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| 1 | Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients显示文摘 | Lu Wen Jingyi Li Huahu Guo Xiaomeng Liu Shengmin Zheng Dafang Zhang Weihua Zhu Jianhui Qu Limin Guo Dexiao Du Xiao Jin Yuhao Zhang Yun Gao Jie Shen Hao Ge Fuchou Tang Yanyi Huang Jirun Peng | 2015 | Cell Research2015，25，11： | 19 |
| 2 | A Survey of Bitmap Index Compression Algorithms for Big Data显示文摘With the growing popularity of Internet applications and the widespread use of mobile Internet, Internet traffic has maintained rapid growth over the past two decades. Internet Traffic Archival Systems(ITAS) for packets or flow records have become more and more widely used in network monitoring, network troubleshooting, and user behavior and experience analysis. Among the three key technologies in ITAS, we focus on bitmap index compression algorithm and give a detailed survey in this paper. The current state-of-the-art bitmap index encoding schemes include: BBC, WAH, PLWAH, EWAH, PWAH, CONCISE, COMPAX, VLC, DF-WAH, and VAL-WAH. Based on differences in segmentation, chunking, merge compress, and Near Identical(NI) features, we provide a thorough categorization of the state-of-the-art bitmap index compression algorithms. We also propose some new bitmap index encoding algorithms, such as SECOMPAX, ICX, MASC, and PLWAH+, and present the state diagrams for their encoding algorithms. We then evaluate their CPU and GPU implementations with a real Internet trace from CAIDA. Finally, we summarize and discuss the future direction of bitmap index compression algorithms. Beyond the application in network security and network forensic, bitmap index compression with faster bitwise-logical operations and reduced search space is widely used in analysis in genome data, geographical information system, graph databases, image retrieval, Internet of things, etc. It is expected that bitmap index compression will thrive and be prosperous again in Big Data era since 1980s. | Zhen Chen Yuhao Wen Junwei Cao Wenxun Zheng Jiahui Chang Yinjun Wu Ge Ma Mourad Hakmaoui Guodong Peng | 2015 | Tsinghua Science and Technology2015，20，1： | 5 |
| 3 | Downregulation of ceramide synthase 1 promotes oral cancer through endoplasmic reticulum stress显示文摘C18 ceramide plays an important role in the occurrence and development of oral squamous cell carcinoma.However,the function of ceramide synthase 1,a key enzyme in C18 ceramide synthesis,in oral squamous cell carcinoma is still unclear.The aim of our study was to investigate the relationship between ceramide synthase 1 and oral cancer.In this study,we found that the expression of ceramide synthase 1 was downregulated in oral cancer tissues and cell lines.In a mouse oral squamous cell carcinoma model induced by 4-nitroquinolin-1-oxide,ceramide synthase 1 knockout was associated with the severity of oral malignant transformation.Immunohistochemical studies showed significant upregulation of PCNA,MMP2,MMP9,and BCL2 expression and downregulation of BAX expression in the pathological hyperplastic area.In addition,ceramide synthase 1 knockdown promoted cell proliferation,migration,and invasion in vitro.Overexpression of CERS1 obtained the opposite effect.Ceramide synthase 1 knockdown caused endoplasmic reticulum stress and induced the VEGFA upregulation.Activating transcription factor 4 is responsible for ceramide synthase 1 knockdown caused VEGFA transcriptional upregulation.In addition,mild endoplasmic reticulum stress caused by ceramide synthase 1 knockdown could induce cisplatin resistance.Taken together,our study suggests that ceramide synthase 1 is downregulated in oral cancer and promotes the aggressiveness of oral squamous cell carcinoma and chemotherapeutic drug resistance. | Wen Chen Chenzhou Wu Yafei Chen Yuhao Guo Ling Qiu Zhe Liu Haibin Sun Siyu Chen Zijian An Zhuoyuan Zhang Yi Li Longjiang Li | 2021 | International Journal of Oral Science2021，13，1： | 3 |
| 4 | Light-Induced Heat Driving Active Ion Transport Based on 2D MXene Nanofluids for Enhancing Osmotic Energy Conversion显示文摘Osmotic energy from the ocean,also called blue energy,serves as a clean,renewable,and vast energy source for the energy demands of the world.Reverse electrodialysis-based blue energy harvesting via ion-selective membranes,by the regulation and manipulation of directional ion transport,has been greatly developed recently.In particular,light has been employed to enhance directional ion transport for energy conversion through an increase in photo-induced surface charge.Here,the authors demonstrate a novel nanofluidic regulation strategy based on the phenomenon of light-induced heat-driven active ion transport through the lamellar MXene membrane.Due to the great light-induced heat effect,a temperature gradient appears as soon as illumination is applied to an off-center position,inducing an actively temperature gradient-driven ionic species transport.By employing this phenomenon,the authors conducted light-induced heat-enhanced osmotic energy conversion and doubled the osmotic energy conversion power density.This study has extended the scope of light-enhanced osmotic energy conversion and could further bring other photothermal materials into this field.Furthermore,the proposed system provides a new avenue of light-controlled ionic transport for ion gathering,desalination,and energy conversion applications. | Pei Liu Teng Zhou Yunfei Teng Lin Fu Yuhao Hu Xiangbin Lin Xiang-Yu Kong Lei Jiang Liping Wen | 2021 | CCS Chemistry2021，3，4： | 1 |
| 5 | Integrated network pharmacology and proteomics to reveal the cognitive improvement effect of Wuzang Wenyang Huayu decoction on vascular dementia显示文摘To the Editor:Vascular dementia(VD)is a clinical disease characterized_by cognitive dysfunction and intellectual decline caused byvarious cerebrovascularfactors.The high incidence of VD in middle-aged and elderly people has become a major medical and social problem worldwide.li Since its specific pathogenesis has not been fully elucidated,clinical practice is stillfocused on improving cognition and sAylmteprntoamtivaetilcy,t rweiathtm heignht,seuffcehc taivse pnierascse atanmd faenwd sdidoen eepffeezcitl.s2,i traditional Chinese medicine has drawn medical attention and become a hotspot in the medical research field. | Yuhao Sun Xiaoyu Wen Zhuoxian Li Lijing Xu Meng Xia | 2022 | Chinese Medical Journal2022，135，19： | 1 |
| 6 | Engineering Multi‑field‑coupled Synergistic Ion Transport System Based on the Heterogeneous Nanofluidic Membrane for High‑Efficient Lithium Extraction显示文摘The global carbon neutrality strategy brings a wave of rechargeable lithium‐ion batteries technique development and induces an ever-growing consumption and demand for lithium(Li).Among all the Li exploitation,extracting Li from spent LIBs would be a strategic and perspective approach,especially with the low energy consumption and eco-friendly membrane separation method.However,current membrane separation systems mainly focus on monotonous membrane design and structure optimization,and rarely further consider the coordination of inherent structure and applied external field,resulting in limited ion transport.Here,we propose a heterogeneous nanofluidic membrane as a platform for coupling multi-external fields(i.e.,lightinduced heat,electrical,and concentration gradient fields)to construct the multi-field-coupled synergistic ion transport system(MSITS)for Li-ion extraction from spent LIBs.The Li flux of the MSITS reaches 367.4 mmol m^(−2)h^(−1),even higher than the sum flux of those applied individual fields,reflecting synergistic enhancement for ion transport of the multi-field-coupled effect.Benefiting from the adaptation of membrane structure and multi-external fields,the proposed system exhibits ultrahigh selectivity with a Li^(+)/Co^(2+)factor of 216,412,outperforming previous reports.MSITS based on nanofluidic membrane proves to be a promising ion transport strategy,as it could accelerate ion transmembrane transport and alleviate the ion concentration polarization effect.This work demonstrated a collaborative system equipped with an optimized membrane for high-efficient Li extraction,providing an expanded strategy to investigate the other membrane-based applications of their common similarities in core concepts. | Lin Fu Yuhao Hu Xiangbin Lin Qingchen Wang Linsen Yang Weiwen Xin Shengyang Zhou Yongchao Qian Xiang‑Yu Kong Lei Jiang Liping Wen | 2023 | Nano-Micro Letters2023，15，8： | 1 |
| 7 | Salacia oblonga improves cardiac fibrosis and inhibits postprandial hyperglycemia in obese zucker rats显示文摘 | Yuhao Li Gang Peng Qian Li Suping Wen Tom Hsun-Wei Huang Basil D Roufogalis Johji Yamahara | 2004 | Life Sciences2004，，14： | 1 |
| 8 | MR-seq:measuring a single cell's transcriptome repeatedly by RNA-seq显示文摘We described a novel single-cell RNA-seq technique called MR-seq(measure a single-cell transcriptome repeatedly),which permits statistically assessing the technical variation and identifying the differentially expressed genes between just two single cells by measuring each single cell twice. We demonstrated that MR-seq gave sensitivity and reproducibility similar to the standard single-cell RNA-seq and increased the positive predicate value. Application of MR-seq to early mouse embryos identified hundreds of candidate intra-embryonic heterogeneous genes among mouse 2-,4-and 8-cell stage embryos. MR-seq should be useful for detecting differentially expressed genes among a small number of cells. | Lu Yang Zhaochun Ma Chen Cao Yuhao Zhang Xinglong Wu Raymond Lee Boqiang Hu Lu Wen Hao Ge Yanyi Huang Kaiqin Lao Fuchou Tang | 2017 | Science Bulletin2017，62，6： | 1 |
| 9 | Brainmask:an ultrasoft and moist microelectrocorticography electrode for accurate positioning and long-lasting recordings显示文摘Bacterial cellulose(BC),a natural biomaterial synthesized by bacteria,has a unique structure of a cellulose nanofiberweaved three-dimensional reticulated network.BC films can be ultrasoft with sufficient mechanical strength,strong water absorption and moisture retention and have been widely used in facial masks.These films have the potential to be applied to implantable neural interfaces due to their conformality and moisture,which are two critical issues for traditional polymer or silicone electrodes.In this work,we propose a micro-electrocorticography(micro-ECoG)electrode named“Brainmask”,which comprises a BC film as the substrate and separated multichannel parylene-C microelectrodes bonded on the top surface.Brainmask can not only guarantee the precise position of microelectrode sites attached to any nonplanar epidural surface but also improve the long-lasting signal quality during acute implantation with an exposed cranial window for at least one hour,as well as the in vivo recording validated for one week.This novel ultrasoft and moist device stands as a next-generation neural interface regardless of complex surface or time of duration. | Bowen Ji Fanqi Sun Jiecheng Guo Yuhao Zhou Xiaoli You Ye Fan Longchun Wang Mengfei Xu Wen Zeng Jingquan Liu Minghao Wang Huijing Hu Honglong Chang | 2023 | Microsystems & Nanoengineering2023，9，5： | 0 |
| 10 | Osmotic-Enhanced-Photoelectrochemical Hydrogen Production Based on Nanofluidics显示文摘Harvesting clean energy such as solar energy and salinity gradient energy directly from the surrounding environment has attracted great attention.A promising proof-of-concept combination of cation-selective membrane-based osmotic energy with photoelectrochemical-based solar energy has been developed,highlighting the great potential for the direct conversion of osmotic energy to hydrogen energy.With the help of a 50-fold concentration gradient,the MXene-CdSe quantum dots system exhibits the highest photocurrent enhancement ratio(Δ/_(L-H)/Δ/_(L-L)),and the hydrogen production is increased by about 33%at a bias of 0 V versus reversible hydrogen electrode.Directly converting osmotic energy and solar energy into hydrogen energy suggests the possibility of coupling osmotic energy with other renewable energy sources. | Pei Liu Xiao-Ya Gao Li-Jun Zhang Weipeng Chen Yuhao Hu Xiang-Yu Kong Xu-Bing Li Liping Wen Chen-Ho Tung Li-Zhu Wu Lei Jiang | 2023 | CCS Chemistry2023，5，9： | 0 |
| 11 | Spacecraft potential variations of the Swarm satellites at low Earth orbital altitudes显示文摘In this study, we provide the first detailed analysis of variations in the spacecraft potential (Vs) of the three Swarm satellites, which are flying at about 400-500 km. Unlike previous studies that have investigated extreme charging events, usually with spacecraft potentials as negative as −100 V, this study is focused on variations of Swarm Vs readings, which fall within a few negative volts. The Swarm observations show that spacecraft at low Earth orbital (LEO) altitudes are charged only slightly negatively, varying between −7 V and 0 V, with the majority of recorded potentials at these altitudes clustering close to −2 V. However, a second peak of Vs data is found at −5.5 V, though the event numbers for these more-negative observations are less, by an order of magnitude, than for incidents near the −2 V peak. These two distinct Vs peaks suggest two different causes. We have thus divided the Swarm spacecraft Vs data into two categories: less-negatively charged (−5 < Vs < 0 V) and more-negatively-charged (−6.5 < Vs < −5 V). These two Vs categories exhibit different spatial and temporal distributions. The Vs observations in the first category remain relatively closer to 0 V above the magnetic equator, but become much more negative at low and middle latitudes on the day side;at high latitudes, these first-category Vs readings are relatively more-negative during local summer. Second-category Vs events cluster into two bands at the middle latitudes (between ±20°-50° magnetic latitude), but with slightly more negative readings at the South Atlantic Anomaly (SAA) region;at high latitudes, these rarer but more-negative second-category Vs events exhibit relatively more-negative values during local winter, which is opposite to the seasonal pattern seen in the first category. By comparing Vs data to the distributions of background plasma density at Swarm altitudes, we find for the first category that more-negative Vs readings are recorded at regions with higher background plasma density, while for the second category the more-negative Vs data are observed at regions with lower background plasma density. This can be explained as follows: the electron and ion fluxes incident on Swarm surface, whose differences determine the potential of Swarm, are dominated by the background “cold” plasma (due to ionization) and “hot” plasma (due to precipitated particles from magnetosphere) for the two Vs categories, respectively. | HaiCheng Jiang Chao Xiong Fan Yin YuHao Zheng ZiYuan Zhu Rui Yan Yi Wen Liu | 2023 | Earth and Planetary Physics2023，7，4： | 0 |
| 12 | Fano resonance-enhanced Si/MoS_(2) photodetector显示文摘In this work,a Si∕MoS_(2) heterojunction photodetector enhanced by hot electron injection through Fano resonance is developed.By preparing Au oligomers using capillary-assisted particle assembly(CAPA)on the silicon substrate with a nanohole array and covering few-layer MoS_(2) with Au electrodes on top of the oligomer structures,the Fano resonance couples with a Si∕MoS_(2) heterojunction.With on-resonance excitation,Fano resonance generated many hot electrons on the surface of oligomers,and the hot electrons were injected into MoS_(2),providing an increased current in the photodetector under a bias voltage.The photodetectors exhibited a broadband photoresponse ranging from 450 to 1064 nm,and a large responsivity up to 52 A/W at a wavelength of 785 nm under a bias voltage of 3 V.The demonstrated Fano resonance-enhanced Si∕MoS_(2) heterojunction photodetector provides a strategy to improve the photoresponsivity of two-dimensional materials-based photodetectors for optoelectronic applications in the field of visible and near-infrared detection. | TIANXUN GONG BOYUAN YAN TAIPING ZHANG WEN HUANG YUHAO HE XIAOYU XU SONG SUN XIAOSHENG ZHANG | 2023 | Photonics Research2023，11，12： | 0 |
| 13 | White-light-driven fluorescence switch for super-resolution imaging guided photodynamic and photoacid therapy显示文摘Photocaged fluorophores with photoactivatable characteristics presented important applications in imaging the biological structures and processes.Taking advantage of their super-resolution imaging merits to manipulate and visualize anti-cancer treatment is always a goal of modern clinical medicine.Traditional photodynamic therapy(PDT) is a noninvasive treatment but limited in intracellular oxygen content.Type I PDT and photoacid therapy(PAT) are two effective supplements of traditional PDT especially in hypoxic condition.Herein,a novel white-light-driven fluorescence switch(7H-dibenzo[c,g]carbazol-7-yl)(2-iodophenyl)methanone(2IB) was designed and synthesized as an unprecedent “all in one” platform for stochastic optical reconstruction microscopy(STORM) imaging guided Type Ⅰ/Ⅱ PDT and PAT.The experimental and theoretical studies revealed that the working mechanism is based on two competing paths under excitation:photosensitization and photocyclization reaction.Efficient intersystem crossing(ISC) ensured the generation of reactive oxygen species(ROS) for PDT,while low energy barrier facilitated the photocyclization reaction that simultaneously yielded emissive fluorophores(2IBC) and H^(+) for super-resolution imaging and photoacid,respectively.Impressively,the fluorescent intensity of mitochondria-targeted 2IBC was positively correlated with treatment efficacy,which is beneficial to spatiotemporally visualized therapeutic process and outcome.As a result,superior anti-tumor performance was achieved in vitro and in vivo.This contribution provided a multifunctional nanodrug paradigm for multimode cancer diagnosis and treatment. | Hao Chen Kaikai Wen Yu Lu Xin Zhang Yuhao Shi Qinqin Shi Han Ma Qian Peng Hui Huang | 2022 | Science China Chemistry2022，65，12： | 0 |
| 14 | A universal functionalization strategy for biomimetic nanochannel via external electric field assisted non-covalent interaction显示文摘Biological ion channels, as fundamental units participating in various daily behaviors with incredible mass transportation and signal transmission, triggered booming researches on manufacturing their artificial prototypes. Biomimetic ion channel with the nanometer scale for smart responding functions has been successfully realized in sorts of materials by employing state-of-art nanotechnology. Ion track-etching technology, as crucial branches of fabricating solid-state nanochannels, exhibits outstanding advantages, such as easy fabrication, low cost, and high customization. To endow the nanochannel with smart responsibility, various modification methods are developed, including chemical grafting, non-covalent adsorption, and electrochemical deposition, enriching the reservoir of accessible stimuli-responses combinations, whereas were limited by their relatively lengthy and complex procedure. Here, based on the electric field induced self-assembly of polyelectrolytes, a universal customizable modifying strategy has been proposed, which exhibits superiorities in their functionalization with convenience and compatibility. By using this protocol, the channels’ ionic transport behaviors could be easily tuned, and even the specific ionic or molecular responding could be realized with superior performance. This strategy surely accelerates the nanochannels functionalization into fast preparing, high efficiency, and large-scale application scenarios. | Yunfei Teng Xiang-Yu Kong Pei Liu Yongchao Qian Yuhao Hu Lin Fu Weiwen Xin Lei Jiang Liping Wen | 2021 | Nano Research2021，14，5： | 0 |
| 15 | Metagenomic next-generation sequencing identified psittacosis among poultry processing workers in Shandong Province,China显示文摘Human infection with Chlamydia psittaci is rare but difficult to recognize.We report an outbreak of psittacosis among poultry processing workers in China.We applied metagenomic next-generation sequencing and identified Chlamydia psittaci reads from samples of all seven patients,four of which were subsequently confirmed by PCR.Epidemiological results suggested that the poultry processed in the factory was the possible source of human infection. | Yuhao Wang Aihua Zhang Xuemin Wei Zhe Zhang Xiujuan Bi Xiao Yuan Yuzhi Geng Nianzheng He Mengting Chen Xiaoying Xu Han Xia Hongling Wen Yifei Xu | 2022 | Infectious Medicine2022，1，2： | 0 |
| 16 | COMBAT:A New Bitmap Index Coding Algorithm for Big Data显示文摘Bitmap indexing has been widely used in various applications due to its speed in bitwise operations.However,it can consume large amounts of memory.To solve this problem,various bitmap coding algorithms have been proposed.In this paper,we present COMbining Binary And Ternary encoding(COMBAT),a new bitmap index coding algorithm.Typical algorithms derived from Word Aligned Hybrid(WAH)are COMPressed Adaptive inde X(COMPAX)and Compressed'n'Composable Integer Set(CONCISE),which can combine either two or three continuous words after WAH encoding.COMBAT combines both mechanisms and results in more compact bitmap indexes.Moreover,querying time of COMBAT can be faster than that of COMPAX and CONCISE,since bitmap indexes are smaller and it would take less time to load them into memory.To prove the advantages of COMBAT,we extend a theoretical analysis model proposed by our group,which is composed of the analysis of various possible bitmap indexes.Some experimental results based on real data are also provided,which show COMBAT’s storage and speed superiority.Our results demonstrate the advantages of COMBAT and codeword statistics are provided to solidify the proof. | Yinjun Wu Zhen Chen Yuhao Wen Wenxun Zheng Junwei Cao | 2016 | Tsinghua Science and Technology2016，21，2： | 0 |
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