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| 1 | MicroRNAs, development of Barrett’s esophagus, and progression to esophageal adenocarcinoma显示文摘Barrett's esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esoph-ageal adenocarcinoma. Whilst it is well accepted that Barrett's esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated in most cellular processes, and the role of miRNAs in disease development is be-coming increasingly evident. Understanding altered miRNA expression is likely to help unravel the molecular mechanisms that underpin the development of Barrett's esophagus and its progression to cancer. | Cameron M Smith David I Watson Michael Z Michael Damian J Hussey | 2010 | World Journal of Gastroenterology2010，16，5： | 23 |
| 2 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 3 | Understanding and predicting private motorized urban mobility 显示文摘 | Cameron I Kenworthy J R Lyons T J | 2003 | Transportation Research PartD2003，，8： | 1 |
| 4 | Aortic stiffness affects the coronary blood flow response to percutaneous coronary intervention显示文摘 | LEUNG M C MEREDITH I T CAMERON J D | 2006 | Am J Physiol Heart Circ Hysiol2006，290，： | 1 |
| 5 | Mycorrhizal ac- quisition of inorganic phosphorus by the green-leaved ter- restrial orchid Goodyera repens 显示文摘 | Cameron D D Johnson I Leake J R | 2007 | Annals of Botany2007，99，： | 1 |
| 6 | Intensive care unit-acquired weakness: clinical phenotypes and molecu- lar mechanisms显示文摘 | Batt J Santos C C Cameron J I | 2013 | Am J Respir Crit Care Med2013，187，3： | 1 |
| 7 | Evidence for the optimal management of acute and chronic phantom pain: A systematic review显示文摘 | HALBERT J CROTTY M CAMERON I D | 2002 | Clin J Pain2002，18，： | 1 |
| 8 | Aortic stiffness affects the coronary blood flow response to percutaneous coronary intervention显示文摘 | LEUNG M C MEREDITH I T CAMERON J D | 2006 | Am J Physiol Heart Circ Physiol2006，290，： | 1 |
| 9 | Pravalence and characters of Barrett's esophagns in patients with adenocarcinoma of the esophagus or esophagugastric junction显示文摘 | Hamilton SR Smith RL Cameron J I | 1998 | Hum Pathol1998，19，： | 1 |
| 10 | Non-steroidal anti-inflammatory drug effect on crypt cell proliferation and apoptosis during initiation of rat colon carcinogenesis显示文摘 | Barnes C J Cameron I L Hardman W E | 1998 | Br J Cancer1998，77，3： | 1 |
| 11 | Evidence for the optimal management of acute and chronic phantom pain:a systematic review显示文摘 | Halbert J Crotty M Cameron I D | 2002 | Clin J Pain2002，18，2： | 1 |
| 12 | Structure of Type I and Type III Heterotypic Collagen Fibrils:An X-Ray Diffraction Study显示文摘 | Cameron G J Alberts I L Laing J H | 2002 | Journal of Structural Biology2002，137，： | 1 |
| 13 | Carbons as supports for precious metal catalysts 显示文摘 | Cameron D S Cooper S J Dodgson I L | 1990 | Catal Today1990，7，： | 1 |
| 14 | Friction measurement in powder die compaction by shear plate technique 显示文摘 | CAMERON I M GETHON D T TWEED J H | 2002 | Powder Metallurgy2002，45，： | 1 |
| 15 | Insulin B- chain reactive CD4 + regulatory T - cells induced by oral insulin treatment protect from 1 diabetes by blocking the cytokine secretion and pancreatic infiltration of diabetogenic effector T - cells 显示文摘 | Bergerot I Arreaza GA Cameron M J | 1999 | Diabetes1999，48，9： | 1 |
| 16 | Insulin B-chain reactive CD40 regulatory T-cells induced by oral insulin treatment protect from type 1 diabetes by blocking the cytokine secretion and pancreat- ic infiltration of diabetogenic effeetor T-cells显示文摘 | Bergerot I Arreaza GA Cameron M J | 1999 | Diabetes1999，48，9： | 1 |
| 17 | Modelling nucleation in wet granulation 显示文摘 | Wildeboer W J Litster J D Cameron I T | 2005 | Chemical Engineering Science2005，60，14： | 1 |
| 18 | Rehabilitationafter traumatic brain injury显示文摘 | KHAN F BAGULEY I J CAMERON I D | 2003 | Med J Aust2003，178，6： | 1 |
| 19 | Risk factors and outcomes in post pancreaticoduodenectomy pancreaticocutanous fistula显示文摘 | Lin J W Cameron J L Yeo C I | 2004 | Gastrointest Surg2004，8，8： | 1 |
| 20 | Analysis of protein com- plexes in wheat amyloplasts reveals functional interactions among starch biosynthetic enzymes 显示文摘 | Tetlow I J Beisel K G Cameron S | 2008 | Plant Physiol2008，146，： | 1 |
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