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| 1 | A scientometric review of biochar research in the past 20 years(1998-2018)显示文摘Biochar is the carbon-rich product obtained from the thermochemical conversion of biomass under oxygen-limited conditions.Biochar has attained extensive attention due to its agronomical and environmental benefits in agro-ecosystems.This work adopts the scientometric analysis method to assess the development trends of biochar research based on the literature data retrieved from the Web of Science over the period of 1998-2018.By analysing the basic characteristics of 6934 publications,we found that the number of publications grew rapidly since 2010.Based on a keyword analysis,it is concluded that scholars have had a fundamental recognition of biochar and preliminarily found that biochar application had agronomic and environmental benefits during the period of 1998-2010.The clustering results of keywords in documents published during 2011-2015 showed that the main research hotspots were“biochar production”,“biochar and global climate change”,“soil quality and plant growth”,“organic pollutants removal”,and“heavy metals immobilization”.While in 2016-2018,beside these five main research hotspots,“biochar and composting”topic had also received greater attention,indicating that biochar utilization in organic solid waste composting is the current research hotspot.Moreover,updated reactors(e.g.,microwave reactor,fixed-bed reactor,screw-feeding reactor,bubbling fluidized bed reactor,etc.)or technologies(e.g.,solar pyrolysis,Thermo-Catalytic Reforming process,liquefaction technology,etc.)applied for efficient energy production and modified biochar for environmental remediation have been extensively studied recently.The findings may help the new researchers to seize the research frontier in the biochar field. | Ping Wu Syed Tahir Ata-Ul-Karim Bhupinder Pal Singh Hailong Wang Tongliang Wu Cun Liu Guodong Fang Dongmei Zhou Yujun Wang Wenfu Chen | 2019 | Biochar2019，1，1： | 36 |
| 2 | Structural Analyses of Short-Chain Prenyltransfemses Identify an Evolutionarily Conserved GFPPS Clade in Brassicaceae Plants显示文摘Terpenoids 是专业化植物的代谢物的最大、很多样的类,它在植物开发期间在多样的生理的进程工作。在植物 terpenoids 的生合成,短链的 prenyltransferases (SC 磅) 和萜烯 synthases (TPS ) ,在决定 terpenoid 的 playcritical 角色差异。有不同的链长度的 SC 磅 biosynthesize prenyl 焦磷酸盐,和这些混合物是 terpenoids 的直接先锋。Arabidopsis thaliana 拥有其功能清楚地不被知道的 SC 磅的亚群。在这研究,我们集中于 10 geranylgeranyl 焦磷酸盐象 synthase 一样[GGPPSL ] 蛋白质,它通常被认为生产 GGPP [C20 ] 。我们发现 Arabidopsis GGPPSL 基因家庭的成员的一个子集经历了 neo-functionalization:GGPPSL6, 7, 9,和 10 主要举办 geranylfarnesyl 焦磷酸盐 synthase 活动(C25;renamedAtGFPPS1, 2, 3,和 4 ) ,并且 GGPPSL8 生产甚至更长的链 prenyl 焦磷酸盐(≥C30;renamedpolyprenyl 焦磷酸盐 synthase 2, AtPPPS2 ) 。由解决 AtGFPPS2, AtPPPS2,和 AtGGPPS11 的水晶结构,我们揭示 SC 磅的产品链长度决心机制并且作为 “three floors” 解释它当模特儿。用这个模型,我们识别了在 Brassicaceae 植物散布并且发现 GFPPS 基因典型地与编码 TPS 的基因一起发生的新奇 GFPPS clade,形成 GFPPS-TPS 基因簇。 | ChengyuanWang Qingwen Chen Dongjie Fan Jianxu Li Guodong Wang Peng Zhang | 2016 | Molecular Plant2016，9，2： | 19 |
| 3 | Cell-Mediated Immunity Imbalance in Patients with Intrahepatic Cholestasis of Pregnancy显示文摘Decidual lymphocytes may mediate fetal trophoblast recognition and regulate maternal immune reaction and play an essential role in the maintenance of normal pregnancy. The aim of this study was to compare the percentage of T cells, natural killer (NK) cells and natural killer T (NKT) cells within decidual parietalis of normal pregnant controls (NP) and patients with intraheptic cholestasis of pregnancy (ICP), and to investigate the production of interleukin-4 (IL-4), interferon-γ (IFN-γ) in the culture supernatant of decidual parietalis mononuclear cells (DPMCs). Compared with controls, the decidua parietalis from ICP were characterized with significant increased percentages of CD3-CD56+ cells, CD3+CD56+ cells, CD56+CD16+ cells, CD56+CD16- cells, CD56+NKG2D+ cells, and the significant decreased percentages of CD3+ cells, CD3+CD4+ cells. There were no differences found for the percentage of CD3+CD8+ cells, CD56+NKG2A+ cells between control and study group. In addition, the enhanced concentration of IFN-γ was presented in culture supernatant of DPMCs from ICP. It was suggested that the increased NK cells, NKT cells and the decreased T cells in the decidual parietalis and over-secretion of IFN-γ could be correlated with the pathophysiology of ICP patients. | Bin Ling Fengqiu Yao Ying Zhou Zhengzheng Chen Guodong Shen Yuanyuan Zhu | 2007 | Cellular & Molecular Immunology2007，4，1： | 19 |
| 4 | Simple and cost-effective methods for precise analysis of trace element abundances in geological materials with ICP-MS显示文摘Inductively coupled plasma mass spectrometry(ICP-MS) is the most commonly used technique to determine the abundances of trace elements in a wide range of geological materials. However, incomplete sample digestion, isobaric interferences and instrumental drift remain obvious problems that must be overcome in order to obtain precise and accurate results. For this reason, we have done many experiments and developed a set of simple, cost-effective and practical methods widely applicable for precise and rapid determination of trace element abundances in geological materials using ICP-MS. Commonly used high-pressure digestion technique is indeed effective in decomposing refractory phases, but this inevitably produces fluoride complexes that create new problems. We demonstrate that the fluoride complexes formed during high-pressure digestion can be readily re-dissolved using high-pressure vessel at 190 °C for only 2 h for 50 mg sample. In the case of isobaric interferences, although oxide(e.g., MO+/M+) and hydroxide(e.g., MOH+/M+) productivity is variable between runs, the(MO+/M+)/(Ce O+/Ce+)and(MOH+/M+)/(Ce O+/Ce+) ratios remain constant, making isobaric interference correction for all other elements of interest straightforward, for which we provide an easy-to-use off-line procedure. We also show that mass-time-intensity drift curve is smooth as recognized previously, for which the correction can be readily done by analyzing a quality-control(QC) solution and using off-line Excel VBA procedure without internal standards. With these methods, we can produce data in reasonable agreement with recommended values of international rock reference standards with a relative error of <8% and precision generally better than 5%. Importantly, compared to the widely used analytical practice, we can effectively save >60% of time(e.g., <24 h vs. >60 h). | Shuo Chen Xiaohong Wang Yaoling Niu Pu Sun Meng Duan Yuanyuan Xiao Pengyuan Guo Hongmei Gong Guodong Wang Qiqi Xue | 2017 | Science Bulletin2017，62，4： | 17 |
| 5 | Effects of dietary alfalfa flavonoids extraction on growth performance,organ development and blood biochemical indexes of Yangzhou geese aged from 28 to 70 days显示文摘This experiment was conducted to study the effects of dietary alfalfa flavonoids extraction supplemental level on growth performance, organ development and blood biochemical indexes of Yangzhou geese at the age of 28 to 70 days. Two hundred and forty 21-day-old healthy male geese with similar body weight were randomly distributed into 4 groups with 6 replicates per group and 10 geese per replicate. Geese in the control group were fed a basal diet and the others in the experimental groups(groups 1,2, and 3) were fed experimental diets supplemented with 150, 300 and 450 mg/kg alfalfa flavonoids extraction(the concentration of it was 81%), respectively. The experiment had 7 days for pre-test and 42 days for formal test.The results showed that the final body weight and average daily intake of group 2 were significantly higher than those of other groups(P < 0.05). The average daily gain of group 2 was significantly higher than that in the control group and group 1(P < 0.05). There was no significant difference in feed-to-gain ratio between each group(P > 0.05). Pre-slaughter live weight, carcass weight, slaughter rate, semieviscerated weight, semi-eviscerated rate, eviscerated weight, eviscerated rate, leg muscle weight and leg muscle rate had no significant difference between each group(P > 0.05). The breast muscle weight and ratio of each test group were significantly higher than those in the control group(P < 0.05) and the group2 was the best. The abdominal fat weight and ratio in the group 1 were significantly higher than those in the control group and group 3(P < 0.05) and the tibia weight in the group 2 was significantly higher than that in the control group and group 1(P < 0.05); There were no significant differences in heart weight,liver weight and the gland stomach weight among all groups(P > 0.05). Spleen weight in test groups was significantly higher than that in the control group(P < 0.05). The bursa weight and muscular stomach weight in the group 2 were significantly higher than those in the control group and group 1(P < 0.05). In serum, total cholesterol, triglycerides, low-density lipoprotein and urea nitrogen in the group 2 were significantly lower comparing with those in the control group(P < 0.05). High-density lipoprotein in the group 2 was significantly higher than that in other groups(P < 0.05). There were no significant differences in total serum protein, albumin, globulin and albumin/globulin among all groups(P > 0.05). Alanine aminotransferase and aspartate transaminase(AST) in groups 2 and 3 were higher than those in the group1 and control group but not obvious(P > 0.05) and alkaline phosphatase(ALP) in groups 1 and 2 was higher than that in the control group and group 3(P > 0.05). It is concluded that alfalfa flavonoids extraction added in dietary feed improve the growth performance, organ development and blood biochemical indexes of Yangzhou geese. It is concluded that 300 mg/kg supplemental level of the dietary alfalfa flavonoids extraction is optimal in this experiment. | Yinyin Chen Xiaoxiao Gong Guodong Li Miao Lin Yongjiu Huo Shengli Li Guoqi Zhao | 2016 | Animal Nutrition2016，，4： | 14 |
| 6 | Effects of metal lead on growth and mycorrhizae of an invasive plant species (Solidago canadensis L.)显示文摘It is less known whether and how soil metal lead (Pb) impacts the invasion of exotic plants. A greenhouse experiment was conducted to estimate the effects of lead on the growth and mycorrhizae of an invasive species (Solidago canadensis L.) in a microcosm system. Each microcosm unit was separated into HOST and TEST compartments by a replaceable mesh screen that allowed arbuscular mycorrhizal (AM) fungal hyphae rather than plant roots to grow into the TEST compartments. Three Pb levels (control, 300, and 600 mg/kg soil) were used in this study to simulate ambient soil and two pollution sites where S. canadensis grows. Mycorrhizal inoculum comprised five indigenous arbuscular mycorrhizal fungal species (Glomus mosseae, Glomus versiform, Glomus diaphanum, Glomus geosporum, and Glomus etunicatum). The 15N isotope tracer was used to quantify the mycorrhizally mediated nitrogen acquisition of plants. The results showed that S. canadensis was highly dependent on mycorrhizae. The Pb additions significantly decreased biomass and arbuscular mycorrhizal colonization (root length colonized, RLC%) but did not affect spore numbers, N (including total N and 15N) and P uptake. The facilitating efficiency of mycorrhizae on nutrient acquisition was promoted by Pb treatments. The Pb was mostly sequestered in belowground of plant (root and rhizome). The results suggest that the high efficiency of mycorrhizae on nutrient uptake might give S. canadensis a great advantage over native species in Pb polluted soils. | YANG Ruyi YU Guodong TANG Jianjun CHEN Xin | 2008 | Journal of Environmental Sciences2008，20，6： | 12 |
| 7 | Recently duplicated sesterterpene(C25) gene clusters in Arabidopsis thaliana modulate root microbiota显示文摘Land plants co-speciate with a diversity of continually expanding plant specialized metabolites(PSMs) and root microbial communities(microbiota).Homeostatic interactions between plants and root microbiota are essential for plant survival in natural environments.A growing appreciation of microbiota for plant health is fuelling rapid advances in genetic mechanisms of controlling microbiota by host plants.PSMs have long been proposed to mediate plant and single microbe interactions.However,the effects of PSMs,especially those evolutionarily new PSMs,on root microbiota at community level remain to be elucidated.Here,we discovered sesterterpenes in Arabidopsis thaliana,produced by recently duplicated prenyltransferase-terpene synthase(PT-TPS) gene clusters,with neo-functionalization.A single-residue substitution played a critical role in the acquisition of sesterterpene synthase(sesterTPS) activity in Brassicaceae plants.Moreover,we found that the absence of two root-specific sesterterpenoids,with similar chemical structure,significantly affected root microbiota assembly in similar patterns.Our results not only demonstrate the sensitivity of plant microbiota to PSMs but also establish a complete framework of host plants to control root microbiota composition through evolutionarily dynamic PSMs. | Qingwen Chen Ting Jiang Yong-Xin Liu Haili Liu Tao Zhao Zhixi Liu Xiangchao Gan Asis Hallab Xuemei Wang Juan He Yihua Ma Fengxia Zhang Tao Jin M. Eric Schranz Yong Wang Yang Bai Guodong Wang | 2019 | Science China(Life Sciences)2019，62，7： | 11 |
| 8 | Integrated energy-oriented cruising control of electric vehicle on highway with varying slopes considering battery aging显示文摘Eco-driving strategies for vehicles with conventional powertrains have been studied for years and attempt to reduce fuel consumption by optimizing the driving velocity profile.For electric vehicles(EVs)with regenerative braking,the speed profile with the best energy efficiency should be different from conventional vehicles.This paper proposes an energy-oriented cruising control strategy for EVs with a hierarchical structure to realize eco-cruising on highways with varying slopes.The upper layer plans the energy-optimized vehicle velocity,and the lower layer calculates the torque allocation between the front and rear axles.However,the resulting speed profile with varying velocity may cause a high charge and discharge rate of the battery,resulting in rapid battery fading.To extend the battery life,we make a tradeoff between the energy consumption and wear of the battery by formulating an optimal control problem,where driving comfort and travel time are also considered.An indirect optimal control method is implemented to derive the optimal control rule.As an extension,the control rule for avoiding rear-end collisions is presented and simulated for driving in the real world. | ZHUANG WeiChao QU LingHu XU ShaoBing LI BingBing CHEN Nan YIN GuoDong | 2020 | Science China(Technological Sciences)2020，63，1： | 10 |
| 9 | Modification of solar radiation model over rugged terrain显示文摘The formula for the duration of possible sunshine has been modified. Two geometrical factors, the circumsolar view factor and the isotropic view factor for calculating solar radiation, have been proposed. The ray-tracing method in computer cartography has been applied to simulating the obstruction of terrain over solar radiation. In addition, the shape factor has been introduced to calculate the reflected radiation from surrounding terrain. | Xin Li Guodong Cheng Xianzhang Chen Ling Lu | 1999 | Chinese Science Bulletin1999，44，15： | 10 |
| 10 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 11 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 12 | Control of Bird Feeding Behavior by Tannin1 through Modulating the Biosynthesis of Polyphenols and Fatty Acid-Derived Volatiles in Sorghum显示文摘Bird predation during seed maturation causes great loss to agricultural production.In this study,through GWAS analysis of a large-scale sorghum germplasm diversity panel,we identified that Tannin1,which encodes a WD40 protein functioning in the WD40/MYB/bHLH complex,controls bird feeding behavior in sorghum.Metabolic profiling analysis showed that a group of sorghum accessions preferred by birds contain mutated tan1-a/b alleles and accumulate significantly lower levels of anthocyanins and condensed tannin compounds.In contrast,a variety of aromatic and fatty acid-derived volatiles accumulate at significantly higher levels in these bird-preference accessions.We subsequently conducted both sparrow feeding and sparrow volatile attractant assays,which confirmed,respectively,the antifeedant and attractant functions of these differentially accumulated metabolites.In addition,the connection between the biosynthesis pathway of anthocyanin and proanthocyanidin and the pathway of fatty acid–derived volatile biosynthesis was demonstrated by discovering that Tannin1 complex modulates fatty acid biosynthesis by regulating the expression of SbGL2 in sorghum,thus affecting the accumulation of fatty acid-derived volatiles.Taken together,our study identified Tannin1 as the gene underlying the major locus controlling bird feeding behavior in sorghum,illustrating an example of the identification of an ecologically impactful molecular mechanism from field observation and providing significant insights into the chemistry of bird–plant ecological interactions. | Peng Xie Jiayang Shi Sanyuan Tang Chengxuan Chen Aimal Khan Fengxia Zhang Ying Xiong Chao Li Wei He Guodong Wang Fumin Lei Yaorong Wu Qi Xie | 2019 | Molecular Plant2019，12，10： | 8 |
| 13 | Relationship between climatic conditions and the relative abundance of modern C_3 and C_4 plants in three regions around the North Pacific显示文摘Using -24‰ and -14‰ as the endpoints of stable carbon isotopic composition of total organic carbon (δ 13CTOC) of surface soil under pure C3 and C4 vegetation, and surface soil δ 13CTOC data from eastern China, Australia and the Great Plains of North America, we estimate the relative abundance of C3/C4 plants (i.e., the ratio of C3 or C4 biomass to local primary production) in modern vegetation for each region. The relative abundance of modern C3/C4 vegetation from each region is compared to the corresponding climatic parameters (mean annual temperature and precipitation) to explore the relationship between relative C4 abundance and climate. The results indicate that temperature controls the growth of C4 plants. However, even where temperature is high enough for the growth of C4 plants, they will only dominate the landscape when precipitation declines as temperatures increase. Our results are consistent with those of other investigations of the geographic distribution of modern C4 plant species. Therefore, our results provide an important reference for interpretation of past C3/C4 relative abundance records in these three regions. | RAO ZhiGuo ZHU ZhaoYu JIA GuoDong CHEN FaHu BARTON Loukas ZHANG JiaWu QIANG MingRui | 2010 | Chinese Science Bulletin2010，55，18： | 7 |
| 14 | Determination of Three Kinds of Polyether Drug Residues in Eggs by QuEChERS dSPE EMR-Lipid-LC/MS/MS显示文摘[Objectives] This study was conducted to establish an LC-MS/MS method for the determination of three kinds of polyether residues in eggs with QuEChERS dSPE EMR-Lipid as a pretreatment method,which was established according to Agilent Bond Elut enhanced lipid removal EMR-Lipid technology.[Methods]Egg was extracted by acidified acetonitrile,purified by Bond Elut EMR-Lipid QuEChERS,and detected by HPLC-MS/MS. [Results]The three kinds of polyether residues had good linear relationships in the range of 2. 0-100 μg/L with peak areas,r > 0. 999. The recoveries ranged from 84. 6% to 107. 0%.[Conclusions]The method is convenient and accurate,and the quantitative results are accurate and reproducible. It is suitable for the determination of the three kinds of polyether residues in eggs. | Guodong ZANG Jingwen FU Qinzhan YANG Zijing HUANG Mengjun CHEN | 2018 | Agricultural Biotechnology2018，7，1： | 6 |
| 15 | NON-YELLOWING2 (NYE2), a Close Paralog of NYE1, Plays a Positive Role in Chlorophyll Degradation in Arabidopsis显示文摘 | Wu, Shouxin Li, Zhongpeng Yang, Lifeng Xie, Zuokun Chen, Junyi Zhang, Wei Liu, Tianqi Gao, Shan Gao, Jiong Zhu, Yihua Xin, Jiwen Ren, Guodong Kuai, Benke | 2016 | Molecular Plant2016，9，4： | 6 |
| 16 | PacBio Sequencing Reveals Transposable Elements as a Key Contributor to Genomic Plasticity and Virulence Variation in Magnaporthe oryzae显示文摘 | Jiandong Bao Meilian Chen Zhenhui Zhong Wei Tang Lianyu Lin Xingtan Zhang Haolang Jiang Deyu Zhang Chenyong Miao Haibao Tang Jisen Zhang Guodong Lu Ray Ming Justice Norvienyeku Baohua Wang Zonghua Wang | 2017 | Molecular Plant2017，10，11： | 5 |
| 17 | Spatio-temporal analysis and simulation on shallow rainfall-induced landslides in China using landslide susceptibility dynamics and rainfall I-D thresholds显示文摘An empirical simulation method to simulate the possible position of shallow rainfall-induced landslides in China has been developed.This study shows that such a simulation may be operated in real-time to highlight those areas that are highly prone to rainfall-induced landslides on the basis of the landslide susceptibility index and the rainfall intensity-duration(I-D) thresholds.First,the study on landslide susceptibility in China is introduced.The entire territory has been classified into five categories,among which high-susceptibility regions(Zone 4-'High' and 5-'Very high') account for 4.15%of the total extension of China.Second,rainfall is considered as an external triggering factor that may induce landslide initiation.Real-time satellite-based TMPA3B42 products may provide real rainfall spatial and temporal patterns,which may be used to derive rainfall duration time and intensity.By using a historical record of 60 significant past landslides,the rainfall I-D equation has been calibrated.The rainfall duration time that may trigger a landslide has resulted between 3 hours and 45 hours.The combination of these two aspects can be exploited to simulate the spatiotemporal distribution of rainfall-induced landslide hazards when rainfall events exceed the rainfall I-D thresholds,where the susceptibility category is 'high' or 'very high'.This study shows a useful tool to be part of a systematic landslide simulation methodology,potentially providing useful information for a theoretical basis and practical guide for landslide prediction and mitigation throughout China. | LI WeiYue LIU Chun Marco SCAIONI SUN WeiWei CHEN Yu YAO DongJing CHEN Sheng HONG Yang ZHANG KaiHang CHENG GuoDong | 2017 | Science China Earth Sciences2017，60，4： | 5 |
| 18 | CRISPR-Cas9-mediated genome editing in one blastomere of two-cell embryos reveals a novel Tet3 function in regulating neocortical development显示文摘学习必要基因的早功能是在发展生物学的一个重要、挑战性的问题。这里,我们为很快在二房间的阶段胚胎的一个分裂球导致 CRISPR-Cas9-mediated 变化建立了一个方法,称为的 2 房间 embryo-CRISPR-Cas9 注射(2CC ) ,学习在里面必需品的 vivo 功能(或未知) 在创始人的基因妄想的鼠标。由注射指向兴趣的基因进的 Cre mRNA 和 CRISPR-Cas9 荧光灯记者老鼠, 2CC 方法能在不同发展阶段跟踪野类型、变异的房间,为变异的房间的 phenotypic 分析的出现内部控制。用这个方法,我们在在发展中的鼠标调整有刺激性、禁止的 synaptic 传播识别了必要基因 Tet3 的新奇函数服的外皮。由产生妄想的变异的老鼠, 2CC 方法允许在多重纸巾和房间的基因功能的快速的屏蔽录入妄想的老鼠创始人,显著地扩展基因工具的当前的一套设备。 | Wang, Lingbo Li, Min-Yin Qu, Chao Miao, Wan-Ying Yin, Qi Liao, Jiaoyang Cao, Hua-Teng Huang, Min Wang, Kai Zuo, Erwei Peng, Guangdun Zhang, Shu-Xin Chen, Guodong Li, Qing Tang, Ke Yu, Qian Li, Zhoujie Wong, Catherine C. L. Xu, Guoliang Jing, Naihe Yu, Xiang Li, Jinsong | 2017 | Cell Research2017，27，6： | 5 |
| 19 | Chinese expert consensus on programming deep brain stimulation for patients with Parkinson’s disease显示文摘Background:Deep Brain Stimulation(DBS)therapy for the treatment of Parkinson’s Disease(PD)is now a well-established option for some patients.Postoperative standardized programming processes can improve the level of postoperative management and programming,relieve symptoms and improve quality of life.Main body:In order to improve the quality of the programming,the experts on DBS and PD in neurology and neurosurgery in China reviewed the relevant literatures and combined their own experiences and developed this expert consensus on the programming of deep brain stimulation in patients with PD in China.Conclusion:This Chinese expert consensus on postoperative programming can standardize and improve postoperative management and programming of DBS for PD. | Shengdi Chen Guodong Gao Tao Feng Jianguo Zhang The Chinese Medical Association neurosurgery branch of functional neurosurgery group The Chinese Medical Association neurology branch of Parkinson’s disease,Movement disorders group The Chinese Physician Association neurosurgeon branch of functional neurosurgery expert committee The Chinese Physician Association neurologist branch of Parkinson’s disease and Movement disorders professional committee Chinese expert committee on Deep Brain Stimulation for Parkinson’s Disease | 2018 | Translational Neurodegeneration2018，7，1： | 5 |
| 20 | A Survey of Bitmap Index Compression Algorithms for Big Data显示文摘With the growing popularity of Internet applications and the widespread use of mobile Internet, Internet traffic has maintained rapid growth over the past two decades. Internet Traffic Archival Systems(ITAS) for packets or flow records have become more and more widely used in network monitoring, network troubleshooting, and user behavior and experience analysis. Among the three key technologies in ITAS, we focus on bitmap index compression algorithm and give a detailed survey in this paper. The current state-of-the-art bitmap index encoding schemes include: BBC, WAH, PLWAH, EWAH, PWAH, CONCISE, COMPAX, VLC, DF-WAH, and VAL-WAH. Based on differences in segmentation, chunking, merge compress, and Near Identical(NI) features, we provide a thorough categorization of the state-of-the-art bitmap index compression algorithms. We also propose some new bitmap index encoding algorithms, such as SECOMPAX, ICX, MASC, and PLWAH+, and present the state diagrams for their encoding algorithms. We then evaluate their CPU and GPU implementations with a real Internet trace from CAIDA. Finally, we summarize and discuss the future direction of bitmap index compression algorithms. Beyond the application in network security and network forensic, bitmap index compression with faster bitwise-logical operations and reduced search space is widely used in analysis in genome data, geographical information system, graph databases, image retrieval, Internet of things, etc. It is expected that bitmap index compression will thrive and be prosperous again in Big Data era since 1980s. | Zhen Chen Yuhao Wen Junwei Cao Wenxun Zheng Jiahui Chang Yinjun Wu Ge Ma Mourad Hakmaoui Guodong Peng | 2015 | Tsinghua Science and Technology2015，20，1： | 5 |
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