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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Researching the Investment of Information Technology in Construction:An Examination of Evaluation Practices 显示文摘 | Iraniz L P Edwards D J | 2005 | Automation in Construction2005，14，8： | 1 |
| 3 | Analysis of stained objects in histological sections by spectral imaging and differential absorption显示文摘 | Woemer B M Edwards D A | 1999 | Journal of Histochemistry & Cytochemistry1999，47，10： | 1 |
| 4 | Measurement ofinterfacial dilational viscosity at high rates of interface expansion using the maximum bubble pressure method 1:Gas-liquid interface显示文摘 | Edwards D A Wasan D T | 1992 | Journal of Colloid and Interface Science1992，148，1： | 1 |
| 5 | Timing, duration, and transitions of the last interglacial asian monsoon 显示文摘 | Yuan D X Cheng H Edwards R L | 2004 | Science2004，304，： | 1 |
| 6 | The application of a piezoelectric bar gauge to shock tube studies显示文摘 | Edwards D H Davies L Lawrence T R | 1964 | J Sci Instrum1964，64，： | 1 |
| 7 | Influence of sorption on the biological utilization of two simple carbon substrates显示文摘 | JONES D L EDWARDS A C | 1998 | Soil Biology & Biochemistry1998，30，： | 1 |
| 8 | Safety of theta burst transcranial magnetic stimulation: a systematic review of the literature 显示文摘 | Oberman L Edwards D Eldaief M | 2011 | Clin Neurophysiol2011，28，1： | 1 |
| 9 | Measurement ofinterfacial dilational viscosity at high rates of interface expansion using the maximum bubble pressure method1:Liquid-liquid interface显示文摘 | Edwards D A Wasan D T | 1993 | Journal of Colloid and Interface Science1993，155，： | 1 |
| 10 | A three-component deformation model for image-guided surgery显示文摘 | Edwards P J Hill D L G Little J A | 1998 | Medical Image Analysis1998，2，4： | 1 |
| 11 | Timing,duration,and transitions of the last interglacial Asian monsoon显示文摘 | Yuan D X Cheng H Edwards R L | 2004 | Science2004，304，5670： | 1 |
| 12 | Characteristic macropores that affect infiltration into nontilled soil显示文摘 | Edwards W M Norton L D Redmond C E | 1988 | Soil Science Society of America Journal1988，52，2： | 1 |
| 13 | Serum surfactant protein D is steroid sensitive and associated with exacerbations of COPD显示文摘 | Lonas D A Silverman E K Edwards L D | 2009 | Eur Respir J2009，34，1： | 1 |
| 14 | Variables influencing the toxic response to organophosphates in humans 显示文摘 | KARALLIEDDE L D EDWARDS P MARRS T C | 2003 | Food Chem Toxicol2003，41，1： | 1 |
| 15 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 16 | The Intemet: A Global Telecommunications Solution 显示文摘 | MATHY L EDWARDS C HUTCHISON D | 2000 | IEEE Network2000，14，4： | 1 |
| 17 | Recent advances: the eytoehrome P450 enzymes 显示文摘 | Slaughter R L Edwards D J | 1995 | Ann Pharmaeother1995，29，6： | 1 |
| 18 | Non-equilibrium behaviour of weld metal in flux-related processes 显示文摘 | Olson D L Edwards G R Liu S | 1993 | Welding in the World1993，31，2： | 1 |
| 19 | Annual growth banding in a cave stalagmite显示文摘 | Baker A Smart P L Edwards R L Richards D A | 1993 | Nature1993，364，： | 1 |
| 20 | Tourniquet-induced wound hypoxia after total knee replacement 显示文摘 | Clarke MT Longstaff L Edwards D | 2001 | J Bone Joint Surg (Br)2001，83，1： | 1 |
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