cataclasite,weakly beresitized granitic cataclasite,beresitized cataclasite,and gouge.These zones exhibit a gradual transitional relation or occur alternately and repeatedly.The mineralization degree of the pyritized cataclastic granite-type ore in the deep part of the Jiaojia metallogenic belt is closely related to the degree of pyrite vein development;that is,the higher the pyrite content,the wider the veins and the higher the gold grade.Compared to the shallow gold ores,the deep-seated gold ores have higher fineness and contain joseite,tetradymite,and native bismuth,suggesting that the deep gold mineralization temperature is higher and that mantle-sourced material may have contributed to this mineralization.ZK01 has also revealed that the deep-seated ore bodies in the Jiaojia metallogenic belt are principally situated above the main fracture plane(gouge)and hosted within the Linglong Granite,contradicting previous findings indicating that the moderately shallow gold ore bodies are usually hosted in the contact zone between the Linglong Granite and Jiaodong Group or meta-gabbro.These new discoveries are particularly significant because they can help correct mineralization prospecting models,determine favorable positions for deep prospecting,and improve metallogenic prediction and resource potential evaluation. | Xue-feng Yu Da-peng Li Jing-xiang Tian De-ping Yang Wei Shan Ke Geng Yu-xin Xiong Nai-jie Chi Peng-fei Wei Peng-rui Liu | 2020 | China Geology2020，3，3： | 2 |
| 17 | Structural basis for gating mechanism of Pannexin 1 channel显示文摘Dear Editor,Pannexin 1(PANX1)plays extensive physiological roles across diverse fields of biology,including cell death,1,2 inflammation,3 cancer progression,4 and neurological disorders.5 As suggested by biochemical analysis,PANX1 forms an oligomeric channel for the facilitated diffusion of ions and large molecules across the plasma membrane upon activation.6 However,the underlying molecular gating mechanism of PANX1 and the structure of human PANX1 are still elusive.In the current study,we report the cryo-EM structures of full-length and carboxyl-terminal(CT)tail-cleaved human PANX1.Combined with single-channel electrophysiological study,we identified the key residues involved in the gating of PANX1. | Luqiu Mou Meng Ke Mengxiao Song Yuanyue Shan Qingjie Xiao Qingting Liu Jialu Li Ke Sun Lei Pu Li Guo Jia Geng Jianping Wu Dong Deng | 2020 | Cell Research2020，30，5： | 2 |
| 18 | Guest selectivity in the supramolecular host networks fabricated by van der Waals force and hydrogen bond显示文摘Here, the structural transformations of H4ETTC induced by coronene (COR) and selective adsorption behaviors of COR in different templates were investigated by seanning tunnelling microscope (STM). It was discovered that the assembled architecture of H4ETTC at the HOPG/ heptanoic acid interface depended on the concentration of COR, and the clusters of COR were obtained in the kagome nanoporous network of H4ETTC molecules at a high concentration of COR solution. In addition, COR clusters can also be formed in the hexagonal porous structure of hexaphenylbenzene (HPB) molecules modified by alkyl chains at the HOPG/heptanoic acid interface. When both H4ETTC and HPB assembly structures, based on hydrogen bonding and van der Waals force respectively, were selected as the host templates, COR showed selectivity for HPB template to form HPB/COR hexagonal host-guest architecture. Density functional theory (DFT) calculations were also performed to disclose the mechanisms involved. | Xuan Peng Yanfang Geng Min Zhang Faliang Cheng Linxiu Cheng Ke Deng Qingdao Zeng | 2019 | Nano Research2019，12，3： | 2 |
| 19 | ACE2-independent infection of T lymphocytes by SARS-CoV-2显示文摘SARS-CoV-2 induced marked lymphopenia in severe patients with COVID-19.However,whether lymphocytes are targets of viral infection is yet to be determined,although SARS-CoV-2 RNA or antigen has been identified in T cells from patients.Here,we confirmed that SARS-CoV-2 viral antigen could be detected in patient peripheral blood cells(PBCs)or postmortem lung T cells,and the infectious virus could also be detected from viral antigen-positive PBCs.We next prove that SARS-CoV-2 infects T lymphocytes,preferably activated CD4+T cells in vitro.Upon infection,viral RNA,subgenomic RNA,viral protein or viral particle can be detected in the T cells.Furthermore,we show that the infection is spike-ACE2/TMPRSS2-independent through using ACE2 knockdown or receptor blocking experiments.Next,we demonstrate that viral antigen-positive T cells from patient undergone pronounced apoptosis.In vitro infection of T cells induced cell death that is likely in mitochondria ROS-HIF-1a-dependent pathways.Finally,we demonstrated that LFA-1,the protein exclusively expresses in multiple leukocytes,is more likely the entry molecule that mediated SARS-CoV-2 infection in T cells,compared to a list of other known receptors.Collectively,this work confirmed a SARS-CoV-2 infection of T cells,in a spike-ACE2-independent manner,which shed novel insights into the underlying mechanisms of SARS-CoV2-induced lymphopenia in COVID-19 patients. | Xu-Rui Shen Rong Geng Qian Li Ying Chen Shu-Fen Li Qi Wang Juan Min Yong Yang Bei Li Ren-Di Jiang Xi Wang Xiao-Shuang Zheng Yan Zhu Jing-Kun Jia Xing-Lou Yang Mei-Qin Liu Qian-Chun Gong Yu-Lan Zhang Zhen-Qiong Guan Hui-Ling Li Zhen-Hua Zheng Zheng-Li Shi Hui-Lan Zhang Ke Peng Peng Zhou | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 20 | Preintercalation of Layered γ-Zirconium Phosphate for Preparation of Immobilized Hemoglobin显示文摘Layeredγ-Zirconium phosphate (γ-ZrP) preintercalated with butylamine, tetra (n-butylammonium)hydroxide, dimethylamine respectively, or only ultrasonificated, for preparation of immobilized hemoglobin were investigated in this report. | Li Na GENG, Na LI*, Xiao Fan WEN, Nan DAI, Feng Lin ZHAO, Ke An LI College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 | 2002 | Chinese Chemical Letters2002，13，8： | 2 |
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