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| 1 | Current status of ultrasound-guided surgery in the treatment of breast cancer显示文摘The primary goal of breast-conserving surgery(BCS) is to obtain tumour-free resection margins. Margins positive or focally positive for tumour cells are associated with a high risk of local recurrence, and in the case of tumour-positive margins, re-excision or even mastectomy are sometimes needed to achieve definite clear margins. Unfortunately, tumour-involved margins and re-excisions after lumpectomy are still reported in up to 40% of patients and additionally, unnecessary large excision volumes are described. A secondary goal of BCS is the cosmetic outcome and one of the main determinants of worse cosmetic outcome is a large excision volume. Up to 30% of unsatisfied cosm-etic outcome is reported. Therefore, the search for better surgical techniques to improve margin status, excision volume and consequently, cosmetic outcome has continued. Nowadays, the most commonly used localization methods for BCS of non-palpable breast cancers are wire-guided localization(WGL) and radioguided localization(RGL). WGL and RGL are invasive procedures that need to be performed pre-operatively with technical and scheduling difficulties. For palpable breast cancer, tumour excision is usually guided by tactile skills of the surgeon performing 'blind' surgery. One of the surgical techniques pursuing the aims of radicality and small excision volumes includes intraoperative ultrasound(IOUS). The best evidence available demonstrates benefits of IOUS with a significantly high proportion of negative margins compared with other localization techniques in palpable and non-palpable breast cancer. Additionally, IOUS is non-invasive, easy to learn and can centralize the tumour in the excised specimen with low amount of healthy breast tissuebeing excised. This could lead to better cosmetic results of BCS. Despite the advantages of IOUS, only a small amount of surgeons are performing this technique. This review aims to highlight the position of ultrasoundguided surgery for malignant breast tumours in the search for better oncological and cosmetic outcomes. | José H Volders Max H Haloua Nicole MA Krekel Sybren Meijer Petrousjka M van den Tol | 2016 | World Journal of Clinical Oncology2016，7，1： | 6 |
| 2 | Lactobacillus rhamnosus induces peripheral hypore- sponsiveness in stimulated CD4 T cells via modula- tion of dendritic cell function 显示文摘 | BRAAT H VAN DEN BRANDE J VAN TOL E | 2004 | The American Jour- nal of Clinical Nutrition2004，80，6： | 1 |
| 3 | Non-structural proteins 2 and 3 interact to modify host cell membranes during the formation of the arterivirus replication complex 显示文摘 | Snijder EJ van Tol H Roos N et ol | 2001 | J Gen Virol2001，82，5： | 1 |
| 4 | Non-structural proteins 2 and 3 interact to modify host cell membranes during the formation of the arterivirus replication complex显示文摘 | SNIJDER E J VAN TOL H ROOS N | 2001 | J Gen Virol2001，82，： | 1 |
| 5 | Magnetoelectric Properities of Ferroelectric Rare Earth Molybdates 显示文摘 | Wiegelmann H Ponomarev B K Van Tol J | 1996 | Ferroelectrics1996，183，： | 1 |
| 6 | Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump显示文摘 | Burger H van Tol H Boersma AW | 2004 | Blood2004，104，9： | 1 |
| 7 | Setting future standards for KRAS testing in colorectal cancer显示文摘 | van Krieken H Tol J | 2009 | Pharmacogenomics2009，10，： | 1 |
| 8 | Escherichia coli antibodies in opsonisation and protection against infection显示文摘 | van Dijk WC Verhoef H van Eme-van der Tol ME | 1981 | Journal of Medical Microbiology1981，14，4： | 1 |
| 9 | The arterivirus replicase is the only viral protein required for genome replication and subgenomic mRNA transcription显示文摘 | Molenkamp R van Tol H Rozier B C | 2000 | J Gen Virol2000，81，： | 1 |
| 10 | Hepatic lipase and lipoprotein lipase are not major determinants of the low density lipoprotein subclass pattern in human subjects with coronary heat disease显示文摘 | Jansen H Hop W Van Tol A | 1994 | Atherosclerosis1994，107，1： | 1 |
| 11 | Imatinib mesylate(STI571) is a substrate for the breast cancer resistance protein(BCRP)/ABCG2 drug pump显示文摘 | Burger H van Tol H Boersma AW | 2004 | Blood2004，104，9： | 1 |
| 12 | Differences in early lin- eage segregation between mammals显示文摘 | Kuijk EW Du Puy L Van Tol H | 2008 | Dev Dyn2008，237，： | 1 |
| 13 | Effects of follicular cells and FSH on the resumption of meiosis is in equine oocytes matured in vitro显示文摘 | TREMOLEDA J I THARANIT T VAN TOL H T | 2003 | Reproduction2003，125，4： | 1 |
| 14 | Cloning of a human dopamine D4 receptor gene with high affinity for the antipsychotic clozapine显示文摘 | Van Tol H H M Bunzow J R Guan H C | 1991 | Nature1991，350，： | 1 |
| 15 | Multiple dopamine D4 receptor variants in the human population显示文摘 | Van Tol H H M Wu C M Guan H C | 1992 | Nature1992，358，： | 1 |
| 16 | Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump 显示文摘 | Burger H Van Tol H Boersma AW | 2004 | Blood2004，104，： | 1 |
| 17 | Repellence of the Red Bud Borer Resseliella oculiperda from Grafted Apple Trees by Impregnation of Rubber Budding Strips with Essential Oils 显示文摘 | VAN TOL R SWARTS H J VAN DER LINDEN A et 01 | 2007 | Pest Management Science2007，63，5： | 1 |
| 18 | Expression of growth differentiation factor9(GDF9),bone morphogenetic protein 15 (BMP15), and BMP receptors in the ovaries of goats 显示文摘 | Silva J R V Van den Hurk R Van Tol H T A | 2005 | Molecular Reproduction and Development2005，70，1： | 1 |
| 19 | Frictional forces required for unrestrained locomotion in dairy cattle显示文摘 | Van DER TOL P P METZ J H NOORDHUIZEN-STASSEN E N | 2005 | J Dairy Sci2005，88，2： | 1 |
| 20 | Lactobacillus rhamnosus induces peripheral hyporesponsiveness in stimulated CD4+T cells via modulation of dendritic cell function显示文摘 | Braat H van den Brande J van Tol E | 2004 | Am J Clin Nutr2004，80，6： | 1 |
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