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| 1 | C-reactive protein is a prognostic indicator in patients with perihilar cholangiocarcinoma显示文摘AIM: To evaluate prognostic indicators for the outcome of patients with perihilar extrahepatic cholangiocarcinoma in an unselected cohort. METHODS: We retrospectively analyzed 98 patients with perihilar cholangiocarcinoma. Twenty-three patients (23.5%) underwent tumor resection. Patients with non- resectable tumors underwent either transpapillary or percutaneous transhepatic biliary drainage. Additionally, 32 patients (32.7%) received photodynamic therapy (PDT) and 18 patients (18.4%) systemic chemotherapy. Predefined variables at the time of diagnosis and characteristics considering the mode of treatment were entered into a Cox’s proportional hazards model. Included in the analysis were age, tumor stage following the modified Bismuth-Corlette classification, bilirubin, prothrombin time (PT), C-reactive protein (CRP), carbohydrate antigen 19-9 (CA19-9), history of weight loss, surgical resection, chemotherapy and PDT. RESULTS: The Kaplan-Meier estimate of overall median survival was 10.5 (95%CI: 8.4-12.6) mo. In the univariate analysis, low Bismuth stage, low CRP and surgical resection correlated significantly with better survival. In the multivariate analysis, only CRP (P = 0.005) and surgical resection (P = 0.029) were found to be independently predictive of survival in the cohort. Receiver operating characteristic (ROC) analysis identified a CRP level of 11.75 mg/L as the value associated with the highest sensitivity and specificity predicting a survival > 5 mo. Applying Kaplan-Meier analysis, patients with a CRP < 12 mg/L at the time of diagnosis had a signifi cantly longer median survival than patients with higher values (16.2 vs 7.6 mo; P = 0.009).CONCLUSION: This retrospective analysis identif ied CRP level at the time of diagnosis as a novel indicator for the prognosis of patients with perihilar cholangiocarcinoma. It should be evaluated in future prospective trials on this entity. | Thomas Gerhardt Sabine Milz Michael Schepke Georg Feldmann Martin Wolff Tilman Sauerbruch Franz Ludwig Dumoulin | 2006 | World Journal of Gastroenterology2006，12，34： | 5 |
| 2 | The skeletal attachment of ten-dons-tendon“entheses”显示文摘 | Benjamin M Kumai T Milz S | 2002 | Comp Biochem Physiol A Mol IntegrPhysiol2002，133，4： | 1 |
| 3 | Evaluation of breast lesions by power Doppler sonography显示文摘 | Milz P Lienemann A Kessler M | 2001 | Eur Radiol2001，11，4： | 1 |
| 4 | Fibrocartilage in the transverse ligament of the hunman acetabulum显示文摘 | Milz S Valassis G Buttner A | 2001 | Anat2001，198，2： | 1 |
| 5 | Dose-dependent new bone formation by extracorporeal shock waves application on the intact femur of rabbits显示文摘 | Tischer T Milz S Weiler C | 2008 | Eur Surg Res2008，41，1： | 1 |
| 6 | Morphometric studies of the ligamentum flavum:a correlative microanatomical and MRI study of the lumbar spine显示文摘 | Winkler PA Zausinger S Milz S | 2007 | Zentralbl Neurochir2007，68，4： | 1 |
| 7 | Evaluation of breast lesions by power Doppler sonography显示文摘 | Milz P Lienemann A Kessler M | 2001 | Eur Radiol2001，11，4： | 1 |
| 8 | Morphometric studies of the ligamentum flavum: a correlative mieroantomical and MRI study of the lumbar spine显示文摘 | Winkler PA Zausinger S Milz S et aI | 2007 | Zentrabl Neurochir2007，68，4： | 1 |
| 9 | The skeletal attachment of tendons:tendon'enthuses”显示文摘 | Benjamin M Kumai T Milz S | | 0，，： | 1 |
| 10 | Grundlagenforschung zur Applikation extrakorporaler Stobwellen am Stiatz-und Bewegungsapparat显示文摘 | Maier M Milz S Wirtz DC | 2002 | Orthopade2002，31，： | 1 |
| 11 | The skeletal attachment of tendons-tendon 'entheses' 显示文摘 | Benjamin M Kumai T Milz S | 2002 | Comp Biochem Physiol A Mol Integr Physiol2002，4，： | 1 |
| 12 | Aortic valve reimplantation in ascending aortic aneurysm: risk factors for early valve failure 显示文摘 | PETHIG K MILZ A HAQL C | 2002 | AnnThoraeSurg2002，73，1： | 1 |
| 13 | Detailed pathological changes of human lumbar facet joints L1-L5 in elderly individuals显示文摘 | Tischer T Aktas T Milz S | 2006 | Eur Spine2006，15，3： | 1 |
| 14 | Detailed pathological changes of human lumbar facet joints L1 - L5 in elderly individuals显示文摘 | Tischer T Aktas T Milz S | 2006 | Eur Spine J2006，15，3： | 1 |
| 15 | Detailed pathological changes of hu- man lumbar facet joints L1 -1_5 in elderly individuals显示文摘 | T Tischer T Aktas S Milz | 2006 | Eur Spine J2006，，15： | 1 |
| 16 | Morphometric studies of the ligamentum flavum: a correlative microanatomical and MRI study of the lumbar spine显示文摘 | Winkler PA Zausinger S Milz S | 2007 | Zentralbl Neurochir2007，68，4： | 1 |
| 17 | Overgrowth of skin in growth hormone transgenic mice depends on the presence of male gonads 显示文摘 | Wanke R Milz S Rieger N | 1999 | J Invest Dermatol1999，113，： | 1 |
| 18 | Morphometric studies of the ligamentum flavum:a correlative microanatomical and MRI study of the lumbar spine 显示文摘 | Winkler PA Zausinger S MilzS | 2007 | Zentralbl Neurochir2007，68，4： | 1 |
| 19 | Brain electrical source imaging in manic and depressive episodes of bipolar disorder显示文摘 | Annamaria Painold Pascal L Faber Patricia Milz Eva Z Reininghaus Anna K Holl Martin Letmaier Roberto D Pascual‐Marqui Bernd Reininghaus Hans‐Peter Kapfhammer Dietrich Lehmann | 2014 | Bipolar Disord2014，，7： | 1 |
| 20 | Anewcyathane-xyloside from the mycelia of Hericium erinaceum 显示文摘 | Ma B J ZhouY MiLZ | 2008 | ZNatur forseh2008，63，： | 1 |
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