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| 1 | Genomic footprints of wheat evolution in China reflected by a Wheat660K SNP array显示文摘Common wheat(Triticum aestiuum L.)is one of the most important crops because it provides about 20%of the total calories for humans.T.aestiuum is an excellent modern species for studying concerted evolution of sub-genomes in polyploid species,because of its large chromosome size and three well-known genome donors.Establishment of common wheat genome reference sequence and development of high-density SNP chips provide an excellent foundation to answer questions of wheat evolution and breeding at the genomic level.By genotyping more than 600 accessions of common wheat and their diploid and tetraploid ancestors using a Wheat660 K SNP array,we found dramatic genome changes due to tetraploidization and hexaploidization,in contrast to weaker influences of domestication and breeding on them.Further,since common wheat was introduced in China in 1500 BCE,Chinese landraces formed two subgroups(T.aestiuum-L1 and T.aestiuum-L2)with considerably diverse geographic distributions and agronomic traits.T.aestiuum-L2,mainly distributed in central and east China is found to have more but smaller oval grains with early maturity characteristics.We found that variation and selection in intergenic regions of the A and B sub-genomes dominated this differentiation,in which chromosomes 7 A and 3 B took the leading roles due to the existence of putative genes related to defense responses and environmental adaption in the highly differentiated regions.Large haplotype blocks were detected on 3 B(232.6-398.3 Mb)and 7 A(211.7-272.9 Mb)in the landraces,forming two distinct haplotypes,respectively.We discovered that artificial crosses in breeding promoted recombination in the whole genome,however,this recombination and differentiation was highly asymmetric among the three sub-genomes in homoeologous regions.In addition,we found that the wide use of European and northern American cultivars in breeding at early era,led dramatic changes in Chinese wheat genome,whereas,the recent breeding functioned to optimize it.This study will provide the insight for reconsideration of wheat evolution and breeding,and a new strategy for parent selection in breeding. | Zhiwei Wang Chenyang Hao Jing Zhao Chang Li Chengzhi Jiao Wei Xi Jian Hou Tian Li Hongxia Liu Xueyong Zhang | 2021 | The Crop Journal2021，9，1： | 2 |
| 2 | Evaluation of the weakening behavior of gas on the coal strength and its quantitative influence on the coal deformation显示文摘The coal strength and deformation properties are key factors affecting safe coal mining and highefficiency coalbed methane(CBM)development.In this paper,reconstituted coal samples are chosen to investigate the weakening behavior of gas on coal strength,meanwhile,its effects on coal deformation are quantitatively evaluated.The results indicate that the weakening degree of gas on coal strength is closely related to the confining stress and gas pressure.Compared with non-gas-saturated coals,the maximum weakening ratios of adsorbed gas to coal strength are 10.58%,18.12%,8.55%and 14.65%under the conditions of confining stress CS=3 MPa and gas pressure GP=1 MPa,CS=3 MPa and GP=2 MPa,CS=4 MPa and GP=1 MPa,and CS=4 MPa and GP=2 MPa,respectively.Furthermore,the maximum weakening ratios of free gas to coal strength are 18.27%,36.54%,14.79%and 29.58%,respectively,under above four conditions.The maximum coal bulk strain decreases as particle sizes of coal powders increase,and it has a maximum value of 0.0227 and a minimum value of 0.0191 in particle size ranges of 0.01–0.041 and 0.5–1 mm.Under the same conditions,the coal bulk strain increases with increasing gas pressure,revealing that coal deformation properties can be enhanced by gas. | Haijun Guo Kai Wang Yuchen Wu Hanlu Tang Jianguo Wu Lianhe Guan Chenyang Chang Chao Xu | 2021 | International Journal of Mining Science and Technology2021，31，3： | 2 |
| 3 | A multicolor nanoprobe for detection and imaging of umor-related mRNAs in living cells显示文摘 | Li Na Chang Chenyang Pan Wei | 2012 | Angew Chem Int Ed2012，51，30： | 1 |
| 4 | De novo DNA methylation during monkey pre-implantation embryogenesis显示文摘首领 embryogenesis 的批评 epigenetic 规定必要 DNA methylome 变化。这里,我们在培植前恒河猴胚胎以及用定序方法的优化基于 tagmentation 的整个染色体的重亚硫酸盐学习的男、女的配偶子报导 DNA methylation 的染色体宽的作文, patterning,和阶段特定的动力学。我们证明在授精之上,父亲、母亲的染色体经历活跃 DNA demethylation,和染色体宽的 de novo DNA methylation 也在一样的时期被开始。由 8 房间阶段, remethylation 变得比 demethylation 更显著,导致全球 DNA methylation 的增加。基因的倡导者与氧化 phosphorylation 联系了,建议精力新陈代谢的这个模式不能被赞成是优先地在 8 房间阶段的 remethylated。在啮齿类动物不同, X 染色体 inactivation 没在猴子培植前开发期间被观察。我们的学习提供蜡的第一幅全面插图并且衰退 DNA methylation 动力学的阶段。最重要地,我们的 DNA methyltransferase loss-of-function 分析显示 DNA methylation 影响早猴子 embryogenesis。 | Fei Gao Yuyu Niu Yi Eve Sun Hanhn Lu Yongchang Chen Siguang Li Yu Kang Yuping Luo Chenyang Ni Juehua Yu Chang Li Nianqin Sun Wei Si Hong Wang Weizhi Ji Tao Tan | 2017 | Cell Research2017，27，4： | 1 |
| 5 | Design and fabrication of a high-density metal microelectrode array for neural reeording显示文摘 | Xu Chenyang William Lemon Liu Chang | 2002 | Sensors and Actuators A2002，96，1： | 1 |
| 6 | Design and fabrication of a high-density metal microelectrode arry for neural recording显示文摘 | Xu Chenyang William Lemon Liu Chang | 2002 | Sensors and Actuators A2002，96，1： | 1 |
| 7 | Design and fabrication of a high density microelectrode array for neuronal recording显示文摘 | Chenyang Y Lemon W and Chang Liu | 2002 | Sensors and Actuators2002，96，1： | 1 |
| 8 | Hydrothermal Syntheses and Structural Phase Transitions of AgNbO <sub>3</sub>显示文摘 | Haibo Chang Mingyu Shang Chenyang Zhang Hongming Yuan Shouhua Feng | 2012 | J Am Ceram Soc2012，，11： | 1 |
| 9 | RNA m^(6)A Modification in Cancers: Molecular Mechanisms and Potential Clinical Applications显示文摘N^(6)-Methyladenosine(m^(6)A)RNA modification brings a new dawn for RNA modification researches in recent years.This posttranscriptional RNA modification is dynamic and reversible,and is regulated by methylases(“writers”),demethylases(“erasers”),and proteins that preferentially recognize m^(6)A modifications(“readers”).The change of RNA m^(6)A modification regulates RNA metabolism in eucaryon,including translation,splicing,exporting,decay,and processing.Thereby the dysregulation ofm^(6)A may lead to tumorigenesis and progression.Given the tumorigenic role of abnormalm^(6)A expression,m^(6)A regulators may function as potential clinical therapeutic targets for cancers.In this review,we emphasize on the underlying mechanisms of m^(6)A modifications in tumorigenesis and further introduce the potential m^(6)A regulators-associated therapeutic targets for tumor therapy. | Chang Gu Xin Shi Chenyang Dai Feng Shen Gaetano Rocco Jiafei Chen Zhengyu Huang Chunji Chen Chuan He Tao Huang Chang Chen | 2020 | The Innovation2020，1，3： | 0 |
| 10 | Intestinal microbiota links to allograft stability after lung transplantation: a prospective cohort study显示文摘Whether the alternated microbiota in the gut contribute to the risk of allograft rejection(AR)and pulmonary infection(Pl)in the setting of lung transplant recipients(LTRs)remains unexplored.A prospective multicenter cohort of LTRs was identified in the four lung transplant centers.Paired fecal and serum specimens were collected and divided into AR,Pl,and event-free(EF)groups according to the diagnosis at sampling.Fecal samples were determined by metagenomic sequencing. | Junqi Wu Chongwu Li Peigen Gao Chenhong Zhang Pei Zhang Lei Zhang Chenyang Dai unpeng Zhang Bowen Shi Mengyang Liu Junmeng Zheng Bo Pan Zhan Chen Chao Zhang Wanqing Liao Weihua Pan Wenjie Fang Chang Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 11 | Tailoring WB morphology enables d-band centers to be highly active for high-performance lithium-sulfur battery显示文摘The d-band centers of catalysts have exhibited excellent performance in various reactions.Among them,the enhanced catalytic reaction is considered a crucial way to power dynamics and reduce the“shuttle”effect in polysulfide conversions of lithium-sulfur batteries.Here,we report two-dimensional-shaped tungsten borides(WB)nanosheets with d-band centers,where the d orbits of W atoms on the(001)facets show greatly promoting the electrocatalytic sulfur reduction reaction.As-prepared WB-based Li-S cells exhibit excellent electrochemical performance for Li-ion storage.Especially,it delivers superior capacities of 7.7 mAh/cm^(2) under the 8.0 mg/cm^(2) sulfur loading,which is far superior to most other electrode catalysts.This study provides insights into the d-band centers as a promising catalyst of twodimensional boride materials. | Yuwei Zhao Chang Liu Chenyang Zha Jing Li Chongguang Lyu Kaixi Wang Junfeng Li Kwan San Hui Linghai Zhang Kwun Nam Hui | 2023 | Chinese Chemical Letters2023，34，11： | 0 |
| 12 | Camouflaging attenuated Salmonella by cryo-shocked macrophages for tumor-targeted therapy显示文摘Live bacteria-mediated antitumor therapies mark a pivotal point in cancer immunotherapy.However,the difficulty in reconciling the safety and efficacy of bacterial therapies has limited their application.Improving bacterial tumor-targeted delivery while maintaining biosafety is a critical hurdle for the clinical translation of live microbial therapy for cancer.Here,we developed“dead”yet“functional”Salmonella-loaded macrophages using liquid nitrogen cold shock of an attenuated Salmonella typhimurium VNP20009-contained macrophage cell line.The obtained“dead”macrophages achieve an average loading of approximately 257 live bacteria per 100 cells.The engineered cells maintain an intact cellular structure but lose their original pathogenicity,while intracellular bacteria retain their original biological activity and are delay freed,followed by proliferation.This“Trojan horse”-like bacterial camouflage strategy avoids bacterial immunogenicity-induced neutrophil recruitment and activation in peripheral blood,reduces the clearance of bacteria by neutrophils and enhances bacterial tumor enrichment efficiently after systemic administration.Furthermore,this strategy also strongly activated the tumor microenvironment,including increasing antitumor effector cells(including M1-like macrophages and CD8+Teffs)and decreasing protumor effector cells(including M2-like macrophages and CD4+Tregs),and ultimately improved antitumor efficacy in a subcutaneous H22 tumor-bearing mouse model.The cryo-shocked macrophage-mediated bacterial delivery strategy holds promise for expanding the therapeutic applications of living bacteria for cancer. | Leyang Wu Zengzheng Du Lin Li Liyuan Qiao Shuhui Zhang Xingpeng Yin Xiaoyao Chang Chenyang Li Zichun Hua | 2024 | Signal Transduction and Targeted Therapy2024，9，2： | 0 |
| 13 | Effects of sulfur on variations in the chemical speciation of heavy metals from fly ash glass显示文摘This work designed a new CaO-Al_(2)O_(3)-SiO_(2)-SO3 glass for the immobilization of multiple heavy metals found in dechlorinated fly ash having high amounts of calcium and sulfur. Increasing the (CaO + SO3)/SiO_(2) mass ratio (M(CS/S)) from 0.28 to 0.85 was found to lower the proportions of Mn, Ni and Zn in an unstable state, while an M(CS/S) ratio of 0.51 gave the lowest proportions of unstable Cr and Pb. Decreasing the degree of polymerization of the glassy network increased the proportions of Mn, Cr, Ni, Pb and Zn in the carbonate bound state. The leaching out of metals in this state was the primary cause of degradation of Q^(3) structural units in the glassy network. The amount of Mn in the iron-manganese oxide bound state was increased by increasing the number of Q^(2) units in the silicate network. Decreasing the CaO/SiO_(2) mass ratio (M(C/S)) raised the proportions of Mn, Ni and Zn in the unstable state. An M(C/S) value of 0.43 lowered the proportions of unstable Cr and Pb. A principal components analysis determined that the leaching of toxic heavy metals from the glass was primarily related to the proportions of these metals in the unstable state while there were no evident correlations between leaching and the proportions in stable states. | Yali Chang Jianwei Cao Wenfeng Song Zhi Wang Chenyang Xu Mengzhuo Long | 2023 | Frontiers of Environmental Science & Engineering2023，17，10： | 0 |
| 14 | A Model for the Connectivity of Horizontal Wells in Water-Flooding Oil Reservoirs显示文摘As current calculation models for inter-well connectivity in oilfields can only account for vertical wells,an updated model is elaborated here that can predict the future production performance and evaluate the connectivity of horizontal wells(or horizontal and vertical wells).In this model,the injection-production system of the considered reservoir is simplified and represented with many connected units.Moreover,the horizontal well is modeled with multiple connected wells without considering the pressure loss in the horizontal direction.With this approach,the production performance for both injection and production wells can be obtained by calculating the bottom-hole flowing pressure and oil/water saturation according to the material balance equation and a saturation front-tracking equation.Some effort is also provided to optimize(to fit known historical production performances)the two characteristic problem parameters,namely,the interwell conductivity and connected volume by means of a SPSA gradient-free algorithm.In order to verify the validity of the model,considering a heterogenous reservoir,three conceptual examples are constructed,where the number ratio between injection and production wells are 1/4,4/1 and 4/5,respectively.It is shown that there is a high consistency between simulation results and field data. | Chenyang Shi Fankun Meng Hongyou Zhang HuiJiang Chang Xun Zhong Jie Gong and Fengling Li | 2022 | Fluid Dynamics & Materials Processing2022，18，5： | 0 |
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