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| 1 | Effect of hepatic artery embolization on liver hypertrophy response in a rabbit liver VX2tumor model显示文摘BACKGROUND:Portal vein embolization not only induces hypertrophy of the non-embolized liver,but also enhances tumor growth.The latter could be prevented by embolizing the hepatic arteries supplying the tumor-bearing liver segments.This study aimed to determine the effects of transcatheter arterial embolization(TAE)on tumor volume and liver regeneration in a rabbit VX2 tumor model.METHODS:Twenty-three rabbits underwent subcapsular tumor implantation with a VX2 tumor.Two weeks after implantation,18 rabbits were used for TAE experiments,5were for sham controls.Tumor response and liver regeneration response of the embolized cranial and non-embolized caudal liver lobes were assessed by CT volumetry,liver to body weight index,and the amount of proliferating hepatocytes.RESULTS:All super-selective arterial tumor embolization procedures were performed successfully.Despite embolization,the tumor volume increased after an initial steady state.The tumor volume after embolization was smaller than that of the sham group,but this difference was not significant.Massive necrosis of the tumor,however,was seen after embolization,without damage of the surrounding liver parenchyma.There was a significant atrophy response of the tumor bearing cranial lobe after super-selective arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized,caudal lobe.This regeneration response was confirmed histologically by a significantly higher number of proliferating hepatocytes on the Ki-67 stained slides.CONCLUSIONS:Super-selective,bland arterial coil embolization causes massive necrosis of the tumor,despite increase of volume on CT scan.Atrophy of the tumor bearing liver lobe is seen after arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized lobe,despite absence of histological damage of the tumor-surrounding liver parenchyma. | Krijn P van Lienden Lisette T Hoekstra Jessica D van Trigt Joris J Roelofs Otto M van Delden Thomas M van Gulik | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 2 |
| 2 | Peritoneal sclerosis in chronic peritoneal dialysis patients: analysis of clinical presentation, risk factors and peritoneal transport kinetics显示文摘 | Hendriks PMEM Ho-dac-Pannekeet MM van Gulik T | 1997 | Perit Kial Int1997，17，： | 1 |
| 3 | Palliative man- agement of hilar cholangiocarcinoma显示文摘 | Singhal D van Gulik T M Gouma D J | 2005 | Surg Oncol2005，14，2： | 1 |
| 4 | Incidence, risk factors, and treatment of pancreatic leakage after pancreaticoduodenectomy: drainage versus resection of the pancreatic remnant显示文摘 | van Berge Henegouwen M I De Wit L T Van Gulik T M | 1997 | J Am Coll Surg1997，185，1： | 1 |
| 5 | A quantitative his- tochemical procedure for the demonstration of purine nucle- oside phosphorylase activity in rat and human liver using Tetranitro BT and xanthine oxidase as auxiliary enzyme 显示文摘 | Frederiks WM Bosch KS Van Gulik T | 1993 | Histochem J1993，25，1： | 1 |
| 6 | IL-10 attenuates hepatic i/r injury and promotes hepato cyte proliferation显示文摘 | Dinant S Vetelainen R L Florquin S van Vliet A K van Gulik T M | 2007 | J Surg Res2007，141，： | 1 |
| 7 | Multidisciplinary management of hilar cholangiocarcinoma(Klatskin tumor):extended resection is associated with improved survival 显示文摘 | VAN GULIK T M KLOEK J J RUYS A T | 2011 | Eur J Surg Oncol2011，37，1： | 1 |
| 8 | Internal drainage of infected pancreatic pseudocysts: safe sorry显示文摘 | Boerma D van Gulik T M Obertop H | 1999 | Dig Surg1999，16，6： | 1 |
| 9 | Prevention of implantation metastases after resection of proximal bile duct tumours with pre-operative low dose radiation therapy显示文摘 | MF Gerhards D Gonzalez Gonzalez H ten Hoopen-Neumann TM van Gulik T Th de Wit DJ Gouma | 2000 | European Journal of Surgical Oncology2000，，5： | 1 |
| 10 | Vascular occlusion techniques during liver resection 显示文摘 | Van Gulik T M De Graaf W Dinant S | 2007 | Dig Surg2007，24，4： | 1 |
| 11 | Evaluation of morbidity and mortality after resection for hilar cholangiocarcinoma-a single center experience显示文摘 | Gerhards M F van Gulik T M de Wit L T | 2000 | Surgery2000，127，4： | 1 |
| 12 | Seventy -two hour preservation of the canine liver by machine perfusion 显示文摘 | Pienaar BH Lindell SL Van Gulik T | 1990 | Transplantation1990，49，25： | 1 |
| 13 | Evaluation of morbidity and mortlity after resection for hilar cholangiocarcinoma - -a single center experience 显示文摘 | Gerhards MF van Gulik TM de Wit LT e t a l | 2000 | Surgery2000，127，4： | 1 |
| 14 | Improved outcome of resectionof hilar cholangiocarcinoma(Klatskin tumor)显示文摘 | Dinant S Gerhards M F Rauws E A Busch O R Gou-ma D J van Gulik T M | 2006 | AnnSurg Oncol2006，13，： | 1 |
| 15 | Results of postoperative radio-therapy for resectable hilar cholangiocarcinoma显示文摘 | Gerhards M F van Gulik T M Gonzalez Gonzalez D Rauws E A Gouma D J | 2003 | World J Surg2003，27，： | 1 |
| 16 | Anastomosis of Riolan revisited:the meandering mesenteric artery显示文摘 | VAN GULIK T M SCHOOTS I | 2005 | Arch Surg2005，140，12： | 1 |
| 17 | Large animal models of fulminant hepatic failure in artificial and bioartificial liver support research显示文摘 | VAN DE KERKHOVEA M P HOEKSTRA R VAN GULIK T M | 2004 | Biomaterials2004，25，9： | 1 |
| 18 | Bacterial translocation from the biliary tract to blood and lymph in rats with obstructive jaundice 显示文摘 | Karsten T M van Gulik T M Spanjaard L | 1998 | J Surg Res1998，74，2： | 1 |
| 19 | Palliative management of hilar cholangiocarcinoma显示文摘 | Singhal D van Gulik T M Gouma D J | 2005 | Surg Oncol2005，14，2： | 1 |
| 20 | Multidisciplinary management of hilar cholangiocarcinoma (Klatskin tumor): extended resection is associated with improved survival 显示文摘 | van Gulik T M Kloek J J Ruys A T | 2011 | Eur J Surg Oncol2011，37，1： | 1 |
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