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| 1 | On the origin and continuing evolution of SARS-CoV-2显示文摘The SARS-Co V-2 epidemic started in late December 2019 in Wuhan, China, and has since impacted a large portion of China and raised major global concern. Herein, we investigated the extent of molecular divergence between SARS-CoV-2 and other related coronaviruses. Although we found only 4% variability in genomic nucleotides between SARS-CoV-2 and a bat SARS-related coronavirus(SARSr-CoV;Ra TG13), the difference at neutral sites was 17%, suggesting the divergence between the two viruses is much larger than previously estimated. Our results suggest that the development of new variations in functional sites in the receptor-binding domain(RBD) of the spike seen in SARS-Co V-2 and viruses from pangolin SARSr-Co Vs are likely caused by natural selection besides recombination. Population genetic analyses of 103 SARS-CoV-2 genomes indicated that these viruses had two major lineages(designated L and S), that are well defined by two different SNPs that show nearly complete linkage across the viral strains sequenced to date. We found that L lineage was more prevalent than the S lineage within the limited patient samples we examined. The implication of these evolutionary changes on disease etiology remains unclear.These findings strongly underscores the urgent need for further comprehensive studies that combine viral genomic data, with epidemiological studies of coronavirus disease 2019(COVID-19). | Xiaolu Tang Changcheng Wu Xiang Li Yuhe Song Xinmin Yao Xinkai Wu Yuange Duan Hong Zhang Yirong Wang Zhaohui Qian Jie Cui Jian Lu | 2020 | National Science Review2020，7，6： | 67 |
| 2 | Graphitic Carbon Quantum Dots Modified Nickel Cobalt Sulfide as Cathode Materials for Alkaline Aqueous Batteries显示文摘Carbon quantum dots(CQDs)as a new class of emerging materials have gradually drawn researchers’concern in recent years.In this work,the graphitic CQDs are prepared through a scalable approach,achieving a high yield with more than 50%.The obtained CQDs are further used as structure-directing and conductive agents to synthesize novel N,S-CQDs/NiCo2S4 composite cathode materials,manifesting the enhanced electrochemical properties resulted from the synergistic effect of highly conductive N,S-codoped CQDs offering fast electronic transport and unique micro-/nanostructured NiCo2S4 microspheres with Faradaic redox characteristic contributing large capacity.Moreover,the nitrogen-doped reduced graphene oxide(N-rGO)/Fe2O3 composite anode materials exhibit ultrahigh specific capacity as well as significantly improved rate property and cycle performance originating from the high-capacity prism-like Fe2O3 hexahedrons tightly wrapped by highly conductive N-rGO.A novel alkaline aqueous battery assembled by these materials displays a specific energy(50.2 Wh kg^−1),ultrahigh specific power(9.7 kW kg^−1)and excellent cycling performance with 91.5%of capacity retention at 3 A g^−1 for 5000 cycles.The present research offers a valuable guidance for the exploitation of advanced energy storage devices by the rational design and selection of battery/capacitive composite materials. | Yirong Zhu Jingying Li Xiaoru Yun Ganggang Zhao Peng Ge Guoqiang Zou Yong Liu Hongshuai Hou Xiaobo Ji | 2020 | Nano-Micro Letters2020，12，2： | 10 |
| 3 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 4 | An improved iterative thresholding algorithm for L_(1)-norm regularization based sparse SAR imaging显示文摘Dear editor,Sparse signal processing techniques have been widely used after being introduced to synthetic aperture radar(SAR)imaging,and have shown desirable potential in imaging performance improvement compared with traditional matched filtering(MF)based methods[1,2]. | Hui BI Yong LI Daiyin ZHU Guoan BI Bingchen ZHANG Wen HONG Yirong WU | 2020 | Science China(Information Sciences)2020，63，11： | 4 |
| 5 | Activation of anterior thalamic reticular nucleus GABAergic neurons promotes arousal from propofol anesthesia in mice显示文摘Propofol is widely used for the induction and maintenance of anesthesia,which causes a rapid loss of consciousness.However,the mechanisms underlying the hypnosis effect of propofol are still not fully understood.The thalamic reticular nucleus(TRN)is crucial for regulating wakefulness,sleep rhythm generation,and sleep stability,while the role of TRN in the process of propofol-induced anesthesia is still unknown.Here,we investigated the function of the anterior TRN in propofol general anesthesia.Our results demonstrated that the neural activity of anterior TRN is suppressed during propofol anesthesia,whereas it is robustly activated from anesthesia by recording the calcium signals using fiber photometry technology.The results showed that the activation of anterior TRN neurons by chemogenetic and optogenetic methods shortens the emergency time without changing the induction time.Conversely,chemogenetic or optogenetic inhibition of the TRN neurons leads to a delay in the recovery time.Our study showed that anterior TRN is crucial for behavioral arousal without affecting the induction time of propofol anesthesia. | Yanjun Liu Bing Chen Yirong Cai Yuan Han Ying Xia Nanqi Li Bingqian Fan Tianjie Yuan Junli Jiang Po Gao Weifeng Yu Yingfu Jiao Wenxian Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 3 |
| 6 | 小窝蛋白-1、基质金属蛋白酶-2在膀胱癌的表达及其关系(英文)显示文摘Objective: To explore the expression of caveolin-1 (CAV-1) and matrix metalloproteinase-2 (MMP-2) in bladder cancer and its clinical significance. Methods: The expression of CAV-1 and MMP-2 were detected by the SP immunohis- tochemical method in 77 cases of bladder cancer. Results: The positive rates of CAV-1, MMP-2 in bladder transitional cell carcinoma (BTCC) and bladder adenocarcinoma were significantly high than those of normal bladder mucosa, the positive rates in the deeper cancer invasion was significantly high than those of superficial bladder cancer (P < 0.01), the positive rates of CAV-1 in grades I, II and III of bladder transitional cell carcinaoma (BTCC) were 15%, 40% and 68%, respectively; the positive rates of MMP-2 in grades I , II and III of bladder transitional cell carcinoma (BTCC) were 20% , 40% and 72%, respectively (P < 0.01). CAV-1 was positive associated with MMP-2 in bladder cancer (r = 0.598, P < 0.001), but not in bladder tissue. Conclusion: CAV-1 and MMP-2 were associated with stage and grade of bladder cancer, which suggested that CAV-1 might improve secretion of MMP-2. | Hengping Li Yirong Chen Dongwen Yan | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，6： | 3 |
| 7 | The use of SARS-CoV-2-related coronaviruses from bats and pangolins to polarize mutations in SARS-Cov-2显示文摘Dear Editor,The coronavirus disease 2019(COVID-19)caused by the SARS-CoV-2 coronavirus has become a global pandemic.The SARS-CoV-2 genome has a similarity of 96.2%to that of RaTG13,a bat SARS-CoV-2-related coronavirus detected in Rhinolophus affinis(Paraskevis et al.,2020;Zhou et al.,2020).The SARS-CoV-2 genome also has 85.5%−92.4%sequence similarity to SARS-CoV-2-related coronaviruses from Malayan pangolins that have been seized in anti-smuggling operations in southern China(Guangdong-Pangolin(GD-Pangolin-CoV)and Guangxi-Pangolin(GX-Pangolin-CoV)genomes)(Liu et al.,2019;Lam et al.,2020). | Tao Li Xiaolu Tang Changcheng Wu Xinmin Yao Yirong Wang Xuemei Lu Jian Lu | 2020 | Science China(Life Sciences)2020，63，10： | 3 |
| 8 | Hippocampus is more vulnerable to neural damages induced by repeated sevoflurane exposure in the second trimester than other brain areas显示文摘During the rapidly developing and sensitive period of the central nervous system (CNS), a harmful stimulus may have serious consequences. The effect of anesthetic exposure on the development of the offspring’s CNS during pregnancy is still unclear and has been widely concerned. In the present study, we compared the susceptibility of the hippocampus with those of other brain regions in offsprings when the mother mice were exposed to repeated sevoflurane. We found that other than affecting motor sensation, emotion, or social behavior of offspring mice, repeated sevoflurane exposure induced significant memory deficiency. Compared with other brain regions, the hippocampus, which is the key component of the brain serving for learning and memory, was more vulnerable to repeated sevoflurane exposure. We also found that repeated sevoflurane exposure to mother mice could inhibit the axon development of hippocampal neurons. We also predicted that N6-methyladenosine modification of mRNA might play an essential role in the vulnerability of the hippocampus to sevoflurane, while the underlying cellular mechanism needs to be explored in the future. Our study may provide a new perspective for studying the mechanism of hippocampus-specific injury induced by sevoflurane exposure. | Bing Chen Yanjun Liu Yirong Cai Dan Tang Saihong Xu Po Gao Weifeng Yu Yingfu Jiao Wenxian Li | 2020 | Acta Biochimica et Biophysica Sinica2020，52，8： | 3 |
| 9 | The emergence of tumor-infiltrating lymphocytes in nasopharyngeal carcinoma:Predictive value and immunotherapy implications显示文摘The clinical study of nasopharyngeal carcinoma(NPC)often reveals a large number of lymphocytes infiltrating the primary tumor site.As an important part of the tumor microenvironment,tumor-infiltrating lymphocytes(TILs)do not exist alone but as a complex multicellular population with high heterogeneity.TILs play an extremely significant role in the occurrence,development,invasion and metastasis of NPC.The latest research shows that they participate in tumorigenesis and treatment,and the composition,quantity,functional status and distribution of TILs subsets have good predictive value for the prognosis of NPC patients.TILs are an independent prognostic factor for TNM stage and significantly correlated with better prognosis.Additionally,adoptive immunotherapy using anti-tumor TILs has achieved good results in a variety of solid tumors including NPC.This review evaluates recent clinical and preclinical studies of NPC,summarizes the role of TILs in promoting and inhibiting tumor growth,evaluates the predictive value of TILs,and explores the potential benefits of TILs-based immunotherapy in the treatment of NPC. | Liu Yang Guohong Liu Yirong Li Yunbao Pan | 2022 | Genes & Diseases2022，9，5： | 3 |
| 10 | A multicomponent micro-Doppler signal decomposition and parameter estimation method for target recognition显示文摘Dear editor,The micro-Doppler modulation caused by the rotors on an unmanned aerial vehicle(TJAV)can be employed to recognize the UAV.However,several rotors on a UAV,as well as multiple targets at the same scene,lead to a multicomponent micro-Doppler signal in the radar echo.Conventional signal decomposition is an important method for extraction of the features from micro-Doppler signals [1].although it is incapable of separating characteristic curves that are overlapping [2] in the lime-frequency(TF)plane in the ease of multicomponent,micro-motion,which can lead to the poor precision of parameter estimation. | Chen SONG Yirong WU Liangjiang ZHOU Ruoming LI Jiefang YANG Wei LIANG Chibiao DING | 2019 | Science China(Information Sciences)2019，62，2： | 2 |
| 11 | Study of stone composition changes in melamine-related urinary calculi and its clinical significance显示文摘 | Li Yuan Chen YiRong Zhang Wei | 2011 | Urology2011，78，2： | 1 |
| 12 | Modified method for estimating the organic carbon density of discontinuous soils in peak-karst regions in southwest China显示文摘 | Hua Zheng Yirong Su Xunyang He Lening Hu Jinshui Wu Daoyou Huang Lei Li Cixian Zhao | 2012 | Environmental Earth Sciences2012，，6： | 1 |
| 13 | Source identification and prediction of nitrogen and phosphorus pollution of Lake Taihu by an ensemble machine learning technique显示文摘Effective control of lake eutrophication necessitates a full understanding of the complicated nitrogen and phosphorus pollution sources,for which mathematical modeling is commonly adopted.In contrast to the conventional knowledge-based models that usually perform poorly due to insufficient knowledge of pollutant geochemical cycling,we employed an ensemble machine learning(ML)model to identify the key nitrogen and phosphorus sources of lakes.Six ML models were developed based on 13 years of historical data of Lake Taihu’s water quality,environmental input,and meteorological conditions,among which the XGBoost model stood out as the best model for total nitrogen(TN)and total phosphorus(TP)prediction.The results suggest that the lake TN is mainly affected by the endogenous load and inflow river water quality,while the lake TP is predominantly from endogenous sources.The prediction of the lake TN and TP concentration changes in response to these key feature variations suggests that endogenous source control is a highly desirable option for lake eutrophication control.Finally,one-month-ahead prediction of lake TN and TP concentrations(R2 of 0.85 and 0.95,respectively)was achieved based on this model with sliding time window lengths of 9 and 6 months,respectively.Our work demonstrates the great potential of using ensemble ML models for lake pollution source tracking and prediction,which may provide valuable references for early warning and rational control of lake eutrophication. | Yirong Hu Wenjie Du Cheng Yang Yang Wang Tianyin Huang Xiaoyi Xu Wenwei Li | 2023 | Frontiers of Environmental Science & Engineering2023，17，5： | 1 |
| 14 | Visual sensing method based on texture analysis for automatic seam tracking sys- tems显示文摘 | Zou Yirong Du Dong Wang Li | 2011 | Lecture Notes in Electrical Engineering2011，133，2： | 1 |
| 15 | Research Progress of Continuous Blood Purification in the Treatment of Severe Sepsis in Children显示文摘Pediatric sepsis is the most common disease in pediatric critical illness,because the main reason for the disease is that children's immune level is not high or the immune system is not perfect,when children's lung,abdominal cavity and blood system are infected,it will cause systemic inflammation and immune dysfunction.Early clinical symptoms are mainly irregular and intermittent fever.When the disease develops to severe sepsis,the children will suffer from acute heart failure,oliguria,respiratory alkalosis and even multiple organ failure.The incidence of death is high.It is reported that the incidence rate of sepsis in children can reach 0.3%,and the mortality rate is 50%.High incidence rate,high mortality rate and high treatment cost are the biggest problems in the pediatric field.In the past,the clinical hope of clearing away heat and toxin,promoting blood circulation and removing stasis,strengthening inflammation and other methods in traditional Chinese medicine,but the treatment effect is not ideal.With the improvement of modem medical understanding of sepsis,continuous blood purification therapy is introduced into the treatment of children with severe sepsis.In order to further explore the effect of continuous blood purification in the treatment of children with severe sepsis,the author summarizes the clinical practice experience and relevant literature,hoping to provide reference for relevant medical staff。 | Weikai Wang Yun Du Aiqin Cheng Shunli Liu Lin Wei Jianna Li Yirong Wang Li Wang | 2021 | Journal of Clinical and Nursing Research2021，5，3： | 1 |
| 16 | IMAGING AND MTI PROCESSING BASED ON DUAL-FREQUENCIES DUAL-APERTURES SPACEBORNE SAR显示文摘Based on dual-frequencies dual-apertures spaceborne SAR (Synthetic Aperture Radar), a new SAR system with four receiving channels and two operation modes is presented in this paper. SAR imaging and Moving Target Indication (MTI) are studied in this system. High resolution imaging with wide swath is implemented by the Mode I, and MTI is completed by the Mode II. High azimuth resolution is achieved by the Displaced Phase Center (DPC) multibeam technique. And the Coherent Accumulation (CA) method, which combines dual channels data of different carrier frequency, is used to enhance the range resolution. For the data of different carrier frequency, the two aperture inter- ferometric processing is executed to implement clutter cancellation, respectively. And the couple of clutter suppressed data are employed to implement Dual Carrier Frequency Conjugate Processing (DCFCP), then both slow and fast moving targets detection can be completed, followed by moving target imaging. The simulation results show the validity of the signal processing method of this new SAR system. | Yin Jianfeng Li Daojing Wu Yirong | 2009 | Journal of Electronics(China)2009，26，1： | 1 |
| 17 | Normal form and critical points of closed orbits for planar autonomous systems显示文摘 | LIN YIRONG LI JIBIN | 1991 | Acta Mathematica Sinica1991，34，： | 1 |
| 18 | Centers and isochronous centers of a class of quasi-analytic switching systems显示文摘In this paper, we study the integrability and linearization of a class of quadratic quasi-analytic switching systems. We improve an existing method to compute the focus values and periodic constants of quasianalytic switching systems. In particular, with our method, we demonstrate that the dynamical behaviors of quasi-analytic switching systems are more complex than those of continuous quasi-analytic systems, by showing the existence of six and seven limit cycles in the neighborhood of the origin and infinity, respectively, in a quadratic quasi-analytic switching system. Moreover, explicit conditions are obtained for classifying the centers and isochronous centers of the system. | Feng Li Pei Yu Yirong Liu Yuanyuan Liu | 2018 | Science China Mathematics2018，61，7： | 1 |
| 19 | Application of BIB polishing technology in cross-section preparation of porous, layered and powder materials: A review显示文摘For the accuracy of experimental results, preparing a high quality polished surface and cross-section of the materials for further analysis using electron backscattered diffraction (EBSD), electron probe microanalysis (EPMA), and scanning probe microscopy (SPM) is extremely important. Broad ion beam (BIB) polishing, a method based on the principle of ion bombardment, has irreplaceable advantages. It makes up for the drawbacks and limitations of traditional polishing methods such as mechanical polishing, electrochemical polishing, and chemical polishing. The ions will not leave the bombardment area during polishing, which makes the BIB method suitable for porous materials. The energy of the ion beam can be adjusted according to the sample to reduce the deformation and strain of the polishing area, especially for fragile, soft, and hard materials. The conditions that need to be controlled during BIB polishing are simple. This paper demonstrated the unique advantages of BIB polishing technology in porous, layered and powder materials characterization through some typical application examples, and guided more researchers to understand and utilize BIB polishing technology in the development of new applications. | Rongrong JIANG Ming LI Yirong YAO Jianmin GUAN Huanming LU | 2019 | Frontiers of Materials Science2019，13，2： | 1 |
| 20 | Controllable gelation of methylcellulose by a salt mixture显示文摘 | Xu Yirong Li Lin Zheng Peijie | 2004 | Langmuir2004，20，15： | 1 |
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