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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Expectant management of severe preeclampsia at 27 (0/7) to 33 ( 6/7 ) weeks gestation : maternal and perinatal outcomes according to gestational age by weeks at onset of expectant management 显示文摘 | BOMBRYS A E BARTON J R HABLI M | 2009 | American Journal of Perinatology2009，26，6： | 1 |
| 3 | The manahement of placenta percreta: con-servative and operative stragtegies 显示文摘 | O'Brien JM Barton J R Donaldson E S | 1996 | Am J Obstet Gynecol1996，175，6： | 1 |
| 4 | Expectant management of severe preeclampsia at 27(0/7) to 33(6/7) weeks' gestation:maternal and perinatal outcomes according to gestational age by weeks at onset of expectant management显示文摘 | Bombrys A E Barton J R Habli M | 2009 | Am J Perinatol2009，26，6： | 1 |
| 5 | Engineering classification of rock masses for the design of tunnel support显示文摘 | Barton N Lien R Lunde J | 1974 | Rock Mech1974，6，4： | 1 |
| 6 | Meehanical Properties of Tough, High Temperature Carbon Fibre Composites from Novel Functionalized Aryl Cyanate Ester Polymers显示文摘 | Barton J M Hamerton 1 Jones J R | 1996 | Polymer1996，37，20： | 1 |
| 7 | Science显示文摘 | Dandliker P J Holmlin R E Barton J K | 1997 | 275:14651997，275，： | 1 |
| 8 | The constitution of sedanolide 显示文摘 | Barton D H R Vries J X D | 1963 | Journal of Chemistry Society1963，，2： | 1 |
| 9 | Absolute orientation of tourmaline by arcomalous dispersion of X-rays ( abst ) 显示文摘 | Barton R J Donnay G | 1968 | Geological Society of America Special Paper1968，101，： | 1 |
| 10 | Marital status, social support, and loneliness in visually impaired elderly people 显示文摘 | Cecilia R Barton PR Martha J | 1994 | J Adv Nurs1994，19，2： | 1 |
| 11 | The health benefits of walking in green spaces of high natural and heritage value 显示文摘 | BARTON J HINE R PRETI'Y J | 2009 | Journal of Integrative Environmental Sciences2009，6，4： | 1 |
| 12 | Science显示文摘 | Murphy C J Arkin M R Jenkins Y Ghatlia N D Bossmann SH Turro N J Barton J K | 1993 | 262:10251993，262，： | 1 |
| 13 | Obesity-asso- ciated activation of angiotensin and endothelin in the cardiovascu- lar system显示文摘 | BARTON M CARMONA R ORTMANN J | 2003 | lnt J Biochem Cell Biol2003，35，6： | 1 |
| 14 | On demonstrating DNA intercalation 显示文摘 | Long E C Barton J R | 1990 | Acc Chem Res1990，23，9： | 1 |
| 15 | Etiology eald consequences of respiratory failure in thermally injured patients显示文摘 | Hollingsed T C Saffle J R Barton R G | 1993 | Am J Surg1993，166，6： | 1 |
| 16 | Inhaled nitric oxide versus conventional therapy:effect on oxygenation in ARDS 显示文摘 | Michael J R Barton R G Saffle J R | 1998 | Am J Respir Crit Care Med1998，157，51： | 1 |
| 17 | A Useful Synthesis of Pyrroles from Nitroolfins 显示文摘 | Barton D H R Kervagoret J Zard S Z | 1990 | Tetrahedron1990，46，21： | 1 |
| 18 | Electron transfer between metal complexes bound to DNA: variations in sepuence, donor, and metal binding mode 显示文摘 | HOLMLIN R E STEMP E D BARTON J K | 1998 | Inorg Chem1998，37，： | 1 |
| 19 | Synergistic Effects of Carbon Fillers in Electrically and Thermally Conductive Liquid Crystal Polymer Based Resins显示文摘 | KING J A BARTON R L HAUSER R A | 2008 | Polym Compos2008，29，： | 1 |
| 20 | Neurotrophic support and oxidative stress: converging effects in the normal and diseased nervous system 显示文摘 | Gardiner J Barton D Overall R | 2009 | Neuroscientist2009，15，1： | 1 |
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