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| 1 | Clinical features of hepatic angiomyolipoma显示文摘BACKGROUND:Hepatic angiomyolipoma(HAML)is a rare hepatic mesenchymal tumor.This study was designed to explore its clinical features. METHODS:Clinical data from 26 patients who had been pathologically confirmed with HAML and had received surgical resection at our hospital were analyzed retrospectively. RESULTS:HAML was seen more frequently in females(18/26) in this series,and most of the patients presented no significant symptoms except for one who had a spontaneous rupture hemorrhage.Serum alpha-fetoprotein(AFP),carbohydrate antigen 19-9(CA19-9)and carcinoembryonic antigen(CEA) were negative in all patients.Imaging presentations were diverse.Pre-operative diagnosis was made in only 3 patients Pathological study showed that the tumor was composed of adipose tissue,smooth muscle and blood vessels in different proportions.One patient showed hepatic vessel invasion HMB-45 immunohistochemical staining was positive in all tumors.All patients underwent surgical resection without significant complications.Except for one patient who died 14 months after operation because of recurrent disease,no tumor recurrence was observed in the remaining 25 patients during a 2-3 years follow-up. CONCLUSIONS:Pre-operative diagnosis of HAML is difficult.There are potential risks of spontaneous rupture and malignant transformation.Surgical resection is the treatment of choice for HAML. | Zhou, Yan-Ming Li, Bin Xu, Feng Wang, Bin Li, Dian-Qi Zhang, Xiao-Feng Liu, Peng Yang, Jia-Mei | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，3： | 9 |
| 2 | Diagnostic analysis of hepatic angiomyolipoma显示文摘BACKGROUND: Hepatic angiomyolipoma (HAML) is a rare tumor containing a variable amount of fat, vessels and smooth muscle. We report the image findings on ultra- sonography and computed tomography ( CT) of huge HAML. METHOD; The clinical, imaging and pathological data of a case of HAML were retrospectively collected and ana- lyzed. RESULTS; A huge heterogeneous hyperecho mass with anecho and hypoecho areas inside was found in the left he- patic lobe on ultrasonography. Color Doppler showed blood flow and arterial spectrum in it. CT scan showed a huge heterogeneous solid mass in the left lobe of the liver, with a low density and hypervascular area in arterial phase. The serum tumor marks were all negative. Ultrasound- guided biopsy was taken twice before resection and both showed necrosis tissue and reaction of inflammatory cells. Postoperative pathological results showed that the tumor was composed of epithelioid smooth muscle cells, thick- walled blood vessels and a few adipose cells with necrosis. The immunohistochemistry results showed appea-rance of typical HAML, with HMB-45 positive and alpha fetopro- tein (AFP) negative. CONCLUSIONS: Preoperative diagnosis of HAML relies on combination of CT, MRI and ultrasonography. Our case of HAML showed heterogeneous hyperecho image on ultra- sonography. Ultrasound-guided biopsy combined with morphological manifestation and specimen examination for HMB-45 may be helpful in the diagnosis of HAML. | Tian-An Jiang, Qi-Yu Zhao, Miao-Yan Chen, Li-Jun Wang and Jian-Yang Ao Hangzhou, China Department of Ultrasonography, First Affiliated Hos- pital , Distance Education Center and Department of Pathology, First Affiliated Hospital , Zhejiang University School of Medicine, Hangzhou 310003, China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，1： | 4 |
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