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| 1 | Dual Functions of Microglia in Ischemic Stroke显示文摘Ischemic stroke is a leading cause of morbidity and mortality worldwide. Resident microglia are the principal immune cells of the brain, and the first to respond to the pathophysiological changes induced by ischemic stroke. Traditionally, it has been thought that microglial activation is deleterious in ischemic stroke, and therapies to suppress it have been intensively explored. However,increasing evidence suggests that microglial activation is also critical for neurogenesis, angiogenesis, and synaptic remodeling, thereby promoting functional recovery after cerebral ischemia. Here, we comprehensively review the dual role of microglia during the different phases of ischemic stroke, and the possible mechanisms controlling the post-ischemic activity of microglia. In addition, we discuss the dynamic interactions between microglia and other cells, such as neurons, astrocytes, oligodendrocytes,and endothelial cells within the brain parenchyma and the neurovascular unit. | Chuan Qin Luo-Qi Zhou Xiao-Tong Ma Zi-Wei Hu Sheng Yang Man Chen Dale B. Bosco Long-Jun Wu Dai-Shi Tian | 2019 | Neuroscience Bulletin2019，35，5： | 64 |
| 2 | Mesenchymal stem cells over-expressing hepatocyte growth factor improve small-for-size liver grafts regeneration显示文摘 | Yu, Y. Yao, A. H. Chen, N. Pu, L. Y. Fan, Y. Lv, L. Sun, B. C. Li, G. Q. Wang, X. H. | 2007 | 南京医科大学学报(自然科学版)2007，27，10： | 45 |
| 3 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 4 | Common Genetic Variants in Pre-MicroRNAs Were Associated With Increased Risk of Breast Cancer in Chinese Women显示文摘 | Hu, Z. B. Liang, J. Wang, Z. W. Tian, T. Zhou, X. Y. Chen, J. P. Miao, R. F. Wang, Y. Wang, X. R. Shen, H. B. | 2009 | 南京医科大学学报(自然科学版)2009，29，4： | 29 |
| 5 | GIS-based risk analysis of debris flow:an application in Sichuan,southwest China显示文摘Debris flow is a serious geologic hazard in China.It is estimated that nationally debris flows cause up to 2 billion RMB(250 million US$) in damages and 300-600 deaths and injuries annually.To mitigate debris flow hazards,it is necessary to map,model,and identify zones of debris flow hazards and vulnerability as to inform the local people about the potential risk with a geographic information system.This research presents a regional scale case study modeling debris flow risk(hazard and vulnerability) in Sichuan Province,Southwestern China.In this area,3,290 debris flows have been identified and the spatial-temporal distribution and activity characteristics of them have been documented.Based on the available meteorological data,a Digital Elevation Model with the rate of 1:250,000 and a regional geological map,the 24-hr rainfall threshold(y) for debris flow occurrence is closely related(significant at 99% confidence level) to the index(x) defined using a geology factor(rock hardness:a) and a topographical factor(channel gradient:d) where y = 21 + 10200 / x,in which x = 2.7 × ea + 1000 × d.The discipline is constructive in developing the rainfall threshold for debris flow activity in remote mountainous areas that lack data.For a given watershed,a four-level debris flow hazard map is developed by comparing the rainfall threshold to the design rainfall intensities with 50-,20-,and 5-year average recurrence intervals,respectively.The degree of debris flow vulnerability is determined by the watershed socio-economic conditions.A four-class debris flow risk map,at the final phase of the research,is generated by combining debris flow hazards and vulnerability.With the debris flow risk assessment,the Sichuan Province is classified into the slight,moderate,severe and very severe regions,which accounts for 36%,19%,20% and 25% of total area respectively. | B. F. DI N. S. CHEN P. CUI Z. L. LI Y. P. HE Y. C. GAO | 2008 | International Journal of Sediment Research2008，23，2： | 19 |
| 6 | PERSPECTIVES IN MECHANICS OF HETEROGENEOUS SOLIDS显示文摘The Microand Nano-mechanics Working Group of the Chinese Society of Theoretical and Applied Mechanics organized a forum to discuss the perspectives,trends,and directions in mechanics of heterogeneous materials in January 2010.The international journal,Acta Mechanica Solida Sinica,is devoted to all fields of solid mechanics and relevant disciplines in science,technology,and engineering,with a balanced coverage on analytical,experimental,numerical and applied investigations.On the occasion of the 30 th anniversary of Acta Mechanica Solida Sinica,its editor-in-chief,Professor Q.S.Zheng invited some of the forum participants to review the state-of-the-art of mechanics of heterogeneous solids,with a particular emphasis on the recent research development results of Chinese scientists.Their reviews are organized into five research areas as reported in different sections of this paper.§I firstly brings in focus on microand nano-mechanics,with regards to several selective topics,including multiscale coupled models and computational methods,nanocrystal superlattices,surface effects,micromechanical damage mechanics,and microstructural evolution of metals and shape memory alloys.§II shows discussions on multifield coupled mechanical phenomena,e.g.,multi-fields actuations of liquid crystal polymer networks,mechanical behavior of materials under radiations,and micromechanics of heterogeneous materials.In §III,we mainly address the multiscale mechanics of biological nanocomposites,biological adhesive surface mechanics,wetting and dewetting phenomena on microstructured solid surfaces.The phononic crystals and manipulation of elastic waves were elaborated in §IV.Finally,we conclude with a series of perspectives on solid mechanics.This review will set a primary goal of future science research and engineering application on solid mechanics with the effort of social and economic development. | C.Q. Chen J.Z. Cui H.L. Duan X.Q. Feng L.H. He G.K. Hu M.J. Huang Y.Z. Huo B.H. Ji B. Liu X.H. Peng H.J. Shi Q.P. Sun J.X. Wang Y.S. Wang H.P. Zhao Y.P. Zhao Q.S. Zheng W.N. Zou | 2011 | Acta Mechanica Solida Sinica2011，24，1： | 18 |
| 7 | 冷水机利用变流量冷冻水的若干设计问题显示文摘目前变水量冷冻水系统的设计一般都采用一、二次双环路方式。但这种双环路配置方式会产生:使用两个水泵增加设备投资;冷冻水送水及回水的混合影响冷水机在部分负荷时的效率;实际的高负荷空调需求条件与最大设计工况条件不吻合时不能充分利用冷水机的全负荷容量等不良后果。设计单环路空调冷冻水系统可以避免上述问题。讨论了单环路变流量系统的长处以及可能产生的问题,并提供在整个运行范围内,能够实现安全、稳定和可靠的冷水机控制策略。 | Original by Thomas B. Hartman Translation by Liu Xuemin Reviewed by Steve Y. Chen | 1997 | 暖通空调1997，27，3： | 18 |
| 8 | Interactions of IL-12A and IL-12B Polymorphisms on the Risk of Cervical Cancer in Chinese Women显示文摘 | Chen, X. J. Han, S. P. Wang, S. N. Zhou, X. Y. Zhang, M. F. Dong, J. Shi, X. Y. Qian, N. F. Wang, X. R. Wei, Q. Y. Shen, H. B. Hu, Z.B. | 2009 | 南京医科大学学报(自然科学版)2009，29，3： | 16 |
| 9 | First report of a novel abluminal groove filled biodegradable polymer rapamycin-eluting stent in de novo coronary artery disease: results of the first in man FIREHAWK trial显示文摘 | QIAN Jie XU Bo Alexandra J. Lansky YANG Yue-jin QIAO Shu-bin WU Yong-jian CHEN Jue HU Feng-huan YANG Wei-xian Gary S. Mintz Martin B. Leon GAO Run-lin | 2012 | Chinese Medical Journal2012，，6： | 14 |
| 10 | Nature:研究鉴定出蛋白Nlrp9b抵抗轮状病毒感染机制显示文摘轮状病毒(rotavirus)是婴儿和儿童罹患肠胃炎和腹泻的一种最为常见的原因,每年导致全世界大约21.5万人死亡。它是高度传染性的和潜在致命性的。这种病毒特异性地感染宿主小肠中的肠上皮细胞,并且已进化出抵抗干扰素和NF-KB信号的策略来躲避免疫系统,这就提出一个问题:其他的宿主因子是否参与肠道粘膜中的抗病毒反应。不过,针对体内(特别是通过NLR炎性体)检测和限制肠道病毒的机制,人们知之甚少。 | Shu Zhu, Zheng Wei, Noah W. Palm, Yi Yang, Hua Yu, Hua-Bing Li, Geng Wang, Xuqiu Lei, Marcel R. de Zoete, Jun Zhao, Yunjiang Zheng, Haiwei Chen, Liang Shan, Richard A. Flavell Siyuan Ding, Ningguo Feng, Harry B. Greenberg Siyuan Ding, Harry B. Greenberg Penghua Wang, Yujiao Zhao Wen Pan, Jun Lu Jun Zhao, Yuval Kluger Kellie A. Jurado, Clara Abraham, Erol Fikrig Erol Fikrig, Richard A. Flavell | 2017 | 现代生物医学进展2017，17，27： | 10 |
| 11 | MICROSTRUCTURE AND PROPERTIES OF HIGH BORON BEARING STEEL显示文摘High boron bearing steel, in which boron homogeneously distributed, was successfully produced in the vacuum induction furnace. The microstructural observations of cast and hot rolled steels showed that the addition of titanium can eliminate the quantity of ferrous borides precipitated at the grain boundaries and break the net microstructure, as a result, its hot workability is improved. The titanium boride TiB2 homogeneously distributes in the matrix of a-Fe. The parameters of hot rolling process. including preheated temperature, initial rolling temperature, finished rolling temperature and the total deformation, have been optimized. | C.S. Liu, S. Y. Chen, Z. T. Wang, B. Yu and Q.K. Cai School of Materials and Metallurgy, Northeastern University, Shenyang 110006, China | 2002 | Acta Metallurgica Sinica(English Letters)2002，15，2： | 8 |
| 12 | Thermoelectric transport across graphene/hexagonal boron nitride/graphene heterostructures显示文摘我们越过 graphene/hexagonal 硼氮化物(h-BN ) 报导热电的运输大小 /graphene heterostructure 设备。用一种交流占据技术,我们能分开热电的贡献到这些重要设备结构的 IV 特征。温度坡度用拉曼光谱学光学地被测量,它使我们能探索在材料接口生产的热电的运输,越过就 12 nm 的长度规模。基于观察热电的电压(V) 和温度坡度(T) , 99.3 V/K 的一个 Seebeck 系数为 heterostructure 设备被查明。获得的 Seebeck 系数能为在新兴的 2D heterostructure 设备的跨飞机的 IV 行为理解热电的部件是有用的。这些结果提供一条途径给在二维的分层的 heterostructures 探查热电的精力变换。 | Chun-Chung Chen Zhen Li Li Shi Stephen B. Cronin | 2015 | Nano Research2015，8，2： | 8 |
| 13 | Microstructures and mechanical properties of Ti3Al/Ni-based superalloy joints brazed with AuNi filler metal显示文摘For the purpose of high-temperature service and the weight reduction in aviation engineering applications, the dissimilar joining of Ti3Al-based alloy to Ni-based superalloy (GH536) was conducted using Au-17.5Ni (wt%) brazing filler metal. The microstructure and chemical composition at the interfaces were investigated by scanning electron microscope, X-ray diffraction and transmission electron microscope. The diffusion behaviors of elements were analyzed as well. The results indicated that the Ti3Al/GH536 joint microstructure was characterized by multiple layer structures. Element Ni from Au-Ni filler metal reacted with Ti3Al base metal, leading to the formation of AlNi2Ti and NiTi compounds. Element Ni from Ti3Al base metal reacted with Ni and thus Ni3Nb phase was detected in the joint central area. Due to the dissolution of Ni-based superalloy,(Ni,Au) solid solution ((Ni,Au)ss) and Ni-rich phase were visible adjacent to the superalloy side. The average tensile strength of all the joints brazed at 1253 K for 5-20 min was above 356 MPa at room-temperature. In particular, the joints brazed at 1253 K/15 min presented the maximum tensile strength of434 MPa at room-temperature, and the strength of 314 MPa was maintained at 923 K. AlNi2Ti compound resulted in the highest hardness area and the fracture of the samples subjected to the tensile test mainly occurred in this zone. | H.S. Ren H.P.Xiong W.M. Long B. Chen Y.X. Shen J. Pang | 2019 | Journal of Materials Science & Technology2019，35，9： | 7 |
| 14 | Variant alleles of TGFB1 and TGFBR2 are associated with a decreased risk of gastric cancer in a Chinese population显示文摘 | Jin, G. F. Wang, L. N. Chen, W. S. Hu, Z. B. Zhou, Y. Tan, Y. F. Wang, J. M. Hua, Z. L. Ding, W. L. Shen, J. Zhang, Z. F. Wang, X. R. Xul, Y. C. Shen, H. B. | 2007 | 南京医科大学学报(自然科学版)2007，27，5： | 7 |
| 15 | Variant genotypes and haplotypes of the epidermal growth factor gene promoter are associated with a decreased risk of gastric cancer in a high-risk Chinese population显示文摘 | Jin, G. F. Miao, R. F. Deng, Y. M. Hu, Z. B. Zhou, Y. Tan, Y. F. Wang, J. M. Hua, Z. L. Ding, W. L. Wang, L. Chen, W. S. Shen, J. Wang, X. R. Xu, Y. C. Shen, H. B. | 2007 | 南京医科大学学报(自然科学版)2007，27，10： | 7 |
| 16 | Interfacial bonding mechanism in Al/coated steel dissimilar refill friction stir spot welds显示文摘Defect-free dissimilar Al/zinc coated steel and Al/AlSi coated steel welds were successfully fabricated by refill friction stir spot welding. However, Al alloy and uncoated steel could not be welded under the same welding condition. Al-Zn eutectic layer formed at the Al/zinc coated steel interface showed nonuniformity in thickness and nanoscale intermetallic(IMC) produced was discontinuous. The bonding formation between the Al-Zn layer and the surrounding materials was attributed to a liquid/solid reaction mechanism. Bonding formation at Al alloy and AlSi coated steel interface was attributed to a solid/solid reaction mechanism, as the joining process did not involve with melting of base metals or AlSi coating materials. Kissing bond formed at the weld boundary acted as a crack initiation and propagation site,and the present study showed that weld strength of Al 5754/AlSi coated steel was greatly influenced by properties of original IMC layer. | Z. Shen Y. Ding J. Chen B. Shalch Amirkhiz J.Z. Wen L. Fu A.P. Gerlich | 2019 | Journal of Materials Science & Technology2019，35，6： | 6 |
| 17 | Interface Structure of Ag/SnO_2 Nanocomposite Fabricated by Reactive Synthesis显示文摘The electric contact material of Ag/SnO2 composite was achieved by reactive synthesis method. The compositions and microstructure of Ag/SnO2 composite were analyzed and characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and high-resolution electron microscopy (HRTEM). The structural feature was typical of the particle reinforced composites. The HRTEM images revealed that the observed Ag/SnO2 interface was absence of the precipitated phase and the lattice contrast across the interface was clear and sharp. The average particle size of SnO2 in composite was near 50 nm and it was well dispersed in spherical shape. The thermodynamic mechanism of reactive synthesis method was also discussed. The electronic density distribution analysis of the interface showed the charges of Ag atoms transmitted to O atoms and the conductivity of the material was also affected. No extra compounds expected such as AgxOy formed at interface. The distribution of electrons was of inequality near the interface which explained why the mechanical property of the metal/ceramic materials was improved but the machining property declined. | Jingchao Chen Jing Feng B. Xiao K.H. Zhang Y.P. Du Z.J. Hong R. Zhou | 2010 | Journal of Materials Science & Technology2010，26，1： | 6 |
| 18 | Combination Therapy With Infliximab and Azathioprine Is Superior to Monotherapy With Either Agent in Ulcerative Colitis显示文摘 | Remo Panaccione Subrata Ghosh Stephen Middleton Juan R. Márquez Boyd B. Scott Laurence Flint Hubert JF. van Hoogstraten Annie C. Chen Hanzhe Zheng Silvio Danese Paul Rutgeerts | 2013 | Gastroenterology2013，，： | 5 |
| 19 | Effects of Boron Addition on Grain Refinement in TiAl-based Alloys显示文摘Solid state phase transformation characteristics of the body centred β(Ti) into the hexagonal closed packed α(Ti) in Ti45Al8Nb-(0, 0.3, 0.5 and 0.8 at. pct) B alloys were investigated by heat treatment to clarify γ/α2 lamellar microstructure refinement induced by B addition. Experimental results confirmed two kinds of boron-reduced grain refinement mechanisms through refining either β phase then α phase (β-refinement) or α phase directly (α-refinement) to refine lamellar microstructure at room temperature; however, the role of α-refinement dominated the as-cast lamellar microstructure refinement over β-refinement in Ti45Al8NbxB alloy. It was also found that during the α-refinement the convoluted flake- and plate-like borides along β grain boundaries assisted nucleation of α phase, and the particle-like borides near β grain boundaries impeded α phase growth. | W.D. Wang,Y.C. Ma,B. Chen,M. Gao,K. Liu and Y.Y. Li Institute of Metal Research,Chinese Academy of Sciences,Shenyang 110016,China | 2010 | Journal of Materials Science & Technology2010，26，7： | 5 |
| 20 | ROR2 gene is associated with risk of non-syndromic cleft palate in an Asian population显示文摘背景受体酷氨酸象kinase一样孤儿受体 2 ( ROR2 )基因最近被显示了在动物模型在腭的开发起重要作用并且居住在连接到的 chromosomal 区域非, syndromic 劈开嘴唇与或没有在学习是调查可能的协会在之间的这的 humans.The 目的劈开腭 ROR2 基因和 non-syndromic 我们测试了的这里的口头的 clefts.Methods 在在 297 non-syndromic 的 ROR2 基因的 38 合格单个核苷酸的多型性( SNP ) | Wang Hong Hetmanski, Jacqueline B. Ruczinski, Ingo Liang, Kung Yee Fallin, M. Daniele Redett, Richard J. Raymond, Gerald V. Chou, Yah-Huei Wu Chen, Philip Kuo-Ting Yeow, Vincent Chong, Samuel S. Cheah, Felicia S. H. Jabs, Ethylin Wang Scott, Alan F. Beaty, Terri H. | 2012 | Chinese Medical Journal2012，，3： | 5 |
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