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| 1 | Differential expression of cell cycle regulators in HCV-infection and related hepatocellular carcinoma显示文摘AIM:To investigate cell cycle proteins in chronic hepatitis C virus infection in order to analyze their role in the process of hepatocyte transformation and to characterize their prognostic properties. METHODS:Subjects of the current study included 50 cases of chronic hepatitis C(CHC) without cirrhosis,30 cases of CHC with liver cirrhosis(LC) ,and 30 cases of hepatitis C-related hepatocellular carcinoma(HCC) admitted to the Department of Hepato-Gastroenterology,Theodor Bilharz Research Institute(TBRI) ,Giza,Egypt.Fifteen wedge liver biopsies,taken during laparoscopic cholecystectomy,were also included as normal controls.Laboratory investigations including urine and stool analysis,liver function tests and prothrombin concentration;serologic markers for viral hepatitis and ultrasonography were done for all cases of the study together with immunohistochemical analysis using primary antibodies against Cyclin D1,Cyclin E,p21,p27 and Rb/p105 proteins. RESULTS:Normal wedge liver biopsies didn't express Cyclin E or Rb/p105 immunostaining but show positive staining for Cyclin D1,p21 and p27.Cyclin D1 expressed nuclear staining that was sequentially increased from CHC to LC(P<0.01) to HCC(P<0.001) cases;meanwhile,Cyclin E revealed nuclear positivity only in the case of HCCs patients that was directly correlated to Rb/p105 immuno-reactivity.The expression of p21 and p27 was significantly increased in CHC and LC cases compared to normal controls and HCCs with no significant difference between well-and poorlydifferentiated tumors.p21 showed only a nuclear pattern of staining,while,p27 presented with either cytoplasmic and/or nuclear reactivity in all studied cases.Correlation analysis revealed a direct relation between Cyclin D1 and p21 in CHC cases(P<0.001) ,between Cyclin D1 and Cyclin E in HCCs(P<0.01);however,an inverserelationship was detected between Cyclin D1 and p21 or p27(P<0.001) and between p21 and Rb/p105(P<0.05) in HCCs. CONCLUSION:Upregulation of Cyclin D1 in CHC plays a vital role in the development and differentiation of HCC;while,Cyclin E may be a useful marker for monitoring tumor behavior.p21 and p27 can be used as predictive markers for HCC.Furthermore,higher expression of Rb/p105 as well as inverse relation with p21 and histologic grades suggests its important role in hepatic carcinogenesis. | Azza E El Bassiouny Mona M Nosseir Mona K Zoheiry Noha A Ameen Ahmed M Abdel-Hadi Ibrahim M Ibrahim Suher Zada Abdel-Hakeem Saad El-Deen Nora E El-Bassiouni | 2010 | World Journal of Hepatology2010，2，1： | 3 |
| 2 | When FESS fails:the inflammatory load hypothesis in refractory chronic rhinosinusitis显示文摘 | BASSIOUNI A NAIDOO Y WORMALD P J | 2012 | The Laryngoscope2012，122，2： | 1 |
| 3 | Prevalence of extramucosal fungal elements in sinonasal polyposis:a mycological and pathologic study in an Egyptian population显示文摘 | Bassiouny A Ragab A Attia AF | 2011 | Am J Otolaryngol2011，32，4： | 1 |
| 4 | Immunohistochemical expression of CD95 (Fas),C-myc and epidermal growth factor receptor in hepatitis C virus infection,cirrhotic liver disease and hepatocellular carcinoma显示文摘 | Bassiouni A NosseirM ZoheiryM | 2006 | APMIS2006，114，： | 1 |
| 5 | Electron microscopy study of peripheral nerves in the uvulae of snorers and obstructive sleep apnoea patients显示文摘 | BASSIOUNY A NASR S MASHALY M | 2009 | J Laryngol Otol2009，123，： | 1 |
| 6 | Accumulation of mitochondrial DNA deletion mutations in aged muscle fibers:evidence for a causal role in muscle fiber loss显示文摘 | Herbst A Pak JW McKenzie D Bua E Bassiouni M Aiken JM | | 0，，： | 1 |
| 7 | Uhrastructural ciliary changes of maxillary sinus mucosa following functional endoscopic sinus surgery : an image analysis quantitative study 显示文摘 | Bassiouny A Atef AM Raouf MA | 2003 | Laryngol Otol2003，117，4： | 1 |
| 8 | Meningiomas of the pos- terior petrous bone : functional outcome after microsurgery 显示文摘 | Bassiouni H Hunold A Asgari S | 2004 | J Neurosurg2004，100，6： | 1 |
| 9 | Juxtalumenal location of plaque necrosis and neoformation in symptomatic carot- id stenosis显示文摘 | Bassiouny H S Sakaguchi Y Mikucki S A McKinsey J F Piano G Gewertz B L | 1997 | J Vasc Surg1997，26，： | 1 |
| 10 | When FESS fails:the in-flammatory load hypothesis in refractory chronic rhinosinusitis显示文摘 | Bassiouni A Naidoo Y Wormald PJ | | 0，，02： | 1 |
| 11 | Ultrastructural ciliary changes of maxillary sinus mucosa following functional endoscopic sinus surgery:an image analysis quantitative study显示文摘 | Bassiouny A AtefAM Raout MA | 2003 | Laryngol Otol2003，117，2： | 1 |
| 12 | Synergistic effect of celecox- ib on 5-fluorouracil-induced apoptosis in hepatocellular carcinoma patients显示文摘 | Bassiouny AR Zaky A Neenaa HM | 2010 | Ann Hepatol2010，9，4： | 1 |
| 13 | Spinal intradural juxtamedullary cysts in the adult:surgical management and outcome显示文摘 | BASSIOUNI H HUNOLD A ASGARI S | | Neurosurgery0，55，6： | 1 |
| 14 | When FESS fails : the inflammatory load hypothesis in refractory chronic rhinosinusitis 显示文摘 | Bassiouni A Naidoo Y Wormald PJ | 2012 | Laryngoscope2012，122，2： | 1 |
| 15 | Role of interleukin-17 in the pathogenesis of vitiligo 显示文摘 | Bassiouny D A Shaker O | 2011 | Clin Exp Demlatol2011，36，3： | 1 |
| 16 | Synergistic effect of celecoxib on 5-fluorouracil-induced apoptosis in hepatocellular carcinoma patients 显示文摘 | Bassiouny AR Zaky A Neenaa HM | 2010 | Ann Hepatol2010，9，4： | 1 |
| 17 | Biocomm- across-layer medium access con- trol (MAC) and routing protocol co-design for biomedical sensor networks显示文摘 | Bag A Bassiouni M A | 2009 | International Journal of Parallel Emergent and Dis- tributed Systems2009，24，： | 1 |
| 18 | Meningiomas of the posterior petrous bone: functional outcome after microsurgery显示文摘 | Bassiouni H Hunold A Asgari S | 2004 | J Neurosurg2004，100，6： | 1 |
| 19 | An analytical and numerical study of solar chimney use for room natural ventilation显示文摘 | RAMADAN BASSIOUNY NADER S A KOURA | 2008 | Energy and Buildings2008，40，： | 1 |
| 20 | Spinal intradural juxtamedullary cysts in the adult:surgical management and outcome显示文摘 | Bassiouni H Hunold A Asgari S | 2004 | Neurosurgery2004，6，： | 1 |
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