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| 1 | Endoscopic submucosal dissection for early gastric cancer:Quo vadis?显示文摘The diagnosis of early gastric cancer(EGC) is of great interest because its endoscopic and surgical treatment presents the best chance for a cure.With technical development,endoscopic submucosal dissection(ESD) has been widely performed for the curative treatment of EGC in Korea.Multinational studies of ESD for EGC will be the next missions that overcome these limitations and global guidelines will be processed for ESD for EGC. | Won Young Cho Joo Young Cho Il Kwun Chung Jin Il Kim Jin Seok Jang Jae Hak Kim | 2011 | World Journal of Gastroenterology2011，17，21： | 3 |
| 2 | Diosgenin stimulates osteogenic activity by increasing bone matrix protein synthesis and bone-specific transcription factor Runx2 in osteoblastic MC3T3-E1 cells显示文摘 | Ethel H. Alcantara Mee-Young Shin Ho-Yong Sohn Youn-Moon Park Taewan Kim Jae-Hwan Lim Hyung-Jin Jeong Soon-Tae Kwon In-Sook Kwun | 2011 | The Journal of Nutritional Biochemistry2011，，11： | 2 |
| 3 | 肺癌全基因组测序显示文摘肺癌是全球肿瘤发病率和病死率的主因,且预后很差。加强对肿瘤生物学的认识对肺癌研究至关重要。被誉为'下一代测序技术'的NGS技术(next-generation sequencing)是一种针对全基因组鉴定的有力工具,可以对致癌体细胞突变进行全面检测。大多数的NGS技术是基于平台特异性DNA文库进行多重聚合酶链反应(polymerase chain reaction,PCR),从而对目的基因扩增后测序。这种技术适用于高通量测序,可以检测出肿瘤中出现的全部基因组变异。缺点是这种技术需要在时间、实验设备、计算机数据分析、生物信息技术等各方面的大量投入。NGS技术已广泛应用于全基因组、外显子组、转录组和表观基因组的研究中,为肺癌研究和医疗模式带来改变。这项新技术的开展将转变当前对致癌信号通路的认识,可为癌症诊疗提供新的分子靶点。肺癌体细胞突变已有NGS技术的分析报道,但大规模基因组研究仍在进行中。个体化治疗策略将改善那些潜在获益患者的治疗方式,避免'无辜'患者受无效治疗带来的高额费用和不良反应。NGS的组织化、计算机化和生物信息化技术推动了科技的进步,同时,患者知情权和数据发布的相关伦理问题也浮现出来。信号通路中,驱动基因(driver gene)突变和传递基因(passenger gene)突变的区别,需要对测序结果进行细致解读。解读准确与否取决于DNA提取的样本类型、样本处理技术和样本含量。肿瘤异质性也会降低肿瘤基因突变的检测效能。NGS技术将推动对肿瘤基因突变的基础和临床研究,而且,也可应用于单细胞和游离的循环DNA,未来还将用于从体液和肿瘤亚群中获取的DNA样本。如果能进一步降低费用、提高检验速度和精度,NGS技术无疑将会成为肺癌研究的绝佳选择。 | Marissa Daniels Felicia Goh Casey M. Wright Krishna B. Sriram Vandana Relan Belinda E. Clarke Edwina E. Duhig Rayleen V. Bowman Ian A Yang Kwun M. Fong 孙岚 何建行 | 2013 | 国际病理科学与临床杂志2013，33，4： | 2 |
| 4 | Solution‑Processed Transparent Conducting Electrodes for Flexible Organic Solar Cells with 16.61% Efficiency显示文摘Nonfullerene organic solar cells(OSCs)have achieved breakthrough with pushing the efficiency exceeding 17%.While this shed light on OSC commercialization,high-performance flexible OSCs should be pursued through solution manufacturing.Herein,we report a solution-processed flexible OSC based on a transparent conducting PEDOT:PSS anode doped with trifluoromethanesulfonic acid(CF3SO3H).Through a low-concentration and low-temperature CF3SO3H doping,the conducting polymer anodes exhibited a main sheet resistance of 35Ωsq−1(minimum value:32Ωsq−1),a raised work function(≈5.0 eV),a superior wettability,and a high electrical stability.The high work function minimized the energy level mismatch among the anodes,hole-transporting layers and electron-donors of the active layers,thereby leading to an enhanced carrier extraction.The solution-processed flexible OSCs yielded a record-high efficiency of 16.41%(maximum value:16.61%).Besides,the flexible OSCs afforded the 1000 cyclic bending tests at the radius of 1.5 mm and the long-time thermal treatments at 85°C,demonstrating a high flexibility and a good thermal stability. | Juanyong Wan Yonggao Xia Junfeng Fang Zhiguo Zhang Bingang Xu Jinzhao Wang Ling Ai Weijie Song Kwun Nam Hui Xi Fan Yongfang Li | 2021 | Nano-Micro Letters2021，13，3： | 2 |
| 5 | Comparative study of MCe_(0.75)Zr_(0.25)O_(y)(M=Cu,Mn,Fe)catalysts for selective reduction of NO by CO:Activity and reaction pathways显示文摘Basic oxygen furnace steelmaking leads to the production of CO-rich off-gas.When CO and NO are combined in off-gas,selective catalytic reduction by CO(CO-SCR)effectively achieves the synergistic removal of both pollutants.In this paper,CuCe_(0.75)Zr_(0.25)O_(y),MnCe_(0.75)Zr_(0.25)O_(y),and FeCe_(0.75)Zr_(0.25)O_(y) catalysts are prepared and evaluated for their CO-SCR activity,and the results show that the reaction system needs to be anaerobic;thus,the CO-SCR reaction can be dominant.The T_(90) values of CuCe_(0.75)Zr_(0.25)O_(y) and FeCe_(0.75)Zr_(0.25)O_(y) are 200℃ and 223℃,respectively.The activities of these two catalysts are higher than that of MnCe_(0.75)Zr_(0.25)O_(y)(T_(90)=375℃).Linear nitrate and bridged bidentate nitrate are the main intermediate species involved in NO conversion on the catalyst surface,and bidentate CO_(3)^(2-)��coordination is the main intermediate species involved in CO conversion on the catalyst surface.CuCe_(0.75)Zr_(0.25)O_(y) has high lattice oxygen mobility and is more likely to react with NO and CO.In the presence of oxygen,most CO is oxidized by O_(2),which increases continuously to 100%,100%,and 98%for CuCe_(0.75)Zr_(0.25)O_(y),FeCe_(0.75)Zr_(0.25)O_(y),and MnCe_(0.75)Zr_(0.25)O_(y),respectively;additionally,CO is oxidized by O_(2),and the CO-SCR reaction cannot be carried out. | Junyao He Running Kang Xiaolin Wei Junqin Huang Feng Bin Kwun Nam Hui Kwan San Hui Dongyin Wu | 2021 | Carbon Resources Conversion2021，4，1： | 2 |
| 6 | Synergistically boosting the elementary reactions over multiheterogeneous ordered macroporous Mo2C/NC-Ru for highly efficient alkaline hydrogen evolution显示文摘Simultaneously enhancing the reaction kinetics,mass transport,and gas release during alkaline hydrogen evolution reaction(HER)is critical to minimizing the reaction polarization resistance,but remains a big challenge.Through rational design of a hierarchical multiheterogeneous three-dimensionally(3D)ordered macroporous Mo_(2)C-embedded nitrogen-doped carbon with ultrafine Ru nanoclusters anchored on its surface(OMS Mo_(2)C/NC-Ru),we realize both electronic and morphologic engineering of the catalyst to maximize the electrocatalysis performance.The formed Ru-NC heterostructure shows regulative electronic states and optimized adsorption energy with the intermediate H*,and the Mo_(2)C-NC heterostructure accelerates the Volmer reaction due to the strong water dissociation ability as confirmed by theoretical calculations.Consequently,superior HER activity in alkaline solution with an extremely low overpotential of 15.5 mV at 10 mAcm^(−2)with the mass activity more than 17 times higher than that of the benchmark Pt/C,an ultrasmall Tafel slope of 22.7 mV dec−1,and excellent electrocatalytic durability were achieved,attributing to the enhanced mass transport and favorable gas release process endowed from the unique OMS Mo_(2)C/NC-Ru structure.By oxidizing OMS Mo_(2)C/NC-Ru into OMS MoO_(3)-RuO_(2)catalyst,it can also be applied as efficient oxygen evolution electrocatalyst,enabling the construction of a quasi-symmetric electrolyzer for overall water splitting.Such a device's performance surpassed the state-of-the-art Pt/C||RuO2 electrolyzer.This study provides instructive guidance for designing 3D-ordered macroporous multicomponent catalysts for efficient catalytic applications. | Kaixi Wang Shuo Wang Kwan San Hui Haixing Gao Duc Anh Dinh Chengzong Yuan Chenyang Zha Zongping Shao Zikang Tang Kwun Nam Hui | 2022 | Carbon Energy2022，4，5： | 2 |
| 7 | Dual effects of hepatitis B virus X protein on the regulation of cell cycle control depending on the status of cellular p53显示文摘 | Ahn JY Jung EY Kwun HJ | 2002 | J Gen Virol2002，83，11： | 1 |
| 8 | Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltrans ferase 1显示文摘 | Lee JO Kwun HJ Jung Jk | 2005 | Oncogene2005，24，44： | 1 |
| 9 | Adventitial cystic disease of com- mon femoral vein显示文摘 | Kwun W H Suh B Y | 2011 | J Korean Surg Soc2011，80，1： | 1 |
| 10 | Effect of tensile loading on the properties of elastic-wave prop- agation in a strand显示文摘 | KWUN H BARTELS K A HANLEY J J | 1998 | Journal of the Acoustical Soci- ety of America1998，103，： | 1 |
| 11 | Effects of tensile loading on the properties of elastic-wave propagation in a strand显示文摘 | Kwun H Keith A B Hanley J J | 1998 | Journal of the Acoustical Society of A meriea1998，103，6： | 1 |
| 12 | Plastic work of fatigue crack propa gation in steels and aluminum alloys 显示文摘 | Liaw P K Kwun S I Fine M E | 1981 | Metallurgical Transactions1981，12，： | 1 |
| 13 | Transcriptional repression of p21(waf1) promoter by hepatitis B virus X protein via a p53 independent pathway 显示文摘 | Ahn JY Chung EY Kwun HJ | 2001 | Gene2001，275，： | 1 |
| 14 | Correlation coefficient of interval-valued intuitionistic fuzzy sets and its application to mul- tiple attribute group decision making problems 显示文摘 | PARK D G KWUN Y C PARK J H | 2009 | Mathematical and Computer Modelling2009，50，910： | 1 |
| 15 | Transcriptional repression of P21(waf1) promoter by hepatitis B virus X protein via a P53 independent pathway显示文摘 | Ahn J Y Chung EY Kwun H J | 2001 | Gene2001，275，1： | 1 |
| 16 | Analysis of clinical and radiologieal outcomes in mierosurgieal and endovaseular treatment of basilar apex aneurysms显示文摘 | Jin SC Ahn JS Kwun BD | 2009 | J Korean Neurosurg Soe2009，45，4： | 1 |
| 17 | Arthroscopic synovectomy of the knee joint in rheumatoid arthritis:surgical steps for complete synovectomy显示文摘 | Kim SJ Jung KA Kwun JD | 2006 | Arthroscopy2006，22，： | 1 |
| 18 | Is zinc deficiency a risk factor for atheroselerosis 显示文摘 | Beattie JH Kwun IS | 2004 | The British Journal of Nutrition2004，91，2： | 1 |
| 19 | Magnetostrictive Sensor Technology and Its Applications显示文摘 | KWUN H BARTELS K A | 1998 | Ultrasonics1998，36，1： | 1 |
| 20 | A model for the effect of stress on the low-frequency harmonic content of the magnetic induction in ferromagnetic materials显示文摘 | Sablik M J Burkhardt G L Kwun H | | 0，，08： | 1 |
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