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| 1 | Plasma cathepsin L:A prognostic marker for pancreatic cancer显示文摘AIM:To assess the prognostic significance of cathepsin L,a cysteine protease that degrades the peri-tumoral tissue,in patients with pancreatic cancer.METHODS:Plasma samples from 127 pancreatic cancer patients were analyzed for cathepsin L levels by ELISA.Out of these patients,25 underwent surgeryand their paraffin-embedded tissue was analyzed for cathepsin L expression by immunohistochemistry.Survival of patients and clinicopathological parameters was correlated with cathepsin L expression in plasma and tissue using appropriate statistical analysis.RESULTS:The mean(±SD)cathepsin L in plasma samples of pancreatic cancer patients was 5.98±2.5ng/m L that was significantly higher compared to the levels in healthy controls(3.83±0.45)or chronic pancreatitis patients(3.97±1.06).Using ROC curve,a cut-off level of 5.0 ng/m L was decided for survival analysis.Elevated plasma levels of cathepsin L were found to be associated with poor prognosis(P=0.01)in multivariate analysis.The plasma levels of the protease decreased after surgery.Though no significant correlation was seen between plasma and tissue expression of this protease,a trend did emerge that high cathepsin L expression in tissue correlated with its high levels in plasma.CONCLUSION:Cathepsin L levels in plasma of pancreatic cancer patients may be used as a potential prognostic marker for the disease. | Nidhi Singh Prasenjit Das Surabhi Gupta Vikas Sachdev Siddhartha Srivasatava Siddhartha Datta Gupta Ravindra Mohan Pandey Peush Sahni Shyam S Chauhan Anoop Saraya | 2014 | World Journal of Gastroenterology2014，20，46： | 2 |
| 2 | Prognostic Significance of Extracellular Matrix Degrading Enzymes—Cathepsin L and Matrix Metalloproteases-2 [MMP-2] in Human Pancreatic Cancer显示文摘 | Nidhi Singh Prasenjit Das Siddhartha Datta Gupta Peush Sahni R. M. Pandey Surabhi Gupta Shyam S. Chauhan Anoop Saraya | 2013 | Cancer Investigation2013，，7： | 2 |
| 3 | A Randomized Controlled Trial of Antioxidant Supplementation for Pain Relief in Patients With Chronic Pancreatitis显示文摘 | Payal Bhardwaj Pramod Kumar Garg Subir Kumar Maulik Anoop Saraya Rakesh Kumar Tandon Subrat Kumar Acharya | 2009 | Gastroenterology2009，，1： | 2 |
| 4 | Early Enteral Nutrition in Severe Acute Pancreatitis: A Prospective Randomized Controlled Trial Comparing Nasojejunal and Nasogastric Routes显示文摘 | Ajay Kumar Namrata Singh Shyam Prakash Anoop Saraya Yogendra Kumar Joshi | 2006 | Journal of Clinical Gastroenterology2006，，5： | 2 |
| 5 | Clinical, radiological and functional assessment of pulmonary status in patients with achalasia cardia before and after treatment显示文摘 | Rajinder Parshad Sudheer Kumar Devana Karthik Panchanatheeswaran Anoop Saraya Govind K. Makharia Surendra Kumar Sharma Ashu Seith Bhalla | 2012 | European Journal of Cardio-Thoracic Surgery2012，，5： | 1 |
| 6 | A Randomized Controlled Trial of Antioxidant Supplementation for Pain Relief in Patients With Chronic Pancreatitis显示文摘 | Payal Bhardwaj Pramod Kumar Garg Subir Kumar Maulik Anoop Saraya Rakesh Kumar Tandon Subrat Kumar Acharya | 2009 | Gastroenterology2009，，1： | 1 |
| 7 | High Levels of Cell-Free Circulating Nucleic Acids in Pancreatic Cancer are Associated With Vascular Encasement, Metastasis and Poor Survival显示文摘 | Nidhi Singh Surabhi Gupta R. M. Pandey Shyam S. Chauhan Anoop Saraya | 2015 | Cancer Investigation2015，，3： | 1 |
| 8 | Vascular complications of chronic pancreatitis and its management显示文摘Chronic pancreatitis is a chronic fibro-inflammatory disorder of the pancreas,resulting in recurrent abdominal pain,diabetes mellitus,and malnutrition.It may lead to various other complications such as pseudocyst formation,benign biliary stricture,gastric outlet obstruction;and vascular complications like venous thrombosis,variceal and pseudoaneurysmal bleed.Development of varices is usually due to chronic venous thrombosis with collateral formation and variceal bleeding can easily be tackled by endoscopic therapy.Pseudoaneurysmal bleed can be catastrophic and requires radiological interventions including digital subtraction angiography followed by endovascular obliteration,or sometimes with a percutaneous or an endoscopic ultrasound-guided approach in technically difficult situations.Procedure-related bleed is usually venous and mostly managed conservatively.Procedure-related arterial bleed,however,may require radiological interventions. | Dinesh Walia Anoop Saraya Deepak Gunjan | 2023 | World Journal of Gastrointestinal Surgery2023，15，8： | 1 |
| 9 | Role of Probiotics on Gut Permeability and Endotoxemia in Patients With Acute Pancreatitis: A Double-Blind Randomized Controlled Trial显示文摘 | Brij Sharma Siddharth Srivastava Namrata Singh Vikas Sachdev Suman Kapur Anoop Saraya | 2011 | Journal of Clinical Gastroenterology2011，，5： | 1 |
| 10 | A Randomized Controlled Trial of Antioxidant Supplementation for Pain Relief in Patients With Chronic Pancreatitis显示文摘 | Payal Bhardwaj Pramod Kumar Garg Subir Kumar Maulik Anoop Saraya Rakesh Kumar Tandon Subrat Kumar Acharya | 2009 | Gastroenterology2009，，1： | 1 |
| 11 | A Randomized Controlled Trial of Antioxidant Supplementation for Pain Relief in Patients With Chronic Pancreatitis显示文摘 | Payal Bhardwaj Pramod Kumar Garg Subir Kumar Maulik Anoop Saraya Rakesh Kumar Tandon Subrat Kumar Acharya | 2009 | Gastroenterology2009，，1： | 1 |
| 12 | Special Considerations in the Management of Autoimmune Hepatitis in COVID-19 Hotspots:A Review显示文摘The ongoing coronavirus disease-2019(COVID-19)pandemic has necessitated special considerations in the management of diseases.The way presence of pre-existing diseases or treatment for it predisposes to,alters course of,and changes the management of COVID-19,is of relevance and is being extensively studied.Autoimmune hepatitis(AIH)is unique in that it is an autoimmune disease mandating treatment with immunosuppressive drugs,as well as a liver disease with potential for varying degrees of underlying fibrosis.The use of immunosuppressive drugs could alter the risk of acquiring COVID-19,the clinical course and severity of COVID-19 and the degree of underlying liver fibrosis could alter the clinical outcomes of patients with COVID-19.In this review,we try to summarize key areas relevant in understanding and improving the clinical care of patients with AIH in the current pandemic.Special considerations required in the management of patients with AIH in COVID-19 hotspots have been outlined based on the current evidence. | Deepak Madhu Sanchit Sharma Ashish Agarwal Anoop Saraya | 2021 | Journal of Clinical and Translational Hepatology2021，9，4： | 0 |
| 13 | Nutrition in acute pancreatitis显示文摘Acute pancreatitis(AP)has varying severity,and moderately severe and severe AP has prolonged hospitalization and requires multiple interventions.These patients are at risk of malnutrition.There is no proven pharmacotherapy for AP,however,apart from fluid resuscitation,analgesics,and organ support,nutrition plays an important role in the management of AP.Oral or enteral nutrition(EN)is the preferred route of nutrition in AP,however,in a subset of patients,parenteral nutrition is required.EN has various physiological benefits and decreases the risk of infection,intervention,and mortality.There is no proven role of probiotics,glutamine supplementation,antioxidants,and pancreatic enzyme replacement therapy in patients with AP. | Srikanth Gopi Anoop Saraya Deepak Gunjan | 2023 | World Journal of Gastrointestinal Surgery2023，15，4： | 0 |
| 14 | COVID-19 in patients with pre-existing chronic liver disease–predictors of outcomes显示文摘Coronavirus disease 2019(COVID-19)has affected patients with pre-existing chronic liver disease(CLD)in various ways.The maximum impact was seen on patients with underlying cirrhosis who have shown to have poor clinical outcomes in the form of increased risk of hepatic decompensation,acute-onchronic liver failure,and even mortality.It is of paramount importance to identify various factors which are associated with unfavorable outcomes for prognostication and making informed management strategy.Many factors have been evaluated in different studies in patients with underlying CLD.Some of these factors include the severity of underlying chronic liver disease,comorbid conditions,age,and severity of COVID-19.Overall,the outcomes are not favorable in patients with cirrhosis as evidenced by data from various studies.The main purpose of this review is to identify the predictors of adverse clinical outcomes including mortality in patients with CLD for risk stratification,prognostication,and appropriate clinical management. | Dinesh Walia Anoop Saraya Deepak Gunjan | 2023 | World Journal of Virology2023，12，1： | 0 |
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