|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Preventive effects of anisodamine against contrast-induced nephropathy in type 2 diabetics with renal insufficiency undergoing coronary angiography or angioplasty显示文摘 | GENG Wei FU Xiang-hua GU Xin-shun WANG Yan-bo WANG Xue-chao LI Wei JIANG Yun-fa HAO Guo-zhen FAN Wei-ze XUE Ling | 2012 | Chinese Medical Journal2012，，19： | 13 |
| 2 | 对比剂肾病的预防及危险分层的研究进展显示文摘随着对比剂的广泛应用,对比剂肾病(CIN)发病率逐年增高。根据CIN的危险因素进行危险分层,合理使用对比剂能够有效预防CIN的发生。本文就CIN的预防及危险分层方面的研究进展进行综述。 | 张功霖 赵卫 | 2012 | 中国介入影像与治疗学2012，9，12： | 13 |
| 3 | ST段抬高型心肌梗死患者中医证型与超敏C反应蛋白、N端脑钠肽前体水平的相关性研究显示文摘目的探讨急性ST段抬高型心肌梗死(STEMI)中医证型与超敏C反应蛋白(hs-CRP)、N-末端脑钠肽前体(NT-pro BNP)的相关性。方法将316例STEMI患者及同期接受的60例健康体检者为研究对象。采用酶联免疫吸附法(ELISA)及电化学发光法(ECL)对STEMI患者及健康体检者hs-CRP、NT-pro BNP进行检测比较。将316例STEMI患者进行中医辨证分型,比较各亚组hs-CRP、NT-pro BNP,将所得数据进行统计,分析hs-CRP、NT-pro BNP与STEMI中医证型相关性。结果 STEMI患者hs-CRP、NT-pro BNP水平显著高于高于健康体检者(P<0.05),且STEMI患者各亚组均显著高于高于健康体检者(P<0.05)。STEMI患者各中医证型间hs-CRP、NT-pro BNP水平从高到低依次为:气虚血瘀型、痰瘀互阻型、寒凝心脉型、气阴两虚型、心肾阳虚型、心阳痹阻型。无法进行分型的20例患者hs-CRP、NT-pro BNP水平与痰瘀互阻型比较,无显著差异(P>0.05)。结论 STEMI中医证型与hs-CRP、NT-pro BNP密切相关,分析hs-CRP、NT-pro BNP有助于中医辨证客观化、揭示证的本质。 | 冷唯 | 2016 | 湖北中医药大学学报2016，18，6： | 7 |
| 4 | Anisodamine accelerates spontaneous passage of single symptomatic bile duct stones ≤ 10 mm显示文摘AIM:To investigate the rate of spontaneous passage of single and symptomatic common bile duct(CBD)stones≤10 mm in diameter in 4 wk with or without a2-wk course of anisodamine.METHODS:A multicenter,randomized,placebocontrolled trial was undertaken.A total of 197 patients who met the inclusion criteria were enrolled.Ninetyseven patients were assigned randomly to the control group and the other 100 to the anisodamine group.The anisodamine group received intravenous infusions of anisodamine(10 mg every 8 h)for 2 wk.The control group received the same volume of 0.9%isotonic saline for 2 wk.Patients underwent imaging studies and liver-function tests every week for 4 wk.The rate of spontaneous passage of CBD stones was analyzed.RESULTS:The rate of spontaneous passage of CBD stones was significantly higher in the anisodamine group than that in the control group(47.0%vs 22.7%).Most(87.2%,41/47)stone passages in the anisodamine group occurred in the first 2 wk,and passages in the control group occurred at a comparable rate each week.Factors significantly increasing the possibility of spontaneous passage by univariate logistic regression analyses were stone diameter(<5 mm vs≥5 mm and≤10 mm)and anisodamine therapy.Multivariate logistic regression analyses revealed that these two factors were significantly associated with spontaneous passage.CONCLUSION:Two weeks of anisodamine administration can safely accelerate spontaneous passage of single and symptomatic CBD stones≤10 mm in diameter,especially for stones<5 mm. | Jun Gao Xue-Mei Ding Shan Ke Yi-Ming Zhou Xiao-Jun Qian Rui-Liang Ma Chun-Min Ning Zong-Hai Xin Wen-Bing Sun | 2013 | World Journal of Gastroenterology2013，19，39： | 7 |
| 5 | 山莨菪碱联合阿托伐他汀对急性下壁心肌梗死行直接PCI患者心肌灌注水平的影响显示文摘目的探讨预防性冠状动脉内应用不同剂量山莨菪碱联合阿托伐他汀对急性下壁心肌梗死(acute inferior myocardial infarction,AIMI)行直接经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)患者心肌灌注水平的影响及其可能的炎症机制。方法选取本院2014年4月至2015年11月AIMI发病12小时内行直接PCI的患者112例为研究对象,将其按照1∶1比例随机分为四组:A组(阿托伐他汀20 mg+山莨菪碱1500μg),B组(阿托伐他汀20 mg+山莨菪碱3000μg),C组(阿托伐他汀40 mg+山莨菪碱1500μg),D组(阿托伐他汀40 mg+山莨菪碱3000μg),每组各28例。以术后心肌梗死溶栓(thrombolysis in myocardial infarction,TIMI)心肌灌注分级(TIMI myocardial perfusion grades,TMPG)(TMPG)3级的比例作为主要终点。以肌酸激酶同工酶-MB(creatine kinase-MB,CK-MB)、心脏肌钙蛋白I(cardiac troponi,cTnI)峰值水平评估心肌梗死面积。术前及术后24 h各检查1次炎性反应标志物[高敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、白介素-6(interleukin,IL-6)、P选择素、细胞间黏附分子-1(intercellular adhesion molecule-1,ICAM-1)]。入院时及术后90 min各查心电图1次,记录各组患者完全ST段回落(ST-segment resolution,STR)的情况。随访术后30 d及6个月的主要不良心血管事件。探讨有助于直接PCI术后达TMPG 3级的独立因素,阐明山莨菪碱和阿托伐他汀各自的主效应及交互作用。结果直接PCI术后,D组TMPG 3级患者占比显著高于其他三组(P=0.011),TIMI 3级和完全STR的患者占比均有高于其他组的趋势(P分别为0.073和0.051)。D组患者CK-MB、cTnI峰值水平最低,术后3 d左室射血分数(left ventricular ejection fraction,LVEF)最高。山莨菪碱联合阿托伐他汀具有降低CK-MB峰值水平的协同效应(P=0.001),仅具有升高LVEF的协同效应趋势(P=0.284)。给予山莨菪碱后,四组患者术中、术后均未见严重的过缓/过速心律失常发生。血栓积分3~4分、冠状动脉舒张压降低均为AIMI患者行直接PCI术后心肌灌注不良(表现为TMPG <3级)的独立危险因素(P_均<0.05),而预防性冠状动脉内应用山莨菪碱3000μg则为其保护性因素(P <0.05)。行直接PCI术后24 h,D组患者hs-CRP、IL-6、P选择素、ICAM-1水平均显著低于其他三组(P均<0.05)。各组患者随访30 d及6个月的主要不良心脏事件发生率均无显著差异(P均>0.05)。结论预防性冠状动脉内应用高剂量山莨菪碱(3000μg)联合高剂量阿托伐他汀(40 mg)可更有效地改善AIMI患者行直接PCI术后的心肌灌注水平,减少无复流的发生,缩小梗死面积,改善患者的临床预后。 | 李伟 范卫泽 傅向华 郝国贞 姜云发 谷新顺 | 2018 | 中国医学前沿杂志(电子版)2018，10，12： | 3 |
| 6 | Optimizing prevention of contrast-induced acute kidney injury in type 2 diabetic patients with at least moderate renal impairment显示文摘Diabetes is a key risk factor for chronic kidney disease,1 and patients with type 2 diabetes and coronary artery disease are at high risk of cardiovascular events particularly when renal function is impaired.2-4 Decision on how and when to proceed to coronary revascularization in an individual type 2 diabetic patient should be based on the extent of coronary disease,ischemic burden, ventricular function, as well as co-morbidities (e.g., renal insufficiency). | SHEN Wei-feng | 2012 | Chinese Medical Journal2012，，19： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员