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| 1 | Constitutive androstane receptor agonist, TCPOBOP,attenuates steatohepatitis in the methionine choline-deficientdiet-fed mouse显示文摘AIM:To ascertain whether constitutive androstane receptor(CAR)activation by 1,4-bis-2-(3,5,-dichloropyridyloxy)benzene(TCPOBOP)modulates steatohepatitis in the methionine choline-deficient(MCD)diet-fed animal.METHODS:C57/BL6 wild-type mice were fed the MCD or standard diet for 2 wk and were treated with either the CAR agonist,TCPOBOP,or the CAR inverse agonist,androstanol.RESULTS:Expression of CYP2B10 and CYP3A11,known CAR target genes,increased 30-fold and 45-fold,respectively,in TCPOBOP-treated mice fed the MCD diet.TCPOBOP treatment reduced hepatic steatosis(44.6 ± 5.4% vs 30.4 ± 4.5%,P < 0.05)and serum triglyceride levels(48 ± 8 vs 20 ± 1 mg/dL,P < 0.05)in MCD diet-fed mice as compared with the standard diet-fed mice.This reduction in hepatic steatosis was accompanied by an increase in enzymes involved in fatty acid microsomal ω-oxidation and peroxisomal β-oxidation,namely CYP4A10,LPBE,and 3-ketoacyl-CoA thiolase.The reduction in steatosis was also accompanied by a reduction in liver cell apoptosis and inflammation.In contrast,androstanol was without effect on any of the above parameters.CONCLUSION:CAR activation stimulates induction of genes involved in fatty acid oxidation,and ameliorates hepatic steatosis,apoptosis and inflammation. | Edwina S Baskin-Bey Akira Anan Hajime Isomoto Steven F Bronk Gregory J Gores | 2007 | World Journal of Gastroenterology2007，13，42： | 3 |
| 2 | Effect of combined physico-chemical preservatives on enterocin AS-48 activity against the enterotoxigenic Staphylococcus aureus CECT 976 sWain显示文摘 | Ananou S Valdivia E | 2004 | Journal of Applied Microbiology2004，97，： | 1 |
| 3 | Association between high homocysteine and ischemic stroke due to large and small-artery disease but not other etiologic subtypes of ischemic stroke显示文摘 | Eikelboom J W Hankey G J Ananal S S | 2000 | Stroke2000，31，5： | 1 |
| 4 | Mechanical properties of warm-extruded Mg-Zn-Gd alloy with coherent 14H Long periodic stacking ordered structure precipitate 显示文摘 | Yamasaki M Anan T Yoshimoto S | 2005 | Scripta Mater2005，53，： | 1 |
| 5 | Model for Recovery and Recrystallisation of Hot Deformed Austenite Considering Structural Heterogeneity显示文摘 | Anan G Nakajima S Miyahara M | 1992 | ISIJ International1992，32，3： | 1 |
| 6 | Biological diagnosis of systemic candidia- sis: difficulties and future prospects 显示文摘 | Anane S Khalfallah F | 2007 | Pathologie Biologie2007，55，5： | 1 |
| 7 | Transportation properties of a high-current magnetically insulated transmission line and dynamics of the electrode plasma显示文摘 | Anan'ev S S Bakshaev Y L Bartov A V | | 0，，07： | 1 |
| 8 | Trace element accumulation in fishes collected from coast-al waters of the Caspian Sea显示文摘 | Anan Y Tanabe S Mitrofanov I | 2005 | Marine Pollution Bulletin2005，51，： | 1 |
| 9 | Microsporidiosis:epidemiology,clinical data and therapy显示文摘 | Anane S Attouchi H | 2010 | Gastroenterol Clin Biol2010，34，89： | 1 |
| 10 | Mechanical properties of warm-extruded Mg-Zn-Gd alloy with coherent 14H long periodic stacking ordered structure precipitate显示文摘 | YAMASAKI M ANAN T YOSHIMOTO S KAWAMURA Y | 2005 | Scripta Materialia2005，53，： | 1 |
| 11 | Mechanical properties of wama-extruded Mg-Zn Gd alloy with coherent 14H long periodic stacking ordered structure precipitate 显示文摘 | YAMASAKI M ANAN T YOSHIMOTO S KAWAMURA Y | 2005 | Scripta Mater2005，53，79： | 1 |
| 12 | Phosphate mine wastes reuse for phosphorus removal from aqueous solutions under dynamic conditions 显示文摘 | JELLALI S WAHAB M A ANANE M RIAHI K BOUSSELMI L | 2010 | J Hazard Mater2010，184，123： | 1 |
| 13 | An in vitro Cytotoxicity Study of 5- fluorouracil Encapsulated Chitosan/Gold Nanocom- posites Towards MCF-7 Cells显示文摘 | NIVENTHAA E A K DHANAVEL S NARAY- ANAN V | 2015 | RSC Adv2015，，5： | 1 |
| 14 | GIS-based multi-criteria analysis for potential wastewater aquifer recharge sites 显示文摘 | KALLALI H ANANE M JELLALI S | 2007 | Desalination2007，215，13： | 1 |
| 15 | Breast cancer in Japanese men,does sex affect prognosis? 显示文摘 | Anan K Mitsuyama S Nishihara K | 2004 | Breast Cancer2004，11，2： | 1 |
| 16 | Les candidoses vulvovaginales :facteurs de risque et particularites cliniques et mycologiques显示文摘 | Anane S Kaouech E Zouari B | 2010 | J Me Myeol2010，20，1： | 1 |
| 17 | Control of Listeriamonocytogenes in model sausages by enterocin AS-48显示文摘 | ANANOU S GARRIGA M HUGAS M | 2005 | InternationalJournal of Food Microbiology2005，103，2： | 1 |
| 18 | The best-so-far ABC with multiple patrilines for clustering problems显示文摘 | Anan B Booncharoen S Tiranee A | 2013 | Neurocomputing2013，116，： | 1 |
| 19 | Mechanical properties of warm-extruded Mg-Zn-Gd alloy with coherent 14H long periodic stacking ordered structure precipitate显示文摘 | Yamasaki M Anan T Yoshimoto S | 2005 | Scr Mater2005，53，7： | 1 |
| 20 | Model for recovery and recrystallization of hot deformed austenite considering structural heterogeneity显示文摘 | Anan G Nakajima S Miyahara M | 1992 | ISIJ International1992，32，3： | 1 |
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