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| 1 | Neoadjuvant and adjuvant treatment strategies for hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is the most common liver malignancy worldwide and a major cause of cancer-related mortality for which liver resection is an important curative-intent treatment option. However, many patients present with advanced disease and with underlying chronic liver disease and/or cirrhosis, limiting the proportion of patients who are surgical candidates. In addition, the development of recurrent or de novo cancers following surgical resection is common. These issues have led investigators to evaluate the benefit of neoadjuvant and adjuvant treatment strategies aimed at improving resectability rates and decreasing recurrence rates. While high-level evidence to guide treatment decision making is lacking, recent advances in locoregional and systemic therapies, including antiviral treatment and immunotherapy, raise the prospect of novel approaches that may improve the outcomes of patients with HCC. In this review, we evaluate the evidence for various neoadjuvant and adjuvant therapies and discuss opportunities for future clinical and translational research. | Clifford Akateh Sylvester M Black Lanla Conteh Eric D Miller Anne Noonan Eric Elliott Timothy M Pawlik Allan Tsung Jordan M Cloyd | 2019 | World Journal of Gastroenterology2019，25，28： | 16 |
| 2 | 基于信号质量评估和卡尔曼滤波的心率估计算法显示文摘目的:研究基于多导重症监护导联心电分析的逐搏心率估计算法。方法:通过开放源码的QRS搏动识别算法计算逐搏心率,通过分析信号的波形特征、统计特性和相互关系导出反映信号质量好坏的信号质量指数(signalqualityindex,SQI)。应用基于信号质量指数调节的卡尔曼滤波方法进行心率估计,通过残差值和信号质量指数的大小来动态调节卡尔曼滤波器的状态变量,获得逐搏心率的最佳估计。应用美国麻省理工学院多参数智能重症监护数据库II中437例病人的6000多小时高质量数据和人为添加真实心电干扰的数据进行算法评价。结果:与直接心率估计及采样保持等算法比较,本算法在严重干扰存在时,心率估计的均方根误差最小。结论:基于信号质量评估和卡尔曼滤波的心率估计算法在严重干扰存在时仍能提供精确的心率估计。 | 李桥 Roger G Mark Gari D Clifford 俞梦孙 | 2007 | 中国医学物理学杂志2007，24，6： | 8 |
| 3 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 4 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 5 | Evalua- tion of iron chemical coagulation and electrocoagulation pretreatment for sur- face water microfiltration 显示文摘 | Bagga A Chellam S Clifford D | 2008 | J Membr Sci2008，309，12： | 1 |
| 6 | Analytical extraction of additives from polymers显示文摘 | Vandenburg H J Clifford A A Bartle K D | 1997 | The Analyst1997，122，： | 1 |
| 7 | Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells 显示文摘 | Lee M E Temizer D H Clifford J A | 1991 | J Biol Chem1991，266，16： | 1 |
| 8 | Campana alluval characteristics, groundwater-surface water exchange and hydrological retention in headwater stream 显示文摘 | John A M Valett H M Clifford N D | 1998 | Hydrological Processes1998，，11： | 1 |
| 9 | USP dissolution appa ratus Ⅲ (reciprocating cylinder) for screening of guar-based colonic delivery formulations 显示文摘 | Wong D Larrabee S Clifford K | 1997 | J Control Release1997，47，2： | 1 |
| 10 | Genes encoding glycin-rich Arabidopsis thaliana proteins with RNA-binding motifs are influenced by cold treatment and an endogenous circadian rhythm 显示文摘 | CLIFFORD D CARPENTER J A KREPS A E | 1994 | Plant Physiology1994，104，： | 1 |
| 11 | The pVHL-associated SCF ubiquitin ligase complex:molecular genetic analysis of elongin B and C, Rbxl and HIF-1 alpha in renal cell carcinoma显示文摘 | Clifford SC Astuti D Hooper L | 2001 | Oncogene2001，20，36： | 1 |
| 12 | Using dynamic time warping to find patterns in time series显示文摘 | Berndt D J Clifford J | 1994 | KDD Workshop1994，10，16： | 1 |
| 13 | Iron coagulation and direct microfiltration to remove arsenic from groundwater显示文摘 | GHUREY G CLIFFORD D TRIPP A | 2004 | J Am Water works Assoc2004，96，4： | 1 |
| 14 | Design of a novel passive solar tracker显示文摘 | Clifford M J Eastwood D | 2004 | Solar Energy2004，，77： | 1 |
| 15 | Hemolymph levels of methyl farnesoate increase in response to osmotic stress in the green crab Carcinus maenas 显示文摘 | Lovett D L Verzi M P Clifford P D | 2001 | Comparative Biochemistry and Physiology2001，128，2： | 1 |
| 16 | Lumbar spinestenosis显示文摘 | TUTHILL H CLIFFORD P D | | 0，，08： | 1 |
| 17 | A dynamical model for generating synthetic electrocardiogram signals显示文摘 | McSharry P E Clifford G D Tarrassenko L | 2003 | IEEE Trans Biomed Eng March2003，50，3： | 1 |
| 18 | Comparison of electrocoagulation and chemical coagulation pretreatment for enhanced virus removal using microfiltration membranes 显示文摘 | B Zhu D Clifford S Chellam | 2005 | Water Research2005，，39： | 1 |
| 19 | Subsurface skin renewal by treatment with a 1450-nm laser in combination with dynamic cooling显示文摘 | Paithankar D Y Clifford J M Saleh B A | 2003 | Journal of Biomedical Optics2003，8，3： | 1 |
| 20 | Drag of yawed pile groups at low ronolds numbers显示文摘 | David J B Clifford D H | 1980 | Journal of the Waterways Harbors and Coastal Engineering Division ASCE1980，106，2： | 1 |
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