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| 1 | Pathogenesis and clinical management of Helicobacter pylori gastric infection显示文摘Helicobacter pylori(H.pylori)is a gram-negative bacterium that infects approximately 4.4 billion individuals worldwide.However,its prevalence varies among different geographic areas,and is influenced by several factors.The infection can be acquired by means of oral-oral or fecal-oral transmission,and the pathogen possesses various mechanisms that improve its capacity of mobility,adherence and manipulation of the gastric microenvironment,making possible the colonization of an organ with a highly acidic lumen.In addition,H.pylori presents a large variety of virulence factors that improve its pathogenicity,of which we highlight cytotoxin associated antigen A,vacuolating cytotoxin,duodenal ulcer promoting gene A protein,outer inflammatory protein and gamma-glutamyl transpeptidase.The host immune system,mainly by means of a Th1-polarized response,also plays a crucial role in the infection course.Although most H.pylori-positive individuals remain asymptomatic,the infection predisposes the development of various clinical conditions as peptic ulcers,gastric adenocarcinomas and mucosa-associated lymphoid tissue lymphomas.Invasive and non-invasive diagnostic methods,each of them with their related advantages and limitations,have been applied in H.pylori detection.Moreover,bacterial resistance to antimicrobial therapy is a major challenge in the treatment of this infection,and new therapy alternatives are being tested to improve H.pylori eradication.Last but not least,the development of effective vaccines against H.pylori infection have been the aim of several research studies. | Breno Bittencourt de Brito Filipe Ant?nio Fran?a da Silva Aline Silva Soares Vinícius Afonso Pereira Maria Luísa Cordeiro Santos Mariana Miranda Sampaio Pedro Henrique Moreira Neves Fabrício Freire de Melo | 2019 | World Journal of Gastroenterology2019，25，37： | 84 |
| 2 | Pancreatitis after endoscopic retrograde cholangiopancreatography:A narrative review显示文摘Acute post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP)is a feared and potentially fatal complication that can be as high as up to 30%in high-risk patients.Pre-examination measures,during the examination and after the examination are the key to technical and clinical success with a decrease in adverse events.Several studies have debated on the subject,however,numerous topics remain controversial,such as the effectiveness of prophylactic medications and the amylase dosage time.This review was designed to provide an update on the current scientific evidence regarding PEP available in the literature. | Igor Braga Ribeiro Epifanio Silvino do Monte Junior Antonio Afonso Miranda Neto Igor Mendonça Proença Diogo Turiani Hourneaux de Moura Mauricio Kazuyoshi Minata Edson Ide Marcos Eduardo Lera dos Santos Gustavo de Oliveira Luz Sergio Eiji Matuguma Spencer Cheng Renato Baracat Eduardo Guimarães Hourneaux de Moura | 2021 | World Journal of Gastroenterology2021，27，20： | 5 |
| 3 | Purification of metallurgical grade silicon by acid leaching显示文摘 | SANTOS I C GONCALVES A P SANTOS C S ALMEIDA M AFONSO M H CRUZ M J | 1990 | Hydrometallurgy1990，23，： | 1 |
| 4 | Phenylalanine hydroxylase deficiency:Molecular epidemiology and predictable BH (4)-responsiveness in South Portugal PKU patients显示文摘 | Rivera I Mendes D Afonso A | 2011 | Mol Genet Metab2011，104，1： | 1 |
| 5 | Insight into p95HER2 in Breast Cancer: Molecular Mechanisms and Targeted Therapies显示文摘 | Ramon Andrade de Mello Alessandro de Vasconcelos Ronaldo A Ribeiro Ines Pousa Noemia Afonso Deolinda Pereira Helena Rodrigues | 2012 | Recent Patents on DNA and Gene Sequences2012，，1： | 1 |
| 6 | Sheeppox virus kelch- like gene SPPV-019 affects virus virulence显示文摘 | Balinsky C A Delhon G Afonso C L | 2007 | J Virol2007，81，20： | 1 |
| 7 | Discovery of 1- ( 4-fluorophenyl )-( 3R ) - -( 4S ) -( 4-hydroxyphenyl )-2-azetidinone ( SCH 58235 ) : a designed, potent, orally active inhibitor of cholesterol absorption 显示文摘 | Huynh T Afonso A Davis HR Jr | 1998 | J Med Chem1998，41，： | 1 |
| 8 | Ionic liquids in dispersive liquid-liquid microextraction显示文摘 | María J. Trujillo-Rodríguez Priscilla Rocío-Bautista Verónica Pino Ana M. Afonso | 2013 | Trends in Analytical Chemistry2013，，： | 1 |
| 9 | Sheeppox virus kelch- like gene SPPV -019 affects virus virulence 显示文摘 | BALINSKY C A DELHON G AFONSO C L | 2007 | J Virol2007，81，11： | 1 |
| 10 | Structural ripple formation in Ge/Sb multilayers induced by laser irradiation显示文摘 | Serna K Afonso C N Petford A K | 1994 | Applied Physics A1994，58，： | 1 |
| 11 | Electric field of grounding electrodes with frequency dependent soil parameters显示文摘 | Alipio R S Schroeder M A O Afonso M M | 2012 | Electric Power Systems Research2012，83，1： | 1 |
| 12 | A new guaiane mannoside from a Eutypa-like fungus isolated from Murraya paniculata in Brazil 显示文摘 | AFONSO D L EDSON R F SOUZA A Q L | 2008 | J Braz Chem Soc2008，19，7： | 1 |
| 13 | An augmented lagrangian approach to the constrained optimization formulation of imaging inverse problems显示文摘 | Afonso M V Bioucas-Dias J M and Figueiredo M A T | 2011 | IEEE Transactions on Image Processing2011，20，3： | 1 |
| 14 | Influenceof cooling rate on microstructure of Ti-Nb alloy for orthopedicimplants 显示文摘 | Afonso CRM Aleixo G T Ramirez A J | 2007 | Materials Science and Engineering C2007，277，： | 1 |
| 15 | Measuring Local Government Spending Efficiency: Evidence for the Lisbonregion 显示文摘 | Afonso A Fernandes S | 2006 | Regional Studies2006，，40： | 1 |
| 16 | Dioxins sources and current remediation technologies-A review显示文摘 | Kulkarni K S Crespo J G Afonso C A M | 2008 | EnvironmentInternational2008，34，： | 1 |
| 17 | Solitary plasmaeytoma of the spine: an unusual presentation显示文摘 | Afonso PD Almeida A | 2010 | AJNR Am J Neuroradiol2010，31，1： | 1 |
| 18 | Microemulsion systerms applied to breakdown petroleum emulsions 显示文摘 | Tereza NCD Afonso A D N Everlane F M | 2001 | J Petrol Sci Engng2001，32，： | 1 |
| 19 | The genetic structure of domestic rabbits 显示文摘 | Carneiro M Afonso S C eraldes A | 2011 | Molecular Biology and Evolution2011，28，6： | 1 |
| 20 | Oxidative stress in digestive gland and gill of the brown mussel (Pema pema) exposed to air and re-submersed 显示文摘 | Eduardo A Almeida Afonso Celso Dias Bainy Alcir Luiz Dafre | 2005 | Journal of Experimental Marine Biology and Ecology2005，318，： | 1 |
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