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| 1 | Gastroenterology case report of mesalazine-induced cardiopulmonary hypersensitivity显示文摘Mesalazine is a 5-aminosalicylic acid derivative that has been widely used to treat patients with inflammatory bowel disease. Accumulating evidence indicates that mesalazine has a very low rate of adverse drug reactions and is well tolerated by patients. However, a few cases of pulmonary and cardiac disease related to mesalazine have been reported in the past, though infrequently, preventing clinicians from diagnosing the conditions early. We describe the case of a 32-yearold man with ulcerative colitis who was admitted with a two-month history of persistent fever following mesalazine treatment initiated 14 mo earlier. At the time of admission, mesalazine dose was increased from 1.5 to 3.0 g/d, and antibiotic therapy was started with no improvement. Three weeks after admission, the patient developed dyspnea, non-productive cough, and chest pain. Severe eosinophilia was detected in laboratory tests, and a computed tomography scan revealed interstitial infiltrates in both lungs, as well as a large pericardial effusion. The bronchoalveolar lavage reported a CD4/CD8 ratio of 0.5, and an increased eosinophil count. Transbronchial biopsy examination showed a severe eosinophilic infiltrate of the lung tissue. Mesalazine-induced cardiopulmonary hypersensitivity was suspected after excluding other possible etiologies. Consequently, mesalazine treatment was suspended, and corticosteroid therapy was initiated, resulting in resolution of symptoms and radiologic abnormalities. We conclude that mesalazine-induced pulmonary and cardiac hypersensitivity should always be considered in the differential diagnosis of unexplained cardiopulmonary symptoms and radiographic abnormalities in patients with inflammatory bowel disease. | José Ferrusquía Isabel Pérez-Martínez Ricardo Gómez de la Torre María Luisa Fernández-Almira Ruth de Francisco Luis Rodrigo Sabino Riestra | 2015 | World Journal of Gastroenterology2015，21，13： | 5 |
| 2 | Toll‐Like Receptors and Cytokines are Upregulated during H elicobacter pylori Infection in Children显示文摘 | Hugo Lagunes‐Servin Javier Torres Carmen Maldonado‐Bernal Martha Pérez‐Rodríguez Sara Huerta‐Yépez Armando Madrazo de la Garza Leopoldo Mu?oz‐Pérez Lourdes Flores‐Luna Guillermo Ramón‐García Margarita Camorlinga‐Ponce | 2013 | Helicobacter2013，，6： | 2 |
| 3 | Protective effect of carnosol on CC14-induced acute liver damage in rats 显示文摘 | Sotelo-Felix J I Martinez-Fong D Muriel De la Torre P | 2002 | Eur J Gastroenterol Hepatol2002，14，9： | 1 |
| 4 | Identification of reciprocal adhesion genes in pathogenic and non-pathogenic Pseudomonas显示文摘 | Duque E de la Torre J Bernal P | | 0，，01： | 1 |
| 5 | Histogram concavity analysis as an aid in threshold seleetion显示文摘 | Ronsenfeld De La Torre P | 1983 | IEEE Transactions on Systems Man Cybernetics1983，13，： | 1 |
| 6 | Molecular identification of new varieties of Nierembergia linariaefolia (Graham), a native Argentinean ornamental plant 显示文摘 | Escandon A S Zelener N de la Torre M P | 2007 | J Appl Genet2007，48，2： | 1 |
| 7 | Urokinase in the treatment of complicated pleural effusion显示文摘 | Cerezal Garrido LJ Oyaguez Ugidos P de La Torre Santos S | 2001 | An Esp Pediatr2001，55，3： | 1 |
| 8 | Enhanced cooperative absorption and up-conversion in Yb^3+ doped YAG nanophosphors 显示文摘 | Diaz Torres L A Rosa E De la Salas P | 2005 | Optical Materials2005，27，： | 1 |
| 9 | Host cells in the spiral canal of Taenia solium (Cestoda) cysticerci显示文摘 | De la Torre P Merchant MT Willms K | 1998 | J Parasitol1998，84，： | 1 |
| 10 | Mobilehealth applications for the most prevalent conditions by the WorldHealth Organization: review and analysis 显示文摘 | Martinez - P^rez B de la Torre - Diez I L6pez - Coronado M | 2013 | J Med Internet Res2013，15，6： | 1 |
| 11 | Role of structural factors in the nonlinear optical properties ofphthalocyanines and related compounds显示文摘 | DE LA TORRE G’ VAZQUEZ P AGQ-LOPEZ F | 2004 | Chem Rev2004，104，： | 1 |
| 12 | TOX is required for development of the CD4 T cell lineage gene program 显示文摘 | Aliahmad P Kadavallore A de la Torre B | 2011 | J lmmunol2011，187，11： | 1 |
| 13 | Relational Quality : Managing Trust in Corporate Alliances显示文摘 | Arino A Jose De La Torre Ring P S | 2001 | California Management Review2001，44，： | 1 |
| 14 | Abdominoplasty repair for abdominal wall hernias显示文摘 | Robertson J D de la Torre J I Gardner P M | 2003 | Ann Plast Surg2003，51，： | 1 |
| 15 | Influence of ceria loading on the NOx storage and reduction performance of model Pt-Ba/A1203 NSR catalyst显示文摘 | Pereda-Ayo B De La Torre U Gonzilez-Marcos M P | 2015 | Catalysis Today2015，241，： | 1 |
| 16 | Hepatic stellate cells (HSC): architects of hepatic fibrosis显示文摘 | Solis-Herruzo JA de la Torre P Munoz-Yague MT | 2003 | Rev Esp Enferm Dig2003，95，： | 1 |
| 17 | Shared dependence on the DNA-binding factor TOX for the development of lymphoid tissue-inducer cell and NK cell lineages显示文摘 | Aliahmad P de la Torre B Kaye J | 2010 | Nat Immunol2010，11，10： | 1 |
| 18 | 显示文摘 | TORRE G DE LA VAZQUEZ P AGULLO-LOPEZ F | 2004 | Chem Rev2004，104，： | 1 |
| 19 | Acute Mycoplasma pneumoniae infection-associated opsoclonus-myoclonus-ataxia syndrome显示文摘 | Huici M de la Torre N P é rez-Due(n)as B | 2013 | An Pediatr (Barc)2013，79，6： | 1 |
| 20 | Modulation of rate of onset and intensity of drug effects reduces abuse potential in healthy males显示文摘 | Roset P Farre M de la Torre R | 2001 | Drug Alcohol Depend2001，64，： | 1 |
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