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| 1 | Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children显示文摘AIM:To investigate the safety and efficacy of a Hansenula-derived PEGylated(polyethylene glycol)interferon(IFN)-alpha-2a(Reiferon Retard)plus ribavirin customized regimen in treatment-na?ve and previously treated(non-responders and relapsers)Egyptian children with chronic hepatitis C infection.METHODS:Forty-six children with chronic hepatitis C virus(HCV)infection were selected from three tertiary pediatric hepatology centers.Clinical and laboratory evaluations were undertaken.Quantitative polymerase chain reaction(PCR)for HCV-RNA was performed before starting treatment,and again at 4,12,24,48,72wk during treatment and 6 mo after treatment cessation.All patients were assigned to receive a weekly subcutaneous injection of PEG-IFN-alpha-2a plus daily oral ribavirin for 12 wk.Thirty-four patients were treatment-na?ve and 12 had a previous treatment trial.Patients were then divided according to PCR results into two groups.GroupⅠincluded patients who continued treatment on a weekly basis(7-d schedule),while groupⅡincluded patients who continued treatment on a 5-d schedule.Patients from either group who were PCR-negative at week 48,but had at least one PCRpositive test during therapy,were assigned to have an extended treatment course up to 72 wk.The occurrence of adverse effects was assessed during treatment and follow up.The study was registered at www.ClinicalTrials.gov(NCT02027493).RESULTS:Only 11 out of 46(23.9%)patients showed a sustained virological response(SVR),two patients were responders at the end of treatment;however,they were lost to follow up at 6 mo post treatment.Breakthrough was seen in 18(39.1%)patients,one patient(2.17%)showed relapse and 14(30.4%)were non-responders.Male gender,short duration of infection,low viral load,mild activity,and mild fibrosis were the factors related to a better response.On the other hand,patients with high viral load and absence of fibrosis failed to respond to treatment.Before treatment,liver transaminases were elevated.After commencing treatment,they were normalized in all patients at week 4 and were maintained normal in responders till the end of treatment,while they increased again significantly in non-responders(P=0.007 and 0.003 at week 24 and 72 respectively).The 5-d schedule did not affect the response rate(1/17 had SVR).Treatment duration(whether 48 wk or extended course to 72 wk)gave similar response rates(9/36 vs 2/8 respectively;P=0.49).Type of previous treatment(short acting IFN vs PEG-IFN)did not affect the response to retreatment.On the other hand,SVR was significantly higher in previous relapsers than in previous non-responders(P=0.039).Only mild reversible adverse effects were observed and children tolerated the treatment well.CONCLUSION:Reiferon Retard plus ribavirin combined therapy was safe.Our customized regimen did not influence SVR rates.Further trials on larger numbers of patients are warranted. | Suzan El Naghi Tawhida Y Abdel-Ghaffar Hanaa El-Karaksy Elham F Abdel-Aty Mona S El-Raziky Aleef A Allam Heba Helmy Hanaa A El-Araby Behairy E Behairy Mohamed A El-Guindi Hatem El-Sebaie Aisha Y Abdel-Ghaffar Nermin A Ehsan Ahmed M El-Hennawy Mostafa M Sira | 2014 | World Journal of Gastroenterology2014，20，16： | 2 |
| 2 | New treatment modalities for granuloma faciale显示文摘 | Ludwig E Allam JP Bieber T | 2003 | Br J Dermatol2003，149，3： | 1 |
| 3 | Crystal engineering of energetic materials:cocrystals of CL-20显示文摘 | Millar D I A Maynard-Caely H E Allam D R | 2012 | Cryst Eng Comm2012，14，10： | 1 |
| 4 | Effects of benzotriazole on the corrosion of Cu10Ni alloy in sulfide-polluted salt water显示文摘 | N K Allam E A Ashour H S Hegazy | 2005 | Corrosion Science2005，47，： | 1 |
| 5 | Flow cytometric comparison of haemocytes from three species of bivalve mollusks显示文摘 | Allam B Ashton-Alcox K A Ford S E | 2002 | Fish & Shellfish Immunology2002，13，： | 1 |
| 6 | Association between total plasma homocysteine level and cognitive functions in elderly Egyptian subjects显示文摘 | Allam M Fahmy E Elatti SA | 2013 | J Neurol Sci2013，332，12： | 1 |
| 7 | Flow cytometric comparison of haemocytes from three species of bivalve mollusks 显示文摘 | Allam B Ashton-Alcox K A Ford S E | 2002 | Fish Shellfish Immunol2002，，13： | 1 |
| 8 | Transforming growthfactor-beta I regulates the expression of the high-affinityreceptor for IgE on CD34 stem cell-derived CDla dendriticcells in vitro显示文摘 | Allam JP Klein E Bieber T | 2004 | J Invest Dermatol2004，123，4： | 1 |
| 9 | Thermal stresses in a harmonic field for an infinite body with a circular cylindrical hole without energy dissipation显示文摘 | Allam M N Elsibai K A AbouElregal A E | 2002 | Journal of Thermal Stresses2002，25，1： | 1 |
| 10 | Diffusion current and its effect on noise in submicron MOSFETs显示文摘 | OBRECHT M S ALLAM E | 2002 | IEEE Transactions on Electron Devices2002，49，3： | 1 |
| 11 | Invasive pulmonary aspergillosis:retrospective case record review显示文摘 | ALLAM M F SERRANO D E L CASTILLO A DIAZ-MOLINA C | 2004 | Rev Iberoam Micol2004，21，1： | 1 |
| 12 | Preparation and characterization of polyacrylic acid/karaya gum and polyacrylic acid/tamarind seed gum adducts and utilization in textile printing显示文摘 | ABO-SHOSHA M H IBRAHIM N A ALLAM E | | 0，，02： | 1 |
| 13 | A review of the effects of benzotriazole on the corrosion of copper and copper alloys in clean and polluted environments显示文摘 | Allam N K Nazeer A A Ashour E A | | 0，，07： | 1 |
| 14 | Microwave characterization and modeling of the surface impedance of fractal structure copper films 显示文摘 | G Ablart L Allam | 1998 | IEEE Trans Antennas Propagat1998，46，3： | 1 |
| 15 | Preparation and properties of novel aromatic poly(thioethers) derived from 4,4' -thiobisbenzenethiol 显示文摘 | Christopher Allam Kuo J Liu James E McGrath | 1999 | Macromol Chem Phys1999，200，： | 1 |
| 16 | Islanding detection method for DFIG wind turbines using artificial neural networks 显示文摘 | ABD-ELKADER A G ALLAM D F TAGELDIN E | 2014 | International Journal of Electrical Power & Energy Systems2014，，62： | 1 |
| 17 | Flow eytometric comparison of haemocytes from three species of bivalve mollusks 显示文摘 | Allam B Ashton-Alcox K A Ford S E | 2002 | Fish & Shellfish Immunology2002，，13： | 1 |
| 18 | Management of the Acute Partial-thickness Burned Hand; Moist Exposed Burn Ointment or Silver Sulphadiazine Cream both Combined with a Polyethylene Bag显示文摘 | Allam AM Mostafa W Zayed E | | 0，，03： | 1 |
| 19 | Magneto- thermoelasticity for an infinite body with a spherical cavity and variable material properties without energy dissipation显示文摘 | Allam M N Elsibai K A Abouelregal A E | 2010 | International Journal of Solids and Structures2010，47，20： | 1 |
| 20 | Compressibility of Single Un-rendered Rice Straw Bales:Characteristics of bales used for building显示文摘 | GIHAN L GARAS MOSTAFA E ALLAM HALA M EL KADY | | 0，，05： | 1 |
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