Extensive exploration of T cell heterogeneity in cancers by single cell sequencing

查看全文 作　　者：Xiaofang [1,2]Wang;Yangqiu [1,2]Li

机构地区：[1]Department of Hematology, First Affiliated Hospital, School of Medicine, Jinan University;[2]Key Laboratory for Regenerative Medicine of Ministry of Education, Institute of Hematology, School of Medicine, Jinan University

出　　处：《Chinese Journal of Cancer Research》索引2019年第31卷第2期,共9页

基　　金：supported by grants from the National Natural Science Foundation of China (No. 81770152, 91642111 and 81570143);the Guangzhou Science and Technology Project (No. 201510010211, 201807010004 and 201803040017) 摘　　要：Human T cells are a highly heterogeneous population and can recognize a wide variety of antigens by their T cell receptors(TCRs). Tumor cells display a large repertoire of antigens that serve as potential targets for recognition,thus making T cells in the tumor micro-environment more complicated. Making a connection between TCRs and the transcriptional information of individual T cells will be interesting for investigating clonal expansion within T cell populations under pathologic conditions. Advances in single cell RNA-sequencing(scRNA-seq) have allowed for comprehensive analysis of T cells. In this review, we briefly describe the research progress on tumor microenvironment T cells using single cell RNA sequencing, and then discuss how scRNA-seq can be used to resolve immune system heterogeneity in health and disease. Finally, we point out future directions in this field and potential for immunotherapy. 关键词：T cells tumor MICRO-ENVIRONMENT SINGLE-CELL RNA-sequencing

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Extensive exploration of T cell heterogeneity in cancers by single cell sequencing

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