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| 1 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 2 | Harvesting vibration energy by a triple-cantilever based triboelectric nanogenerator显示文摘摩擦电 nanogenerators (TENG ) ,为基于摩擦电效果收获周围的机械精力的一种唯一的技术,被证明了是为自我动力的系统的一条划算、简单、柔韧的途径。这里,我们为收获颤动精力表明讲道理地设计的三倍伸臂的基于的 TENG。与制作到金皮铜合金陪衬的表面上的 nanowire 数组的帮助,最新设计的 TENG 与 252.3 mW/m2 的山峰功率密度生产开电路的电压直到 101 V 和 55.7 A 的电线走火电流。TENG 系统地为即刻地照亮 40 根商业轻射出的二极管作为直接力量来源被调查并且示威。第一次,一台 TENG 设备为收获颤动精力被设计了,特别在低频率,打开它象一种新精力技术的申请。 | Weiqing Yang Jun Chen Guang Zhu Xiaonan Wen Peng Bai Yuanjie Su Yuan Lin Zhonglin Wang | 2013 | Nano Research2013，6，12： | 13 |
| 3 | Oxidation kinetics regularity in spontaneous combustion of gas coal显示文摘In order to investigate the oxidation kinetics of gas coal at low temperatures, we derived a rate equation of oxygen con-sumption during low-temperature oxidation of gas coal and deduced an E-c equation, expressing the relation between active energy E and oxygen concentration c. The reaction order n and active energy E were calculated with this equation based on experiments of static oxygen consumption tests. In addition, we proved the rationality of the E-c equation using a kinetic compensation effect and obtained the isokinetic temperature Tc. The results show that: 1) the gas coal oxidizes easily with increasing temperature and the oxidation tends to be spontaneous at higher temperatures; 2) the oxygen concentration c affects oxygen consumption very much at lower temperatures but has only a small effect at higher temperatures; 3) the isokinetic temperature Tc was 127 °C which has been experimentally validated as the key turning point during low-temperature spontaneous combustion of gas coal. | WANG Lanyun JIANG Shuguang WU Zhengyan SHAO Hao ZHANG Weiqing CHEN Yueqin ZOU Lili | 2010 | Mining Science and Technology2010，20，1： | 13 |
| 4 | A novel peptide, selected from phage display library of random peptides, can efficiently target into human breast cancer cell显示文摘To develop a targeting vector for breast cancer biotherapy, MDA-MB-231 cell, a human breast cancer cell line, was co-cultured with pC89 (9 aa) phage display library of random peptides. In multiple inde- pendent peptide-presenting phage screening trials, subtilisin was used as a protease to inactivate ex- tra-cellular phages. The internalized phages were collected by cell lysising and amplified in E. coli XLI-Blue. Through five rounds of selection, the peptide-presenting phages which could be internalized in MDA-MB-231 cells were isolated. A comparison was made between internalization capacities of pep- tide-presenting phages isolated from MDA-MB-231 cells and RGD-integrin binding phage by cocultur- ing them with other human tumor cell lines and normal cells. The nucleotide sequences of isolated peptide-presenting phages were then determined by DNA sequencing. To uncover whether phage coat protein or amino acid order was required for the character of the peptide to MDA-MB-231 cells, three peptides were synthesized. They are CASPSGALRSC, ASPSGALRS and CGVIFDHSVPC (the shifted sequence of CASPSGALRSC), and after coculturing them with different cell lines, their targeting ca- pacities to MDA-MB-231 cells were detected. These data suggested that the internalization process was highly selective, and capable of capturing a specific peptide from parent peptide variants. Moreover, the targeting internalization event of peptides was an amino acid sequence dependent manner. The results demonstrated the feasibility of using phage display library of random peptides to develop new targeting system for intracellular delivery of macromolecules, and the peptide we obtained might be modified as a targeting vector for breast cancer gene therapy. | DONG Jian LIU WeiQing ZHANG KeJian JIANG AiMei CHEN MingQing | 2008 | Chinese Science Bulletin2008，53，6： | 12 |
| 5 | Study on air flow dynamic characteristic of mechanical ventilation of a lung simulator显示文摘As an important life support treatment, mechanical ventilation is usually adopted in clinics. With the development of the res-piratory diagnostic and treatment technologies, air flow dynamics of mechanical ventilation is usually referenced in the evaluation of pulmonary status and assessment of respiratory therapy. In order to improve the ventilation efficiency and provide a reference for pulmonary diagnostics, in this paper, a new mathematical model of mechanical ventilation system was set up. Furthermore, a prototype mechanical ventilation system for an artificial simulating lung was designed and experimentally studied. Lastly, in order to improve the ventilation efficiency and provide a reference for pulmonary diagnostics, the air flow dynamics of the mechanical ventilation system was illustrated through simulation and experimental studies. The study can be helpful to the optimization of the mechanical ventilation system. | NIU JingLong SHI Yan CAO ZhiXin CAI MaoLin CHEN Wei ZHU Jian XU WeiQing | 2017 | Science China(Technological Sciences)2017，60，2： | 8 |
| 6 | Triglycerides and ratio of triglycerides to high-density lipoprotein cholesterol are better than liver enzymes to identify insulin resistance in urban middle-aged and older non-obese Chinese without diabetes显示文摘 | Sun Yu Li Wenjuan Hou Xinguo Wang Chuan Li Chengqiao Zhang Xiuping Yang Weifang Ma Zeqiang Wang Weiqing Ning Guang Zheng Huizhen Ma Aixia Song Jun Lin Peng Liang Kai Liu Fuqiang Gong Lei Wang Meijian Xiao Juan Yan Fei Yang Junpeng Wang Lingshu Tian Meng Liu Jidong Zhao Ruxing Zhu Ping Chen Li | 2014 | Chinese Medical Journal2014，，10： | 7 |
| 7 | Effect of Boron Content on the Microstructure and Magnetic Properties of Non-oriented Electrical Steels显示文摘The effects of boron content in the range of 0-0.0082 wt%, on the inclusion type, microstructure, texture and magnetic properties of non-oriented electrical steels have been studied. After fi nal annealing, the addition of excess boron(w(Bt)>0.004 1 wt%) led to the formation of Fe2 B particles. As boron content increased, grain size increased and reached a maximum in steel with 0.004 1 wt% boron. Furthermore, steel containing 0.004 1 wt% boron had the strongest {100} fi ber texture, Goss texture and the weakest {111} fi ber texture among the fi ve tested steels. Flux density fi rstly rapidly increased and then suddenly decreased with increasing boron content and reached a maximum in steel with 0.004 1 wt% boron. Conversely, core loss fi rst sharply decreased and then abruptly increased with the increase of boron content and reached a minimum in steel containing 0.004 1 wt% boron. Steel containing 0.004 1 wt% boron obtained the best magnetic properties, predominantly through the development of optimum grain size and favorable texture. | 万勇 CHEN Weiqing | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，3： | 5 |
| 8 | Ultraflat, broadband, and highly coherent supercontinuum generation in all-solid microstructured optical fibers with all-normal dispersion显示文摘High flatness, wide bandwidth, and high-coherence properties of supercontinuum(SC) generation in fibers are crucial in many applications. It is challenging to achieve SC spectra in a combination of the properties, since special dispersion profiles are required, especially when pump pulses with duration over 100 fs are employed. We propose an all-solid microstructured fiber composed only of hexagonal glass elements. The optimized fiber possesses an ultraflat all-normal dispersion profile, covering a wide wavelength interval of approximately 1.55 μm. An SC spectrum spanning from approximately 1030 to 2030 nm(corresponding to nearly one octave) with flatness<3 dB is numerically generated in the fiber with 200 fs pump pulses at 1.55 μm. The results indicate that the broadband ultraflat SC sources can be all-fiber and miniaturized due to commercially achievable 200-fs fiber lasers. Moreover, the SC pulses feature high coherence and a single pulse in the time domain, which can be compressed to 13.9-fs pulses with high quality even for simple linear chirp compensation. The Fourier-limited pulse duration of the spectrum is 3.19 fs, corresponding to only 0.62 optical cycles. | CHUNLEI HUANG MEISONG LIAO WANJUN BI XIA LI LILI HU LONG ZHANG LONGFEI WANG GUANSHI QIN TIANFENG XUE DANPING CHEN WEIQING GAO | 2018 | Photonics Research2018，6，6： | 4 |
| 9 | Synthesis of a Novel UV-curable Prepolymer Polypropyleneglycol Diglycidyl Ether Diacrylate显示文摘A novel UV-curable prepolymer polypropyleneglycol diglycidyl ether diacrylate(PPGGEA) was synthesized by utilizing polypropyleneglycol diglycidyl ether(PPGGE)and acrylic acid(AA)as starting materials,N,N-dimethylbenzylamine as catalyst and p-hydroxyanisole as inhibitor.The optimum synthetic conditions were in the following:the concentration of N,N-dimethylbenzylamine was 0.80 wt%of reactants,the concentration of p-hydroxyanisole was 0.3 wt%of reactants,the reaction temperature was 90-110℃,and the molar ratio of PPGGE to AA was 1:2.2.Meanwhile,1-hydroxycyclohexyl phenyl ketone of a UV-cured initiator was added to the synthesized PPGGEA to prepare a kind of UV-cured coating.The mechanical properties of the UV-cured films were determined,giving 29.99 MPa of tensile strength,834.27 MPa of the Young's modulus and 5.66% of elongation at tear. | HUANG Biwu HUANG Bofen DU Guoping CHEN Weiqing | 2008 | Journal of Wuhan University of Technology(Materials Science)2008，23，4： | 3 |
| 10 | Serum uric acid and risk of incident diabetes in middle-aged and elderly Chinese adults: prospective cohort study显示文摘The association between serum uric acid and the risk of incident diabetes in Chinese adults remains unknown.This study aimed to investigate this association in a community-dwelling population aged≥40 years in Shanghai,China.Oral glucose tole3rance test was conducted during baseline and follow-up visits.Relative risk regression was utilized to examine the associations between baseline gender-specific serum uric acid levels and incident diabetes risk.A total of 613(10.3%)incident diabetes cases were identified during the follow-up visit after 4.5 years.Fasting plasma glucose,postload glucose,and glycated hemoglobin A1c during the follow-up visit progressively increased across the sex-specific quartiles of serum uric acid(all Ps<0.05).The incidence rate of diabetes increased across the quartiles of serum uric acid(7.43%,8.77%,11.47%,and 13.43%).Multivariate adjusted regression analysis revealed that individuals in the highest quartile had 1.36-fold increased risk of diabetes compared with those in the lowest quartile of serum uric acid(odds ratio(95%confidence interval)=1.36(1.06−1.73)).Stratified analysis indicated that the association was only observed in women.Accordingly,serum uric acid was associated with the increased risk of incident diabetes among middle-aged and elderly Chinese women. | Di Cheng Chunyan Hu Rui Du Hongyan Qi Lin Lin Xueyan Wu Lina Ma Kui Peng Mian Li Min Xu Yu Xu Yufang Bi Weiqing Wang Yuhong Chen Jieli Lu | 2020 | Frontiers of Medicine2020，14，6： | 3 |
| 11 | Formation of CaO-TiO_2-MgO-Al_2O_3 dual phase inclusion in Ti stabilized stainless steel显示文摘The formation of CaO-TiO_2-MgO-Al_2O_3 dual phase inclusion in 321 stainless steel was investigated in the laboratory. The result indicated that the condition for the formation of CaOTiO_2-MgOAl_2O_3 in 321 steel is [Ca]>0.001wt%, [Ti]>0.1wt%, and [Al]>0.01wt%. The mechanism is the following: Al_2O_3 inclusion turns into CaO-Al_2O_3 after Ca-Si wire is fed into the molten steel; [Mg] is then obtained by reducing MgO in slag or crucible wall by [Al] and [Ti]; finally CaO-Al_2O_3 inclusion is changed into CaO-TiO_2-MgO-Al_2O_3 by the reaction with [Mg], [Ti], and [O] in the molten steel simultaneously. | Hongguang Zheng Weiqing Chen | 2006 | Journal of University of Science and Technology Beijing2006，13，1： | 2 |
| 12 | H_(2)S promotes developmental brain angiogenesis via the NOS/NO pathway in zebrafish显示文摘Background Hydrogen sulphide(H_(2)S)is considered as the third member of the gasotransmitter family,along with nitric oxide(NO)and carbon monoxide.H_(2)S has been reported to induce angiogenesis by promoting the growth,migration and tube-like structure formation of endothelial cells.Those studies were conducted in conditions of cell culture,mouse Matrigel plug assay model,rat wound healing model or rat hindlimb ischaemia model.Recent in vivo studies showed the physiological importance of H_(2)S in muscle angiogenesis.However,the importance of endogenous H_(2)S for brain angiogenesis during development remains unknown.We therefore aimed at determining the role of H_(2)S in brain vascular development.Methods and results Both knockdown and knockout of H2S-producing enzymes,cystathionineβ-synthase(cbs)and cystathionineγ-lyase(cth),using morpholino oligonucleotides and clustered regularly interspaced short palindromic repeats/Cas9-mediated mutation,impaired brain vascular development of larval zebrafish.Incubation with the slow-releasing H_(2)S donor GYY4137 alleviated the defects of brain vascular development in cbs and cth morphants.Quantitative analysis of the midbrain vascular network showed that H_(2)S enhances angiogenesis without affecting the topological structure of the brain vasculature.Mechanically,nitric oxide synthase 2a(nos2a)expression and NO production were decreased in both cbs and cth morphants.Overexpression of nos2a by coinjection of cbs or cth MO with full-length zebrafish nos2a mRNA alleviated the brain vascular developmental defects in cbs and cth morphants.Conclusion We conclude that H_(2)S promotes brain developmental angiogenesis via the NOS/NO pathway in zebrafish. | Weiqing Jiang Chen Liu Mingzhu Deng Fei Wang Xiao Ren Yilin Fan Jiulin Du Yonggang Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 2 |
| 13 | Working Mechanism of a Kind of Non-resonant Linear Piezoelectric Motor with Flexible Driving End显示文摘A non-resonant piezoelectric linear motor with a flexible driving end,which has an extensive working frequency range and good operation stability,is studied theoretically and experimentally.Based on the microscopic vibration characteristics of the motor stator,the longitudinal vibration model is established for the whole motor system.According to the Coulomb friction model and the motor vibration model,the friction mechanism of the nonresonant piezoelectric linear motor is investigated by dynamical analysis of the whole motor system.Furthermore,the vibration characteristics and mechanical output characteristics of the stator are simulated and experimentally studied on the basis of the friction drive mechanism model.Finally,both the simulation and experimental results show that this kind of motor remain stable in the frequency domain from 2.2 kHz to 3.5 kHz and that when the pre-stress is 4 Nand the driving voltage is 90 V,the maximum velocity of the motor is above 4 mm/s and the maximum thrust is nearly 0.5 N. | Chen Xifu Huang Weiqing Lu Qian Li Ming Ren Yaoqing | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，5： | 2 |
| 14 | Kinetics of Evaporation of Zn and Pb from Carbon-bearing Pellets Made of Dust Containing Zn-Pb-Fe Oxides显示文摘The influence of reduction temperature, size of coal powder and the carbon content on the evaporation rates of Zn and Pb in pellets made of ZnO-PbO-FeO bearing dust has been investigated between 1100-1300℃. The evaporation rate of Zn and Pb obtained from the experiments has been analyzed with kinetic models. The results show that the control step for evaporation of Zn is reduction reaction of ZnO by CO at the interface,and that the evaporation rate of Pb is controlled by the volatilization of reduction products, i.e. liquid lead. The overall apparent activation energies of Zn and Pb evaporation from the pellet are 79.42kJ/mol and 88.74kJ/mol respectively. | Weiqing Chen, Dongyan Wang, Rongzhang Zhou, Zongcai Lin (Metallurgy School, University of Science and Technology Beijing, Beijing 100083, China) | 2000 | International Journal of Minerals,Metallurgy and Materials2000，14，3： | 2 |
| 15 | Purification and Characterization of the Glucoside 3-Dehydrogenase Produced by a Newly Isolated Sphingobacterium faecium ZJF-D6 CCTCC M 2013251显示文摘 | Jian-Fen Zhang Bo Yang Weiqing Chen Jing Chen | 2014 | Applied Biochemistry and Biotechnology2014，，8： | 1 |
| 16 | Dynamics of Chaotic Systems with Attractive and Repulsive Couplings显示文摘 | Yuehua Chen Jinghua Xiao Weiqing Liu | 2009 | Phys Rev:E2009，，04： | 1 |
| 17 | Effect of ultrasonic treatment on the solidification structure of high carbon steel containing rare earth elements 显示文摘 | Li Jie Chen Weiqing Liu Qing Wang Xiaofeng | 2008 | Steel Research International2008，79，5： | 1 |
| 18 | Diversity of Cultivated and Uncultivated Actinobacterial Endophytes in the Stems and Roots of Rice显示文摘 | Xinli Tian Lixiang Cao Hongming Tan Weiqing Han Ming Chen Yuhuan Liu Shining Zhou | 2007 | Microbial Ecology2007，，4： | 1 |
| 19 | Discrimination model for macroscopic traffic conditions of urban networks using two-fluid theory显示文摘 | WANGDH CHENS WEIQ | 2011 | Journal of Southeast University(Natural Science Edition)2011，17，5： | 1 |
| 20 | Synthesis of 1,1,3,3,5,5-hexamethyl-1,5-bis[(3-ethyl-3-methoxyoxetane)propyl]trisiloxane and Research on Its UV-curing Performance显示文摘A compound,3-ethyl-3-hydroxymethyloxetane(EHO),was synthesized with diethyl carbonate and trihydroxypropane as raw materials,3-ethyl-3-allylmethoxy oxetane(EAMO)was synthesized with EHO and allyl bromide,and 1,1,3,3,5,5-hexamethyl-1,5-bis[(3-ethyl-3-methoxyoxetane)propyl]trisiloxane(HMBEMOPTS)was synthesized with EAMO and 1,1,3,3,5,5-hexamethyltrisiloxane(HMTS).HMBEMOPTS is a novel UV-curable oligomer.The test of photo-DSC shows the photosensitivity of HMBEMOPTS is better than the ordinary oxetane,3-ethyl-3-[(3-ethyloxetan-3-yl)methoxymethyl]oxetane.HMBEMOPTS was mixed with bisphenol A type epoxy resin E-51 to prepare a cationic UV-curable system,and triarylsulfonium hexafluoroantimonate(UV-6976)was used as a cationic photoinitiator.The mechanical tests of coating films prove that when the mass fraction of HMBEMOPTS is 50%,the mechanical properties of the curing system are the best.The impact strength of the UV-curable films is measured to be 40 kg·cm and the flexibility is 2 mm;the tensile strength and flexural strength of the prepared specimens are 20.74 MPa and 13.43 MPa,respectively.The experimental results show that HMBEMOPTS can effectively improve photosensitivity and flexibility of the photosensitive resin. | 胡思炜 黄笔武 CHEN Weiqing | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，6： | 1 |
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