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| 1 | Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children显示文摘AIM:To investigate the safety and efficacy of a Hansenula-derived PEGylated(polyethylene glycol)interferon(IFN)-alpha-2a(Reiferon Retard)plus ribavirin customized regimen in treatment-na?ve and previously treated(non-responders and relapsers)Egyptian children with chronic hepatitis C infection.METHODS:Forty-six children with chronic hepatitis C virus(HCV)infection were selected from three tertiary pediatric hepatology centers.Clinical and laboratory evaluations were undertaken.Quantitative polymerase chain reaction(PCR)for HCV-RNA was performed before starting treatment,and again at 4,12,24,48,72wk during treatment and 6 mo after treatment cessation.All patients were assigned to receive a weekly subcutaneous injection of PEG-IFN-alpha-2a plus daily oral ribavirin for 12 wk.Thirty-four patients were treatment-na?ve and 12 had a previous treatment trial.Patients were then divided according to PCR results into two groups.GroupⅠincluded patients who continued treatment on a weekly basis(7-d schedule),while groupⅡincluded patients who continued treatment on a 5-d schedule.Patients from either group who were PCR-negative at week 48,but had at least one PCRpositive test during therapy,were assigned to have an extended treatment course up to 72 wk.The occurrence of adverse effects was assessed during treatment and follow up.The study was registered at www.ClinicalTrials.gov(NCT02027493).RESULTS:Only 11 out of 46(23.9%)patients showed a sustained virological response(SVR),two patients were responders at the end of treatment;however,they were lost to follow up at 6 mo post treatment.Breakthrough was seen in 18(39.1%)patients,one patient(2.17%)showed relapse and 14(30.4%)were non-responders.Male gender,short duration of infection,low viral load,mild activity,and mild fibrosis were the factors related to a better response.On the other hand,patients with high viral load and absence of fibrosis failed to respond to treatment.Before treatment,liver transaminases were elevated.After commencing treatment,they were normalized in all patients at week 4 and were maintained normal in responders till the end of treatment,while they increased again significantly in non-responders(P=0.007 and 0.003 at week 24 and 72 respectively).The 5-d schedule did not affect the response rate(1/17 had SVR).Treatment duration(whether 48 wk or extended course to 72 wk)gave similar response rates(9/36 vs 2/8 respectively;P=0.49).Type of previous treatment(short acting IFN vs PEG-IFN)did not affect the response to retreatment.On the other hand,SVR was significantly higher in previous relapsers than in previous non-responders(P=0.039).Only mild reversible adverse effects were observed and children tolerated the treatment well.CONCLUSION:Reiferon Retard plus ribavirin combined therapy was safe.Our customized regimen did not influence SVR rates.Further trials on larger numbers of patients are warranted. | Suzan El Naghi Tawhida Y Abdel-Ghaffar Hanaa El-Karaksy Elham F Abdel-Aty Mona S El-Raziky Aleef A Allam Heba Helmy Hanaa A El-Araby Behairy E Behairy Mohamed A El-Guindi Hatem El-Sebaie Aisha Y Abdel-Ghaffar Nermin A Ehsan Ahmed M El-Hennawy Mostafa M Sira | 2014 | World Journal of Gastroenterology2014，20，16： | 2 |
| 2 | Effect of wetting and drying on shear strength 显示文摘 | Allam M M Sridharan S | 1981 | J Geotech Engrg Div ASCE1981，107，4： | 1 |
| 3 | Effect of wetting and drying on shear strength 显示文摘 | ALLAM M M SRIDHARAM S | 1981 | Journal of Geotechnical Engineering1981，107，4： | 1 |
| 4 | The B-lynch and other uterine com- pression suture techniques 显示文摘 | Allam M S B-lynch C | 2005 | [nt Cynaecol obstet2005，89，3： | 1 |
| 5 | The B -Lynch and other uterine compression suture techniques显示文摘 | Allam M S B -Lynch C | 2007 | Int J Gynaccol Obstet2007，89，3： | 1 |
| 6 | Long-term load forecasting and economical operation of wind farms for Egyptian electrical network显示文摘 | Abou A A El-zaftawy A A Allam S M | 2009 | Electric Power Systems Research2009，79，7： | 1 |
| 7 | Analysis of cable-stayed bridges under multi-component random ground motion by response spectrum method显示文摘 | Allam S M Datta T K | 2000 | Engineering Structures2000，22，10： | 1 |
| 8 | Synthesis of Some New Benzothiazole Derivatives as Potential Antinicrobial and Antiparasitic Agents显示文摘 | Mahran M A El-nassry S M Allam S R | | 0，，08： | 1 |
| 9 | Seismic Behavior of Cable Stayed Bridges Under Multi-Component Random Ground Motion显示文摘 | Allam S M Datta T K | | 0，，01： | 1 |
| 10 | Analysis of cable-stayed bridges under multi-component random ground motion by response spectrum method显示文摘 | ALLAM S M DATTA T K | 2000 | Eng Struct2000，22，： | 1 |
| 11 | Analysis of Cable-stayed Bridges Under Multi-component Random Ground Motion by Response Spectrum Method 显示文摘 | ALLAM S M DATA T K | 2000 | Engineering Structures2000，22，10： | 1 |
| 12 | Seismic Behaviour of Cable- stayed Bridges under Multi-component Random Ground Motion显示文摘 | ALLAM S M DATA T K | 1999 | Engineering Structures1999，21，3： | 1 |
| 13 | Discussion on 'A dual interface apparatus for testing unrestricted friction of soil along solid surfaces'显示文摘 | Subba Rao K S Allam M M Robinson R G | 1996 | Geotechnical Testing Journal GTJODJ1996，19，44： | 1 |
| 14 | The B-Lynch and other uterine compression suture techniques 显示文摘 | Allam M S B-Lynch C | 2005 | Int J Gynaecol Obstet2005，89，3： | 1 |
| 15 | Physicochemical characteristics,fatty acids composition and oxid ativestability of some seed kernel oils of Prunus genus显示文摘 | ALLAM S ASSIUT S M | 2001 | Journal of Agricultural Sciences2001，32，1： | 1 |
| 16 | Discussion on a Dual Interface Aratusfor Testing Unrestricted Friction of Soil Along Solid Surface显示文摘 | Rao S Allam K S Mand M | 1996 | Geotechnical Testing Journal1996，19，4： | 1 |
| 17 | The B-Lynch and other uterine compression suture techniques 显示文摘 | Allam M S B-Lynch C | 2005 | Int J Gynaecol Obstet2005，89，3： | 1 |
| 18 | Diffusion current and its effect on noise in submicron MOSFETs显示文摘 | OBRECHT M S ALLAM E | 2002 | IEEE Transactions on Electron Devices2002，49，3： | 1 |
| 19 | Physicochemical characteristics, fatty acids composition and oxidativestability of some seed kernel oils of Prunus genus 显示文摘 | Allam S Assiut S M | 2001 | Journal of Agricultural Sciences2001，32，1： | 1 |
| 20 | Initial Stages of Atmospheric Corrosion of Steel in the Arabian Gulf显示文摘 | ALLAM I M ARLOW J S SARICIMEN H | 1991 | Corro- sion Science1991，32，： | 1 |
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