Expression of PCNA and CD44mRNA in colorectal cancer with venous invasion and its relationship to liver metastasis

查看全文 作　　者：Shu-Qiang Yue Yan-Ling Yang Ke-Feng Dou Kai-Zong Li Department of Hepatobiliary Surgery,Xijing Hospital,Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China

出　　处：《World Journal of Gastroenterology》索引2003年第9卷第12期,共3页

摘　　要：AIM: To investigate the expression of proliferating cell nuclear antigen (PCNA) and CD44mRNA in colorectal cancer with venous invasion and its relationship with liver metastasis.METHODS: Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to detect the expression of PCNA and CD44mRNA in 31 cases of colorectal cancer with venous invasion.RESULTS: Positive expression rates of PCNA and CD44mRNA in colorectal cancer were higher than those without liver metastasis (P<0.05 and P<0.01). In case of colorectal cancer with liver metastasis, strongly positive rates of PCNA and CD44mRNA were 94.1% and 70.6 %,respectively, significantly higher than those without liver metastasis. There was a positive relationship between the expressions of PCNA and CD44mRNA (r=0.67, P<0.05).CONCLUSION: Detection of PCNA and CD44mRNA expression in colorectal cancer may be useful for evaluating liver metastasis of cancer cells. 关键词：PCNA CD44mRNA RT-PCR 结直肠癌肝转移肿瘤标志物

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Expression of PCNA and CD44mRNA in colorectal cancer with venous invasion and its relationship to liver metastasis

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