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| 1 | 新生儿HBe Ag在HBV宫内感染中的作用显示文摘目的:探讨新生儿HBeAg在HBV宫内感染中的作用.方法:收集HBsAg阳性住院待产孕妇,采ELISA方法和abbott试剂对产妇和新生儿HBeAg、HBsAg进行检测结果:57例孕妇血清经实验室复查,HBsAg均阳性,其中HBeAg阳性孕妇15例.15例HBeAg阳性孕妇所产的16例新生儿有11例HBeAg阳性(68.75%).新生儿HBsAg阳性3例,全部产自于HBeAg阳性母亲,且其外周血HBeAg均阳性.统计分析显示新生儿HBeAg是HBV宫内感染的危险因素(P<0.05).结论:新生儿HBeAg在HBV官内感染过程中起重要作用. | 邵中军 门可 徐剑秋 徐德忠 闫永平 张景霞 | 2004 | 世界华人消化杂志2004，12，2： | 11 |
| 2 | ALT在献血者肝炎筛查中的应用显示文摘 | 梁兵 刘仿 | 2009 | 海南医学2009，20，3： | 11 |
| 3 | Expression of PCNA and CD44mRNA in colorectal cancer with venous invasion and its relationship to liver metastasis显示文摘AIM: To investigate the expression of proliferating cell nuclear antigen (PCNA) and CD44mRNA in colorectal cancer with venous invasion and its relationship with liver metastasis.METHODS: Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to detect the expression of PCNA and CD44mRNA in 31 cases of colorectal cancer with venous invasion.RESULTS: Positive expression rates of PCNA and CD44mRNA in colorectal cancer were higher than those without liver metastasis (P<0.05 and P<0.01). In case of colorectal cancer with liver metastasis, strongly positive rates of PCNA and CD44mRNA were 94.1% and 70.6 %,respectively, significantly higher than those without liver metastasis. There was a positive relationship between the expressions of PCNA and CD44mRNA (r=0.67, P<0.05).CONCLUSION: Detection of PCNA and CD44mRNA expression in colorectal cancer may be useful for evaluating liver metastasis of cancer cells. | Shu-Qiang Yue Yan-Ling Yang Ke-Feng Dou Kai-Zong Li Department of Hepatobiliary Surgery,Xijing Hospital,Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China | 2003 | World Journal of Gastroenterology2003，9，12： | 11 |
| 4 | Effect of SEN virus coinfection on outcome of lamivudine therapy in patients with hepatitis B显示文摘AIM: Interactions between hepatitis B virus (HBV) and other viral hepatitis infections are well known, whether the newly discovered SEN virus (SENV) has any effect on lamivudine antiHBV activity is unclear. Our aim was to clarify the effect on treatment outcome of coinfection with SEN virus in patients with hepatitis B during lamivudine therapy. METHODS: Nested polymerase chain reaction (PCR) amplification was used to detect SENV-D and SENV-H strains in serum from 45 patients with chronic hepatitis B treated with lamivudine 100 mg daily for 12 mo. HBV DNA load was detected with fluorescence quantitative PCR (FQPCR) and YMDD (tyrosine, methionine, aspartate, aspartate) motif mutation of HBV DNA was investigated with cDNA microarray. RESULTS: SENV DNA was detected in 5 of 45(11.1%) cases after 12 mo they received lamivudine treatment. SENV-D and SENV-H were 4.4% and 6.7% respectively. HBV DNA failed to respond to lamivudine therapy in 4 of 5 SENV coinfected patients while only 10 of 40 patients became SENV positive and the difference was statistically significant. Response of ALT and HBeAg to lamivudine had no significant difference between coinfection patients and single HBV infection ones. CONCLUSION: Coinfection with SEN virus in chronic hepatitis B patients may adversely affect the outcome of lamivudine treatment. | DongXu De-YingTian Zhen-GangZhang Hong-YunChen Pei-HuiSong | 2004 | World Journal of Gastroenterology2004，10，7： | 3 |
| 5 | 百色少数民族地区结核病患者TTV和HGV感染的调查显示文摘目的了解百色少数民族地区结核病患者输血传播病毒(transfusion transmitted virus,TTV)和庚型肝炎病毒(hepeatitis G virus,HGV)的感染状况及临床意义。方法应用酶联免疫法(ELISA)检测712例结核病患者及500人健康人群血清抗-TTV和抗-HGV,对抗-TTV阳性者用PCR法检测TTV DNA,抗-HGV阳性者用逆转录套式聚合酶链反应法(PT-nPCR)检测HGV RNA,分析结核病患者TTV DNA或HGV RNA阳性者临床特征。结果结核病患者TTV感染率16.71%,健康人群5.60%;结核病患者HGV感染率14.61%,健康人群2.60%;配对比较差异有显著性(P<0.01);结核病患者TTV与HGV感染率具有随年龄增长呈递增趋势,男性高于女性(P<0.05),感染者有过输血史和注射史的比率比非感染者高(P<0.05),在抗结核治疗中感染者比非感染者容易出现抗结核药物所致肝损害(P<0.01)。结论结核病患者对TTV和HGV有较高的感染率,反复注射及免疫功能低下可能是增加TTV和HGV感染的原因,感染者在抗结核治疗中可能更容易出现肝损害。 | 黄其文 黄重敏 覃亚勤 喻文强 黄美金 | 2006 | 中国防痨杂志2006，28，1： | 1 |
| 6 | 庚型肝炎病毒感染对慢性肝炎发生发展的影响显示文摘目的 探讨庚型肝炎病毒(GBvirusC)感染对慢性肝炎发生发展的影响及临床意义。方法 采用免疫组化方法对143例慢性肝炎患者肝组织标本进行GBvirusC非结构蛋白5(NS5)抗原的检测,结合组织学改变进行分析。结果 慢性肝炎肝组织中GBvirus C总检出率为24.5%,其中单纯GBvirus C感染占11.9%;单纯GBvirus C感染和病原不明组炎症活动度程度较轻,只有8.9%达到3~4级,显著低于HBV/HCV感染病例和GB virus C& HBV/HCV混合感染组(26.5%)。结论 GB virus C的致病性值得怀疑或者仅具有较弱的致病性,GB virus C可能不是慢性肝炎的主要致病因子,它和HBV/HCV混合感染并不加重肝损害程度,不影响慢性肝炎的发生发展。 | 胡中杰 金荣华 郎振为 | 2006 | 临床荟萃2006，21，17： | 0 |
| 7 | GBV-C/HGV在血清学非甲~戊型急性肝炎发生中的作用显示文摘探讨GBV-C/HGV在血清学非甲~戊型急性肝炎发生中的作用及临床意义.采用免疫组化方法对56例血清学非甲~戊型急性肝炎患者肝组织标本进行GBV-C/HGV NS5抗原的检测,结合临床资料进行分析.血清学非甲~戊型急性肝炎肝组织中GBV-C/HGV NS5抗原检出率为53.6%,主要是以和HBV/HCV重叠感染的形式存在,重叠感染组的ALT升高和HBV/HCV感染组差异无显著意义.单纯GBV-C/HGV感染占16.1%,所引起的血清ALT升高明显低于HBV/HCV感染,而与病原不明病例差异无显著意义.GBV-C/HGV可能没有致病性或者有弱致病性,不是血清学非甲~戊型急性肝炎的主要致病因子. | 胡中杰 金荣华 郎振为 | 2007 | 临床肝胆病杂志2007，23，2： | 0 |
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