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| 1 | Expression of triggering receptor on myeloid cell 1 and histocompatibility complex molecules in sepsis and major abdominal surgery显示文摘AIM: To evaluate the surface expression of triggering receptor on myeloid cell 1 (TREM-1), class Ⅱ major histocompatibility complex molecules (HLA-DR), andthe expression of the splicing variant (svTREM-1) ofTREM-1 in septic patients and those subjected to major abdominal surgery.METHODS: Using flow cytometry, we examined the surface expression of TREM-1 and HLA-DR in peripheral blood monocytes from 11 septic patients, 7 elective gastrointestinal surgical patients, and 10 healthy volunteers. svTREM-1 levels were analyzed by RT-PCR. RESULTS: Basal expression of TREM-1 and HLA-DR in healthy volunteers was 35.91±14.75 MFI and75.8±18.3%, respectively. In septic patients, TREM-1 expression was 59.9±23.9 MFI and HLA-DR expression was 44.39±20.25%, with a significant differencebetween healthy and septic groups (P<0.05) for bothmolecules. In the surgical patients, TREM-1 and HLA-DR expressions were 56.8±20.85 MFI and 71±13.8% before surgery and 72.65±29.92 MlFI and 72.82±22.55% after surgery. TREM-1 expression was significantly different(P = 0.0087) between the samples before and aftersurgery and svTREM-1 expression was 0.8590±0.1451 MF1, 0.8820±0.1460 MF1, and 2.210±0.7873MF1 in the healthy, surgical (after surgery) and septic groups, respectively. There was a significant difference (P = 0.048) in svTREM-1 expression between the healthy and surgical groups and the septic group.CONCLUSION: TREM-1 expression is increased during systemic inflammatory conditions such as sepsis and the postoperative phase. Simultaneous low expression of HLA-DR molecules correlates with the severity of illness and increases susceptibility to infection. Additionally, TREM-1 expression is distinctly different in surgical patients at different stages of the inflammatory response before and after surgery. Thus, surface TREM-1 appears to be an endogenous signal during the course of the inflammatory response. svTREM-1 expression is significantly increased during sepsis, appearing to be an indicator of severity of illness. Together, these data indicate that TREM-1 may play an important role in establishing and amplifying the systemic inflammatory response. TREM-1, HLA-DR, and svTREM-1 expression analysis can provide useful diagnostic and prognostic indicators during SIRS, CARS, and sepsis. | Nestor González-Roldán Eduardo Ferat-Osorio Rosalía Aduna-Vicente Isabel Wong-Baeza Noemí Esquivel-Callejas Horacio Astudillo-de la Vega Patricio Sánchez-Fernández Lourdes Arriaga-Pizano Miguel Angel Villasís-Keever Constantino López-Macías Armando Isibasi | 2005 | World Journal of Gastroenterology2005，11，47： | 9 |
| 2 | Early Experience with the Incisionless Operating Platform? (IOP) for the Treatment of Obesity显示文摘 | J. C. Espinós R. Turró A. Mata M. Cruz M. Costa V. Villa J. N. Buchwald J. Turró | 2013 | Obesity Surgery2013，，9： | 3 |
| 3 | Direct characterization of a nonlinear photonic circuit’s wave function with laser light显示文摘Integrated photonics is a leading platform for quantum technologies including nonclassical state generation1–4,demonstration of quantum computational complexity5 and secure quantum communications6.As photonic circuits grow in complexity,full quantum tomography becomes impractical,and therefore an efficient method for their characterization7,8 is essential.Here we propose and demonstrate a fast,reliable method for reconstructing the two-photon state produced by an arbitrary quadratically nonlinear optical circuit.By establishing a rigorous correspondence between the generated quantum state and classical sum-frequency generation measurements from laser light,we overcome the limitations of previous approaches for lossy multimode devices9,10.We applied this protocol to a multi-channel nonlinear waveguide network and measured a 99.28±0.31%fidelity between classical and quantum characterization.This technique enables fast and precise evaluation of nonlinear quantum photonic networks,a crucial step towards complex,largescale,device production. | Francesco Lenzini Alexander N Poddubny James Titchener Paul Fisher Andreas Boes Sachin Kasture Ben Haylock Matteo Villa Arnan Mitchell Alexander S Solntsev Andrey A Sukhorukov Mirko Lobino | 2018 | Light(Science & Applications)2018，7，1： | 2 |
| 4 | Polychlorinated naphthalenes in air and snow in the Norwegian Arctic: a local source or an Eastern Arctic phenomenon? 显示文摘 | Herbert B M J Halsall C J Villa S | 2005 | Science of the Environment2005，342，： | 1 |
| 5 | Adjuvant radiotherapy for rectal can-cer:Recent results,new questions显示文摘 | Rivera S Villa J Quero L | 2010 | Clin Res Hepatol Gastroenterol2010，23，： | 1 |
| 6 | Prognostic implication of clinical,radiologic, and pathologic features in patients with anaplastic gliomas显示文摘 | Tortosa A Vinolas N Villa S | 2003 | Cancer2003，97，4： | 1 |
| 7 | Centralized target setting for regional recycling operations using DEA显示文摘 | Lozano S Villa G Adenso D B | 2004 | Omega: The International Journal of Management Science2004，32，2： | 1 |
| 8 | The genetic and biochemical basis of Omenn syndrome显示文摘 | Santagata S Villa A Sobacchi C | 2000 | Immunol Rev2000，178，： | 1 |
| 9 | Centralized Resource Allocation Using Data En-velopment Analysis显示文摘 | Lozano S Villa G | 2004 | Journal of Productive Analysis2004，22，： | 1 |
| 10 | Variability of anthropogenic and natural compounds in high altitude-high accumulation alpine glaciers 显示文摘 | Maggi V Villa S Finizio A | 2006 | Hydrobiologia2006，562，： | 1 |
| 11 | Nonspecific B and T cell-stimulatory activity mediated by mast cells is associated with exosomes显示文摘 | Skokos D Le-Panse S Villa I | 2001 | Int Arch Allergy Immunol2001，124，1： | 1 |
| 12 | Importance of radiotherapy in the outcome of patients with primary CNS lymphoma: an analysis of the CHOD/BVAM regimen fol- lowed by two different radiotherapy treatments 显示文摘 | Bessell EM Lopez-Guillermo A Villa S | 2002 | J Clin Oncol2002，20，： | 1 |
| 13 | Failure analysis of a jet engine gearbox drive gearshaft ball bearing显示文摘 | VILLA R ROSWURM S | 2013 | Journal of Failure Analysis and Prevention2013，13，3： | 1 |
| 14 | DEA - based pre - merger planning tool显示文摘 | LOZANO S VILLA G | 2010 | Journal of the Operational Research Society2010，61，： | 1 |
| 15 | Celecoxib and heterotopic bone formation after total hip arthroplasty 显示文摘 | Lavernia C J Contreras J S Villa J M | 2014 | J Arthroplasty2014，29，2： | 1 |
| 16 | Fetal and neonatal echocardiographic findings in twin-twin transfusion 显示文摘 | Villa L Nava S | 1998 | Am J Obstet Gynecol1998，179，4： | 1 |
| 17 | Organoehlorine compounds in ice melt water from Italian Alpine rivers 显示文摘 | Villa S Negrelli C Finizio A | 2006 | Ecotoxicology and Environmental Safety2006，63，： | 1 |
| 18 | Early administra-tion of low-dose aspirin for the prevention of severe andmild preeclampsia: a systematic review and meta-analysis显示文摘 | Roberge S Giguere Y Villa P | 2012 | Am J Perinatol2012，29，7： | 1 |
| 19 | Metacarpophalangeal subluxation:locked finger显示文摘 | Vernet AB Lopez-Sicilia S Villas C | | 0，，06： | 1 |
| 20 | Therapeutic outcome according to histologic subtype in 121 patients with malignant pleural mesothelioma显示文摘 | Giovanni Luca Ceresoli Laura Deborah Locati Andrés José Mar??a Ferreri Cesare Cozzarini Paolo Passoni Giulio Melloni Piero Zannini Angelo Bolognesi Eugenio Villa | 2001 | Lung Cancer2001，，2： | 1 |
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