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| 1 | 越橘属植物的研究进展显示文摘本文综述了越橘属植物的富含的类黄酮等化学成分,以及其抗菌、抗癌防癌、抗氧化、抗糖尿病、预防心血管疾病等多方面的药理活性。 | 刘会灵 曹建新 | 2009 | 天然产物研究与开发2009，21，5： | 21 |
| 2 | Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats显示文摘AIM:To evaluate the ameliorative effect of naringenin(NG)during ulcerative colitis(UC)in rats.METHODS:Rats were treated with three different doses(25,50 and 100 mg/kg per day)of NG and a single dose of mesalazine(MES,300 mg/kg per day)for seven days prior to ulcerative colitis induction by4%acetic acid(AA).Twenty four hours after AA rectal administration,animals were scarified and the colonic tissues were dissected.Colonic mucus content was estimated using Alcian blue dye binding technique.In colon tissues,levels of total glutathione sulphadryls(T-GSH),non-protein sulphadryls(NP-SH)and thiobarbituric acid reactive substances(TBARS)were evaluated.The activities of the antioxidant enzymes,catalase(CAT)and superoxide dismutase(SOD)were measured.Concentrations of nucleic acids(DNA and RNA)and total protein were also estimated in colon tissues.Colonic levels of tumor necrosis factor-(TNF-),interleukin-1(IL-1),interleukin-6(IL-6),prostaglandin E2(PGE2)and nitric oxide(NO)were estimated.In cross section of colitis tissue the histopathological changes were observed.RESULTS:Colonic mucus content was decreased in AA compared to controls(587.09±65.59 mg/kg vs941.78±68.41 mg/kg,P<0.001).AA administration markedly reduced T-GSH(5.25±0.37 nmol/L vs 3.04±0.24 nmol/L,P<0.01),NP-SH(3.16±0.04 nmol/L vs 2.16±0.30 nmol/L,P<0.01),CAT(6.77±0.40 U/mg vs 3.04±0.2 U/mg,P<0.01)and SOD(3.10±0.11U/mg vs 1.77±0.18 U/mg,P<0.01)while TBARS,TNF-,IL-1,IL-6,PGE2 and NO levels(15.09±3.84nmol/L vs 59.90±16.34 nmol/L,P<0.01;113.56±1.91 pg/mg vs 134.24±4.77 pg/mg,P<0.01;209.20±36.38 pg/mg vs 422.19±31.47 pg/mg,P<0.01;250.83±25.09 pg/mg vs 638.58±115.9 pg/mg,P<0.01;248.19±36.98 pg/mg vs 541.74±58.34 pg/mg,P<0.01 and 81.26±2.98 mmol/g vs 101.90±10.73 mmol/g,P<0.001)were increased in colon of rats with UC compared controls respectively.Naringenin supplementation,significantly and dose dependently increased the colonic mucus content.The elevated TBARS levels were significantly decreased(39.35±5.86nmol/L,P<0.05;26.74±3.17 nmol/L,P<0.01 nmol/L and 17.74±2.69 nmol/L,P<0.01)compared to AA(59.90±16.34 nmol/L)group while the decreased levels of T-GSH and NP-SH and activities of CAT and SOD found increased by NG treatments in dose dependent manner.The decreased values of nucleic acids and total protein in AA group were also significantly(P<0.01)increased in all three NG supplemented groupsrespectively.NG pretreatment inhibited the TNF-levels(123.76±3.76 pg/mg,122.62±3.41 pg/mg and121.51±2.61 pg/mg vs 134.24±4.78 pg/mg,P<0.05)compared to AA group,respectively.Interleukins,IL-1 and IL-6 levels were also decreased in NG50+AA(314.37±16.31 pg/mg and 292.58±23.68 pg/mg,P<0.05)and NG100+AA(416.72±49.62 pg/mg and 407.96±43.87 pg/mg,P<0.05)when compared to AA(352.46±8.58 pg/mg and 638.58±115.98pg/mg)group.Similar decrease(P<0.05)was seen in PGE2and NO values when compared to AA group.The group pretreated with MES,as a reference drug,showed significant(P<0.01)protection against the changes induced in colon tissue by AA administration respectively.CONCLUSION:In present study,NG produced antioxidant and anti-inflammatory effects demonstrating protective effect in inflammatory bowel disease. | Salim S Al-Rejaie Hatem M Abuohashish Maher M Al-Enazi Abdullah H Al-Assaf Mihir Y Parmar Mohammed M Ahmed | 2013 | World Journal of Gastroenterology2013，19，34： | 20 |
| 3 | 食源性天然产物中多糖干预炎症性肠病的研究进展显示文摘多糖类物质是具有生物活性的大分子物质,广泛存在于多种食源性物质中。炎症性肠病对结肠有广泛的损伤作用,并可能破坏免疫系统的动态平衡。尽管药物能够在一定程度上缓解炎症性肠病,但许多临床实践中的药物都有不良反应。研究表明,多糖类物质能有效预防和改善炎症性肠病引起的结肠损伤和免疫系统紊乱。本文主要对食源性天然产物中多糖类物质干预炎症性肠病的研究进展和发挥保护作用的相关分子机制进行综述,以期为预防炎症性肠病和营养干预机制的进一步研究提供参考。 | 陈国伟 邱春红 田灵敏 白卫滨 | 2019 | 食品科学2019，40，13： | 11 |
| 4 | 天然药物中抗氧化成分研究进展显示文摘自由基是人体进行生命活动时所产生的一种活性分子,在正常代谢过程中,自由基具有调节细胞间的信号传递和细胞生长、抑制病毒和细菌的作用;但如果体内自由基过多,将导致细胞和组织器官损伤,并诱发各种疾病、加速机体衰老。正常情况下,机体通过自我产生或者从外界摄取的方式获得超氧化物歧化酶(SOD)、过氧化氢酶(CAT)等内源性抗氧化剂和维生素、微量元素等外源性抗氧化剂,这些抗氧化剂对自由基的损害构成了一个天然的屏障。 | 于腾飞 刘屏 | 2009 | 中国中医药信息杂志2009，16，7： | 11 |
| 5 | 植物多糖抗炎活性机制及其构效关系研究进展显示文摘植物多糖是多糖的主要来源之一,具有多种重要的药理活性功能。本文综述了近年来植物多糖在抗炎活性方面的相关研究进展,重点从抗氧化应激、调节细胞因子分泌、调控中性粒细胞、改善肠道菌群和肠黏膜屏障等四个视角阐述了其抗炎机制。进一步分析了植物多糖的平均分子量、单糖组成和糖苷键类型、主链与支链、化学修饰及高级结构与抗炎活性之间的构效关系,最后对植物多糖抗炎活性的研究进行了展望和总结,为其在抗炎药物、食品上的开发应用奠定了理论基础。 | 刘闯 吴现华 刘静 张仁堂 | 2022 | 食品工业科技2022，43，11： | 10 |
| 6 | 响应面法优化大豆纤维蔓越莓饼干配方研究显示文摘以低筋面粉、大豆纤维粉、蔓越莓为主要原料,探究大豆纤维蔓越莓饼干的最佳配方。在单因素试验明确面料质量比、油糖质量比、蔓越莓添加量对大豆纤维蔓越莓饼干感官评分影响的基础上,按Box-Behnken设计试验,采用响应面分析法建立二阶多项式非线性回归方程和数值模型,并优化大豆纤维蔓越莓饼干配方。结果表明,大豆纤维蔓越莓饼干最佳配方:面料质量比为4.38∶1,油糖质量比为1.59∶1,蔓越莓添加量15.90 g,优化后验证试验的感官评分为91.65分(n=3),与预测值92.91分接近,偏差为1.37%,可以用于大豆纤维蔓越莓饼干配方的理论预测。此配方下的饼干不仅具有良好的酥脆性,还兼具有大豆纤维、蔓越莓和黄油的风味,品质最优。 | 张臣飞 夏秋良 尹乐斌 赵良忠 周晓洁 雷志明 杨莹 | 2017 | 食品研究与开发2017，38，3： | 9 |
| 7 | 远志橙皮复合饮料研制及抗运动性疲劳作用研究显示文摘以远志多糖和橙皮苷为原料,研制远志橙皮复合饮料,并考察其抗运动性疲劳作用。采用单因素实验与响应面设计优化该饮料的最佳组分配比,同时利用动物实验观察其体内活性。实验结果表明,该复合饮料的最佳配方为:远志多糖与橙皮苷的溶液体积比1:1、蔗糖用量4.5%、柠檬酸用量0.25%、羧甲基纤维素钠用量0.41%,制得的饮料浅黄透亮、色泽均匀,混有远志与橙皮香味,酸甜适中,且静置后未有明显沉淀与分层,感官评分(88.53±0.64)分。动物实验结果表明:与空白对照组相较,不同剂量的该复合饮料均可明显延长大鼠的游泳力竭时间(P<0.05或P<0.01),加快运动时体内乳酸代谢(P<0.01),并显著减少尿素氮的生成(P<0.01)。远志橙皮复合饮料具有较好的抗运动性疲劳功效。 | 岳天翔 黄冬琴 邓云兵 | 2020 | 食品科技2020，45，12： | 4 |
| 8 | Antioxidant Activity of Bioactive Polysaccharides Isolated from Natural Sources显示文摘Some polysaccharides isolated from natural sources show various important biological activities including antitumor,and are known to act as immunomodulators and specifically,antioxidants.These activities are strongly affected by their chemical structures and chain conformations.This article reviewed the current literature on the antioxidant properties of some important bioactive polysaccharides isolated from natural sources,including plants,microorganisms,algae and animals.Possible antioxidant mechanisms of polysaccharides are also summarized.The continuing evaluation of bioactive polysaccharides provides a unique opportunity for the discovery of novel pharmaceuticals and healthcare products that exhibit beneficial antioxidant properties. | Hui Wang Xia Zhang and Fusheng Cheng | 2011 | Journal of Animal Science and Biotechnology2011，2，4： | 1 |
| 9 | 天然药物抗氧化成分改善微循环的临床分析显示文摘微循环是指微(细)动脉和微(细)静脉之间微血管的血液循环。微循环发生障碍,可能导致人体器官功能低下,引起一系列疾病。自由基(FR)在人体正常代谢过程中参与调节细胞间的信号传递、细胞生长,抑制病毒和细菌的过程,如过多将导致细胞和组织器官损伤,诱发中风、老年性痴呆、糖尿病、动脉粥样硬化等。天然药物中有很多药物能清除人体过量自由基的抗氧化成分,这些天然的抗氧成分很多又对微循环有着很好的改善作用,因此对人体疾病起到不错的预防和治疗作用。笔者参考文献资料对天然药物抗氧化成分改善微循环的进展汇总如下。 | 周春玲 | 2013 | 临床合理用药杂志2013，6，27： | 0 |
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