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| 1 | 槲皮素对药物代谢酶调控作用的研究进展显示文摘目的:综述近年来槲皮素对药物代谢酶的影响的研究进展。方法:查阅近年来国内外报道中槲皮素对药物代谢酶的影响的文献,并进行归纳、分析、总结。结果:槲皮素通过对Ⅰ相药物代谢酶细胞色素P450(cytochrome P450,CYP)和Ⅱ相药物代谢酶尿苷二磷酸-葡萄糖醛酸转移酶(UDP-glucuronosyltransferase,UGTs),硫酸基转移酶(sulfotransferase,SULTs)和谷胱甘肽S-转移酶(glutathione S-transferase,GSTs)等的调控作用,从而影响多种常用药物在体内、外的代谢。同时,槲皮素对代谢酶的调控作用需要各种核受体的参与。结论:槲皮素对多种药物代谢酶均具有抑制或诱导作用,因此槲皮素将与其他药物发生相互作用。 | 杨婷玉 刘亚妮 师少军 | 2016 | 中国药师2016，19，3： | 5 |
| 2 | Understanding the physiological functions of the host xenobiotic-sensing nuclear receptors PXR and CAR on the gut microbiome using genetically modified mice显示文摘Pharmacological activation of the xenobiotic-sensing nuclear receptors pregnane X receptor(PXR) and constitutive androstane receptor(CAR) is well-known to increase drug metabolism and reduce inflammation. Little is known regarding their physiological functions on the gut microbiome. In this study, we discovered bivalent hormetic functions of PXR/CAR modulating the richness of the gut microbiome using genetically engineered mice. The absence of PXR or CAR increased microbial richness, and absence of both receptors synergistically increased microbial richness. PXR and CAR deficiency increased the pro-inflammatory bacteria Helicobacteraceae and Helicobacter. Deficiency in both PXR and CAR increased the relative abundance of Lactobacillus, which has bile salt hydrolase activity, corresponding to decreased primary taurine-conjugated bile acids(BAs) in feces, which may lead to higher internal burden of taurine and unconjugated BAs, both of which are linked to inflammation, oxidative stress, and cytotoxicity. The basal effect of PXR/CAR on the gut microbiome was distinct from pharmacological and toxicological activation of these receptors. Common PXR/CAR-targeted bacteria were identified, the majority of which were suppressed by these receptors. h PXR-TG mice had a distinct microbial profile as compared to wild-type mice. This study is the first to unveil the basal functions of PXR and CAR on the gut microbiome. | Mallory Little Moumita Dutta Hao Li Adam Matson Xiaojian Shi Gabby Mascarinas Bruk Molla Kris Weigel Haiwei Gu Sridhar Mani Julia Yue Cui | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
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