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| 1 | A novel anti-slip control approach for railway vehicles with traction based on adhesion estimation with swarm intelligence显示文摘Anti-slip control systems are essential for railway vehicle systems with traction.In order to propose an effective anti-slip control system,adhesion information between wheel and rail can be useful.However,direct measurement or observation of adhesion condition for a railway vehicle in operation is quite demanding.Therefore,a proportional–integral controller,which operates simultaneously with a recently proposed swarm intelligencebased adhesion estimation algorithm,is proposed in this study.This approach provides determination of the adhesion optimum on the adhesion-slip curve so that a reference slip value for the controller can be determined according to the adhesion conditions between wheel and rail.To validate the methodology,a tram wheel test stand with an independently rotating wheel,which is a model of some low floor trams produced in Czechia,is considered.Results reveal that this new approach is more effective than a conventional controller without adhesion condition estimation. | Abdulkadir Zirek Altan Onat | 2020 | Railway Engineering Science2020，28，4： | 5 |
| 2 | High adiponectin levels fail to protect against the risk of hypertension and,in women,against coronary disease:involvement in autoimmunity?显示文摘AIM:To investigate whether serum adiponectin protects against cardiometabolic risk in a population sample with prevailing metabolic syndrome.METHODS:Middle-aged adults representative of a general population with baseline circulating adiponectin measurements(n=1224)were analyzed prospectively at a mean of 3.8 years’follow-up,using continuous values or sex-specific tertiles.Total adiponectin was assayed by an ELISA kit.Type-2 diabetes was identified by criteria of the American Diabetes Association.Hypertension was defined as a blood pressure≥140 mmHg and/or≥90 mmHg and/or use of antihypertensive medication.Outcomes were predicted using Cox proportional hazards regression analysis in models that were controlled for potential confounders.RESULTS:In models of multiple linear regression,sex hormone-binding globulin,fasting insulin(inverse)and,in men,age were significant independent covariates of serum adiponectin which further tended in women to be positively associated with serum creatinine.Cox regression analyses for incident coronary heart disease(CHD),adjusted for sex,age,non-HDL cholesterol,waist circumference and C-reactive protein,revealed significant inverse association with adiponectin tertiles in men but not women(HR=0.66;95%CI:0.32-1.38 for highest tertile).Cox regression for type-2 diabetes in a similar model(wherein glucose replaced non-HDL cholesterol),adiponectin tertiles appeared to protect in each gender.HR for incident hypertension roughly displayed unity in each of the adiponectin tertiles(P-trend=0.67).CONCLUSION:High adiponectin levels failed to protect against the development of hypertension and,in women,against CHD,presumably paralleling impairment in renal function as well.Involvement of adiponectin in autoimmune complex with loss of antioxidative-antiatherogenic properties may be underlying. | Altan Onat Mesut Aydln Günay Can Bayram Kroglu Ahmet Karagz Servet Altay | 2013 | World Journal of Diabetes2013，4，5： | 3 |
| 3 | Determinants and definition of abdominal obesity as related to risk of diabetes, metabolic syndrome and coronary disease in Turkish men: A prospective cohort study显示文摘 | Altan Onat Hüseyin Uyarel Gülay Hergen? Ahmet Karabulut Sinan Albayrak Günay Can | 2006 | Atherosclerosis2006，，1： | 2 |
| 4 | Risk factors and cardiovascular disease in Turkey显示文摘 | Altan Onat | 2001 | Atherosclerosis2001，，1： | 2 |
| 5 | Elevated serum uric acid in nondiabetic people mark pro-inflammatory state and HDL dysfunction and independently predicts coronary disease显示文摘 | Altan Onat Günay Can Ender ?rnek Servet Altay Murat Yüksel Evin Ademo?lu | 2013 | Clinical Rheumatology2013，，： | 1 |
| 6 | Fasting, non-fasting glucose and HDL dysfunction in risk of pre-diabetes, diabetes, and coronary disease in non-diabetic adults显示文摘 | Altan Onat Günay Can G?khan ?i?ek Erkan Ayhan Yüksel Do?an Hasan Kaya | 2013 | Acta Diabetologica2013，，4： | 1 |
| 7 | Low-grade inflammation, and dysfunction of high-density lipoprotein and its apolipoproteins as a major driver of cardiometabolic risk显示文摘 | Altan Onat Gülay Hergen? | 2011 | Metabolism2011，，4： | 1 |
| 8 | Coronary disease risk and fasting glucose levels in a non-diabetic population显示文摘 | Altan Onat Günay Can G?khan ?i?ek Yüksel Do?an Hüsniye Yüksel | 2010 | Diabetes Research and Clinical Practice2010，，2： | 1 |
| 9 | Impaired protection against diabetes and coronary heart disease by high-density lipoproteins in Turks显示文摘 | Altan Onat Günay Can Erkan Ayhan Zekeriya Kaya Gülay Hergen? | 2009 | Metabolism2009，，10： | 1 |
| 10 | Lipoprotein(a) is associated with coronary heart disease independent of metabolic syndrome显示文摘 | Altan Onat Gülay Hergen? Hakan ?zhan Zekeriya Kaya Serkan Bulur Erkan Ayhan Günay Can | 2008 | Coronary Artery Disease2008，，3： | 1 |
| 11 | Sex difference in development of diabetes and cardiovascular disease on the way from obesity and metabolic syndrome显示文摘 | Altan Onat Gülay Hergen? ?brahim Kele? Yüksel Do?an Serdar Türkmen Vedat Sansoy | 2005 | Metabolism2005，，6： | 1 |
| 12 | Abdominal obesity as related to risk of diabetes, metabolic syndrome and coronary disease in turkish men: a prospective study 显示文摘 | Altan Onat Huseyin Uyarel Gulay | 2006 | European Journal of Cardiovascular Prevention& Rehabilitation2006，13，1： | 1 |
| 13 | Serum creatinine is associated with coronary disease risk even in the absence of metabolic disorders显示文摘 | Altan Onat Hü sniye Yü ksel Gü nay Can Bayram Kö ro&gbreve lu Ay&scedil em Kaya Servet Altay | 2013 | Scandinavian Journal of Clinical & Laboratory Investigation2013，，7： | 1 |
| 14 | Determinants and definition of abdominal obesity as related to risk of diabetes, metabolic syndrome and coronary disease in Turkish men: A prospective cohort study显示文摘 | Altan Onat Hüseyin Uyarel Gülay Hergen? Ahmet Karabulut Sinan Albayrak Günay Can | 2006 | Atherosclerosis2006，，1： | 1 |
| 15 | Fatty liver disease:Disparate predictive ability for cardiometabolic risk and all-cause mortality显示文摘AIM: To assess the association of a surrogate of fatty liver disease(FLD) with incident type-2 diabetes, coronary heart disease, and all-cause mortality.METHODS: In a prospective population-based study on 1822 middle-aged adults, stratified to gender, we used an algorithm of fatty liver index(FLI) to identify associations with outcomes. An index ≥ 60 indicated the presence of FLD. In Cox regression models, adjusted for age, smoking status, high-density lipoprotein cholesterol, and systolic blood pressure, we assessed the predictive value of FLI for incident diabetes, coronary heart disease(CHD), and all-cause mortality.RESULTS: At a mean 8 year follow-up, 218 and 285 incident cases of diabetes and CHD, respectively, and 193 deaths were recorded. FLD was significantly associated in each gender with blood pressure, total cholesterol, apolipoprotein B, uric acid, and C-reactive protein; weakly with fasting glucose; and inversely with high-density lipoprotein-cholesterol and sex hormonebinding globulin. In adjusted Cox models, FLD was(with a 5-fold HR) the major determinant of diabetes development. Analyses further disclosed significant independent prediction of CHD by FLD in combined gender [hazard ratio(HR) = 1.72, 95% confidence interval(CI): 1.17-2.53] and men(HR = 2.35, 95%CI: 1.25-4.43). Similarly-adjusted models for all-cause mortality proved, however, not to confer risk, except for a tendency in prediabetics and diabetic women.CONCLUSION: A surrogate of FLD conferred significant high risk of diabetes and coronary heart disease, independent of some metabolic syndrome traits. Allcause mortality was not associated with FLD, except likely in the prediabetic state. Such a FLI may reliably be used in epidemiologic studies. | Altan Onat Günay Can Aysem Kaya Tugba Akbas Fatma Ozpamuk-Karadeniz Baris Simsek Hakan Cakir Hüsniye Yüksel | 2015 | World Journal of Gastroenterology2015，21，48： | 1 |
| 16 | Serum Uric Acid Is a Determinant of Metabolic Syndrome in a Population-Based Study显示文摘 | Altan Onat Hüseyin Uyarel Gülay Hergenc? Ahmet Karabulut Sinan Albayrak Ibrahim Sar? Mehmet Yaz?c? Ibrahim Kele? | 2006 | American Journal of Hypertension2006，，10： | 1 |
| 17 | Impaired fasting glucose:Pro-diabetic,“atheroprotective”and modified by metabolic syndrome显示文摘AIM:To investigate whether impaired fasting glucose(IFG)confers cardiovascular risk.METHODS:A non-diabetic population-based sample representative of middle-aged and elderly Turks was studied at 8.5 years’follow-up for incident diabetes and coronary heart disease(CHD).Metabolic syndrome(MetS)was defined by ATP-Ⅲcriteria modifiedfor male abdominal obesity,and IFG and type 2 diabetes were identified by criteria of the American Diabetes Association.Stratification by presence of MetS was used.Outcomes were predicted providing estimates for hazard ratio(HR)obtained by use of Cox proportional hazards regression analysis in models that controlled for potential confounders.RESULTS:In 3181 adults(aged 52±11.5 years at baseline),analysis stratified by MetS,gender and IFG status distinguished normoglycemic subjects by a'hypertriglyceridemic waist'phenotype consisting of significantly higher waist circumference,fasting triglyceride and lower high-density lipoprotein-cholesterol,regardless of gender and MetS.Additionally,lipoprotein(Lp)(a)tended to be lower in(especially female)participants with MetS.Multivariable linear regression in a subset of the sample demonstrated decreased Lp(a)levels to be associated with increased fasting glucose and insulin concentrations,again particularly in women.In Cox regression analysis,compared with normoglycemia,baseline IFG adjusted for major confounders significantly predicted incident diabetes at a 3-fold HR in men and only women with MetS.Cox models for developing CHD in 339 individuals,adjusted for conventional risk factors,revealed that IFG status protected against CHD risk[HR=0.37(95%CI:0.14-0.998)]in subjects free of MetS,a protection that attenuated partly in male and fully in female participants with MetS.CONCLUSION:IFG status in non-diabetic people without MetS displays reduced future CHD risk,yet is modulated by MetS,likely due to autoimmune activation linked to serum Lp(a). | Altan Onat Mesut Aydln Günay Can H Altug Cakmak Bayram Kroglu Aysem Kaya Evin Ademoglu | 2013 | World Journal of Diabetes2013，4，5： | 0 |
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