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| 1 | Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment显示文摘The Hedgehog(HH) signaling pathway plays important roles in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment(TME). Aberrant HH signaling activation may accelerate the growth of gastrointestinal tumors and lead to tumor immune tolerance and drug resistance.The interaction between HH signaling and the TME is intimately involved in these processes, for example, tumor growth, tumor immune tolerance, inflammation, and drug resistance. Evidence indicates that inflammatory factors in the TME, such as interleukin 6(IL-6) and interferon-g(IFN-g), macrophages, and T cell-dependent immune responses, play a vital role in tumor growth by affecting the HH signaling pathway. Moreover, inhibition of proliferating cancer-associated fibroblasts(CAFs) and inflammatory factors can normalize the TME by suppressing HH signaling. Furthermore, aberrant HH signaling activation is favorable to both the proliferation of cancer stem cells(CSCs) and the drug resistance of gastrointestinal tumors. This review discusses the current understanding of the role and mechanism of aberrant HH signaling activation in gastrointestinal carcinogenesis, the gastrointestinal TME,tumor immune tolerance and drug resistance and highlights the underlying therapeutic opportunities. | Jinghui Zhang Jiajun Fan Xian Zeng Mingming Nie Jingyun Luan Yichen Wang Dianwen Ju Kai Yin | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 5 |
| 2 | Growth of covellite crystal onto azurite surface during sulfurization and its response to flotation behavior显示文摘In this work,the growth of copper sulfide crystal onto azurite surfaces during sulfurization and its response to flotation are investigated.Filed emission scanning electron microscopy-energy dispersive X-ray spectroscopy(FESEM) and X-ray diffraction(XRD) studies confirmed that the sulfurization of azurite is not limited to the mineral surface,but rather penetrates into the bulk to form covellite crystal(synCuS),creating favorable conditions for the stable adsorption of xanthate and greatly promoting the azurite flotation.Additionally,as demonstrated by X-ray photoelectron spectroscopy(XPS) and time of flight secondary ion mass spectrometry(TOF-SIMS) analyses,a redox reaction occurred during this process,and Cu(Ⅱ) onto the mineral surface was reduced to Cu(Ⅰ).Correspondingly,reduced S^(2-) was oxidized to(S_(2))^(2-),(S_n)^(-2),and even to deeper oxidation state S~0,(S_(x)O_(y))^(n-) and SO_(4)^(2-).Excess sodium sulfide strengthens copper sulfide to form onto the azurite surface,and provides enough raw material for crystal copper sulfide to grow,resulting in the formation of 'flake-like' covellite with a better crystallinity.However,the floatability of azurite decreased dramatically under this condition,because the generated massive colloidal copper sulfide in flotation pulp deteriorates the flotation environment,resulting in a decreased effective adsorption of collector onto azurite surfaces. | Jinpeng Cai Peilun Shen Dianwen Liu Xiaolin Zhang Jianjun Fang Chao Su Xingcai Yu Jiangli Li Han Wang | 2021 | International Journal of Mining Science and Technology2021，31，6： | 4 |
| 3 | Overexpression of cytoglobin gene inhibits hypoxic injury to SH-SY5Y neuroblastoma cells显示文摘A plasmid for cytoglobin expression, pAcGFP1-C1-cytoglobin, was transfected into SH-SY5Y cells. Cobalt chloride was used to establish a model of hypoxia. Western blotting indicated that cytoglobin was overexpressed and there was low expression of hypoxia-inducible factor-1α in SH-SY5Y cells after transfection. Following cobalt chloride-induced hypoxia, cytoglobin and hypoxia-inducible fac-tor-1α expression gradually increased in SH-SY5Y cells. Flow cytometry showed that with increas-ing duration of hypoxia, the proportion of normal cells significantly diminished in the transfected and non-transfected groups. The proportion of cells in the early stages of apoptosis increased. However, the proportion of apoptotic cells was significantly lower in the transfected group compared with the non-transfected group. These results demonstrate that cytoglobin and hypoxia-inducible factor-1α are strongly up-regulated by hypoxia, and that there is a strong relationship between hy-poxia-inducible factor-1α and cytoglobin during hypoxic injury. | Xiuling Yu Dianwen Gao | 2013 | Neural Regeneration Research2013，8，23： | 3 |
| 4 | Overexpression of the neuroglobin gene delivered by ultrasound-targeted microbubble destruction protects SH-SY5Y cells against cobalt chloride induced hypoxia显示文摘In this study, we examined the effects of neuroglobin gene (Ngb) transfection into SH-SY5Y cells, using ultrasound-targeted microbubble destruction (UTMD), on cobalt chloride-induced hypoxia. With an ultrasound intensity of 0.8 W/cm2, a 60-second exposure duration, 50% duty cycle, and 20% microbubble concentration, pAcGFP1-C1-Ngb-transfected cells exhibited the highest cell viability and transfection efficiency. The efficiency of plasmid delivery was significantly higher with UTMD than transfection with plasmid alone, transfection with plasmid using microbubbles, or transfection of plasmid by ultrasound. In addition, during cobalt chloride-induced hypoxia, caspase-3 activity in pAcGFP1-C1-Ngb-transfected cells was significantly lower than in untransfected cells. Ngb protein and mRNA expression were significantly higher in cells transfected by UTMD than in cells transfected with the other methods. These results demonstrate that UTMD can very efficiently mediate exogenous gene delivery, and that Ngb overexpression protects cells against cobalt chloride-induced hypoxia. | Qian Yang Dianwen Gao Qingzhu Nie Zhengang Cai Jian Du Lujuan Shan Yuejian Liu | 2011 | Neural Regeneration Research2011，6，25： | 3 |
| 5 | A biomimetic and bioactive scaffold with intelligently pulsatile teriparatide delivery for local and systemic osteoporosis regeneration显示文摘Osteoporosis is one of the most disabling consequences of aging,osteoporotic fractures and higher risk of the subsequent fractures leading to substantial disability and deaths,indicating both local fractures healing and the early anti-osteoporosis therapy are of great significance.Teriparatide is strong bone formation promoter effective in treating osteoporosis,while side effects limit clinical applications.Traditional drug delivery is lack of sensitive and short-term release,finding a new non-invasive and easily controllable drug delivery to not only repair the local fractures but also improve total bone mass has remained a great challenge.Thus,bioinspired by the natural bone components,we develop appropriate interactions between inorganic biological scaffolds and organic drug molecules,achieving both loaded with the teriparatide in the scaffold and capable of releasing on demand.Herein,biomimetic bone microstructure of mesoporous bioglass,a near-infrared ray triggered switch,thermosensitive liposomes based on a valve,and polydopamine coated as a heater is developed rationally for osteoporotic bone regeneration.Teriparatide is pulsatile released from intelligent delivery,not only rejuvenating osteoporotic bone defect,but also presenting strong systemic anti-osteoporosis therapy.This biomimetic bone carrying novel drug delivery platform is well worth expecting to be a new promising strategy and clinically commercialized to help patients survive from the osteoporotic fracture. | Lingbin Che Ying Wang Dongyong Sha Guangyi Li Ziheng Wei Changsheng Liu Yuan Yuan Dianwen Song | 2023 | Bioactive Materials2023，，1： | 3 |
| 6 | Role of ammonium sulfate in sulfurization flotation of azurite:Inhibiting the formation of copper sulfide colloid and its mechanism显示文摘In this study,the role of(NH_(4))_(2)SO_(4)during the sulfurization of azurite and its response to flotation were investigated.The flotation results showed that adding(NH_(4))_(2)SO_(4)prior to sulfurization decreased the formation of colloid in flotation pulp,and the floatability of the suppressed azurite caused by excess sodium sulfide was restored.After adding(NH_(4))_(2)SO_(4)prior to sulfurization,the formation of Cu(NH_(3))_(n) ^(2+)intermediate products changed the path of the sulfurization reaction,which slowed the direct impact of HSon the azurite surface.The nucleation rate was reduced,and the growth of copper sulfide crystal was improved.Covellite(syn,CuS)with larger crystal grains was formed on the azurite surface,thereby enhancing the mechanical stability of copper sulfide products onto the mineral surface.Therefore,the generated copper sulfide colloid significantly reduced,ultimately promoting the effective adsorption of xanthate on the azurite surface. | Jinpeng Cai Chao Su Yinyu Ma Xingcai Yu Rong Peng Jiangli Li Xiaolin Zhang Jianjun Fang Peilun Shen Dianwen Liu | 2022 | International Journal of Mining Science and Technology2022，32，3： | 2 |
| 7 | Anti-depression effect of sulphuric acid on the flotation of ilmenite 显示文摘 | Bingliang X Dianwen Liu Guoyin Xu | 2012 | Advanced Materials Research2012，，5： | 1 |
| 8 | A comparison of percutaneous reduction and screw fixation versus open reduction and plate fixation of traumatic symphysis pubis diastasis显示文摘 | Linwei Chen Guoyou Zhang Dianwen Song Xiaoshan Guo Wen Yuan | 2012 | Archives of Orthopaedic and Trauma Surgery2012，，2： | 1 |
| 9 | Biotransformation pathways of ginsenoside Rb1 to compound K by β-glucosidases in fungus Paecilomyces Bainier sp. 229显示文摘 | Qin Yan Wei Zhou XunLong Shi Pei Zhou DianWen Ju MeiQing Feng | 2010 | Process Biochemistry2010，，9： | 1 |
| 10 | Immunogenicity of Iodine 131 chimeric tumor necrosis therapy monoclonal antibody in advanced lung cancer patients显示文摘 | Hui Wang Chuanping Cao Beilei Li Shaoliang Chen Jun Yin Jing Shi Dan Ye Qun Tao Peisheng Hu Alan Epstein Dianwen Ju | 2008 | Cancer Immunology Immunotherapy2008，，5： | 1 |
| 11 | Effect of Palrnatine on lipopolysaccharide-induced acute lung injury by inhibiting activation of the Akt/NF-κB pathway显示文摘Inflammation plays an important role in the development of acute lung injury(ALI).Severe pulmonary inflammation can cause acute respiratory distress syndrome(ARDS)or even death.Expression of proinflammatory interleukin-1β(IL-1β)and inducible nitric oxide synthase(iNOS)in the process of pulmonary inflammation will further exacerbate the severity of ALI.The purpose of this study was to explore the effect of Palrnatine(Pa)on lipopolysaccharide(LPS)-induced mouse ALI and its underlying mechanism.Pa,a natural product,has a wide range of pharmacological activities with the potential to protect against lung injury.Western blotting and quantitative real-time polymerase chain reaction(qRT-PCR)assays were performed to detect the expression and translation of inflammatory genes and proteins in vitro and in vivo.Immunoprecipitation was used to detect the degree of P65 translocation into the nucleus.We also used molecular modeling to further clarify the mechanism of action.The results showed that Pa pretreatment could significantly inhibit the expression and secretion of the inflammatory cytokine IL-1β,and significantly reduce the protein level of the proinflammatory protease iNOS,in both in vivo and in vitro models induced by LPS.Further mechanism studies showed that Pa could significantly inhibit the activation of the protein kinase B(Akt)/nuclear factor-κB(NF-κB)signaling pathway in the LPS-induced ALI mode and in LPS-induced RAW264.7 cells.Through molecular dynamics simulation,we observed that Pa was bound to the catalytic pocket of Akt and effectively inhibited the biological activity of Akt.These results indicated that Pa significantly relieves LPS-induced ALI by activating the Akt/NF-κB signaling pathway. | Xingchi KAN Yingsheng CHEN Bingxu HUANG Shoupeng FU Wenjin GUO Xin RAN Yu CAO Dianwen XU Ji CHENG Zhanqing YANG Yanling XU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，11： | 1 |
| 12 | Fasudil, a Rho-associated protein kinase inhibitor, attenuates retinalischemia and reperfusion injury in rats显示文摘 | Haishan Song Dianwen Gao | 2011 | International Journal of Molecular Medicine2011，，2： | 1 |
| 13 | Synergistic activation of smithsonite with copper-ammonium species for enhancing surface reactivity and xanthate adsorption显示文摘Copper ions(Cu^(2+))are usually added to activate the sulfidized surface of zinc oxide minerals to enhance xanthate attachment using sulfidization xanthate flotation technology.The adsorption of Cu^(2+)and xanthate on the sulfidized surface was investigated in various systems,and its effect on the surface hydrophobicity and flotation performance was revealed by multiple analytical methods and experiments.X-ray photoelectron spectroscopy(XPS)and time-of-flight secondary ion mass spectrometry(To F-SIMS)characterization demonstrated that the adsorption of Cu^(2+)on sulfidized smithsonite surfaces increased the active Cu—S content,regardless of treatment in any activation system.The sulfidized surface pretreated with NH_(4)^(+)-Cu^(2+)created favorable conditions for the adsorption of more Cu^(2+),significantly enhancing the smithsonite reactivity.Zeta potential determination,ultraviolet(UV)-visible spectroscopy,Fourier transform-infrared(FT-IR)measurements,and contact angle detection showed that xanthate was chemically adsorbed on the sulfidized surface,and its adsorption capacity in various systems was illustrated from qualitative and quantitative aspects.In comparison to the Na2S–Cu^(2+)and Cu^(2+)–Na2S–Cu^(2+)systems,xanthate exhibited a higher adsorption capacity on sulfidized smithsonite surfaces in NH_(4)^(+)-Cu^(2+)–Na2S–Cu^(2+)system.Hence,activation with Cu^(2+)–NH4+synergistic species prior to sulfidization significantly enhanced the mineral surface hydrophobicity,thereby increasing its flotation recovery. | Wenjuan Zhao Bin Yang Yahui Yi Qicheng Feng Dianwen Liu | 2023 | International Journal of Mining Science and Technology2023，33，4： | 1 |
| 14 | Study on influence of residual magnetite in Panzhihua ilmenite flotation显示文摘 | Zhang Xiaolin Liu Dianwen FangJianjun | 2011 | Procedia Earth and Planetary Science2011，，2： | 1 |
| 15 | Targeting Hedgehog signaling pathway and autophagy overcomes drug resistance of BCR-ABL-positive chronic myeloid leukemia显示文摘 | Xian Zeng Hui Zhao Yubin Li Jiajun Fan Yun Sun Shaofei Wang Ziyu Wang Ping Song Dianwen Ju | 2015 | Autophagy2015，，2： | 1 |
| 16 | Existence and Stability of Supersonic Euler Flows Past Lipschitz Wedges显示文摘 | Gui-Qiang Chen Yongqian Zhang Dianwen Zhu | 2006 | Archive for Rational Mechanics and Analysis2006，，2： | 1 |
| 17 | Similarity representation of pattern-information fMRI显示文摘Representational similarity analysis (RSA) is a rapidly developing multivariate platform to investigate the structure of neural activities. Similarity/dissimilarity is the core concept of RSA, realized by the construction of a representational dissimilarity matrix, that addresses the closeness/distance for each pair of research elements (e.g., one minus the correlation between the brain responses to 2 different stimuli) and in turn, constitutes a multivariate pattern as its analytic foundation. This approach is also welcome for its sensitivity in detecting subtle differences of distributed experimental effects in the brain. Importantly, RSA is not only an experimental tool but a promising data-analytical framework that can integrate cross-modal imaging signals, explore brain-behavior link, and verify computational models according to measured neural activities. RSA substantiates its integrative power by relating similarity structure in one domain (e.g., stimulus features) to that in another domain (e.g., neural activities). This review summarizes dissimilarity/similarity definition of RSA, introduces how to derive the dissimilarity structure in neural response pattern, and carry out connectivity analysis based on RSA platform. Several recent advances are highlighted, such as the extraction of across-subjects regularity, cross-validation of brain reactivity in human beings and monkeys, the incorporation of computational models and behavioral profiles into RSA. Voxel receptor field modeling, another promising multivariate tool of pattern elucidation, is presented and compared. The application of RSA is expected to surge and extend in many fields of neuro-science, computation, psychology and medicine. We also discuss the limitations of RSA and some critical questions that need to be addressed in future research. | XUE ShaoWei WENG XuChu HE Sheng LI DianWen | 2013 | Chinese Science Bulletin2013，58，11： | 1 |
| 18 | Advances in depressants for flotation separation of Cu–Fe sulfide minerals at low alkalinity:A critical review显示文摘The flotation separation of Cu–Fe sulfide minerals at low alkalinity can be achieved using selective depressants.In the flotation system of Cu–Fe sulfide minerals,depressants usually preferentially interact with the pyrite surface to render the mineral surface hydrophilic and hinder the adsorption of the collector.This review summarizes the advances in depressants for the flotation separation of Cu–Fe sulfide minerals at low alkalinity.These advances include use of inorganic depressants (oxidants and sulfur–oxygen compounds),natural polysaccharides (starch,dextrin,konjac glucomannan,and galactomannan),modified polymers (carboxymethyl cellulose,polyacrylamide,lignosulfonate,and tricarboxylate sodium starch),organic acids (polyglutamic acid,sodium humate,tannic acid,pyrogallic acid,salicylic acid,and lactic acid),sodium dimethyl dithiocarbamate,and diethylenetriamine.The potential application of specific inorganic and organic depressants in the flotation separation of Cu–Fe sulfide minerals at low alkalinity is reviewed.The advances in the use of organic depressants with respect to the flotation separation of Cu–Fe sulfide minerals are comprehensively detailed.Additionally,the depression performances and mechanisms of different types of organic depressants on mineral surfaces are summarized.Finally,several perspectives on depressants vis-à-vis flotation separation of Cu–Fe sulfide minerals at low alkalinity are proposed. | Qicheng Feng Wenhang Yang Maohan Chang Shuming Wen Dianwen Liu Guang Han | 2024 | International Journal of Minerals,Metallurgy and Materials2024，31，1： | 0 |
| 19 | Dosimetry of chimeric TNT in lung tumor patients显示文摘The purpose of this study was to assess the absorbed dose of tumor and main critical organs in 131I labeled chimeric tumor necrotic treatment (chTNT). In 9 patients, a single intravenous dose of (29.6±3.7) MBq/kg was administered. Blood samples were drawn at different time intervals, and urine was collected for up to one week. Tissue distribution of 131I-chTNT was followed for up to one week by gamma camera imaging. Absorbed doses to the whole body and to normal organs were computed according to the MIRD scheme using Mirdose-3 software. S-factors for lung tumors were estimated by comparison with lungs of similar mass and position in the body. It was found that mean serum disappearance half time values for 131I-chTNT were (4.93±9.36) h and (61.7±21.2) h for α, β respectively, while that for whole body was(99±10) h. Mean urine biological clearance half time value was (90±10) h. The absorbed dose to tumor was (8.28±2.65) Gy, and the tumor-to-nontumor dose ratio was 3.95±1.55. And the mean effective dose to patients was (1.02±0.29) mSv/MBq. | CHEN Yangchun CHEN Shaoliang JU Dianwen SHI Hongcheng YAO Zhifeng | 2007 | Nuclear Science and Techniques2007，18，4： | 0 |
| 20 | Targeted and intracellular delivery of protein therapeutics by a boronated polymer for the treatment of bone tumors显示文摘The treatment of malignant bone tumors by chemotherapeutics often receives poor therapeutic response due to the specific physiological bone environment,and thus calls for the development of new therapeutic options.Here,we reported a bone-targeted protein nanomedicine for this purpose.Saporin,a toxin protein,was co-assembled with a boronated polymer for intracellular protein delivery,and the formed nanoparticles were further coated with an anionic polymer poly(aspartic acid)to shield the positive charges on nanoparticles and provide the bone targeting function.The prepared ternary complex nanoparticles showed high bone accumulation both in vitro and in vivo,and could reverse the surface charge property from negative to positive after locating at tumor site triggered by tumor extracellular acidity.The boronated polymer in the de-shielded nanoparticles further promote intracellular delivery of saporin into tumor cells,exerting the anticancer activity of saporin by inactivation of ribosomes.As a result,the bone-targeted and saporin-loaded nanomedicine could kill cancer cells at a low saporin dose,and efficiently prevented the progression of osteosarcoma xenograft tumors and bone metastatic breast cancer in vivo.This study provides a facile and promising strategy to develop protein-based nanomedicines for the treatment of malignant bone tumors. | Yang Yan Lei Zhou Zhengwang Sun Dianwen Song Yiyun Cheng | 2022 | Bioactive Materials2022，7，1： | 0 |
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