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| 1 | 炎症反应与卒中后抑郁显示文摘背景:卒中后抑郁是脑卒中常见并发症,其病理生理学机制复杂,炎症反应学说是目前研究的热点。一些相关炎症因子不仅介导卒中后抑郁的患病机制,还是卒中后抑郁诊断及预后预判的重要指标。目的:归纳并总结不同类型的炎症因子在卒中后抑郁病理生理学机制及诊断中的作用,提出可能的应用前景。方法:以“卒中后抑郁、抑郁或脑卒中,联合炎症反应、炎症因子、细胞因子”为中文检索词,以“post-stroke depression,depression,stroke,inflammation reaction,inflammatory factor,cytokine”为英文检索词,分别检索万方数据、中国知网及PubMed数据库。检索时间范围重点为2010年1月至2021年2月,同时纳入少数经典远期文献。通过阅读文题和摘要进行初步筛选;排除中英文文献重复性研究、低质量期刊及内容不相关的文献,最后纳入69篇文献进行综述。结果与结论:①在大量的炎症因子中,共16种被筛选出来可能与卒中后抑郁关联,包括促炎因子(白细胞介素1β、白细胞介素6、白细胞介素8、白细胞介素18、肿瘤坏死因子α及干扰素γ)、抗炎因子(白细胞介素4、白细胞介素10及转化生长因子β1)和其他非特异因子(C-反应蛋白、新蝶呤、脂联素、NLRP3炎症小体、基质金属蛋白酶9、生长分化因子15及血清淀粉样蛋白A)。②拮抗促炎因子表达或补充外源性抗炎因子有益于卒中后抑郁症状缓解,而抗卒中后抑郁治疗可引起血清炎症因子变化。③各炎症因子通过与自身受体、细胞内信号通路、神经递质或下丘脑-垂体-肾上腺轴等相互作用,参与卒中后抑郁发生发展。④检测血清炎症标志物或基因多态性对卒中后抑郁诊断具有重要预测价值,但是目前相关研究仍不充分,缺少系统性、多层次及高质量的研究。⑤在应用前景方面,构建标准化的卒中后抑郁动物模型有助于在基础研究方面深入了解炎症因子对卒中后抑郁的具体作用机制,而构建可靠的炎症因子卒中后抑郁预测临床模型需要未来多中心大样本的纵向临床研究来实现。 | 唐文静 伍思源 杨晨 陶希 | 2022 | 中国组织工程研究2022，26，8： | 18 |
| 2 | An injectable and self-healing hydrogel with controlled release of curcumin to repair spinal cord injury显示文摘The harsh local micro-environment following spinal cord injury(SCI)remains a great challenge for neural regeneration.Local reconstitution of a favorable micro-environment by biocompatible scaffolds with desirable functions has thus been an area of concern.Herein,a hybrid hydrogel was developed using Fmoc-grafted chitosan(FC)and Fmoc peptide(FI).Dynamic reversibleπ-πstacking interactions of the fluorenyl rings enabled the FC/FI hybrid hydrogel to exhibit excellent injectable and self-healing properties,as characterized by visual appearances and rheological tests.Furthermore,the FC/FI hybrid hydrogel showed a slow and persistent release of curcumin(Cur),which was named as FC/FI-Cur hydrogel.In vitro studies confirmed that with the support of FC/FI-Cur hydrogel,neurite outgrowth was promoted,and Schwann cell(SC)migration away from dorsal root ganglia(DRG)spheres with enhanced myelination was substantiated.The FC/FI-Cur hydrogel well reassembled extracellular matrix at the lesion site of rat spinal cord and exerted outstanding effects in modulating local inflammatory reaction by regulating the phenotypes of infiltrated inflammatory cells.In addition,endogenous SCs were recruited in the FC/FI-Cur graft and participated in the remyelination process of the regenerated nerves.These outcomes favored functional recovery,as evidenced by improved hind limbs movement and enhanced electrophysiological properties.Thus,our study not only advanced the development of multifunctional hydrogels but also provided insights into comprehensive approaches for SCI repair. | Jinghua Luo Xueshuang Shi Liming Li Zan Tan Feng Feng Jun Li Mao Pang Xiaoying Wang Liumin He | 2021 | Bioactive Materials2021，6，12： | 4 |
| 3 | 脊髓损伤后神经环路重建的研究进展显示文摘成年哺乳类脊髓损伤后的修复与再生是一项复杂且尚未解决的挑战.随着全球经济的增长,脊髓损伤的发生率呈上升趋势.脊髓损伤可能导致永久性的运动功能障碍和感觉丧失,给患者及其家属带来极大的经济压力和心理负担.因此,迫切需要开发有效的治疗脊髓损伤的新策略.近年来,应用外源性或内源性神经元中继的治疗手段为脊髓损伤后环路重建提供了新的思路.将干细胞或生物材料等移植物作用于脊髓损伤区,可改善损伤区局部微环境,诱导神经干细胞定向分化为神经元,促进脊髓环路重建和功能恢复,因此成为较有临床应用前景的方法.本综述主要介绍细胞移植治疗、组织工程策略和基因调控等方法在修复受损脊髓的神经网络中的应用,并讨论了脊髓损伤后新生神经元是否具有潜在的功能整合,重建受损神经环路,并恢复其运动和感觉功能等问题. | 王子珏 高钰丹 赵文 郝飞 郝鹏 段红梅 李晓光 杨朝阳 | 2022 | 中国科学:生命科学2022，52，10： | 3 |
| 4 | 可注射水凝胶在脊髓损伤中的应用显示文摘背景:近年来,可注射水凝胶在治疗严重脊髓损伤方面有很大的应用前景和独特的治疗可塑性。目的:综述可注射水凝胶材料在脊髓损伤中的研究进展。方法:检索PubMed、Web of Science、Embase、中国知网、万方、维普、中国生物医学文献数据库等数据库,中文检索词为“脊髓损伤、脊柱骨折、可注射水凝胶”等,英文检索词为“Spinal Cord Trauma、Myelopathy、Traumatic、Injuries、Spinal Cord、Spinal Cord Injury、Spinal Cord Transection、Spinal Cord Laceration、Post-Traumatic Myelopathy、Spinal Cord Contusion、injectable Hydrogel”等。筛选可注射水凝胶治疗脊髓损伤的相关研究。结果与结论:在动物及细胞实验中,可注射水凝胶具有修复脊髓损伤的效果。可注射水凝胶具有创伤小、能够贴合不规则缺损的特性;具有导电性和温敏性能的可注射水凝胶,在理化特性方面对脊髓损伤具有较好的修复功能;搭载干细胞或神经营养因子的可注射水凝胶,有利于神经再生和脊髓损伤局部微环境的修复。可注射复合水凝胶材料具有临床应用前景。 | 陶经纬 范筱 蒋昇源 邓博文 张亚奇 刘港 左心玮 周卓荦 赵毅 任敬佩 徐林 穆晓红 | 2023 | 中国组织工程研究2023，27，16： | 3 |
| 5 | Injectable and thermosensitive hydrogels mediating a universal macromolecular contrast agent with radiopacity for noninvasive imaging of deep tissues显示文摘It is very challenging to visualize implantable medical devices made of biodegradable polymers in deep tissues.Herein,we designed a novel macromolecular contrast agent with ultrahigh radiopacity(iodinate content>50%)via polymerizing an iodinated trimethylene carbonate monomer into the two ends of poly(ethylene glycol)(PEG).A set of thermosensitive and biodegradable polyester-PEG-polyester triblock copolymers with varied polyester compositions synthesized by us,which were soluble in water at room temperature and could spontaneously form hydrogels at body temperature,were selected as the demonstration materials.The addition of macromolecular contrast agent did not obviously compromise the injectability and thermogelation properties of polymeric hydrogels,but conferred them with excellent X-ray opacity,enabling visualization of the hydrogels at clinically relevant depths through X-ray fluoroscopy or Micro-CT.In a mouse model,the 3D morphology of the radiopaque hydrogels after injection into different target sites was visible using Micro-CT imaging,and their injection volume could be accurately obtained.Furthermore,the subcutaneous degradation process of a radiopaque hydrogel could be non-invasively monitored in a real-time and quantitative manner.In particular,the corrected degradation curve based on Micro-CT imaging well matched with the degradation profile of virgin polymer hydrogel determined by the gravimetric method.These findings indicate that the macromolecular contrast agent has good universality for the construction of various radiopaque polymer hydrogels,and can nondestructively trace and quantify their degradation in vivo.Meanwhile,the present methodology developed by us affords a platform technology for deep tissue imaging of polymeric materials. | Xiaohui Wu Xin Wang Xiaobin Chen Xiaowei Yang Qian Ma Guohua Xu Lin Yu Jiandong Ding | 2021 | Bioactive Materials2021，6，12： | 1 |
| 6 | GelMA/LPN/MC水凝胶的挤出式3D打印工艺与性能研究显示文摘挤出式3D打印水凝胶用于组织修复是近年的研究热点。然而,高形状保真度的水凝胶打印过程仍然离不开复杂的交联策略,这大大增加了打印难度,限制了水凝胶材料在组织工程领域的应用。制备一种室温下可打印水凝胶,其打印过程不需要任何辅助交联便可实现高保真度打印。水凝胶由甲基丙烯酰胺酯化明胶(Gelatin methacrylate,GelMA),纳米黏土(Laponite XLG,LPN)和甲基纤维素(Methylcellulose,MC)组成。通过挤出测试筛选出适合打印的复合材料配比,打印工艺试验分析了挤出速度、喷头移动速度对出丝连续性和微丝线宽的影响。当喷头内径为400μm时,GelMA/LPN/MC水凝胶实现顺畅出丝(φ400~600μm)的条件为挤出速度在8.6~13 mm/h,喷头移动速度在6~10 mm/s。流变结果表明LPN和MC的加入赋予了材料优异的剪切稀化特性,使其具备室温下打印并维持结构稳定的性能。压缩结果表明改变交联时间,GelMA/LPN/MC水凝胶的压缩模量提高5倍,压缩强度提高3倍。细胞试验显示GelMA/LPN/MC水凝胶具有良好的生物相容性。 | 董兰兰 李亘 熊胤泽 张航 王蕾 李祥 | 2022 | 机械工程学报2022，58，9： | 1 |
| 7 | Bioinspired porous microspheres for sustained hypoxic exosomes release and vascularized bone regeneration显示文摘Exosomes derived from mesenchymal stem cells(MSCs)have demonstrated regenerative potential for cell-free bone tissue engineering,nevertheless,certain challenges,including the confined therapeutic potency of exosomes and ineffective delivery method,are still persisted.Here,we confirmed that hypoxic precondition could induce enhanced secretion of exosomes from stem cells from human exfoliated deciduous teeth(SHEDs)via comprehensive proteomics analysis,and the corresponding hypoxic exosomes(H-Exo)exhibited superior potential in promoting cellular angiogenesis and osteogenesis via the significant up-regulation in focal adhesion,VEGF signaling pathway,and thyroid hormone synthesis.Then,we developed a platform technology enabling the effective delivery of hypoxic exosomes with sustained release kinetics to irregular-shaped bone defects via injection.This platform is based on a simple adsorbing technique,where exosomes are adsorbed onto the surface of injectable porous poly(lactide-co-glycolide)(PLGA)microspheres with bioinspired polydopamine(PDA)coating(PMS-PDA microspheres).The PMS-PDA microspheres could effectively adsorb exosomes,show sustained release of H-Exo for 21 days with high bioactivity,and induce vascularized bone regeneration in 5-mm rat calvarial defect.These findings indicate that the hypoxic precondition and PMS-PDA porous microsphere-based exosome delivery are efficient in inducing tissue regeneration,hence facilitating the clinical translation of exosome-based therapy. | Yike Gao Zuoying Yuan Xiaojing Yuan Zhuo Wan Yingjie Yu Qi Zhan Yuming Zhao Jianmin Han Jianyong Huang Chunyang Xiong Qing Cai | 2022 | Bioactive Materials2022，7，8： | 1 |
| 8 | 医用水凝胶神经接口研究进展显示文摘神经损伤可导致永久性感觉功能丧失,神经接口材料可有效修复受损神经。传统神经接口由金属电极材料制成,阻抗较高,易腐蚀且灵敏度低,胶质细胞阻碍电极与组织接触,影响神经再生。水凝胶生物相容性高,可以模拟细胞外基质,是一种新兴神经接口材料。水凝胶神经接口分为电极型和支架型两类,可以接收并记录神经信号,调控细胞行为与生物活性物质释放,或连通信号传导通路,诱导神经再生。本文将对水凝胶神经接口功能修饰方法、受损神经修复机理及实践应用进行较全面地介绍,提出水凝胶神经接口在治疗神经损伤中亟需解决的问题,为水凝胶神经接口在神经修复领域的医学应用提供有益参考。 | 吴烨堃 刘延浩(综述) 王路(审校) | 2022 | 卫生研究2022，51，2： | 0 |
| 9 | Bioinspired supramolecular nanofiber hydrogel through self-assembly of biphenyl-tripeptide for tissue engineering显示文摘Supramolecular nanofiber peptide assemblies had been used to construct functional hydrogel biomaterials and achieved great progress.Here,a new class of biphenyl-tripeptides with different C-terminal amino acids sequences transposition were developed,which could self-assemble to form robust supramolecular nanofiber hydrogels from 0.7 to 13.8 kPa at ultra-low weight percent(about 0.27 wt%).Using molecular dynamics simulations to interrogate the physicochemical properties of designed biphenyl-tripeptide sequences in atomic detail,reasonable hydrogen bond interactions and“FF”brick(phenylalanine-phenylalanine)promoted the formation of supramolecular fibrous hydrogels.The biomechanical properties and intermolecular interactions were also analyzed by rheology and spectroscopy analysis to optimize amino acid sequence.Enhanced L929 cells adhesion and proliferation demonstrated good biocompatibility of the hydrogels.The storage modulus of BPAA-AFF with 10 nm nanofibers self-assembling was around 13.8 kPa,and the morphology was similar to natural extracellular matrix.These supramolecular nanofiber hydrogels could effectively support chondrocytes spreading and proliferation,and specifically enhance chondrogenic related genes expression and chondrogenic matrix secretion.Such biomimetic supramolecular short peptide biomaterials hold great potential in regenerative medicine as promising innovative matrices because of their simple and regular molecular structure and excellent biological performance. | Yong Sun Xing Li Mingda Zhao Yafang Chen Yang Xu Kefeng Wang Shaoquan Bian Qing Jiang Yujiang Fan Xingdong Zhang | 2022 | Bioactive Materials2022，7，2： | 0 |
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