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| 1 | 胸腺肽α1免疫治疗联合抗感染对重症肺部感染的影响显示文摘目的探讨胸腺肽α1(Tα1)联合抗感染治疗对重症肺炎转归的影响,并分析其发挥作用的可能机制。方法重症肺感染患者71例,随机分为治疗组38例,对照组33例。对照组予以常规抗感染及对症支持治疗,治疗组在对照组的基础上联合皮下注Tα1 11.6 mg 1次/每天,连续7 d,1周后改为2次/周。Tα1治疗前后测定外周血T细胞亚群和自然杀伤(NK)细胞,酶联免疫吸附法测定炎症因子如TNF-α、IL-10等水平,并比较两组患者的抗生素使用时间、住院时间及病死率。结果两组患者在性别、年龄、心率、呼吸频率、动脉血氧分压(PaO2)、氧合指数(PaO2/FiO2)、收缩压、痰培养阳性无明显差异(P>0.05),具有可比性。治疗组患者死亡6例,病死率为15.78%;对照组患者死亡7例,病死率为21.21%,较治疗组明显增加(P<0.05)。治疗组抗生素应用时间及住院天数明显较对照组缩短[分别为(12.95±1.94)vs.(15.98±2.01)d,(15.73±2.13)vs.(18.74±3.60)d](P<0.05)。治疗前,两组患者的CD3、CD4、CD8、CD4/CD8、NK细胞数无明显差异;治疗后,两组患者的CD3、CD4、CD8、NK细胞数明显增加,且治疗组患者CD3、CD4、CD8、NK细胞数[分别为(48.57±7.21)%、(32.83±4.20)%、(24.89±3.05)%、(20.01±2.96)%]较对照组[分别为(45.89±6.72)%、(29.04±3.16)%、(21.53±2.56)%、(16.72±2.03)%]明显增加(P<0.05)。治疗前,两组患者的TNF-α、IL-10水平无明显差异。治疗后,两组患者TNF-α水平均较治疗前明显降低,而且治疗组TNF-α水平明显较对照组低[(17.95±2.28)vs.(20.79±3.02)](P<0.05)。治疗后,两组患者IL-10水平均较治疗前明显升高,而且治疗组IL-10水平明显较对照组高[(12.82±1.12)vs.(9.79±1.02)](P<0.05)。结论重症肺炎患者存在免疫细胞功能紊乱,Tα1免疫治疗能够很好地调节免疫细胞功能、减轻体内炎症反应,增强抗感染治疗效果。 | 严锡祥 郑爱东 张振恩 潘国翠 崔永华 | 2021 | 中华肺部疾病杂志(电子版)2021，14，3： | 4 |
| 2 | TLR8 in the Trigeminal Ganglion Contributes to the Maintenance of Trigeminal Neuropathic Pain in Mice显示文摘Trigeminal neuropathic pain(TNP)is a significant health problem but the involved mechanism has not been completely elucidated.Toll-like receptors(TLRs)have recently been demonstrated to be expressed in the dorsal root ganglion and involved in chronic pain.Here,we show that TLR8 was persistently increased in the trigeminal ganglion(TG)neurons in model of TNP induced by partial infraorbital nerve ligation(pIONL).In addition,deletion or knockdown of Tlr8 in the TG attenuated pIONL-induced mechanical allodynia,reduced the activation of ERK and p38-MAPK,and decreased the expression of pro-inflammatory cytokines in the TG.Furthermore,intra-TG injection of the TLR8 agonist VTX-2337 induced pain hypersensitivity.VTX-2337 also increased the intracellular Ca^(2+)concentration,induced the activation of ERK and p38,and increased the expression of pro-inflammatory cytokines in the TG.These data indicate that TLR8 contributes to the maintenance of TNP through increasing MAPK-mediated neuroinflammation.Targeting TLR8 signaling may be effective for the treatment of TNP. | Lin-Xia Zhao Ming Jiang Xue-Qiang Bai De-Li Cao Xiao-Bo Wu Jing Zhang Jian-Shuang Guo Tong-Tong Chen Juan Wang Hao Wu Yong-Jing Gao Zhi-Jun Zhang | 2021 | Neuroscience Bulletin2021，37，4： | 1 |
| 3 | Reducing host aldose reductase activity promotes neuronal differentiation of transplanted neural stem cells at spinal cord injury sites and facilitates locomotion recovery显示文摘Neural stem cell(NSC)transplantation is a promising strategy for replacing lost neurons following spinal cord injury.However,the survival and differentiation of transplanted NSCs is limited,possibly owing to the neurotoxic inflammatory microenvironment.Because of the important role of glucose metabolism in M1/M2 polarization of microglia/macrophages,we hypothesized that altering the phenotype of microglia/macrophages by regulating the activity of aldose reductase(AR),a key enzyme in the polyol pathway of glucose metabolism,would provide a more beneficial microenvironment for NSC survival and differentiation.Here,we reveal that inhibition of host AR promoted the polarization of microglia/macrophages toward the M2 phenotype in lesioned spinal cord injuries.M2 macrophages promoted the differentiation of NSCs into neurons in vitro.Transplantation of NSCs into injured spinal cords either deficient in AR or treated with the AR inhibitor sorbinil promoted the survival and neuronal differentiation of NSCs at the injured spinal cord site and contributed to locomotor functional recovery.Our findings suggest that inhibition of host AR activity is beneficial in enhancing the survival and neuronal differentiation of transplanted NSCs and shows potential as a treatment of spinal cord injury. | Kun Zhang Wen-Can Lu Ming Zhang Qian Zhang Pan-Pan Xian Fang-Fang Liu Zhi-Yang Chen Chung Sookja Kim Sheng-Xi Wu Hui-Ren Tao Ya-Zhou Wang | 2022 | Neural Regeneration Research2022，17，8： | 0 |
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