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| 1 | Differential expression of cell cycle regulators in HCV-infection and related hepatocellular carcinoma显示文摘AIM:To investigate cell cycle proteins in chronic hepatitis C virus infection in order to analyze their role in the process of hepatocyte transformation and to characterize their prognostic properties. METHODS:Subjects of the current study included 50 cases of chronic hepatitis C(CHC) without cirrhosis,30 cases of CHC with liver cirrhosis(LC) ,and 30 cases of hepatitis C-related hepatocellular carcinoma(HCC) admitted to the Department of Hepato-Gastroenterology,Theodor Bilharz Research Institute(TBRI) ,Giza,Egypt.Fifteen wedge liver biopsies,taken during laparoscopic cholecystectomy,were also included as normal controls.Laboratory investigations including urine and stool analysis,liver function tests and prothrombin concentration;serologic markers for viral hepatitis and ultrasonography were done for all cases of the study together with immunohistochemical analysis using primary antibodies against Cyclin D1,Cyclin E,p21,p27 and Rb/p105 proteins. RESULTS:Normal wedge liver biopsies didn't express Cyclin E or Rb/p105 immunostaining but show positive staining for Cyclin D1,p21 and p27.Cyclin D1 expressed nuclear staining that was sequentially increased from CHC to LC(P<0.01) to HCC(P<0.001) cases;meanwhile,Cyclin E revealed nuclear positivity only in the case of HCCs patients that was directly correlated to Rb/p105 immuno-reactivity.The expression of p21 and p27 was significantly increased in CHC and LC cases compared to normal controls and HCCs with no significant difference between well-and poorlydifferentiated tumors.p21 showed only a nuclear pattern of staining,while,p27 presented with either cytoplasmic and/or nuclear reactivity in all studied cases.Correlation analysis revealed a direct relation between Cyclin D1 and p21 in CHC cases(P<0.001) ,between Cyclin D1 and Cyclin E in HCCs(P<0.01);however,an inverserelationship was detected between Cyclin D1 and p21 or p27(P<0.001) and between p21 and Rb/p105(P<0.05) in HCCs. CONCLUSION:Upregulation of Cyclin D1 in CHC plays a vital role in the development and differentiation of HCC;while,Cyclin E may be a useful marker for monitoring tumor behavior.p21 and p27 can be used as predictive markers for HCC.Furthermore,higher expression of Rb/p105 as well as inverse relation with p21 and histologic grades suggests its important role in hepatic carcinogenesis. | Azza E El Bassiouny Mona M Nosseir Mona K Zoheiry Noha A Ameen Ahmed M Abdel-Hadi Ibrahim M Ibrahim Suher Zada Abdel-Hakeem Saad El-Deen Nora E El-Bassiouni | 2010 | World Journal of Hepatology2010，2，1： | 3 |
| 2 | Electron microscopy study of peripheral nerves in the uvulae of snorers and obstructive sleep apnoea patients显示文摘 | BASSIOUNY A NASR S MASHALY M | 2009 | J Laryngol Otol2009，123，： | 1 |
| 3 | Accumulation of mitochondrial DNA deletion mutations in aged muscle fibers:evidence for a causal role in muscle fiber loss显示文摘 | Herbst A Pak JW McKenzie D Bua E Bassiouni M Aiken JM | | 0，，： | 1 |
| 4 | Biocomm- across-layer medium access con- trol (MAC) and routing protocol co-design for biomedical sensor networks显示文摘 | Bag A Bassiouni M A | 2009 | International Journal of Parallel Emergent and Dis- tributed Systems2009，24，： | 1 |
| 5 | Risk factors and outcomes for primary, revision, and modified Lothrop (Draf III) frontal sinus surgery显示文摘 | Naidoo Y Bassiouni A Keen M | 2013 | Int Forum Allergy Rhino12013，3，5： | 1 |
| 6 | Modeling of heat transfer for flow across tube banks显示文摘 | Wilson A S Bassiouny M K | | 0，，01： | 1 |
| 7 | Risk factors and outcomes for primary, revision, and modified Lothrop ( Draf III) frontal sinus surgery 显示文摘 | Naidoo Y Bassiouni A Keen M | 2013 | Int Forum Allergy Rhinol2013，3，5： | 1 |
| 8 | Design and implementation of extended Boolean and comparison operators for time-oriented query languages显示文摘 | Mukherjee A Llewellyn M | 1994 | The Computer Journal1994，37，7： | 1 |
| 9 | Time-based operators for relational algebra query languages显示文摘 | Llewellyn M Mukherjee A | 1993 | Journal of Computer Languages1993，19，4： | 1 |
| 10 | Synergistic effect of celecoxib on 5fluorouracilinduced apoptosis in hepatocellular carcinoma patients显示文摘 | Bassiouny A R Zaky A Neenaa H M | 2010 | Ann Hepatol2010，9，4： | 1 |
| 11 | Long - term outcomes for the endoscopic modified lothrop/draf m procedure: a 10 -year re- view显示文摘 | Naidoo Y Bassiouni A Keen M | 2014 | Laryngoscope2014，124，1： | 1 |
| 12 | Predictive schemes for handoff prioritization in cellular networks based on mobile positioning显示文摘 | CHIU M H BASSIOUNI M A | 2000 | IEEE J Select Areas Commun2000，18，3： | 1 |
| 13 | Circu- lating and hepatic Fas expression in HCV-induced chronic liver disease and hepatocellular carcinoma显示文摘 | E1 Bassiouny A E E1-Bassiouni N E Nosseir M M | 2008 | Medseape J Med2008，10，6： | 1 |
| 14 | Estimation of components reliabil ity in a para显示文摘 | Sarhan A M E1 Bassiouny A H | 2003 | Applied Mathematics and Computation2003，138，1： | 1 |
| 15 | System and program models of storage allocation for reducing seek delay显示文摘 | Bassiouni M A | 1986 | The Computer Journal1986，29，1： | 1 |
| 16 | Experimental intravenous inoculation of Klebsiella rhinoscleromatis bacilli in albino rats:a histopathological and bacteriological study显示文摘 | GAAFAR H A BASSIOUNY M EL MOFTY M | 2000 | Acta Otolaryngol2000，120，： | 1 |
| 17 | Modeling of heat transfer for flow across tube banks 显示文摘 | WILSON A S BASSIOUNY M K | 2000 | Chem Eng Process2000，39，： | 1 |
| 18 | Laparoscopic radical cystectomy with orthotopic neobladder显示文摘 | Abdel-hakim A M Bassiouny F Abdel azim M S | 2002 | J Endourol2002，16，： | 1 |
| 19 | Detubularized sigmoid neobladder versus delubular ized W-shaped Ileal neobladder as a bladder substitute after radical cystectomy for carcinoma of the urinary bladder:a study of 60 patients 显示文摘 | Bassiouny M Zaghloul A S El Sherbiny M | 2004 | J Egypl Natl Canc Inst2004，16，2： | 1 |
| 20 | Five-year experience in the treatment of alopecia areata with DPC显示文摘 | El-Zawahry B M Bassiouny D A Khella A | 2010 | J Eur Acad Dermatol Venereol2010，24，3： | 1 |
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