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| 1 | Cementomimetics——constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides显示文摘Cementum is the outer-,mineralized-tissue covering the tooth root and an essential part of the system of periodontal tissue that anchors the tooth to the bone. Periodontal disease results from the destructive behavior of the host elicited by an infectious biofilm adhering to the tooth root and left untreated,may lead to tooth loss. We describe a novel protocol for identifying peptide sequences from native proteins with the potential to repair damaged dental tissues by controlling hydroxyapatite biomineralization. Using amelogenin as a case study and a bioinformatics scoring matrix,we identified regions within amelogenin that are shared with a set of hydroxyapatite-binding peptides (HABPs) previously selected by phage display. One 22-amino acid long peptide regions referred to as amelogenin-derived peptide 5 (ADP5) was shown to facilitate cell-free formation of a cementum-like hydroxyapatite mineral layer on demineralized human root dentin that,in turn,supported attachment of periodontal ligament cells in vitro. Our findings have several implications in peptide-assisted mineral formation that mimic biomineralization. By further elaborating the mechanism for protein control over the biomineral formed,we afford new insights into the evolution of protein-mineral interactions. By exploiting small peptide domains of native proteins,our understanding of structure-function relationships of biomineralizing proteins can be extended and these peptides can be utilized to engineer mineral formation. Finally,the cementomimetic layer formed by ADP5 has the potential clinical application to repair diseased root surfaces so as to promote the regeneration of periodontal tissues and thereby reduce the morbidity associated with tooth loss. | Mustafa Gungormus Ersin E Oren Jeremy A Horst Hanson Fong Marketa Hnilova Martha J Somerman Malcolm L Snead Ram Samudrala Candan Tamerler Mehmet Sarikaya | 2012 | International Journal of Oral Science2012，4，2： | 5 |
| 2 | Perioperative outcomes of major hepatic resections under low central venous pressure anesthesia: blood loss, blood transfusion, and the risk of postoperative renal dysfunction显示文摘 | Jose A Melendez Vittoria Arslan Mary E Fischer David Wuest William R Jarnagin Yuman Fong Leslie H Blumgart | 1998 | Journal of the American College of Surgeons1998，，6： | 2 |
| 3 | Relative CEO underpayment and CEO behav- ior towards R&D spending 显示文摘 | Fong E A | 2010 | Journal of Management Studies2010，47，6： | 1 |
| 4 | Prevalence of colorectal polyps in pediatric colonoscopy显示文摘 | Thakkar K Alsarraj A Fong E et al | 2012 | Dig Dis Sci2012，57，4： | 1 |
| 5 | Expression of Caveolin-1 and Caveolin-2 in urothclial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiatlon显示文摘 | Fong A Garcia E Gwynn L ct al | 2003 | Am J Clin Pathol2003，120，1： | 1 |
| 6 | Effect of chlortetraeycline of honeybee worker reared in vitro 显示文摘 | Peng CYS Mussen E Fong A | 1992 | Invertebr Pathol1992，60，： | 1 |
| 7 | Diagnostic molecular biomarkers for malignant pleural effusions显示文摘 | Krishna B Sriram Vandana Relan Belinda E Clarke Edwina E Duhig Ian A Yang Rayleen V Bowman YC Gary Lee Kwun M Fong | 2011 | Future Oncol2011，，6： | 1 |
| 8 | Retroviral oncoprotein Tax induces processing of NF- κ B2/p100 in T cells: evidence for the involvement of IKK α 显示文摘 | Xiao G Cvijic M E Fong A | 2001 | EMBO J2001，20，： | 1 |
| 9 | Paleomagnetic analysis using SQUID microscopy显示文摘 | Weiss B P Lima E A Fong L E | 2007 | Journal of Geophysical Research-Solid Earth2007，112，09： | 1 |
| 10 | Relative CEO underpayment and CEO behavior towards R:D spending显示文摘 | Fong E A | 2012 | Journal of Management Studies2012，47，6： | 1 |
| 11 | Paleointensity of the Earth's magnetic field using SQUID microscopy显示文摘 | Weiss B P Lima E A Fong L E | 2007 | Earth and Planetary Science Letters2007，264，12： | 1 |
| 12 | Expression of caveolin-1 and caveolin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation显示文摘 | FONG A GARCIA E GWYNN L | 2003 | Am J Clin Pathol2003，120，2： | 1 |
| 13 | Retroviral oncoprotein Tax in- duces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha显示文摘 | Xiao G Cvijic M E Fong A | 2001 | EMBO2001，20，23： | 1 |
| 14 | Stanley: The robot that won the DARPA grand challenge 显示文摘 | THRUN S MONTEMERLO M DAHLKAMP H STAVENS D ARON A DIEBEL J FONG P GALE J HALPENNY M HOFFMANN G LAU K OAKLEY C PALATUCCI M PRATT V STANG P STROHBAND S DUPONT C JENDROSSEK L E KOELEN C MARKEY C RUMMEL C VAN N J JENSEN E ALESSANDRINI P BRADSKI G DAVIES B ETTINGER S KAEHLER A NEFIAN A MAHONEY P | 2006 | Journal of Field Robotics2006，23，9： | 1 |
| 15 | The effect of CEO pay deviations on CEO withdrawal, firm size, and firm profits显示文摘 | Fong E A Misangyi V F Tosi J R H L | 2010 | Strategic Management Journal2010，31，6： | 1 |
| 16 | The Effect of CEO Pay Deviations on CEO Withdrawal,Firm Size,and Firm Profits显示文摘 | FONG E A MISANGYI V F TOSI H L | 2010 | Strategic Manage-ment Journal2010，31，6： | 1 |
| 17 | Expression of caveolin-1 and caveolin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation显示文摘 | FONG A GARCIA E GWYNN L | 2003 | Am J Clin Pathol2003，120，1： | 1 |
| 18 | Expression of caveolin-1 and caveolin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation显示文摘 | Fong A Garcia E Gwynn L | 2003 | J Am J Clin Pathol2003，120，： | 1 |
| 19 | Immune-correlates analysis of an HIV-1 vaccine efficacy trial 显示文摘 | Haynes BF Gilbert PB McElrath MJ Zolla-Pazner S Tomaras GD Alam SM Evans DT Montefiori DC Kar- nasuta C Sutthent R Liao HX DeVico AL Lewis GK Williams C Pinter A Fong Y Janes H DeCamp A Huang Y Rao M Billings E Karasavvas N Robb ML Ngauy V de Souza MS Paris R Ferrari G Bailer RT Soderberg KA Andrews C Berman PW Frahm N De Ro- sa SC Alpert MD Yates NL Shen X Koup RA Pitisut- tithum P Kaewkungwal J Nitayaphan S Rerks-Ngarm S Michael NL Kim JH | 2012 | N Engl J Med2012，366，14： | 1 |
| 20 | Expression of caveolin- 1 and caveolin-2 in urothe lialcarcinoma of the urinary bladder correlates with tum or grade and squamous differentiation显示文摘 | Fong A Garcia E Gwynn L | 2003 | Am J Clin Pathol2003，120，2： | 1 |
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