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| 1 | H pylori receptor MHC classⅡcontributes to the dynamic gastric epithelial apoptotic response显示文摘AIM: To investigate the role of MHC classⅡin the modulation of gastric epithelial cell apoptosis induced by H pylon infection. METHODS: After stimulating a human gastric epithelial cell line with bacteria or agonist antibodies specific for MHC classⅡand CD95, the quantitation of apoptotic and anti-apoptotic events, including caspase activation, BCL-2 activation, and FADD recruitment, was performed with a fluorometric assay, a cytometric bead array, and confocal microscopy, respectively. RESULTS: Pretreatment of N87 cells with the anti-MHC classⅡIgM antibody RFD1 resulted in a reduction in global caspase activation at 24 h of H pylori infection. When caspase 3 activation was specifically measured, crosslinking of MHC class n resulted in markedly reduced caspase activation, while simple ligation of MHC classⅡdid not. Crosslinking of MHC class n also resulted in an increased activation of the anti-apoptosis molecule BCL-2 compared to simple ligation. Confocal microscope analysis demonstrated that the pretreatment of gastric epithelial cells with a crosslinking anti-MHC classⅡIgM blocked the recruitment of FADD to the cell surface. CONCLUSION: The ability of MHC class n to modulate gastric epithelial apoptosis is at least partially dependent on its crosslinking. The crosslinking of this molecule has anti-apoptotic effects during the earlier time points of H pylori infection. This effect is possibly mediated by the ability of MHC classⅡto modulate the activation of the pro-apoptotic receptor Fas by blocking the recruitment of the accessory molecule FADD, and this delay in apoptosis induction could allow for prolonged cytokine secretion by H pylori-infected gastric epithelial cells. | David A Bland Giovanni Suarez Ellen J Beswick Johanna C Sierra Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，29： | 3 |
| 2 | Charitable programs and the retailer: do they mix?显示文摘 | Pam Scholder Ellen Lois A Mohr Deborah J Webb | 2000 | Journal of Retailing2000，，： | 2 |
| 3 | H pylori receptor MHC class Ⅱ contributes to the dynamic gastric epithelial apoptotic response显示文摘AIM: To investigate the role of MHC class Ⅱ in the modulation of gastric epithelial cell apoptosis induced by H pylori infection.METHODS: After stimulating a human gastric epithelial cell line with bacteria or agonist antibodies specifi c for MHC class Ⅱ and CD95, the quantitation of apoptotic and anti-apoptotic events, including caspase activation, BCL-2 activation, and FADD recruitment, was performed with a ? uorometric assay, a cytometric bead array, and confocal microscopy, respectively.RESULTS: Pretreatment of N87 cells with the anti-MHC class Ⅱ IgM antibody RFD1 resulted in a reduction in global caspase activation at 24 h of H pylori infection. When caspase 3 activation was specifically measured, crosslinking of MHC class Ⅱ resulted in a marked re-duced caspase activation, while simple ligation of MHC class Ⅱ did not. Crosslinking of MHC class Ⅱ also re-sulted in an increased activation of the anti-apoptosis molecule BCL-2 compared to simple ligation. Confocal microscope analysis demonstrated that the pretreatment of gastric epithelial cells with a crosslinking anti-MHC class Ⅱ IgM blocked the recruitment of FADD to the cell surface.CONCLUSION: The results presented here demonstrate that the ability of MHC class Ⅱ to modulate gastric epi-thelial apoptosis is at least partially dependent on its crosslinking. Furthermore, while previous research has demonstrated that MHC class Ⅱ signaling can be pro-apoptotic during extended ligation, we have shown that the crosslinking of this molecule has anti-apoptotic ef-fects during the earlier time points of H pylori infection. This effect is possibly mediated by the ability of MHC class Ⅱ to modulate the activation of the pro-apoptotic receptor Fas by blocking the recruitment of the accessory molecule FADD, and this delay in apoptosis induction could allow for prolonged cytokine secretion by H pylori-infected gastric epithelial cells. | David A Bland Giovanni Suarez Ellen J Beswick Johanna C Sierra Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，33： | 2 |
| 4 | Bond strength of visible light-cured ionomer orthodontic cement显示文摘 | Sejal B Waldemar G Ellen A | 1997 | Am J Orthod Dentofacial Orthop1997，112，2： | 1 |
| 5 | Self - management program improves anticoaglation control and quality of life : A prospective randomized study 显示文摘 | Mohamed A Soliman H Ellen Van E | 2009 | Eur J Cardiothorac Surg2009，35，2： | 1 |
| 6 | Nutrientremoval by NF and romembranes in a decentralized sanitation system 显示文摘 | Ellen M Van Voorthuizen Zwijnenburg A | 2005 | Water Research2005，，39： | 1 |
| 7 | Peak discharge estimates of glacia-lake outburst floods and 'normal' climatic floods in the Mount Everest region,Nepal显示文摘 | DANIEL A C ELLEN E W | 2001 | Geomorphology2001，，1： | 1 |
| 8 | Building Corporate Associations:Consumer Attributions for Corporate Socially Responsible Programs 显示文摘 | Ellen P S Webb D J Mohr L A | 2006 | Journal of the Academy of Marketing Science2006，34，2： | 1 |
| 9 | Evaluation of a fully covered self-ex- pandable metal stent in liver transplant patients with bile leaks : mid-term analysis 显示文摘 | Phillips M S Saue B Bonatti H Rehan M E Smith L A Ellen K | 2009 | Gastrointest Endosc2009，69，： | 1 |
| 10 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008，，6： | 1 |
| 11 | Charitable programs and the retailer: do they mix?显示文摘 | Pam Scholder Ellen Lois A Mohr Deborah J Webb | 2000 | Journal of Retailing2000，，3： | 1 |
| 12 | Consumer brand confusion: A conceptual framework 显示文摘 | Ellen R F Phil W B Joseph A C | 1992 | Psychology and Marketing1992，9，2： | 1 |
| 13 | Organic amendments to enhance herbicide biodegradation in conta minated soils显示文摘 | Thomas B M Jennifer K C Ellen L A | 2001 | Biology and Fertility of Soils2001，33，6： | 1 |
| 14 | The potential for phytoremediation of MTBE显示文摘 | Ellen R B Ramaswami A | 2001 | Water Research2001，35，5： | 1 |
| 15 | Sm2 in BAM:fluorescent probe for the number of luminescing sites of Eu2+ in BAM显示文摘 | ELLENS A ZWASCHKA F KUMMER F | 2001 | J Lumin2001，93，： | 1 |
| 16 | Transformation of dilative and contractive landslide debris into debris flowAn example from Marin Country,California显示文摘 | Fleming R W Ellen S D Algus M A | 1989 | Engineering Geology1989，27，： | 1 |
| 17 | 16 MDCT angiography of aortoiliac and lower extremity arteries:comparison with digital subtraction angiography显示文摘 | Thomas A Ellen F Robin H | 2007 | AmJ Roentgenol2007，189，3： | 1 |
| 18 | Building corporate associa?tions: consumer attributions for corporate socially responsi?ble programs显示文摘 | Ellen P S Webb DJ Mohr L A | 2006 | Journal of the Academy of Marketing Sci?ence2006，34，2： | 1 |
| 19 | Self - manage- ment program improves anticoaglation control and quality of life: A prospective randomized study显示文摘 | Mohamed A Soliman H Ellen Van E | 2009 | Eur J Cardiothorac Surg2009，35，2： | 1 |
| 20 | Free wall rupture in the elderly Deleterious effect of fibrinolytic therapy on the ageie elderly deleterious effect of fibrinolytic on the ageing heart显示文摘 | Ellen C Keeley A James A | 2005 | Euro pean Heart Journal2005，26，17： | 1 |
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