|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 中医药治疗急性缺血性脑卒中RCT结局指标的现状分析显示文摘为评价中医药治疗急性缺血性脑卒中随机对照试验中结局指标的选择现状,给未来相关研究提供建议。该研究系统全面检索了4大中文数据库、3大英文数据库,检索时间为2017年1月至2019年6月,按照预先制定的遴选标准筛选出中医药治疗急性缺血性脑卒中的随机对照试验。并根据Cochrane偏倚风险评估工具对纳入研究进行质量评价。初步检索出20 651篇相关文献,剔除重复后剩余11 662篇,最终纳入42篇文献,其中中文36篇,英文6篇;40篇随机对照试验,2篇为随机对照试验的注册方案。结果显示,42个随机对照试验的结局指标主要分为7大类,即临床结局指标,血生化指标,评价精神状态指标,脑血流动力学指标,评价颈动脉狭窄程度的指标,安全性指标和其他指标。血生化指标为出现频次最高的指标,临床结局指标次之。在17个研究中使用了中医证候积分作为疗效结局指标。分析后发现,中医药治疗急性缺血性脑卒中随机对照试验中结局指标遴选存在着较多问题,如主要结局指标极少选择终点指标和硬指标,绝大多数为中间替代指标,不能获得较为公认的疗效;关注的结局指标种类过多,异质性过大,阻碍中医药优势治疗措施在临床实践中的推广。为此应该借鉴国际核心指标结局指标集的创建方法,构建中医药治疗急性缺血性脑卒中的核心指标结局指标集,研制符合中医药治疗措施疗效特色的结局指标集,可以有效解决相关问题。 | 李慧敏 廖星 胡瑞学 于丹丹 顾浩 王乐 赵晖 张允岭 | 2020 | 中国中药杂志2020，45，9： | 53 |
| 2 | 近三年针刺治疗急性缺血性脑卒中随机对照试验中结局指标现状分析显示文摘该研究旨在分析近三年针刺治疗急性缺血性脑卒中随机对照试验中结局指标的使用情况,为构建针刺治疗急性缺血性脑卒中核心结局指标集提供依据。通过计算机检索国内外8个中、英文数据库及2个临床试验注册库,收集近三年针刺治疗急性缺血性脑卒中的随机对照试验,筛选文献后提取资料,对已发表的研究采用“Cochrane 6.1偏倚风险评估”工具进行偏倚风险评价,汇总结局指标进行分析。最终纳入47项随机对照试验,包括3项试验注册方案,将结局指标按照功能属性分为6类:症状/体征、理化检查、生活质量、中医症状/证候、安全性事件、远期预后。研究发现,针刺治疗急性缺血性脑卒中随机对照试验中结局指标选择现状涵盖了既往研究的共性问题之外,尚存在以下问题:重视宏观疗效指标,忽视针刺特异性指标,缺乏中医治疗特色及经济学指标,指标测量工具及测量时点不统一。未来应开展针刺治疗急性缺血性脑卒中结局指标集建设工作,构建符合中医治疗特色的核心结局指标集。 | 代玲玲 徐榛敏 梁晓 邱文然 刘少姣 王柳丁 郭春艳 王业飞 金香兰 廖星 | 2021 | 中国中药杂志2021，46，12： | 20 |
| 3 | Neuroprotective Effect of Electroacupuncture Against Acute Ischemic Stroke via PI3K‑Akt‑mTOR Pathway‑Mediated Autophagy显示文摘Acupuncture has been used to treat ischemic stroke,and mounting evidence demonstrates the neuroprotective and autophagy‑mediated actions of electroacupuncture(EA).This review summarizes the evidence that EA affects different stages of autophagy,its neuroprotective action,and effects of different acupoints in treating ischemic stroke.Systematic searches were conducted on English and Chinese databases(MEDLINE,Elsevier,ScienceDirect,Cochrane Library,and China National Knowledge Infrastructure).Studies published up until February 2021 were considered for inclusion,and a final of fifty articles were included in this review.There is evidence that acupuncture promotes neuroprotection by modulating autophagy,and the treatment effectiveness is related to the acupoint selection and timing of treatment administration. | Velika Yovitania QinHui Fu Jian Pei Hua Zhou | 2022 | World Journal of Traditional Chinese Medicine2022，8，3： | 1 |
| 4 | Bloodletting puncture in the treatment of acute ischemic stroke:protocol for a mixed-method study of a multi-center randomized controlled trial and focus group显示文摘This study is to investigate the effectiveness and safety of bloodletting puncture(BP)for acute ischemic stroke(AIS)when used in combination with standard treatment,as well as the patients'feelings and attitudes toward the treatment.This is a mixed method research which includes a multi-center,superiority,randomized controlled clinical trial,and focus group interview.A total of 360 AIS participants will be enrolled.They will be randomized into one of the following two groups for 7 d:(a)BP with standard treatment group(n=180);(b)standard treatment group(n=180).The primary outcome will be National Institute of Health stroke scale(NIHSS)score at day 7 after treatment.Secondary outcomes will be changes of Glasgow Coma Scale score,NIHSS score,mRS and Traditional Chinese Medicine syndrome score from baseline to 7,14,and 30 d after treatment,recurrence rate and all-cause mortality rate within 30 d,and the safety assessments.The focus group will be conducted with a purposive sample of 1-2 acupuncturists and 1-2 patients respectively at each center at 7 and 30 d after treatment.We designed a mixed method study to evaluate the effect of BP,an acupuncture therapy for patients with AIS.If the findings of this study confirm the effectiveness of BP to reduce the NIHSS score and other related outcomes and patients are willing to accept the therapy,we believe this study will help the implementation of this therapy in clinical practice,and provide new evidence for the treatment of AIS. | DAI Zeqi LIAO Xing GUAN Yueyue ZENG Zixiu TANG Jun HU Jing | 2023 | Journal of Traditional Chinese Medicine2023，43，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员