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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Label-retaining liver cancer cells are relatively resistant to sorafenib显示文摘 | Hong-Wu Xin Chenwi M Ambe Danielle M Hari Gordon W Wiegand Tyler C Miller Jin-Qiu Chen Andrew J Anderson Satyajit Ray John E Mullinax Tomotake Koizumi Russell C Langan Douglas Burka Michelle A Herrmann Paul K Goldsmith Alexander Stojadinovic Udo Rudloff S | 2013 | Gut2013，，12： | 2 |
| 3 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 4 | Customer Loyalty Isn't Enough Grow Your Share of Wallet显示文摘 | Timothy L K Lerzan A Alexander Buoye Bruce Cooii | 2011 | Harvard Business Review2011，，10： | 1 |
| 5 | Haemato- immunological and stress responses of Labeo rohita (Hamilton) fingerlings: effect of rearing temperature and dietary gelatinized carbohydrate 显示文摘 | ALEXANDER C SAHU N P PAL A K | 2011 | Journal of Animal Physiology and Animal Nutrition2011，95，5： | 1 |
| 6 | Characteristics and in-hospital outcomes of patients with non-ST-segment elevation myocardial infarctionundergoing an invasive strategy according to hemoglobin levels显示文摘 | Hanna E B Alexander K P Chen A Y | 2013 | Am J Cardiol2013，111，8： | 1 |
| 7 | A geochemical reconstruction of oil generation in the Barrow Sub-basin of Western Australia显示文摘 | Volkman J K Alexander R Kagi R I Noble R A Woodhouse G W | 1983 | Geochim Cosmochim Acta1983，47，12： | 1 |
| 8 | Seeing I to I:A pathway to interpersonal connectedness显示文摘 | Pinel E Long A Landau M Alexander K Pyszczynski T | | 0，，90： | 1 |
| 9 | A geometric analysis of diffusion tensor measurements of the human brain显示文摘 | Alexander A L Hasan K Kindlmann G | 2000 | Magn Reson Med2000，44，： | 1 |
| 10 | Profiling the differences in students' knowledge, interest, and student motivation显示文摘 | Murphy P K | 1998 | Journal of educational psychology1998，84，： | 1 |
| 11 | Positive and nega- tive impacts of specialty malts on beer foam: a comparison of various ce- real products for their foaming properties显示文摘 | ALEXANDER L C JUSTIN K A CHARLES W B | 2013 | J Sei Food Agr2013，93，9： | 1 |
| 12 | The Effects of Enrichment by H2 on Propagation Speeds in Adiabatic Flat and Cellular Premixed Flames of CH4+O2+CO2 显示文摘 | Frederic H V C Alexander A K | 2008 | Fuel2008，87，： | 1 |
| 13 | Outer mem- brane protein(OMP) based vaccine for Neisseria meningitidis serogroup B显示文摘 | PILLAI S HOWELL A ALEXANDER K | 2005 | Vaccine2005，23，1718： | 1 |
| 14 | New alternating copolyimides by high temperature synthesis in benzoic acid medium显示文摘 | Alexander A K Marina Y Y Pavel V B | 2004 | High Performance Poly?mers2004，16，： | 1 |
| 15 | Haemato -immunological and stress responses of Labeo rohita(Hamilton) fingerlings :effect of rearing temperatureand dietary gelatinized carbohydrate 显示文摘 | Alexander C Sahu N P Pal A K | 2011 | Journal ofAnimal Physiology and Animal Nutrition2011，95，5： | 1 |
| 16 | Effects of pulsed electric fields on cell membrances in real food systems显示文摘 | Alexander A U Volker H Dietrich K | 2000 | Innovative Food Science and Emerging Technologies2000，1，2： | 1 |
| 17 | Grain Boundary Segregation of Grain Dopants in ct - A12 03 Scales 显示文摘 | Pint B A Alexander K B | 1998 | J Electrochem Soc1998，145，26： | 1 |
| 18 | Continuous online auditing: a program of research显示文摘 | ALEXANDER K EPHRAIM F S MIKLOS A V | 1999 | Journal of Information Sys- tems1999，13，2： | 1 |
| 19 | RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cells显示文摘 | HALL A H ALEXANDER K A | 2003 | J Virol2003，77，10： | 1 |
| 20 | A comparison of fill density obtained by supplementing cold lateral condensation with ultrasonic condensation 显示文摘 | Alexander K Frederick R Lesley A | 2002 | J Endod2002，28，9： | 1 |
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