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| 1 | Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival显示文摘BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: Fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (<400 ng/ml) (Odds ratio=3.3) and PR as best response to TACE (Odds ratio=6.7) were significantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major complications was 5.4% (n=6). All complications were managed conservatively. The mortality within 6 weeks after TACE was 2.1% (one patient). CONCLUSIONS: DSM and Lipiodol were combined successfully in the palliative TACE treatment of advanced HCC resulting in high rates of tumor response and survival at limited toxicity. Favourable tumor response was associated with tumor extent and vascularization. TACE using DSM and Lipiodol can be considered a suitable palliative measure in patients who might not tolerate long acting embolizing agents. | Timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd Frericks Lars Zender Nisar P Malek Tim F Greten Stefan Kubicka Michael P Manns Michael Galanski | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 15 |
| 2 | Noninvasive detection and evaluation of atherosclerotic coronary plaques with multislice computed tomography 1 1 This study was performed without additional financial support.显示文摘 | Stephen Schroeder Andreas F Kopp Andreas Baumbach Christoph Meisner Axel Kuettner Christian Georg Bernd Ohnesorge Christian Herdeg Claus D Claussen Karl R Karsch | 2001 | Journal of the American College of Cardiology2001，，5： | 3 |
| 3 | Best supportive care (BSC) versus oxaliplatin, folinic acid and 5-fluorouracil (OFF) plus BSC in patients for second-line advanced pancreatic cancer: A phase III-study from the German CONKO-study group显示文摘 | Uwe Pelzer Ingo Schwaner Jens Stieler Mathias Adler J?rg Seraphin Bernd D?rken Hanno Riess Helmut Oettle | 2011 | European Journal of Cancer2011，，11： | 2 |
| 4 | Allogeneic partially HLA-matched dendritic cells pulsed with autologous tumor cell lysate as a vaccine in metastatic renal cell cancer显示文摘 | Anne Fl?rcken Joachim Kopp Antje van Lessen Kamran Movassaghi Anna Takvorian Korinna J?hrens Markus M?bs Constanze Sch?nemann Birgit Sawitzki Karl Egerer Bernd D?rken Antonio Pezzutto J?rg Westermann | 2013 | Human Vaccines & Immunotherapeutics2013，，： | 2 |
| 5 | Modeling of pharmacokinetic/pharmcodynamic (PK/PD) Relationships: Concepts and perspectives显示文摘 | Hartmut D Bernd M | 1999 | Pharm Res1999，16，： | 1 |
| 6 | Effects of hyerinsulinemia on plasma levels of circulating adhesion molecules显示文摘 | Bernd J Susanne D Nicde H | 2000 | J Clin Endocrinol Metab2000，85，5： | 1 |
| 7 | Antisense therapy in oncology:new hope for an old idea显示文摘 | INGO T BERND D GUNTHER H | 2001 | Lancet2001，358，9280： | 1 |
| 8 | Limb-salvage reconstruction with MUTARS hemipelvic endoprosthesis: a prospective multi- center study显示文摘 | Witte D Bernd L Bruns J | 2009 | Eur J Surg Oncol2009，35，12： | 1 |
| 9 | Biomass for heat or as transportatioo fuel? A comparison between two modelbased studies 显示文摘 | GRAHN M AZAR C LINDGREN K BERNDES G GIELEN D | 2007 | Biomass Bioenergy2007，31，1112： | 1 |
| 10 | Outer product analysis of electronic nose and visible spectra: application to the measurement of peach fruit characteristics显示文摘 | Corrado Di Natale Manuela Zude-Sasse Antonella Macagnano Roberto Paolesse Bernd Herold Arnaldo D’Amico | 2002 | Analytica Chimica Acta2002，，1： | 1 |
| 11 | New chemical tools for investigating human mitotic kinesin Eg5显示文摘 | Emmanuel K Salvatore D Bernd T | 2007 | Bioorganic & Medicinal ChemistD2007，15，： | 1 |
| 12 | The ekeko mutant demonstrates a role for tetraspanins-like protein in plant development显示文摘 | Ernesto O Bernd R Koen D | 2003 | Biochemical and Biophysical Research Communications2003，310，： | 1 |
| 13 | Antisense therapy in oncology: new hope for an old idea显示文摘 | Ingo T Bernd D Gunther H | 2001 | Lancet2001，358，： | 1 |
| 14 | Hybrid PET/MRI of Intracranial Masses: Initial Experiences and Comparison to PET/CT显示文摘 | Boss Andreas Bisdas Sotirios Kolb Armin Hofmann Matthias Ernemann Ulrike Claussen Claus D Pfannenberg Christina Pichler Bernd J Reimold Matthias Stegger Lars | 2010 | The Journal of Nuclear Medicine2010，，8： | 1 |
| 15 | Brain electrical source imaging in manic and depressive episodes of bipolar disorder显示文摘 | Annamaria Painold Pascal L Faber Patricia Milz Eva Z Reininghaus Anna K Holl Martin Letmaier Roberto D Pascual‐Marqui Bernd Reininghaus Hans‐Peter Kapfhammer Dietrich Lehmann | 2014 | Bipolar Disord2014，，7： | 1 |
| 16 | Chemical Modification of Polyu- rethanes by Radiation-induced Grafting显示文摘 | Bernd Jansen M D Ph D | 1986 | Journal of Bio- material Application1986，1，： | 1 |
| 17 | Chemical and biological processes leading to the neutralisation of acidity in soil incubated with litter materials显示文摘 | Bernd Marschner Andrew D Noble | 2000 | Soil Biology and Biochemistry2000，，6： | 1 |
| 18 | Dynamic QoS control of multimedia applications based on RTP显示文摘 | BERND D HENNING S | 1996 | Computer Communications1996，19，1： | 1 |
| 19 | The first step in the biosynthesis of cocaine in Erythroxylum coca : the charac- terization of arginine and ornithine decarboxylases 显示文摘 | Teresa D Michael R Bernd S | 2012 | Plant Molecular Biology2012，78，： | 1 |
| 20 | Effects of hyerinsuline-mia on plasma levels of circulating adhesion molecules显示文摘 | Bernd J Susanne D Nicde H | 2000 | J Clin Endocrinol Metab2000，85，10： | 1 |
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