|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Safety and Efficacy of Low Dosage of Urokinase for Catheter-directed Thrombolysis of Deep Venous Thrombosis显示文摘 | Xiao-Long Du Ling-Shang Kong Qing-You Meng Aimin Qian Wen-Dong Li Hong Chen Xiao-Qiang Li Cheng-Long Li | 2015 | Chinese Medical Journal2015，，13： | 35 |
| 2 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 3 | Delivery of triptolide with reduction-sensitive polymer nanoparticles for liver cancer therapy on patient-derived xenografts models显示文摘Hepatocellular carcinoma(HCC)has become the fourth predominant cause of cancer-related deaths worldwide,and HCC is still one of the worst prognoses for survival as it is poorly responsive to both chemotherapy and surgical treatment due to drug resista nce and great toxic effects.Triptolide(TP),a key ingredient from the traditional Chinese medical herb,has been utilized to treat inflammation and antitumor for centuries.However,investigations of this potent agent have been met with only limited success due to the severe systemic toxicities in patients and low water solubility as well as its high toxicity over the past two decades.Herein,we reported the development of a reduction-responsive drug delive ry system loaded with TP fo r glutathione(GSH)-trigge red drug release for cancer therapy.With the GSH-sensitive TP loaded nanoparticles,the remarkable increases in tumor accumulation and amelioration of drug toxicity in animals are demonstrated,which is likely due to sustained stepwise release of active TP within cancer cells.Moreover,in a patient-derived tumor xenograft model of liver cancer,administration of tritolide nanoparticles enhances the antitumor efficacy relative to administration of free TP.These findings indicate that GSH-sensitive release of TP may be a promising strategy for cancer treatment. | Mengxue He Ling Yu Yuanyuan Yang Binhua Zou Wen Ma Meng Yu Jiandong Lu Guoliang Xiong Zhiqiang Yu Aimin Li | 2020 | Chinese Chemical Letters2020，31，12： | 5 |
| 4 | CXCR4-guided liposomes regulating hypoxic and immunosuppressive microenvironment for sorafenib-resistant tumor treatment显示文摘Clinical sorafenib treatment could activate C-X-C receptor type 4(CXCR4)/stromal source factor-1α(SDF-1α)axis to aggravate intra-tumoral hypoxia of hepatocellular carcinoma(HCC),which further leads to progression,invasion,metastasis,and immunosuppression of tumors and in return causes resistance to sorafenib therapy.Therefore,a multi-functional oxygen delivery nanoplatform was rationally constructed based on an oxygen-saturated perfluorohexane(PFH)-cored liposome,with the CXCR4 antagonist LFC131 peptides modifying on the surface to simultaneously deliver sorafenib and the CSF1/CSF1R inhibitor PLX3397(named PFH@LSLP)for sorafenib-resistant HCC treatment.The PFH@LSLP was developed to overcome sorafenib resistance by syner-gistic effects of the following 3 roles:1)the O_(2)-saturated PFH core could alleviate the tumor hypoxia by O_(2) supply;2)the LFC131 peptide recognized the hypoxia-related overexpressed CXCR4 and then blocked SDF-1α/CXCR4 axis to re-sensitize the HCC cells to sorafenib;3)PLX3397 activated the immune responses via inhibiting the CSF1/CSF1R pathway in TAMs,further enhanced CD8^(+)T cell infiltration to reverse immunosuppression in tumors.Antitumor performance on H22 tumor-bearing mice and HCC patient-derived tumor xenograft(PDX)model showed that PFH@LSLP could overcome sorafenib resistance by synergistic effect of hypoxia attenuation,resistance-related gene regulation,and immune-microenvironment modification. | Yuehua Wang Zhenjie Wang Fei Jia Qing Xu Zhilin Shu Junlin Deng Aimin Li Meng Yu Zhiqiang Yu | 2022 | Bioactive Materials2022，7，11： | 3 |
| 5 | Temperature-dependent photoluminescence of CuInS2 quantum dots显示文摘 | Shi Aimin Wang Xiuying Meng Xiangdong | | 0，，： | 1 |
| 6 | Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells显示文摘 | Yong Wang Lingbo Liu Senthil K. Pazhanisamy Hongliang Li Aimin Meng Daohong Zhou | 2009 | Free Radical Biology and Medicine2009，，2： | 1 |
| 7 | Ionizing radiation and busulfan inhibit murine bone marrow cell hematopoietic function via apoptosis-dependent and -independent mechanisms显示文摘 | Aimin Meng Yong Wang Stephen A Brown Gary Van Zant Daohong Zhou | 2003 | Experimental Hematology2003，，12： | 1 |
| 8 | Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells显示文摘 | Yong Wang Lingbo Liu Senthil K. Pazhanisamy Hongliang Li Aimin Meng Daohong Zhou | 2009 | Free Radical Biology and Medicine2009，，2： | 1 |
| 9 | Aging effects on rheological properties of high viscosity modified asphalt显示文摘This work investigated the aging effects on the rheological properties of high viscosity modified asphalt(HVMA).First,the high-and low-temperature rheological properties were measured by a dynamic shear rheometer and a bending beam rheometer,respectively.The aging mechanism was then tested using an Fourier transform infrared spectroscopy and a scanning electron microscope.Besides,a study was performed to compare the aging effects on the rheological properties of HVMA,crumb rubber modified asphalt(CRMA),and neat asphalt(SK-90).The experimental results showed that the effects of the long-term aging on HVMA exceeded those of short-term aging.The complex shear modulus of the HVMA was improved by the aging in the whole frequency range.The complex shear modulus of the HVMA after the long-term aging was larger than after the short-term aging.Thus,the aging improved the high-temperature viscoelastic performance of HVMA.With a decrease in temperature from-12℃to-24℃,the low-temperature viscoelastic performance of HVMA decreased since its stiffness modulus and low continuous grading temperature increase.Both of the short-and long-term aging of HVMA were caused by an oxidation reaction,while modifier swelling also happened after long-term aging.Compared to CRMA and SK-90,aging had a limited influence on the high-and low-temperature rheological properties of HVMA. | Wei Jiang Dongdong Yuan Zheng Tong Aimin Sha Jingjing Xiao Meng Jia Wanli Ye Wentong Wang | 2023 | Journal of Traffic and Transportation Engineering(English Edition)2023，10，2： | 1 |
| 10 | Preparation of new chelating fiber with waste PET as adsorbent for fast removal of Cu 2+ and Ni 2+ from water: Kinetic and equilibrium adsorption studies显示文摘 | Jinnan Wang Li Xu Cheng Cheng Ying Meng Aimin Li | 2012 | Chemical Engineering Journal2012，，： | 1 |
| 11 | Ionizing radiation and busulfan inhibit murine bone marrow cell hematopoietic function via apoptosis-dependent and -independent mechanisms显示文摘 | Aimin Meng Yong Wang Stephen A Brown Gary Van Zant Daohong Zhou | 2003 | Experimental Hematology2003，，12： | 1 |
| 12 | Subspace clustering via graph auto-encoder network for unknown encrypted traffc recognition显示文摘The traffic encryption brings new challenges to the identification of unknown encrypted traffc.Currently,machine learning is the most commonly used encrypted traffic recognization technology,but this method relies on expensive prior label information.Therefore,we propose a subspace clustering via graph auto-encoder network(SCGAE)to recognize unknown applications without prior label information.The SCGAE adopts a graph encoder-decoder structure,which can comprehensively utilize the feature and structure information to extract discriminative embedding representation.Additionally,the self-supervised module is introduced,which use the clustering labels acts as a supervisor to guide the learning of the graph encoder-decoder module.Finally,we obtain the self-expression coefficient matrix through the self-expression module and map it to the subspace for clustering.The results show that SCGAE has better performance than all benchmark models in unknown encrypted traffic recognization. | Ruipeng Yang Aimin Yu Lijun Cai Dan Meng | 2023 | Cybersecurity2023，6，2： | 0 |
| 13 | Covalence bridge atomically precise metal nanocluster and metalorganic frameworks for enhanced photostability and photocatalysis显示文摘Metal nanoclusters(NCs)with precise structure and ultrasmall size have attracted great interests in catalysis.However,the poor stability has limited its large-scale use.Herein,we proposed the“covalence bridge”strategy to effectively connect atomically precise metal NCs and metal-organic frameworks.Benefiting from the covalent linkage,the synthesized UiO-66-NH2-Au25(LCys)18 showed outstanding stability after 16 h photocatalysis.Moreover,the covalence bridge created a strong metal-support interaction between the two components and provided an effective charge transport channel and thereby enhanced photocatalytic activity.UiO-66-NH2-Au25(L-Cys)18 displayed an exceptional photocatalytic H2 production rate,which is 21 and 90 times higher than that of UiO-66-NH2/Au25(PET)18(made by physically combination)and bare UiO-66-NH2,respectively.Thermodynamic and kinetic studies demonstrated that UiO-66-NH2-Au25(L-Cys)18 exhibited higher charge transfer efficiency,lower overpotential of water reduction and activation energy barrier compared with its counterparts. | Aimin Yao Yuanxin Du Meng Han Yan Wang Jiashen Hu Qingtao Zhu Hongting Sheng Manzhou Zhu | 2023 | Nano Research2023，16，1： | 0 |
| 14 | HMGB1 increases radiosensitivity by interacting with HDAC1显示文摘 | He Xin Meng Qinghui Meng Aimin Liu Qiang Wang Haichao Fan Saijun HeXin MengQinghui MengAimin LiuQiang WangHaichao FanSaijun | 2015 | 中华放射医学与防护杂志2015，35，1： | 0 |
| 15 | Development of radiation countermeasure agents for acute radiation syndromes显示文摘The risk of internal and external exposure to ionizing radiation(IR)has increased alongside the development and implementation of nuclear technology.Therefore,serious security issues have emerged globally,and there has been an increase in the number of studies focusing on radiological prevention and medical countermeasures.Radioprotective drugs are particularly important components of emergency medical preparedness strategies for the clinical management of IR-induced injuries.However,a few drugs have been approved to date to treat such injuries,and the related mechanisms are not entirely understood.Thus,the aim of the present review was to provide a brief overview of the World Health Organization's updated list of essential medicines for 2023 for the proper management of national stockpiles and the treatment of radiological emergencies.This review also discusses the types of radiation-induced health injuries and the related mechanisms,as well as the development of various radioprotective agents,including Chinese herbal medicines,for which significant survival benefits have been demonstrated in animal models of acute radiation syndrome. | Bowen Guan Deguan Li Aimin Meng | 2023 | Animal Models and Experimental Medicine2023，6，4： | 0 |
| 16 | Security-first architecture:deploying physically isolated active security processors for safeguarding the future of computing显示文摘It is fundamentally challenging to build a secure system atop the current computer architecture.The complexity in software,hardware and ASIC manufacture has reached beyond the capability of existing verification methodologies.Without whole-system verification,current systems have no proven security.It is observed that current systems are exposed to a variety of attacks due to the existence of a large number of exploitable security vulnerabilities.Some vulnerabilities are difficult to remove without significant performance impact because performance and security can be conflicting with each other.Even worse,attacks are constantly evolving,and sophisticated attacks are now capable of systematically exploiting multiple vulnerabilities while remain hidden from detection.Eagering to achieve security hardening of current computer architecture,existing defenses are mostly ad hoc and passive in nature.They are normally developed in responding to specific attacks spontaneously after specific vulnerabilities were discovered.As a result,they are not yet systematic in protecting systems from existing attacks and likely defenseless in front of zero-day attacks.To confront the aforementioned challenges,this paper proposes Security-first Architecture,a concept which enforces systematic and active defenses using Active Security Processors.In systems built based on this concept,traditional processors(i.e.,Computation Processors)are monitored and protected by Active Security Processors.The two types of processors execute on their own physically-isolated resources,including memory,disks,network and I/O devices.The Active Security Processors are provided with dedicated channels to access all the resources of the Computation Processors but not vice versa.This allows the Active Security Processors to actively detect and tackle malicious activities in the Computation Processors with minimum performance degradation while protecting themselves from the attacks launched from the Computation Processors thanks to the resource isolation. | Dan Meng Rui Hou Gang Shi Bibo Tu Aimin Yu Ziyuan Zhu Xiaoqi Jia Peng Liu | 2018 | Cybersecurity2018，1，1： | 0 |
| 17 | The protective effects of Xuebijing injection on intestinal injuries of mice exposed to irradiation显示文摘Background:Gastrointestinal(GI)injury is one of the most common side effects of radiotherapy.However,there is no ideal therapy method except for symptomatic treatment in the clinic.Xuebijing(XBJ)is a traditional Chinese medicine,used to treat sepsis by injection.In this study,the protective effects of XBJ on radiation-i nduced intestinal injury(RⅢ)and its mechanism were explored.Methods:The effect of XBJ on survival of irradiated C57BL/6 mice was monitored.Histological changes including the number of crypts and the length of villi were evaluated by H&E.The expression of Lgr5^(+)intestinal stem cells(ISCs),Ki67^(+)cells,villin and lysozymes were examined by immunohistochemistry.The expression of cytokines in the intestinal crypt was detected by RT-PCR.DNA damage and apoptosis rates in the small intestine were also evaluated by immunofluorescence.Results:In the present study,XBJ improved the survival rate of the mice after 8.0and 9.0 Gy total body irradiation(TBI).XBJ attenuated structural damage of the small intestine,maintained regenerative ability and promoted proliferation and differentiation of crypt cells,decreased apoptosis rate and reduced DNA damage in the intestine.Elevation of IL-6 and TNF-α was limited,but IL-1,TNF-β and IL-10 levels were increased in XBJ-treated group after irradiation.The expression of Bax and p53 were decreased after XBJ treatment.Conclusions:Taken together,XBJ provides a protective effect on RⅢby inhibiting inflammation and blocking p53-related apoptosis pathway. | Yinping Dong YuanYang Zhang Xinyue Wang Wenxuan Li Junling Zhang Lu Lu Hui Dong Saijun Fan Aimin Meng Deguan Li | 2022 | Animal Models and Experimental Medicine2022，5，6： | 0 |
| 18 | Morphine analgesia in male inbred genetic diversity mice recapitulates the among-individual variance in response to morphine in humans显示文摘Morphine is a widely used analgesic, but its use in clinical precision medicine is limited by the variance in response among individuals. Although previous studies have shown that individual differences in morphine can be explained in terms of pharmacodynamics and pharmacokinetics, genetic polymorphisms also play an important role. However, the genetic basis of different sensitivity and tolerance susceptibility to morphine remains ambiguous. Using 15 strains of inbred Genetic Diversity(GD) mice,a new resource with wide genetic and phenotypic variation, we demonstrated great variance in sensitivity to morphine analgesia and susceptibility to morphine tolerance between different GD strains. Among-i ndividual variance in response to morphine analgesia in the population can be modeled in GD mice. Two loci respectively may be associated with the among-i ndividual variance in morphine sensitivity and tolerance,confirming the role of genetic factors in among-i ndividual different responses to morphine. These results indicate that GD mice may be a potential tool for the identification of new biomarkers to improve the clinical administration of morphine. | Yin Yang Bowen Guan Qiang Wei Wei Wang Aimin Meng | 2022 | Animal Models and Experimental Medicine2022，5，3： | 0 |
| 19 | Screening for urinary markers predicting hematopoietic stem cell injury induced by busulfan using genetically diverse mice显示文摘Background:Busulfan(BU)is an alkylating agent used as a conditioning agent prior to hematopoietic stem cell(HSC)transplantation as it is known to be cytotoxic to host hematopoietic stem and progenitor cells.The susceptibility of HSCs to BU injury plays an important role in the myeloablative efficacy of BU.Different susceptibilities were demonstrated in genetically diverse(GD)mice in our preliminary research.Methods:Three strains of GD mice with different susceptibilities to BU-i nduced HSC injury were used for screening biological markers of HSC injury susceptibility in urine.The urine proteins were analyzed using liquid chromatography coupled with tandem mass spectrometry to screen for differentially expressed proteins.Screening for possible biomarkers based on differences in protein expression abundance was validated using enzyme-l inked immunoassay(ELISA).Results:Functional analysis showed that the differential proteins were all involved in a series of biological pathways related to cellular senescence,apoptosis,and angiogenesis;whereas the differential proteins of the high-susceptible strain were enriched for the regulation of bone marrow microenvironment pathways,those of low-susceptible strain were enriched for the proapoptotic effect of GTPase pathways.Based on protein abundance differences,several urinary proteins that may be indicative of susceptibility were screened,and ELISA validation results showed that angiotensin-converting enzyme may be a potential biomarker predicting HSC susceptibility for BU conditioning.Conclusions:This study indicates that urinary protein levels can reflect differences in susceptibility to BU-i nduced HSC injury.Using GD mice to construct genetic difference models will provide preclinical data for screening BU-related biological markers. | Yuhang Sun Bowen Guan Xing Liu Lingyan Zhang Xinpei Wang Aimin Meng Ran Gao | 2023 | Animal Models and Experimental Medicine2023，6，2： | 0 |
| 20 | Investigation of silicon on insulator fabricated by two-step O^+ implantation显示文摘In this paper,we investigated the dose window of forming a continuous buried oxide(BOX) layer by single implantation at the implantation energy of 200 keV. Then,an improved two-step implantation process with second implantation dose of 3×1015 cm-2 was developed to fabricate high quality separation by implanted oxygen(SIMOX) silicon on insulator(SOI) wafers. Compared with traditional single implantation,the implantation dose is reduced by 18.2%. In addition,the thickness and uniformity of the BOX layers were evaluated by spectroscopic ellipsometry. Defect-free top Si as well as atomic-scale sharp top Si/buried oxide interfaces were observed by transmission electron microscopy,indicating a high crystal quality and a perfect structure of the SOI fabricated by two step implantation. The top Si/BOX interface morphology of the SOI wafers fabricated by single or two-step implantation was also investigated by atomic force microscopy. | WEI Xing XUE ZhongYing WU AiMin WANG Xiang LI XianYuan YE Fei CHEN Jie CHEN Meng ZHANG Box LIN ChengLu ZHANG Miao WANG Xi | 2011 | Chinese Science Bulletin2011，56，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员