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| 1 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 2 | Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade显示文摘 | Clifford R Jack David S Knopman William J Jagust Leslie M Shaw Paul S Aisen Michael W Weiner Ronald C Petersen John Q Trojanowski | 2010 | Lancet Neurology2010，，1： | 4 |
| 3 | 动脉瘤性蛛网膜下腔出血患者出血后脑血管痉挛的介入治疗显示文摘本临床实践标准述及动脉瘤性蛛网膜下腔出血患者出血后脑血管痉挛(post—hemorrhagiccerebralvasospasm,PHCV)的介入治疗。这些结论基于神经介入外科学学会的标准委员会的评估,包括使用由美国心脏协会卒中委员会和牛津大学循证医学中心提出的循证医学指南进行的文献回顾。特别关注现有介入治疗方法的安全性和有效性,包括腔内球囊血管成形术(transluminalballoonangioplasty,TBA)和动脉内血管扩张药物输注治疗(intra-arterialvasodilatorinfusiontherapy,IAVT)。评估结果显示,这些侵袭性介入治疗可能有益,并可考虑用于PHCV,如伴有脑缺血症状和最佳的药物治疗无效的患者的治疗。概括起来,IAVT对累及近端和(或)远端颅内脑循环的PHCV可能有益,而TBA则可能对累及近端颅内脑循环的PHCV有益。评估结果显示,对于上述适应证,根据美国心脏协会指南可将TBA和IAVT归为IIb级推荐和B级证据,根据牛津大学循证医学中心指南则可归为4级推荐和C级证据。 | Todd Abruzzo Christopher Moran Kristine A Blacldaam Clifford J Eskey Raisa Lev Philip Meyers Sandra Narayanan Charles Joseph Prestigjacol~ 黄凯滨(译) 吴永明(译) | 2013 | 国际脑血管病杂志2013，21，1： | 4 |
| 4 | Gene expression profiling of MYC-driven tumor signatures in porcine liver stem cells by transcriptome sequencing显示文摘AIM:To identify the genes induced and regulated by the MYC protein in generating tumors from liver stem cells.METHODS:In this study,we have used an immortal porcine liver stem cell line,PICM-19,to study the role of c-MYC in hepatocarcinogenesis.PICM-19 cells were converted into cancer cells(PICM-19-CSCs)by overexpressing human MYC.To identify MYC-driven differential gene expression,transcriptome sequencing was carried out by RNA sequencing,and genes identified by this method were validated using real-time PCR.In vivo tumorigenicity studies were then conducted by injecting PICM-19-CSCs into the flanks of immunodeficient mice.RESULTS:Our results showed that MYC-overexpressing PICM-19 stem cells formed tumors in immunodeficient mice demonstrating that a single oncogene was sufficient to convert them into cancer cells(PICM-19-CSCs).By using comparative bioinformatics analyses,we have determined that>1000 genes were differentially expressed between PICM-19 and PICM-19-CSCs.Gene ontology analysis further showed that the MYCinduced,altered gene expression was primarily associated with various cellular processes,such as metabolism,cell adhesion,growth and proliferation,cell cycle,inflammation and tumorigenesis.Interestingly,six genes expressed by PICM-19 cells(CDO1,C22orf39,DKK2,ENPEP,GPX6,SRPX2)were completely silenced after MYC-induction in PICM-19-CSCs,suggesting that the absence of these genes may be critical for inducingtumorigenesis.CONCLUSION:MYC-driven genes may serve as promising candidates for the development of hepatocellular carcinoma therapeutics that would not have deleterious effects on other cell types in the liver. | Rajagopal N Aravalli Neil C Talbot Clifford J Steer | 2015 | World Journal of Gastroenterology2015，21，7： | 3 |
| 5 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 6 | Persistent postsurgical pain: risk factors and prevention显示文摘 | Henrik Kehlet Troels S Jensen Clifford J Woolf | 2006 | The Lancet . 2006 (9522)2006，，9522： | 2 |
| 7 | Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis显示文摘 | Clifford G M Smith J S Plummer M | 2003 | Br J Cancer2003，88，1： | 1 |
| 8 | Postmenopausal osteoporosis显示文摘 | Clifford J | 2005 | The new England J of Medicine2005，353，6： | 1 |
| 9 | Analytical extraction of additives from polymers显示文摘 | Vandenburg H J Clifford A A Bartle K D | 1997 | The Analyst1997，122，： | 1 |
| 10 | Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells 显示文摘 | Lee M E Temizer D H Clifford J A | 1991 | J Biol Chem1991，266，16： | 1 |
| 11 | Preoperative analgesia - treating post - operative pain by preventing the establish- ment of centeral sensi - tization 显示文摘 | CLIFFORD J WOOLF MB | 1993 | Anesth Analg1993，77，： | 1 |
| 12 | Growth regulators have rapid effects on photosynthetic unloading from seed coats of Phaseolus vulgaris L显示文摘 | CLIFFORD P E OFFLER C E PATRIC J M | 1986 | Plant Physiology1986，80，： | 1 |
| 13 | Obituary 显示文摘 | Grant H Clifford J | 2003 | J Laryngol Otol2003，117，10： | 1 |
| 14 | Genes encoding glycin-rich Arabidopsis thaliana proteins with RNA-binding motifs are influenced by cold treatment and an endogenous circadian rhythm 显示文摘 | CLIFFORD D CARPENTER J A KREPS A E | 1994 | Plant Physiology1994，104，： | 1 |
| 15 | Private benefits from control of public corporations显示文摘 | Barclay Michael J Holderness Clifford G | 1989 | Journal of Financial Economics1989，25，： | 1 |
| 16 | The association between IGF-Ⅰ and bone mineraldensity in women and men: the Framingham heart study显示文摘 | Jean I A Clifford J R Visser M | 1998 | J Clin Endocrinol Metab1998，83，： | 1 |
| 17 | Imroved particle filter fornonlinear problems显示文摘 | Carpenter J Clifford P | 1999 | IEEE Proceedings of Radar Sonar and Navigation1999，100，1： | 1 |
| 18 | Using dynamic time warping to find patterns in time series显示文摘 | Berndt D J Clifford J | 1994 | KDD Workshop1994，10，16： | 1 |
| 19 | Design of a novel passive solar tracker显示文摘 | Clifford M J Eastwood D | 2004 | Solar Energy2004，，77： | 1 |
| 20 | Nanomedicine: current status and future prospects显示文摘 | S Moein Moghimi A Christy Hunter J Clifford Murray | 2005 | The FASEB Journal2005，19，： | 1 |
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