An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis

查看全文 作　　者：Junzhong [1]Liu;Lili [1,2,3]Feng;Xueting [1,2]Gu;Xian [4]Deng;Qi [2,4]Qiu;Qun [1]Li;Yingying [1]Zhang;Muyang [1,5]Wang;Yiwen [1]Deng;Ertao [1]Wang;Yuke [1]He;Isabel [6]Baurle;Jianming [5,7]Li;Xiaofeng [2,4,8]Cao;Zuhua [1,3]He 机构地区：[1]National Key Laboratory of Plant Molecular Genetics,CAS Center for Excellence in Molecular Plant Sciences,Shanghai Institute of Plant Physiology&Ecology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200032,China;[2]University of the Chinese Academy of Sciences,Beijing 100049,China;[3]School of Life Science and Technology,Shanghai Tech University,Shanghai 201210,China;[4]State Key Laboratory of Plant Genomics and National Center for Plant Gene Research(Beijing),Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China;[5]Shanghai Center for Plant Stress Biology,Chinese Academy of Sciences,Shanghai 201602,China;[6]Institute of Biochemistry and Biology,University of Potsdam,Potsdam,Germany;[7]Department of Molecular,Cellular,and Developmental Biology,University of Michigan,Ann Arbor,MI 48109,USA;[8]CAS Center for Excellence in Molecular Plant Sciences,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China 出　　处：《Cell Research》索引2019年第29卷第5期,共12页 基　　金：the National Natural Science Foundation of China(91640114 and 31330061 to Z.H,31788103 and 91540203 to X.C.,31600207 to J.L.and 31770323 to X.D);Chinese Academy of Sciences(XDB27040201 to Z.H,QYZDYSSW-SMC022 to X.C.);the National Key Laboratory of Plant Molecular Genetics and the State Key Laboratory of Plant Genomics,the China Postdoctoral Science Foundation(2016M590386 to J.L);the Youth Innovation Promotion Association of CAS(2018131 to X.D.). 摘　　要：Global warming has profound effects on plant growth and fitness.Plants have evolved sophisticated epigenetic machinery to respond quickly to heat,and exhibit transgenerational memory of the heat-induced release of post-transtriptional gene silencing(PTGS).However,how thermomemory is transmitted to progeny and the physiological relevance are elusive.Here we show that heat-induced HEAT SHOCK TRANSCRIPTION FACTOR A2(HSFA2)directly activates the H3K27me3 demethylase RELATIVE OF EARLY FLOWERING 6(REF6),which in turn derepresses HSFA2.REF6 and HSFA2 establish a heritable feedback loop,and activate an E3 ubiquitin ligase,SUPPRESSOR OF GENE SILENCING 3(SGS3)-INTERACTING PROTEIN 1(SGIP1).SGIP1-mediated SGS3 degradation leads to inhibited biosynthesis of trans-acting siRNA(tasiRNA).The REF&HSFA2 loop and reduced tasiRNA converge to release HEAT-INDUCED TAS1 TARGET 5(HTT5),which drives early flowering but attenuates immunity.Thus,heat induces transmitted phe no types via a coordi nated epigenetic network involvi ng histone demethylases,tran scriptio n factors,and tasiRNAs,ensuring reproductive success and transgenerational stress adaptation. 关 键 词：AN H3K27me3 demethylase-HSFA2 GLOBAL WARMING