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| 1 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 2 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 3 | ES显示文摘 | Alexander J Gretel B Peter K | 2005 | European Journal of Trauma2005，1，： | 1 |
| 4 | Characteristics and in-hospital outcomes of patients with non-ST-segment elevation myocardial infarctionundergoing an invasive strategy according to hemoglobin levels显示文摘 | Hanna E B Alexander K P Chen A Y | 2013 | Am J Cardiol2013，111，8： | 1 |
| 5 | Developments in Cancer Immunotherapy显示文摘 | Maries van den B Lotta von B Alexander K | 2010 | Dig Dis2010，28，： | 1 |
| 6 | Internal stresses and the martensite start temperature in alumina-zirconia composites: effects of composition and microstructure显示文摘 | ALEXANDER K B BECHER P F WANG X | 1995 | J Am Ceram Soc1995，78，1： | 1 |
| 7 | Academic- practice collaboration in nursing education service-learn- ing for injury prevention显示文摘 | Alexander G K Canclini S B Krauser D L | 2014 | Nurse Educ2014，39，4： | 1 |
| 8 | Positive and nega- tive impacts of specialty malts on beer foam: a comparison of various ce- real products for their foaming properties显示文摘 | ALEXANDER L C JUSTIN K A CHARLES W B | 2013 | J Sei Food Agr2013，93，9： | 1 |
| 9 | New alternating copolyimides by high temperature synthesis in benzoic acid medium显示文摘 | Alexander A K Marina Y Y Pavel V B | 2004 | High Performance Poly?mers2004，16，： | 1 |
| 10 | Higher plant biomarkers reflect palaeovegetation changes during Jurassic times显示文摘 | van Aarssen B G K Alexander R Kagi R I | 2000 | Geochimica et Cosmochimica Acta2000，64，8： | 1 |
| 11 | Grain Boundary Segregation of Grain Dopants in ct - A12 03 Scales 显示文摘 | Pint B A Alexander K B | 1998 | J Electrochem Soc1998，145，26： | 1 |
| 12 | Evaluation of automated isocratic and gradient nano -liquid chromatog- raphy and capillary electrochromatography 显示文摘 | Alexander J N Poli J B Markides K E | 1999 | Analyti- cal Chemistry1999，71，： | 1 |
| 13 | Residual stress evalua-tion at the micrometer scale : Analysis of thin coatings by FIBmilling and digital image correlation显示文摘 | Alexander M K Marco S Edoardo B | 2010 | Surface & CoatingsTechnology2010，，205： | 1 |
| 14 | Assessment of nondiagnostic ultrasound-guided fine needle aspirations of thyroid nodules显示文摘 | ALEXANDER E K HEERING J P BENSON C B | 2002 | Clin Endocrinol Metab2002，87，： | 1 |
| 15 | Global geometry optimization of (Ar)n and B(Ar)n clusters using a modified genetic algorithm 显示文摘 | Alexander M H Hartke B | | J Chem Phys0，104，： | 1 |
| 16 | Cooperative luminescence and absorption in ytterbium-doped silica fiber and the fiber nonlinear transmission coefficient at λ=980 nm with a regard to the Ytterbium ions-pairs'effect显示文摘 | Alexander V K Yuri O B Itzel L M | 2006 | Optics Express2006，14，9： | 1 |
| 17 | Soluble complexes from poly (ethylene oxide)-block-polymethacrylate anions and Nalkylpyridinium cations显示文摘 | K B Tatiana V K Alexander | 1997 | Macromolecules1997，30，12： | 1 |
| 18 | Influence of proteoglycan removal on opening up in the beamhouse显示文摘 | Alexander K Haines B Walker M | 1986 | JALCA1986，81，： | 1 |
| 19 | Distributions of methylated naphthalenes in crude oils:indicators of maturity,biodegradation and mixing显示文摘 | van Aarssen B G K Bastow T P Alexander R | 1999 | Organic Geochemistry1999，30，： | 1 |
| 20 | Isolation and characterization of human cytotrophoblast cells显示文摘 | Daniels SM Alexander K Irving B | 1987 | Trophoblast Res1987，2，： | 1 |
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