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| 1 | Association between thrombotic risk factors and extent of fibrosis in patients with non-alcoholic fatty liver diseases显示文摘AIM: To evaluate the prevalence of genetic and acquired prothrombotic risk factors and their association with the extent of fibrosis and fatty infiltration in patients with non-alcoholic fatty liver disease (NAFLD).METHODS: Forty-four patients with chronic hepatitis (28 men and 16 women, with mean age of 45±11 and 49±12 years, respectively) constituted the patient population of this study. The groups were divided as follows: 15 patients with fatty liver (FL); 15 with non-alcoholic steatohepatitis (NASH); 14 with chronic viral hepatitis (CH) diagnosed by histology and liver technetium scan or ultrasound; and 10 healthy individuals. Thrombophilic, coagulation factors and genetic mutations were diagnosed by standard hemostatic and molecular coagulation assays.RESULTS: Activated protein C (APC) resistance and protein S were the most prevalent thrombotic risk factors (6% and 10% in NAFLD vs 21% and 14% in CH; P<0.01 and P<0.05, respectively). One thrombotic risk factor was identified in 41% of patients (23% mild fibrosis, 18% severe fibrosis) and two thrombotic risk factors in 6% of patients with NAFLD and severe fibrosis. While no differences in APC ratio, lupus anticoagulant, fibrinogen, factor V Leiden,prothrombin, and MTHFR mutation were found. Protein S levels were significantly lower in NASH patients than in patients with FL alone (92±19 vs106±2, P<0.01). Protein C levels were markedly higher in patients with NAFLD and mild or severe fibrosis as compared to the patients with CH, respectively (128±40 vs96±14, P<0.001 or 129±36 vs 88±13, P<0.01).CONCLUSION: Up to 46% of patients with NAFLD may have thrombotic risk factors, and the presence of thrombotic risk factors is correlated with the extent of hepatic fibrosis,suggesting a crucial role of the coagulation system in the pathogenesis of hepatic fibrosis. | N Assy I Bekirov Y Mejritsky L Solomon S Szvalb O Hussein | 2005 | World Journal of Gastroenterology2005，11，37： | 3 |
| 2 | Antioxidant activity, ascorbic acid and total phenol of exotic fruits occurring in Brazil显示文摘 | Aparecida de Assis S Vellosa J C R Brunetti I L | 2008 | International journal of food sciences and nutrition2008，60，5： | 1 |
| 3 | Optimisation of COREX process 显示文摘 | ASSIS P S GUO L FANG J | 2008 | Ironmaking and Steelmaking2008，35，4： | 1 |
| 4 | Corrosion characterization of titanium alloys by electrochemical techniques显示文摘 | Assis S L D Wolynec S Costa I | | 0，，： | 1 |
| 5 | Effect of platelet-activating factor antagonists(BN-52021,WEB-2170,and BB-882)on bacterial translocation in acute pancreatitis显示文摘 | de Souza L J Sampietre S N Assis R S | 2001 | J Gastrointest Surg2001，5，4： | 1 |
| 6 | Effect of the composition and sintering process on the electrical properties in Pb(Mg1/3 Nb2/3) O3-PbTiO3 ceramics显示文摘 | Zanin A L Assis S B | 2004 | Journal of the European Ceramic Society2004，24，6： | 1 |
| 7 | First evidences of the occurrence of polycyclic synthetic musk fragrances in surface water systems in Italy: Spatial and temporal trends in the Molgora River (Lombardia Region, Northern Italy) 显示文摘 | Villa S Assi L Ippolito A | 2012 | Science of the Total Environment2012，416，： | 1 |
| 8 | Corrosion characterization of titanium alloys by electrochemical techniques 显示文摘 | ASSIS S L D WOLYNEC S COSTA I | 2006 | Eleetrochim Acta2006，51，89： | 1 |
| 9 | Effect of the Composition and Sintering Process on the Electrical Properties in Pb(Mg1/3Nb2/3) O3–PbTiO3 Ceramics显示文摘 | Lente M H Zanin A L Assis S B | 2004 | Journal of the European Ceramic Society2004，24，6： | 1 |
| 10 | A regulatory instead of an IL-17 T response predominates in Helicobacter pylori -associated gastritis in children显示文摘 | Fabrício Freire de Melo Andreia Maria Camargos Rocha Gifone Aguiar Rocha Silvia Helena Sousa Pietra Pedroso Sérgio de Assis Batista Lúcia Porto Fonseca de Castro Simone Diniz Carvalho Paulo Fernando Souto Bittencourt Celso Afonso de Oliveira Rodrigo Corrê | 2011 | Microbes and Infection2011，，4： | 1 |
| 11 | Utilisation of hydroxamates in minerals froth flotation original research article 显示文摘 | ASSIS S M MONTENEGRO L C M PERES A E C | 1996 | Minerals Engineering1996，9，1： | 1 |
| 12 | Corrosion resistance evaluation of a Ca-and P-based bioceramic thin coating in Ti-fAl-4V 显示文摘 | Coelho P G de Assis S L Costa I | 2009 | Journal of Materials Science- Materials in Medicine2009，20，1： | 1 |
| 13 | A compara-tive study of the in vitro corrosion behavior and cytotoxic-ity of a superferritic stainless steel,a Ti-13Nb-13Zr al-loy,and an austenitic stainless steel in Hank's solution显示文摘 | Assis S L Rogero S O Antunes R A | 2005 | J Biomed Mater Res B Appl Biomater2005，73，1： | 1 |
| 14 | Self-assembling molecules as corrosion inhibitors for1050 aluminum 显示文摘 | de Souza S Yoshikawa D S Izaltino WAS Assis S L Costa I | 2010 | Surface Coatings Technology2010，204，32： | 1 |
| 15 | Utilisation of hydroxamates in minerals foth flotation显示文摘 | Assis S M Montenegro L C M Peres A E C | | 0，，01： | 1 |
| 16 | Tumor necrosis factor alpha activates release of B lymphocyte stimulator by neutrophils infiltrating the rheumatoid joint显示文摘 | Assi L K Wong S H Ludwig A | 2007 | Arthritis Rheum2007，56，6： | 1 |
| 17 | Exposures to synthetic estrogens at different times during the life,and their effect on breast cancer risk显示文摘 | Hilakivi-Clarke L de Assis S Warri A | 2013 | J Mammary Gland Biol Neoplasia2013，18，1： | 1 |
| 18 | On the co-existence of 10G-EPONs and WDM-PONs:a scheduling and bandwidth allocation approach显示文摘 | Kiaei M S Assi C Meng L | 2011 | Journal of Lightwave Technology2011，29，10： | 1 |
| 19 | A simple dynamic integrated provisioning/protection scheme in IP over WDM networks显示文摘 | YE Ying-hua ASSI C DIXIT S et a l | 2001 | IEEE Communication Magazine2001，39，11： | 1 |
| 20 | Effect of the Composition and Sintering Process on the Electrical Properties in Pb(Mg1/3 Nb2/3)O3-PbTiO3 Ceramics显示文摘 | Lente M H Zanin A L Assis S B | 2004 | Journal of the European Ceramic Society2004，24，6： | 1 |
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