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| 1 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 2 | 扁桃体鳞癌中HPV感染与EGFR、VEGF表达的相关性研究显示文摘目的:研究扁桃体鳞癌(squamous cell carcinomas of the tonsil tonsillar,SCCs)中人乳头瘤病毒(human papillomavirus,HPV)感染与血管内皮生长因子(vascular endothelial growth factor,VEGF)和表皮生长因子受体(epidermal growth factor,EGFR)表达的关系,探讨HPV与EGFR和VEGF在扁桃体鳞癌发生中的交互效应。方法:采用多重实时荧光定量聚合酶链反应(multiplex real-time polymerase chain reaction,MT-PCR)检测85例扁桃体鳞癌HPV DNA及型别,通过HPV DNA分析进行HPV感染状况的测定;同时采用半定量免疫组化检测HPV(+)组和HPV(-)组中VEGF、EGFR蛋白表达情况。结果:扁桃体鳞癌中HPV感染率为49.4%(42/85),HPV-16型占所有感染者的比例为90.5%(38/42),明显高于其他型别;HPV(+)组EGFR蛋白表达明显低于HPV(-)组(P值均<0.01);HPV(+)组与HPV(-)组VEGF蛋白表达无明显差异;此外,VEGF表达与EGFR、患者的年龄、性别、TNM分期、组织学分级均无明显相关性。结论:HPV感染与扁桃体鳞癌的发生存在相关性,HPV相关的扁桃体鳞癌中,HPV基因可能通过改变EGFR表达致癌,为HPV致癌机理进一步研究提供一个新的视角,具有重要的理论意义。 | 费继敏 Timothy A Dobbins Deanna Jones C Soon Lee Christine Loo Jonathan Clark Barbara Rose | 2015 | 现代肿瘤医学2015，23，4： | 3 |
| 3 | The effect of osteogenic growth factors on bone growth into a ceramic-filled defect around an implant显示文摘 | Clarke S A Brooks R A Lee P T | 2004 | Bone Joint Surg Br2004，22，5： | 1 |
| 4 | Locating monitoring stations in water distribution systems显示文摘 | Deininger R A Clark R M | 1991 | J AWWA1991，83，7： | 1 |
| 5 | The effect of osteogenic growth factors on bone growth into a ceramic filled defect around an implant 显示文摘 | Clarke S A Brooks R A Lee P T | 2004 | J Orthop Res2004，22，5： | 1 |
| 6 | Diagnostic molecular biomarkers for malignant pleural effusions显示文摘 | Krishna B Sriram Vandana Relan Belinda E Clarke Edwina E Duhig Ian A Yang Rayleen V Bowman YC Gary Lee Kwun M Fong | 2011 | Future Oncol2011，，6： | 1 |
| 7 | Levels of metal ions after small and large diametermetal on metal hiparthrop lasty显示文摘 | Clarke MT Lee PT Arora A | 2003 | J Bone Joint Surg (Br)2003，85，： | 1 |
| 8 | Use of intravenous lipid enmlsion to treat iverrnectin toxicosis ina Border Collie显示文摘 | CLARKE D L LEE J A MURPHY L A | 2011 | J Am Vet Med Assoc2011，239，： | 1 |
| 9 | Fibre damage in the manufacture of advanced three-dimensional woven composites 显示文摘 | Rudov Clark S Mouritz A P Lee L | 2003 | Compsotes Part A2003，34，： | 1 |
| 10 | Examination of adverse events fol-lowing black widow antivenom use in California 显示文摘 | Nordt S P Clark R F Lee A | 2012 | Clin Toxicol(Phila)2012，50，1： | 1 |
| 11 | Retrieval of human anti- bodies from phage-display libraries using enzymatic cleavage显示文摘 | Ward Pt L Clark M A Lees J | 1996 | J Immunol Methods1996，189，1： | 1 |
| 12 | U87MG decoded:the genomic sequence of a cytogenetically aberrant human cancer cell line显示文摘 | Clark MJ Homer N O'Connor BD Chen Z Eskin A Lee H | | PLoS Genet0，6，00： | 1 |
| 13 | Accentuation of gas exchange gradients in flushes of ponderosa pine exposed to ozone显示文摘 | Clark C S Weber J A Lee E H | 1995 | Tree Physiology1995，15，： | 1 |
| 14 | Development and Vali- dation of Brief Measures of Positive and Negative Affect: The Panas Scales显示文摘 | Watson David Clark Lee A Tellegen Auke | 1988 | Journal of Personality and Social Psychology1988，，54： | 1 |
| 15 | Locating monitoring stations in water distribution systems显示文摘 | LEE B H DEININGER R A CLARK R M | 1991 | Journal of the American Water Works Association1991，83，7： | 1 |
| 16 | Locating monitoring stations in water distribution systems 显示文摘 | Lee B H Deininger R A Clark R M | 1991 | J AWWA1991，83，7： | 1 |
| 17 | Prevention and treatment of the complica- tions of diabetes mellitus显示文摘 | Clark C M Jr Lee D A | 1995 | N Engl J Med1995，332，18： | 1 |
| 18 | Levels of metal ions after small-and large-diameter metal-on-metal hip arthroplasty 显示文摘 | Clarke M T Lee P T Arora A | 2003 | J Bone Joint Su rg Br2003，85，6： | 1 |
| 19 | Retrieval of human antibody from phage-display libraries using enzymatic cleavage 显示文摘 | WARD R L CLARK M A LEES J | 1996 | Journal of Immunology Method1996，18，9： | 1 |
| 20 | Levels-of metal ions after small-and large-diameter metal-on-metal hip arthroplasty显示文摘 | Clarke MT Lee PT Atom A | 2003 | J Bone Joint Surg (Br)2003，85，： | 1 |
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